CN102061021B - Method for preparing natural clove extract-containing medical rubber plug used for sterilization and disinfection - Google Patents
Method for preparing natural clove extract-containing medical rubber plug used for sterilization and disinfection Download PDFInfo
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- CN102061021B CN102061021B CN 201010515943 CN201010515943A CN102061021B CN 102061021 B CN102061021 B CN 102061021B CN 201010515943 CN201010515943 CN 201010515943 CN 201010515943 A CN201010515943 A CN 201010515943A CN 102061021 B CN102061021 B CN 102061021B
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- flos caryophylli
- extract powder
- caryophylli extract
- rubber
- vulcanizing agent
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Abstract
The invention provides a natural clove extract-containing medical rubber plug used for sterilization and disinfection, relating to a preparation method of a medical rubber plug. The raw material used by the preparation method of the medical rubber plug contains clove extract powder. In the invention, the clove extract powder is added, so that the prepared rubber plug can realize sterilization and disinfection. Besides, the invention is simple in process and is easy to operate, the raw material cost is low, the vulcanization rate is improved, the raw material usage is reduced, and the performances of products meet the requirements of the national standard.
Description
[technical field]
The present invention relates to a kind of preparation method of medical grade rubber plug.
[background technology]
Current rubber plug is widely used in the medical or medicinal peristome of shutoff; This is because the rubber high resilience; Can produce remarkable sealing, shroud of gas, anti-acupuncture etc. to the content of container; But because tree elastomer receives the pollution of bacterium, plant leaf, pollen etc. inevitably in rubber tapping and the course of processing, cause its composition complicacy, exist impurity such as foreign preteins to cause injection thermal source, clarity and particulate matter etc.; Stay the problem of serious hidden danger to drug safety, the deployment of progressively eliminating common natural plug packing medicine by the time limit has been made by China in nineteen ninety-five.For this reason; National correlation department is from " eight or five " begin period; Through support policies such as encouragement, the research and development of supporting substitute products, technological transformations; Promote medicine and eliminate the common natural plug sacker work of use; State Food and Drug Administration has successively eliminated 13 kinds of antibiotic powder injections such as leucomycin and has used common natural plug packing July 1 calendar year 2001, eliminated biological products, blood products, lyophilize injection antibiotic powder injection on January 1st, 2002 and used common natural plug packing.The present invention is directed to above-mentioned situation, develop a kind of antibacterial rubber plug of Chinese medical extract, this rubber plug belongs to characteristics such as nontoxic, non-stimulated, no burn into is easy to use.
[summary of the invention]
The present invention aims to provide a kind of preparation method of medical grade rubber plug of ability sterilization and disinfection.
A kind of preparation method who contains natural Flos Caryophylli extract sterilization and disinfection medical grade rubber plug of the present invention contains the Flos Caryophylli extract powder in the employed raw material.
The extraction way of described Flos Caryophylli extract powder is:
(1) cloves is cleaned back input Universalpulverizer and be crushed to 50 orders;
(2) crushed material is transported in the multi-function extractor, adds 10 times to the water of mixture quality, regulating extractor pressure is that 0.2MPa, temperature are 30-40 ℃, extracts after 2 hours, leaves standstill 24 hours;
(3) at the middle and upper levels in the extracting solution suction storage tank, make it extractor from top to bottom successively through multistorey strainer mesh, filtered liq;
(4) with in the filtered liq suction vacuum concentration pot, under 4 ℃, vacuum tightness 0.07Mpa, vapor pressure 0.20MPa, concentrate 0.5-1 hour, cloves medicinal extract;
(5) cloves medicinal extract being carried out drying through vacuum spray dehydrator can the Flos Caryophylli extract powder.
Wherein, the mass ratio of described rubber and Flos Caryophylli extract powder is preferably 100: 0.2-0.7.Preferred mass ratio is 100: 0.4 or 100: 0.6.
In a preferred embodiment, described method is after rubber and Flos Caryophylli extract thing powder are mixed, to add vulcanizing agent and promoting agent, to be mixedly carries out mixing sulfuration after evenly and die-cut cleaning gets final product.
