CN102058612B - Compound emulsion for animals and preparation method thereof - Google Patents
Compound emulsion for animals and preparation method thereof Download PDFInfo
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- CN102058612B CN102058612B CN2011100018092A CN201110001809A CN102058612B CN 102058612 B CN102058612 B CN 102058612B CN 2011100018092 A CN2011100018092 A CN 2011100018092A CN 201110001809 A CN201110001809 A CN 201110001809A CN 102058612 B CN102058612 B CN 102058612B
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Abstract
The invention belongs to the technical field of veterinary medicaments, and particularly relates to a compound emulsion for animals and a preparation method thereof. The compound emulsion for animals comprises tylosin tartrate, azithromycin, emulsifier, poloxamer, propylene glycol, soybean oil for injection and water for injection. The compound emulsion for animals has high safety; and because the emulsion contains no organic solvent, the toxicity of the organic solvent is reduced, and the emulsion has good environmental friendliness.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to a kind of animal compound emulsion and preparation method thereof.
Background technology
Developing rapidly of aquaculture had benefited from the progress of science and technology to the full extent, but also brought hidden danger simultaneously.The progress of science and technology makes aquaculture to intensification and batch production development, and poultry increase the susceptibility of pathogenic microorganism, and disease frequently takes place, cross infection, and mixed infection is serious, on producing, causes very big economic loss.
In recent years; Along with the development of pig industry, the appearance in succession on large-scale intensification pig farm, thing followed disease problem also comes one after another; Various livestock and poultries frequently take place; As calendar year 2001 Henan, Anhui, Jiangsu etc. economize " innominate high fever " that 6-10 part is taken place, " hyperpyrexia disease " that takes place in a big way up to the whole nation in 2006 shows relevant with respiratory tract disease from clinical and breadboard diagnostic result.Therefore, the porcine respiratory disease has not only become regular incidence, the frequently-occurring disease on China pig farm, the direct death, weightening finish that causes swinery slowly, deliver delay for sale, and pig carries multiple related diseases substance for a long time, becomes the source of infection of new round eqpidemic disease outburst.As everyone knows; Treatment ordinary circumstance to livestock and poultry needs medication every day 2-3 times; Logotype 3-5 days, like this since through repeatedly giving the medication of ill domestic animal fowl, catching and grab etc., cause pessimal stimulation to poultry; Impel the many stress diseases of poultry to take place, and then the generation that causes disease resistance of livestock and poultry to descend causing many livestock and poultries, spread etc.Because the technical force of each plant is uneven; Diagnostic detection device is also very limited; Cause many clinical veterinarys comparatively chaotic aspect medication, abusing and not having medication problem targetedly becomes universal phenomenon, so just further impels the bacterial resistance strain constantly to produce; The prevention of livestock and poultry and treatment be difficulty more, even fails to respond to any medical treatment.
Present domestic livestock and poultry cultivation general development is very fast; Cultural technique, medical diagnosis on disease technology, treatment technology all generally improve significantly, and the veterinary drug manufacturing technology is also brought in constant renewal in improvement, at present with regard to China's veterinary drug production industry; Most of manufacturer is main to produce conventional medicine still; Be aided with some Chinese powder medicines of exploitation, injection, the new drug development aspect mainly is the fugitive preparation of folk prescription, and the exploitation producer of emulsion novel form knows clearly very few.
Summary of the invention
Goal of the invention of the present invention is animal compound emulsion that provides a kind of high safety and preparation method thereof.
The present invention adopts following technical scheme:
A kind of animal compound emulsion, its prescription is:
Tylosin tartrate 5-11g
Azithromycin 2-7g
Emulsifying agent 0.9-1.5g
Poloxamer 0.1-0.3g
Propylene glycol 2-2.5ml
Injection soybean oil 15-20ml
Water for injection adds to 100.0ml.
Said emulsifying agent is soybean phospholipid, polysorbate 60, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate or sodium lauryl sulfonate.
The method for preparing of animal compound emulsion may further comprise the steps: emulsifying agent and azithromycin are dissolved in the injection soybean oil jointly become oil phase; Poloxamer, propylene glycol and tylosin tartrate be dissolved in jointly become water in the water for injection; Oil phase slowly is injected into aqueous phase and constantly stirring; With mixed liquor even matter 1-2min under 137.8MPa.
