CN102038496B - Acquisition device for rising PaCO2 and monitor system - Google Patents
Acquisition device for rising PaCO2 and monitor system Download PDFInfo
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- CN102038496B CN102038496B CN2010106026810A CN201010602681A CN102038496B CN 102038496 B CN102038496 B CN 102038496B CN 2010106026810 A CN2010106026810 A CN 2010106026810A CN 201010602681 A CN201010602681 A CN 201010602681A CN 102038496 B CN102038496 B CN 102038496B
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Abstract
The invention relates to the field of medical treatment equipment, and discloses a method for improving PaCO2, an acquisition device, a monitor system and medical treatment purpose. The system comprises an autologous CO2 suction PaCO2 rising device, and a breath acquisition device, a signal acquisition device, a communication interface module, a signal processing device and a display device, which are connected sequentially. After the system is adopted, the non-invasive detection of the cerebrovascular reserving function is realized, the result is accurate and reliable, and the clinical practicability is high. The invention has the following advantages that: the financial burden of patients is relived; the risk of cross-infection is eliminated; the risk of CO2 anesthesia is eliminated; it is easy to monitor the PaCO2 accurately; and gas at mouths and noses in a face mask are exhaled by the patients, the collected gas is not influenced by outside, and the change of ETCO2 can be reflected really, so that the change of the PaCO2 can be monitored accurately.
Description
Technical field
The present invention relates to field of medical, relate in particular to a kind of rising examinee PaCO
2Method, ETCO
2Signal pickup assembly, cerebrovascular reserve function monitor system and medical application thereof.
Background technology
Cerebrovascular deposit (cerebrovascular reserve; CVR) claim cerebral blood flow deposit, cerebral circulation deposit etc. again; Being meant at physiology or pathological factor stimulates down, and brain small artery and telangiectasis or contraction are kept cerebral blood flow and stablized or regulate and control cerebral blood flow to adapt to the needs of brain function.Its function is impaired to play an important role in the ischemic cerebrovascular morbidity, is the independent hazard factor of Ischemic Stroke.Therefore, correctly detect and estimate CVR, the diagnoses and treatment that can be ischemic cerebrovascular provides the reference index of usefulness.
The most frequently used CVR assay method is to utilize TCD to detect the CO in the arterial blood
2Dividing potential drop (PaCO
2) change the VPV of forward and backward arteria basilaris, calculate the percentage rate that CBFV changes, thereby resistance vessels such as reflection brain arteriole are to PaCO
2The reserve capabillity that changes.PaCO
2Change be the reason that cerebral blood flow changes, the variation of cerebral blood flow is PaCO
2The result who changes.In this course except that accurately measuring the cerebral blood flow, manual intervention PaCO accurately and effectively also
2That is to say effectively (or reduction) PaCO that raises
2, be correct one of the essential condition of CVR that detects and estimate.In addition, the velocity variations of measuring cerebral blood flow merely can only provide intermediate object program, also must monitoring PaCO
2Rising (or reduce) degree.Because except that cause effect relation, PaCO
2Change the relation that on degree, also has dose-effect, i.e. PaCO with cerebral blood flow
2Changing more obvious cerebral blood flow changes just remarkable more.The CBFV that TCD measures changes, and has only the PaCO of using
2The weighting of change degree after, could correctly detect and estimate CVR.
PaCO raises in the prior art
2Method then have multiple:
1, intravenous injection acetazolamide.This method is effective, but the domestic acetazolamide sale that does not have injection.
2, breath holding test.Let patient's no breathing of initiatively holding one's breath, adhere to the long as far as possible time.Though this method is simple, effect is unreliable, and can't monitor expiration end-expiratory gas body CO owing to hold one's breath
2Dividing potential drop (ETCO
2), can't monitor PaCO
2The degree that changes.
3, suck the CO of variable concentrations
2Mist is (like the CO of variable concentrations such as 2%, 3%, 4%, 5%, 7%
2Mist).Can effectively change PaCO
2, but the CO of variable concentrations
2Gas will arrive oxygen installation's custom-made, higher CO
2The gas of concentration has CO
2The risk of anesthesia.And CO
2The suction of gas and ETCO
2The gas that monitoring is gathered all is the mouth and nose places patient, causes ETCO
2Monitoring numerical value receives considerable influence.