In a preferred embodiment, the mass fraction of the mixture of described rubber and Flos Caryophylli extract powder and vulcanizing agent, promoting agent is:
100 parts in the mixture of rubber and Flos Caryophylli extract powder
Vulcanizing agent 1-2 part
Promoting agent 1-2 part.
Wherein, can further preferably make mixture and the vulcanizing agent of described rubber and Flos Caryophylli extract powder, the mass fraction of promoting agent be:
100 parts in the mixture of rubber and Flos Caryophylli extract powder
1 part of vulcanizing agent
1 part of promoting agent.
Above-mentioned vulcanizing agent and promoting agent are present technique field vulcanizing agent and promoting agent commonly used; Like vulcanizing agent can be that sulphur, selenium, tellurium, sulfur monochloride, sulfur dichloride, dithiodimorpholine, Lucidol, biconjugate chlorobenzoyl peroxide, p-benzoqui(o)none dioxime, tetrachloro are for para benzoquinone, Triethylenetetramine (TETA), tetren, p-tert-butylphenol mela mine-formaldehyde resin, 2,4 toluene diisocyanate; Promoting agent can be zinc oxide, plumbous oxide, Natural manganese dioxide, Triple Pressed Stearic Acid, pyridine zinc chloride complex, zinc carbonate, magnesiumcarbonate, quicklime or their mixture.
In another preferred embodiment, mixing temperature is 50-80 ℃, and the time is 12-30 minute.In another preferred embodiment, the sulfurized temperature is 160-180 ℃, and the time is 10-30 minute.
The present invention is through adding the Flos Caryophylli extract powder, makes the plug for preparing can sterilization and disinfection.Technology of the present invention in addition is simple, easy to operate, raw material with low cost, and improved vulcanization rate, reduce the raw material consumption, the requirement of performance of products National standard.
[embodiment]
Embodiment one
(1) prepares 100 kilograms of rubber, 0.4 kilogram in Flos Caryophylli extract powder, 1 kilogram of vulcanizing agent, 1 kilogram of promoting agent;
(2) earlier rubber and Flos Caryophylli extract powder are mixed, add vulcanizing agent and promoting agent again;
(3) mix afterwards to descend mixing 20 minutes at 65 ℃;
(4) vulcanized 15 minutes down at 170 ℃ then;
(5) die-cut cleaning gets final product.
Embodiment two
(1) prepares 100 kilograms of rubber, 0.6 kilogram in Flos Caryophylli extract powder, 1 kilogram of vulcanizing agent, 1 kilogram of promoting agent;
(2) earlier rubber and Flos Caryophylli extract powder are mixed, add vulcanizing agent and promoting agent again;
(3) mix afterwards to descend mixing 15 minutes at 70 ℃;
(4) vulcanized 10 minutes down at 180 ℃ then;
(5) die-cut cleaning gets final product.
Embodiment three
(1) prepares 100 kilograms of rubber, 0.2 kilogram in Flos Caryophylli extract powder, 1 kilogram of vulcanizing agent, 3 kilograms of promoting agents;
(2) earlier rubber and Flos Caryophylli extract powder are mixed, add vulcanizing agent and promoting agent again;
(3) mix afterwards to descend mixing 25 minutes at 50 ℃;
(4) vulcanized 20 minutes down at 160 ℃ then;
(5) die-cut cleaning gets final product.
Embodiment four
(1) prepares 100 kilograms of rubber, 0.7 kilogram in Flos Caryophylli extract powder, 5 kilograms of vulcanizing agents, 0.5 kilogram of promoting agent;
(2) earlier rubber and Flos Caryophylli extract powder are mixed, add vulcanizing agent and promoting agent again;
(3) mix afterwards to descend mixing 12 minutes at 80 ℃;
(4) vulcanized 15 minutes down at 170 ℃ then;
(5) die-cut cleaning gets final product.
