CN102085292A - Medicament for treating chronic pelvic inflammation - Google Patents

Abstract

The invention discloses a Chinese medicine composition for treating chronic pelvic inflammation. The composition is prepared from the following raw material medicines in parts by weight: 30-50 parts of rhizoma smilacis glabrae, 40-60 parts of golden cypress, 70-90 parts of cockscomb, 80-100 parts of saururus chinensis, 80-100 parts of rhizoma corydalis and 60-80 parts of moutan bark. The Chinese medicine has the effects of clearing heat, detoxifying, dehumidifying, eliminating stasis, stopping pains, and the like and has the advantages of obvious effect, convenience for taking and no toxic and side effects while being used for treating chronic pelvic inflammation. The invention also discloses a preparation method of the Chinese medicine composition.

Description

A kind of medicine for the treatment of chronic pelvic inflammatory disease

Technical field

The present invention relates to the pharmaceutical preparations technology field, relate to a kind of pharmaceutical composition for the treatment of chronic pelvic inflammatory disease and preparation method thereof or rather.

Background technology

Chronic pelvic inflammatory disease is the commonly encountered diseases of gynecological, frequently-occurring disease, and the prevalence height reports that according to interrelated data its sickness rate is about 30%～60%, and easily outbreak repeatedly, is a kind of disease that heals than refractory.Its multiple age is 25～40 years old, and sexy in recent years metachromia factor increases, and prevalence is tending towards rising gradually.Estimate according to World Health Organization (WHO), sexually transmitted disease (STD) is spread unchecked and is caused annual newly-increased more than the 300000000 3 thousand ten thousand property patients in the whole world, wherein have 10%～20% will develop into chronic pelvic inflammatory disease, consequently bring a series of families and social problems such as long-term chronic pelvic pain, infertility or ectopic pregnancy.Some experts and scholar claim that chronic pelvic inflammatory disease is the new challenge of this century to WomanHealth.

Because the pathogeny to chronic pelvic inflammatory disease still lacks enough understandings at present, has every year thousands of patient to stay a series of sequela because of can not get in time treating completely.The western medical treatment of pelvic inflammatory disease is at present still with antibiotic, antiinflammatory is main, antibiotic infects comparatively effective to control pelvic inflammatory disease acute stage sensitive bacterial in the Western medicine, but for chronic pelvic inflammation, because tissue adhesionization, the local circulation obstacle, antibiotic is difficult to infiltrate the part and plays a role, relatively poor to fibrous tissue and the connective tissue effect of eliminating inflammatory infiltration, and antibiotic does not possess the adhesion of alleviation and analgesic effect so that obstinate, outbreak repeatedly, and the life-time service antibiotic easily causes fastbacteria and produces and superinfection, so chronic pelvic inflammatory disease is used antibiotic therapy merely, curative effect is not fully up to expectations.Chinese medicine treatment to primary disease in secular clinical practice has accumulated rich experience, has shown the obvious characteristic and the advantage of Chinese medicine primary disease.

Summary of the invention

Purpose of the present invention just provides a kind of pharmaceutical composition of new treatment chronic pelvic inflammatory disease, and this Drug therapy chronic pelvic inflammatory disease curative effect is better, and side effect is little, and safety is good.

Another object of the present invention provides a kind of preparation method of medicine of above-mentioned treatment chronic pelvic inflammatory disease.

The technical solution adopted for the present invention to solve the technical problems is:

A kind of medicine for the treatment of chronic pelvic inflammatory disease, it is made by following raw materials in weight portion medicine:

30～50 parts of Rhizoma Smilacis Glabraes, 40～60 parts of Cortex Phellodendris, 70～90 parts of Flos Celosiae Cristataes,

80～100 parts of Rhizoma Saururi (Herba Saururi)s, 80～100 parts of Rhizoma Corydalis, 60～80 parts of Cortex Moutans.

The weight proportion of each crude drug can be preferably in the said medicine:

35～45 parts of Rhizoma Smilacis Glabraes, 45～55 parts of Cortex Phellodendris, 75～85 parts of Flos Celosiae Cristataes,

85～95 parts of Rhizoma Saururi (Herba Saururi)s, 85～95 parts of Rhizoma Corydalis, 65～75 parts of Cortex Moutans.