Rising PaCO in view of above prior art
2The deficiency of method causes present cerebrovascular reserve function detection method to meet clinical needs.
Summary of the invention
The technical problem that the present invention will solve is, to the above-mentioned defective of prior art, a kind of rising examinee PaCO is provided
2Method, ETCO
2Signal pickup assembly, cerebrovascular reserve function monitor system and medical application thereof, it has advantage simple in structure, easy to use.
The technical scheme that technical solution problem of the present invention is adopted is following:
A kind of cerebrovascular reserve function monitor system wherein, comprising:
From body CO
2Suck rising PaCO
2Device, the examinee's that is used to raise PaCO
2
The breath harvester is used to gather examinee's ETCO
2Signal;
Signal pickup assembly is used for cerebral blood flow signal and ETCO
2Signal carries out synchronized sampling, and with cerebral blood flow signal and ETCO
2Conversion of signals becomes corresponding digital signal;
Signal processing apparatus is used for cerebral blood flow signal and ETCO to obtaining synchronously
2Signal is handled, and obtains serial CVR index;
Display device is used to show the CVR index;
Wherein, breath harvester, signal pickup assembly, communication interface module, signal processing apparatus, display device connect successively.
Described cerebrovascular reserve function monitor system, wherein, signal pickup assembly comprises: at least one is used to gather the transcranial doppler module of cerebral blood flow signal; At least one is used to gather ETCO
2The CO of signal
2Gas analysis module;
Each transcranial doppler module and CO
2Gas analysis module comprises that respectively at least one signals collecting path and sampling keep path;
The outfan of each signals collecting path connects a sampling hold circuit; Sampling hold circuit is under the control with the synchronous sampling control signal of clock pulses; Signal to each signals collecting path output carries out synchronized sampling, and sampling control signal is produced by control module;
The outfan of sampling hold circuit is connected with the input of multi-channel a/d converter, and A/D converter is used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation informs that A/D changes completed A/D EOC signal; The outfan of A/D converter is connected with control module;
Control module is connected with communication interface module; Control module utilizes main clock pulse to produce the A/D conversion start signal and A/D reads control signal; The A/D conversion start signal is used to control A/D converter and begins to carry out the A/D conversion; When A/D converts and after control module received that A/D converts signal, control module was sent A/D and read control signal control A/D converter dateout.
Described cerebrovascular reserve function monitor system, wherein, from body CO
2Suck rising PaCO
2Device by the noinvasive Ventilation mask be connected in the vertical respirator circuit ventilation of face shield pipe and form.
Described cerebrovascular reserve function monitor system wherein, adopts and closes face shield replacement noinvasive Ventilation mask.
A kind of ETCO
2Signal pickup assembly wherein, comprising:
From body CO
2Suck rising PaCO
2Device, the examinee's that is used to raise PaCO
2
The breath harvester is used to gather examinee's ETCO
2Signal.
Described ETCO
2Signal pickup assembly, wherein, from body CO
2Suck rising PaCO
2Device by the noinvasive Ventilation mask be connected in the vertical respirator circuit ventilation of face shield pipe and form.
Described ETCO
2Signal pickup assembly wherein, adopts and closes face shield replacement noinvasive Ventilation mask.
Described ETCO
2Signal pickup assembly, wherein, the breath harvester comprises CO
2A gas collecting pipe and a CO
2Gas analysis module, CO
2One end of gas collecting pipe is arranged in the noinvasive Ventilation mask, CO
2The other end of gas collecting pipe and said CO
2Gas analysis module connects, through CO
2Gas collecting pipe continuous acquisition examinee's breath imports to CO
2Gas analysis module obtains ETCO
2Signal.