Claims (7)
1. a preparation method who contains natural Flos Caryophylli extract sterilization and disinfection medical grade rubber plug is characterized in that containing in its raw material the Flos Caryophylli extract powder, and the mass ratio of described rubber and Flos Caryophylli extract powder is 100:0.2-0.7; The extraction way of wherein said Flos Caryophylli extract powder is:
(1) cloves is cleaned back input Universalpulverizer and be crushed to 50 orders;
(2) crushed material is transported in the multi-function extractor, adds 10 times to the water of mixture quality, regulating extractor pressure is that 0.2MPa, temperature are 30-40 ℃, extracts after 2 hours, leaves standstill 24 hours;
(3) at the middle and upper levels in the extracting solution suction storage tank, make it extractor from top to bottom successively through multistorey strainer mesh, filtered liq;
(4) with in the filtered liq suction vacuum concentration pot, under 4 ℃, vacuum tightness 0.07MPa, vapor pressure 0.20MPa, concentrate 0.5-1 hour, cloves medicinal extract;
(5) cloves medicinal extract is carried out drying through vacuum spray dehydrator and can obtain the Flos Caryophylli extract powder.
2. the method for claim 1, the mass ratio that it is characterized in that described rubber and Flos Caryophylli extract powder is 100: 0.4.
3. the method for claim 1 after it is characterized in that rubber and Flos Caryophylli extract powder mixed, adds vulcanizing agent and promoting agent, to be mixedly carries out mixing sulfuration after evenly and die-cut cleaning gets final product.
4. method as claimed in claim 3 is characterized in that mixture and the vulcanizing agent of described rubber and Flos Caryophylli extract powder, the mass fraction of promoting agent are:
100 parts in the mixture of rubber and Ground Cloves
Vulcanizing agent 1-5 part
Promoting agent 0.5-3 part.
5. method as claimed in claim 4 is characterized in that mixture and the vulcanizing agent of described rubber and Flos Caryophylli extract powder, the mass fraction of promoting agent are:
100 parts in the mixture of rubber and Ground Cloves
1 part of vulcanizing agent
1 part of promoting agent.
6. like claim 4 or 5 described methods, it is characterized in that mixing temperature is 50-80 ℃, the time is 12-30 minute.
7. like claim 4 or 5 described methods, it is characterized in that the sulfurized temperature is 160-180 ℃, the time is 10-30 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010515943 CN102061021B (en) | 2010-10-22 | 2010-10-22 | Method for preparing natural clove extract-containing medical rubber plug used for sterilization and disinfection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010515943 CN102061021B (en) | 2010-10-22 | 2010-10-22 | Method for preparing natural clove extract-containing medical rubber plug used for sterilization and disinfection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102061021A CN102061021A (en) | 2011-05-18 |
| CN102061021B true CN102061021B (en) | 2012-07-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010515943 Expired - Fee Related CN102061021B (en) | 2010-10-22 | 2010-10-22 | Method for preparing natural clove extract-containing medical rubber plug used for sterilization and disinfection |
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| CN (1) | CN102061021B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105936684A (en) * | 2016-06-13 | 2016-09-14 | 芜湖卓越线束系统有限公司 | Antibacterial rubber for automobile left-front door wiring harness and preparation method thereof |
| CN105936685A (en) * | 2016-06-13 | 2016-09-14 | 芜湖卓越线束系统有限公司 | Antibacterial rubber for automobile storage battery wire harness and preparation method thereof |
| CN116941642A (en) * | 2023-05-22 | 2023-10-27 | 广州奕华生物科技有限公司 | Preparation method and application of natural plant bacteriostat |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270183A (en) * | 1999-04-12 | 2000-10-18 | 施顺清 | Process for preparing antibacterial rubber product |
| CN101530385A (en) * | 2009-04-14 | 2009-09-16 | 北京工商大学 | Flos caryophylli extract as well as preparation method and application thereof |
-
2010
- 2010-10-22 CN CN 201010515943 patent/CN102061021B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270183A (en) * | 1999-04-12 | 2000-10-18 | 施顺清 | Process for preparing antibacterial rubber product |
| CN101530385A (en) * | 2009-04-14 | 2009-09-16 | 北京工商大学 | Flos caryophylli extract as well as preparation method and application thereof |
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| Publication number | Publication date |
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| CN102061021A (en) | 2011-05-18 |
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