Animal compound emulsion of the present invention is that the consumption of intramuscular dose when using is the 0.2ml/Kg body weight, once-a-day, and logotype 3 days.
Animal compound emulsion of the present invention has been compared following advantage with general formulation: 1, high safety, emulsion have reduced its toxicity without organic solvent, ensure human and mammiferous safety and health; 2, the feature of environmental protection is good, and emulsion is avoided the murder by poisoning to operator and user without organic solvent, reduces environmental pollution, helps ecological environmental protection; 3, drug effect is high, and the liquid footpath of Emulsion is thinner, contains active component and surfactant, and ultralow table (boundary) surface tension is arranged, and can reduce the dosage of medicament, reduces the infringement to carcass; 4, better stability of preparation, because Emulsion is stable dispersion on the thermodynamics, in the scope of confirming, as long as condition does not change, can long-term storage and layering and breakdown of emulsion do not take place, be convenient to deposit and store and transport.
The major function of animal compound emulsion of the present invention: most gram positive bacterias, gram negative bacteria, anaerobe, mycoplasma, chlamydia there are good effect, strong to the Mycoplasma effect.Be mainly used in respiratory tract, skin soft-tissue infection property disease due to the sensitive organism.The stronger curative effect that has for the acute bronchitis due to hemophilus influenza, streptococcus pneumoniae and the mora mucositis bacterium etc., chronic obstructive lung illness concurrent infection, pneumonia etc.
Animal compound emulsion of the present invention is mainly used in the control poultry by mycoplasma, chlamydia, antibacterial, the caused comprehensive respiratory system disease of virus mixed infection, the respiratory symptom that causes like reasons such as asthma (mycoplasmal pneumonia of swine), porcine contagious pleuropneumonia, pig lung plague, influenza, breeding and respiratory complication, circovirus disease, infectious atrophic rhinitis, pig streptococcicosis, haemophilus disease, toxoplasmosis, lung filaricide, ascaris suums.
The specific embodiment
Embodiment 1
Tylosin tartrate 8g
Azithromycin 4 g
Emulsifying agent 1.2g
Poloxamer 0.1g
Glycerol 2ml
Injection soybean oil 15ml
Water for injection adds to 100.0ml.
Embodiment 2
Tylosin tartrate 10g
Azithromycin 5g
Emulsifying agent 1.5g
Poloxamer 0.3g
Propylene glycol 2.2ml
Injection soybean oil 17ml
Water for injection adds to 100.0ml.
Embodiment 3
Tylosin tartrate 6g
Azithromycin 6g
Emulsifying agent 1.5g
Poloxamer 0.2g
Propylene glycol 2.5ml
Injection soybean oil 20ml
Water for injection adds to 100.0ml.
Embodiment 1-3 step in the preparation is: emulsifying agent and azithromycin are dissolved in the injection soybean oil jointly become oil phase; Poloxamer, propylene glycol and tylosin tartrate be dissolved in jointly become water in the water for injection; Oil phase slowly is injected into aqueous phase and constantly stirring; With mixed liquor even matter 1-2min under 137.8mPa
The clinical efficacy test:
In October, 2009, Zhongmou County city pig farm growing and fattening pigs 200 bulls (about 90 jin) have 50 hairs sick approximately, and main clinic symptoms: conjunctivitis appears in swinery, and the eye discharge of morbidity pig increases; The swinery feed intake descends or does not have appetite; Show dyspnea, breathe, cough, occur serious ventral breathing; The Corii Sus domestica skin pastiness that ear, extremity, eyelid etc. are located skin cyanosis, had; The temperature of pig body of acute onset raises, and sudden death can take place.The sick pig of larger proportion can become chronicly by acute, a pig poor growth, becomes thin, and becomes cad pig, and dead, the rate of washing in a pan of whole swinery raise.