Described ETCO
2Signal pickup assembly rising examinee PaCO
2Method, wherein, comprise step:
A, wear from body CO at examinee's mouth and nose place
2Suck rising PaCO
2The noinvasive Ventilation mask of device;
B, connect respirator circuit ventilation pipe, perhaps connect other pipeline, perhaps directly increase the face shield volume, to increase the physiology of respiration dead space on the top of face shield;
C, from body CO
2Suck rising PaCO
2After device installs, in face shield, gather 3-5 minute examinee's ETCO
2Signal, and keep end operation after 1-2 minute, promptly accomplish rising examinee PaCO
2
The medical application of described cerebrovascular reserve function monitor system wherein, comprising:
Synchronous acquisition examinee's cerebral blood flow and ETCO under the baseline state of eupnea
2Signal 10 minutes, and be labeled as the baseline state;
Install from body CO
2Suck rising PaCO
2Device, synchronous acquisition examinee's cerebral blood flow and ETCO
2Signal 3-5 minute, and be masked as expression rising PaCO
2State;
When treating that the cerebral blood flow signal recovers the baseline state, hyperventilation reduces PaCO
2, synchronous acquisition examinee's cerebral blood flow and ETCO
2Signal 3-5 minute, and be masked as reduction PaCO
2State;
Obtain three sections cerebral blood flow and ETCO
2Behind the signal, adopt following formula to calculate the cerebrovascular reserve function:
Wherein, CVRI
ExpansionExpression cerebral vasodilators reserve function; CVRI
ShrinkThe expression cerebrovascular shrinks reserve function; CVRI
WholeThe overall reserve function of expression cerebrovascular; V
BaselineWith ET CO
2 baselinesBe illustrated in TAV and ETCO under the baseline state
2V
High CO2And ETCO
2 high CO2Expression rising PaCO
2After TAV and ETCO
2V
Low CO2And ETCO
2 low CO2: reduce PaCO
2After TAV and ETCO
2
Beneficial effect of the present invention is: after adopting the present invention, realized that the noinvasive of cerebrovascular reserve function detects, the result accurately and reliably, clinical practice property is strong.Concrete advantage is following:
1., alleviate patient's financial burden: the CO that need not to customize and buy acetazolamide and variable concentrations
2Gas has been removed this a part of financial burden of patient from.
2., avoid the risk of cross infection: face shield and mechanical ventilation pipe are disposable, have avoided the possibility of cross infection.
3., avoid CO
2The risk of anesthesia: because that suction is the CO that the patient breathes out
2Gas, concentration can not obviously raise moment, has avoided suction excessive concentrations CO
2Gas causes CO
2The risk of anesthesia.
4., help PaCO
2Accurate monitoring: the gas at mouth and nose place is patient expired gas in the face shield, does not receive ectocine at the gas of this collection, can truly reflect ETCO
2Variation, thereby can accurately monitor PaCO
2Variation.
Description of drawings
Fig. 1 is the sketch map of cerebrovascular reserve function monitor system.
Fig. 2 is the sketch map of the signal pickup assembly among Fig. 1.
Fig. 3 is from body CO
2Suck rising PaCO
2The sketch map of first kind of occupation mode of device.
Fig. 4 is from body CO
2Suck rising PaCO
2The sketch map of second kind of occupation mode of device.
Fig. 5 is the ETCO of the embodiment of the invention
2The signal pickup assembly structural representation.
The specific embodiment
The invention provides a kind of rising examinee PaCO
2Method, ETCO
2Signal pickup assembly, cerebrovascular reserve function monitor system and medical application thereof, clearer, clear and definite for making the object of the invention, technical scheme and advantage, below develop simultaneously embodiment to further explain of the present invention with reference to accompanying drawing.Should be appreciated that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.
Wherein, a kind of cerebrovascular reserve function monitor system is provided, this system synchronization is gathered transcranial doppler (TCD) cerebral blood flow signal and CO
2The CO of the expiration end-expiratory gas body of gas analyser
2Dividing potential drop (ETCO
2) signal.Respectively at the baseline of eupnea, from body CO
2Suck rising arterial partial pressure of carbon dioxide (PaCO
2) and hyperventilation reduction PaCO
2Each synchronous acquisition cerebral blood flow and ETCO under three kinds of states
2Signal calculates the CVR index, realizes detecting and monitoring cerebrovascular reserve function.
See also Fig. 1, cerebrovascular reserve function monitor system comprises signal pickup assembly, communication interface module, signal processing apparatus, display device, from body CO
2Suck rising PaCO
2Device, breath harvester.