The weight proportion of each crude drug is more preferably in the said medicine:

40 parts of Rhizoma Smilacis Glabraes, 50 parts of Cortex Phellodendris, 80 parts of Flos Celosiae Cristataes,

90 parts of Rhizoma Saururi (Herba Saururi)s, 90 parts of Rhizoma Corydalis, 80 parts of Cortex Moutans.

The dosage form of said medicine is selected from tablet, capsule, granule, oral liquid, drop pill.

Said medicine can prepare by the method that comprises following key step:

(1), pulverizes Cortex Moutan: get the Cortex Moutan of described weight portion proportioning, be ground into fine powder, sieve;

(2), extract Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae and Rhizoma Saururi (Herba Saururi): Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae, the Rhizoma Saururi (Herba Saururi) of getting described weight portion proportioning, after adding 8～12 times of weight water logging bubbles, decoct and extract, filter, it is 1.15～1.20 thick paste that extracting solution is concentrated into relative density, be dried to dried cream, pulverize, get extract fine powder 1;

(3), extract Cortex Phellodendri and Rhizoma Corydalis: get described raw materials in weight portion medicine Cortex Phellodendri and Rhizoma Corydalis, the alcohol reflux with 70～90% filters, extracting solution reclaims ethanol, be concentrated into relative density is 1.15～1.20 thick paste, be dried to dried cream, pulverize, get extract fine powder 2;

(4), get the extract fine powder 2 that extract fine powder 1 that Cortex Moutan fine powder, (2) step that (1) step makes makes and (3) step make, add an amount of pharmaceutic adjuvant, perhaps do not add adjuvant, mixing, preparation gets final product.

The used various raw medicinal materials of the present invention are the Chinese crude drug that meets national drug standards regulation.

Compared with prior art, the invention has the beneficial effects as follows: above 6 flavor Chinese medicine composition are not used for the treatment of together the technical scheme of chronic pelvic inflammatory disease in (1) prior art, medicine of the present invention provides a kind of new selection for the chronic pelvic inflammatory disease patient; Show through pharmacodynamics test and toxicological test that (2) it is better that medicine of the present invention is used for the treatment of the chronic pelvic inflammatory disease curative effect of disease, and toxic and side effects is little, safety is good.

The specific embodiment

The present invention is described in further detail below in conjunction with the specific embodiment.

Embodiment 1

The present embodiment medicine is made by following materials of weight proportions medicine:

50 parts of Rhizoma Smilacis Glabraes, 40 parts of Cortex Phellodendris, 75 parts of Flos Celosiae Cristataes,

95 parts of Rhizoma Saururi (Herba Saururi)s, 80 parts of Rhizoma Corydalis, 65 parts of Cortex Moutans.

Embodiment 2

The present embodiment medicine is made by following materials of weight proportions medicine:

30 parts of Rhizoma Smilacis Glabraes, 45 parts of Cortex Phellodendris, 90 parts of Flos Celosiae Cristataes,

100 parts of Rhizoma Saururi (Herba Saururi)s, 85 parts of Rhizoma Corydalis, 80 parts of Cortex Moutans.

Embodiment 3

The present embodiment medicine is made by following materials of weight proportions medicine:

35 parts of Rhizoma Smilacis Glabraes, 60 parts of Cortex Phellodendris, 85 parts of Flos Celosiae Cristataes,

80 parts of Rhizoma Saururi (Herba Saururi)s, 100 parts of Rhizoma Corydalis, 75 parts of Cortex Moutans.

Embodiment 4

The present embodiment medicine is made by following materials of weight proportions medicine:

45 parts of Rhizoma Smilacis Glabraes, 55 parts of Cortex Phellodendris, 70 parts of Flos Celosiae Cristataes,

85 parts of Rhizoma Saururi (Herba Saururi)s, 95 parts of Rhizoma Corydalis, 60 parts of Cortex Moutans.