Cut open the inspection pathological changes: visible dissimilar and respiratory apparatus pathological changes in various degree: lung swelling, congestion, pneumonia, interstitial pneumonia, the change of lung carnification regulating liver-QI, pneumorrhagia, the focal scleroma of lung or abscess, pulmonary fibrosis, " rubber lung "; It is thus clear that protopathy and deuteropathic some characteristic pathological changes: infarction kitchen range etc. is arranged like the large intestine of chronic swine fever (return, caecum) button shape ulcer, spleen edge; The sick fiber disposition of haemophilus parasuis pleuropneumonia, hydrothorax and arthritis; The anemia of eperythrozoonosis and the dark brown long-pending urine of bladder etc.
50 morbidity pigs only are divided into two groups at random, and 25 every group, wherein one group is experimental group, and another group is matched group.Experimental group: the product of the intramuscular injection embodiment of the invention 1, the 0.2ml/Kg body weight, once-a-day, logotype 3 days; Matched group: adopt the florfenicol injection of Henan Yawei Animal Medicine Co., Ltd., specification is 10ml:0.5g, once-a-day, and logotype 3 days.
After emergent management, only dead 1 of experimental group morbidity pig, 2 are clearly better, all the other 22 transference cure recoveries from illness, effective percentage reaches 96%, and cure rate reaches 88%; And only dead 4 of matched group morbidity pig, 5 are clearly better, all the other 16 transference cures recoveries from illness, and effective percentage is 84%, cure rate is 64%.
This shows that experimental group is because of the compound recipe emulsion of the injection embodiment of the invention 1, outstanding to the clinical efficacy of respiratory tract disease, its effect obviously is superior to the matched group medicine.
Claims (2)
1. animal compound emulsion, its prescription is:
Tylosin tartrate 5-11g
Azithromycin 2-7g
Emulsifying agent 0.9-1.5g
Poloxamer 0.1-0.3g
Propylene glycol 2-2.5ml
Injection soybean oil 15-20ml
Water for injection adds to 100.0ml;
Said emulsifying agent is soybean phospholipid, polysorbate 60, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate or sodium lauryl sulfonate.
2. the method for preparing of animal compound emulsion as claimed in claim 1 is characterized in that, may further comprise the steps: emulsifying agent and azithromycin are dissolved in the injection soybean oil jointly become oil phase; Poloxamer, propylene glycol and tylosin tartrate be dissolved in jointly become water in the water for injection; Oil phase slowly is injected into aqueous phase and constantly stirring; With mixed liquor even matter 1-2min under 137.8MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100018092A CN102058612B (en) | 2011-01-06 | 2011-01-06 | Compound emulsion for animals and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100018092A CN102058612B (en) | 2011-01-06 | 2011-01-06 | Compound emulsion for animals and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102058612A CN102058612A (en) | 2011-05-18 |
| CN102058612B true CN102058612B (en) | 2012-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011100018092A Expired - Fee Related CN102058612B (en) | 2011-01-06 | 2011-01-06 | Compound emulsion for animals and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846650B (en) * | 2012-08-24 | 2015-04-08 | 郑州后羿制药有限公司 | Florfenicol compound composition and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1572301A (en) * | 2003-06-15 | 2005-02-02 | 王玉万 | Tylosin containing antibiotic injection for animals |
| CN1720065A (en) * | 2002-12-19 | 2006-01-11 | 法玛西雅厄普约翰美国公司 | Dispersible pharmaceutical compositions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995031180A1 (en) * | 1992-12-08 | 1995-11-23 | Bimeda Research And Development Limited | A veterinary composition |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720065A (en) * | 2002-12-19 | 2006-01-11 | 法玛西雅厄普约翰美国公司 | Dispersible pharmaceutical compositions |
| CN1572301A (en) * | 2003-06-15 | 2005-02-02 | 王玉万 | Tylosin containing antibiotic injection for animals |
Non-Patent Citations (2)
| Title |
|---|
| 王长虹等.甲苯咪唑O/W型口服混悬乳液的制备及理化特性研究.《地方病通报》.2001,第16卷(第4期),第13-17页. * |
| 郭宽等.氟苯尼考注射用混悬乳剂的制备及性质考察.《上海畜牧兽医通讯》.2009,(第5期),第7-9页. * |
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| CN102058612A (en) | 2011-05-18 |
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