Wherein, from body CO
2Suck rising PaCO
2Device mainly is to collect the human body breath, and concentrates on human body mouth and nose place, thereby circulation sucks the container that returns human body again.This container is provided with and the alternative perforate of ambient atmos, is not causing under the anoxybiotic prerequisite effectively increasing respiration dead space, thereby can guarantee that the circulation again of not outflowing of gases such as carbon dioxide that human body is breathed out sucks and returns human body.As shown in Figure 3, from body CO
2Suck rising PaCO
2Device is by noinvasive Ventilation mask (closing face shield) and be connected in the vertical respirator circuit ventilation of face shield pipe and form; Perhaps connect other pipeline; Perhaps directly increase the face shield volume and constitute, its objective is effective increase respiration dead space, and then through effectively raise examinee's PaCO of proper handling
2
Wherein, the breath harvester is used to gather examinee's ETCO2 signal.Described ETCO2 signal pickup assembly can be arranged on said on body CO2 suction rising PaCO2 device, and as shown in Figure 3, the breath harvester comprises CO
2A gas collecting pipe and a CO
2Gas analysis module, CO
2One end of gas collecting pipe places examinee's mouth and nose place, CO
2The other end of gas collecting pipe and said CO
2Gas analysis module connects, through CO
2Gas collecting pipe continuous acquisition examinee's breath imports to CO
2Gas analysis module obtains ETCO
2Signal.Perhaps save CO
2The gas collecting pipe is directly with CO
2Gas analysis module places examinee's mouth and nose place, METHOD FOR CONTINUOUS DETERMINATION ETCO
2Signal, and signal sent into signal pickup assembly.Can certainly adopt the breath harvester to include only a CO
2Gas analysis module, as shown in Figure 4, with CO
2Gas analysis module is directly inserted in the noinvasive Ventilation mask, obtains ETCO
2Signal.
Signal pickup assembly is used for cerebral blood flow signal and the CO that synchronized sampling obtains transcranial doppler (TCD) monitoring
2The ETCO that gas analysis module is obtained
2Signal, and with the corresponding digital signal of these conversion of signals one-tenth.
See also Fig. 2, signal pickup assembly specifically comprises: at least one is used to gather the transcranial doppler module of cerebral blood flow signal; At least one is used to gather ETCO
2The CO of signal
2Gas analysis module.
Each transcranial doppler module and CO
2Gas analysis module comprises that respectively at least one signals collecting path and sampling keep path.
The outfan of each signals collecting path connects a sampling hold circuit, and sampling hold circuit is under the control with the synchronous sampling control signal of clock pulses, and the signal that each signals collecting path is exported carries out synchronized sampling.Sampling control signal is produced by control module.
The outfan of sampling hold circuit is connected with the input of multi-channel a/d converter (or multi-disc A/D converter); A/D converter is used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation informs that A/D changes completed A/D EOC signal.
The outfan of A/D converter is connected with control module, and the digital signal of A/D converter output exports signal processing apparatus to behind the control module buffer memory.
Control module is connected with communication interface module; Control module utilizes main clock pulse to produce the A/D conversion start signal and A/D reads control signal; The A/D conversion start signal is used to control A/D converter and begins to carry out the A/D conversion; When A/D converts and after control module received that A/D converts signal, control module was sent A/D and read control signal control A/D converter dateout.
Control module can adopt CPLD, and (Complex Programmable Logic Device CPLD) realizes.
Signal processing apparatus is connected with signal pickup assembly by communication interface module.Signal processing apparatus is used for cerebral blood flow signal and the ETCO to obtaining synchronously
2Signal is handled, and obtains serial CVR index.
Display device is used for the CVR index is shown.
Signal processing apparatus and display device can adopt the PC system to realize.
The medical application of cerebrovascular reserve function monitor system of the present invention comprises:
A, let the examinee lie on the back on examinating couch, let the examinee remain silent and use respiratory nasal.Synchronous acquisition cerebral blood flow and ETCO under the baseline state of eupnea
2Signal 10 minutes, and be labeled as the baseline state.Had a rest 5 minutes.
The baseline state is meant not the base state to patient respiration is intervened, patient is in eupnea.