Embodiment 5

The present embodiment medicine is made by following materials of weight proportions medicine:

40 parts of Rhizoma Smilacis Glabraes, 50 parts of Cortex Phellodendris, 80 parts of Flos Celosiae Cristataes,

90 parts of Rhizoma Saururi (Herba Saururi)s, 90 parts of Rhizoma Corydalis, 80 parts of Cortex Moutans.

The various embodiments described above medicine prepares according to the method that comprises following key step:

(1), pulverizes Cortex Moutan: get the Cortex Moutan of described weight portion proportioning, be ground into fine powder, sieve;

(2), extract Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae and Rhizoma Saururi (Herba Saururi): Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae, the Rhizoma Saururi (Herba Saururi) of getting described weight portion proportioning, after adding 8～12 times of weight water logging bubbles, decoct and extract, filter, it is 1.15～1.20 thick paste that extracting solution is concentrated into relative density, be dried to dried cream, pulverize, get extract fine powder 1;

(3), extract Cortex Phellodendri and Rhizoma Corydalis: get described raw materials in weight portion medicine Cortex Phellodendri and Rhizoma Corydalis, the alcohol reflux with 70～90% filters, extracting solution reclaims ethanol, be concentrated into relative density is 1.15～1.20 thick paste, be dried to dried cream, pulverize, get extract fine powder 2.

(4), get the extract fine powder 2 that extract fine powder 1 that Cortex Moutan fine powder, (2) step that (1) step makes makes and (3) step make, mixing adds pharmaceutic adjuvant again, the medicine of the various different dosage forms of preparation.

Claims (5)

1. medicine for the treatment of chronic pelvic inflammatory disease, it is made by following raw materials in weight portion medicine:

30～50 parts of Rhizoma Smilacis Glabraes, 40～60 parts of Cortex Phellodendris, 70～90 parts of Flos Celosiae Cristataes,

80～100 parts of Rhizoma Saururi (Herba Saururi)s, 80～100 parts of Rhizoma Corydalis, 60～80 parts of Cortex Moutans.

2. according to the medicine of claim 1, it is characterized in that the weight proportion of each crude drug in the described medicine is:

35～45 parts of Rhizoma Smilacis Glabraes, 45～55 parts of Cortex Phellodendris, 75～85 parts of Flos Celosiae Cristataes,

85～95 parts of Rhizoma Saururi (Herba Saururi)s, 85～95 parts of Rhizoma Corydalis, 65～75 parts of Cortex Moutans.

3. according to the medicine of claim 2, it is characterized in that the weight proportion of each crude drug in the described medicine is:

40 parts of Rhizoma Smilacis Glabraes, 50 parts of Cortex Phellodendris, 80 parts of Flos Celosiae Cristataes,

90 parts of Rhizoma Saururi (Herba Saururi)s, 90 parts of Rhizoma Corydalis, 80 parts of Cortex Moutans.

4. according to each described medicine in the claim 1 to 3, it is characterized in that the dosage form of said medicine is selected from tablet, capsule, granule, oral liquid, drop pill.

5. the preparation method of each described medicine in the claim 1 to 3 comprises following key step:

(1), pulverizes Cortex Moutan: get the Cortex Moutan of described weight portion proportioning, be ground into fine powder, sieve;

(2), extract Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae and Rhizoma Saururi (Herba Saururi): Rhizoma Smilacis Glabrae, Flos Celosiae Cristatae, the Rhizoma Saururi (Herba Saururi) of getting described weight portion proportioning, after adding 8～12 times of weight water logging bubbles, decoct and extract, filter, it is 1.15～1.20 thick paste that extracting solution is concentrated into relative density, be dried to dried cream, pulverize, get extract fine powder 1;

(3), extract Cortex Phellodendri and Rhizoma Corydalis: get described raw materials in weight portion medicine Cortex Phellodendri and Rhizoma Corydalis, the alcohol reflux with 70～90% filters, extracting solution reclaims ethanol, be concentrated into relative density is 1.15～1.20 thick paste, be dried to dried cream, pulverize, get extract fine powder 2;

(4), get the extract fine powder 2 that extract fine powder 1 that Cortex Moutan fine powder, (2) step that (1) step makes makes and (3) step make, add an amount of pharmaceutic adjuvant, perhaps do not add adjuvant, mixing, preparation gets final product.