B, wear noinvasive Ventilation mask (closing face shield) at examinee's mouth and nose place, suitably pressurization contacts well the air cushion of face shield and examinee's skin of face, and the interior gas of face shield does not leak outside.Also can use the face shield of other form, as long as guarantee that gas separates with OFP gas in the face shield.Connect respirator circuit ventilation pipe on the top of face shield, perhaps connect other pipeline, perhaps directly increase the face shield volume, its objective is effective increase respiration dead space, and then through effectively raise examinee's PaCO of proper handling
2
Because face shield has connected breather, the CO that expiratory phase is breathed out in the patient respiratory process
2Gas can not in time all dissipate, and sucks the CO of gas so as to the rising inspiratory phase
2Concentration is just with the portion C O that oneself breathes out
2Gas sucks again, thereby effectively raises PaCO
2
Fig. 3 is from body CO
2Suck rising PaCO
2The sketch map of first kind of occupation mode of device places examinee's mouth and nose place with two-chamber Oxygen tube or similar pipeline, utilizes negative pressure continuous acquisition examinee's breath, imports CO
2Gas analysis module is measured ETCO
2Signal, and signal sent into signal pickup assembly.
Fig. 4 is from body CO
2Suck rising PaCO
2The sketch map of second kind of occupation mode of device is with CO
2Gas analysis module is directly implanted in the face shield, perhaps directly places examinee's mouth and nose place, the ETCO of gas or examinee's mouth and nose place gas in the METHOD FOR CONTINUOUS DETERMINATION face shield
2Signal, and signal sent into signal pickup assembly.
C, from body CO
2Suck rising PaCO
2After device connects, examinee's ETCO
2Numerical value begins to raise.Instruct the examinee to breathe energetically, continue 3-5 minute, ETCO with fast and dark as far as possible mode
2Can reach the cerebrovascular reserve function and detect required ideal concentration.Synchronous acquisition cerebral blood flow and ETCO
2Signal 3-5 minute, and be masked as expression rising PaCO
2State.Had a rest 10 minutes, or the cerebral blood flow signal recovers the baseline state.
D, hyperventilation reduce PaCO
2, synchronous acquisition cerebral blood flow and ETCO
2Signal 3-5 minute, and be masked as reduction PaCO
2State.Had a rest 10 minutes, or the cerebral blood flow signal recovers the baseline state.
E, three sections cerebral blood flow of acquisition and ETCO
2Behind the signal, calculate the cerebrovascular reserve function with following formula.
Wherein, CVRI
ExpansionExpression cerebral vasodilators reserve function; CVRI
ShrinkThe expression cerebrovascular shrinks reserve function; CVRI
WholeThe overall reserve function of expression cerebrovascular; V
BaselineAnd ETCO
2 baselinesBe illustrated in TAV and ETCO under the baseline state
2V
High CO2And ETCO
2 high CO2Expression rising PaCO
2After TAV and ETCO
2V
Low CO2And ETCO
2 low CO2: reduce PaCO
2After TAV and ETCO
2
Based on the cerebrovascular reserve function monitor system and the medical application thereof of the foregoing description, the embodiment of the invention also provides a kind of ETCO
2Signal pickup assembly, as shown in Figure 5, comprising:
From body CO
2Suck rising PaCO
2Device, the examinee's that is used to raise PaCO
2
The breath harvester is used to gather examinee's ETCO
2Signal.
Wherein, from body CO
2Suck rising PaCO
2Device mainly is to collect the human body breath, and concentrates on human body mouth and nose place, thereby circulation sucks the container that returns human body again.This container is provided with and the alternative perforate of ambient atmos, is not causing under the anoxybiotic prerequisite effectively increasing respiration dead space, thereby can guarantee that the circulation again of not outflowing of gases such as carbon dioxide that human body is breathed out sucks and returns human body.As shown in Figure 3, from body CO
2Suck rising PaCO
2Device is by noinvasive Ventilation mask (closing face shield) and be connected in the vertical respirator circuit ventilation of face shield pipe and form; Perhaps connect other pipeline; Perhaps directly increase the face shield volume and constitute, its objective is effective increase respiration dead space, and then through effectively raise examinee's PaCO of proper handling
2
Because face shield has connected breather, the CO that expiratory phase is breathed out in the patient respiratory process
2Gas can not in time all dissipate, and sucks the CO of gas so as to the rising inspiratory phase
2Concentration is just with the portion C O that oneself breathes out
2Gas sucks again, thereby effectively raises PaCO
2
The breath harvester can be arranged on said from body CO
2Suck rising PaCO
2On the device, as shown in Figure 3, the breath harvester comprises CO
2A gas collecting pipe and a CO
2Gas analysis module, CO
2One end of gas collecting pipe is arranged in the noinvasive Ventilation mask, CO
2The other end of gas collecting pipe and said CO
2Gas analysis module connects, through CO
2Gas collecting pipe continuous acquisition examinee's breath imports to CO
2Gas analysis module obtains ETCO
2Signal, and then carry this signal to signal processing apparatus.Can certainly adopt the breath harvester to include only a CO
2Gas analysis module, as shown in Figure 4, with CO
2Gas analysis module is directly inserted in the noinvasive Ventilation mask, obtains ETCO
2Signal.
Fig. 3 is from body CO
2Suck rising PaCO
2The sketch map of first kind of occupation mode of device places examinee's mouth and nose place with two-chamber Oxygen tube or similar pipeline, utilizes negative pressure continuous acquisition examinee's breath, imports CO
2Gas analysis module is measured ETCO
2Signal.
Fig. 4 is from body CO
2Suck rising PaCO
2The sketch map of second kind of occupation mode of device is with CO
2Gas analysis module is directly implanted in the face shield, perhaps directly places examinee's mouth and nose place, directly measures ETCO
2Signal.
Based on the foregoing description, it is a kind of based on from body CO that the embodiment of the invention also provides
2Suck rising PaCO
2Device rising examinee PaCO
2Method, comprise the steps:
The first step, examinee lie on the back on examinating couch, wear from body CO at examinee's mouth and nose place
2Suck rising PaCO
2Device noinvasive Ventilation mask (closing face shield), like Fig. 3 and shown in Figure 4, suitably pressurization makes the air cushion of face shield contact well with the quilt person of picking up skin of face, and gas does not leak outside in the face shield.Or use other form face shield, guarantee that gas separates with OFP gas in the face shield.
Second step, connect respirator circuit ventilation pipe on the top of face shield, like Fig. 3 and shown in Figure 4.Perhaps connect other pipeline, perhaps directly increase the face shield volume, increase the physiology of respiration dead space.
After the 3rd step, device connect, examinee's ETCO
2Numerical value begins to raise.After 3-5 minute, ETCO
2Can reach the cerebrovascular deposit and detect required ideal concentration, stablize end operation after 1-2 minute.
The 4th step, physiological foundation: increase the physiology of respiration dead space.Owing to connected the mechanical ventilation pipe through face shield, the CO that expiratory phase is breathed out in the patient respiratory process
2Gas can not in time all dissipate, and sucks the CO of gas so as to the rising inspiratory phase
2Concentration is just with the portion C O that oneself breathes out
2Gas sucks again, thereby effectively raises PaCO
2
The embodiment of the invention provide based on from body CO 2 Suck rising PaCO 2 Device rising examinee PaCO 2 Method, can improve examinee PaCO effectively 2 And the PaCO through (or reduction) detected person that raises effectively 2 This intermediate steps through breath harvester monitoring rising effect, can obtain ETCO again 2 Signal as correct detection with estimate one of two conditions of CVR, is measured a CBFV and can not directly be drawn CVR promptly only merely, has only provided an intermediate object program, and (or reduction) PaCO also needs effectively to raise 2 , and will change the weighting that effect is used for final result.(or reduction) PaCO conversely speaking, raises separately 2 This intermediate steps, alsoCan not directly draw C
VR.
In sum, adopt the present invention after, realized that the noinvasive of cerebrovascular reserve function detects, the result accurately and reliably, clinical practice property is strong.Concrete advantage is following:
1., alleviate patient's financial burden: the CO that need not to customize and buy acetazolamide and variable concentrations
2Gas has been removed this a part of financial burden of patient from.
2., avoid the risk of cross infection: face shield and mechanical ventilation pipe are disposable, have avoided the possibility of cross infection.
3., avoid CO
2The risk of anesthesia: because that suction is the CO that the patient breathes out
2Gas, concentration can not obviously raise moment, has avoided suction excessive concentrations CO
2Gas causes CO
2The risk of anesthesia.
4., help PaCO
2Accurate monitoring: the gas at mouth and nose place is patient expired gas in the face shield, does not receive ectocine at the gas of this collection, can truly reflect ETCO
2Variation, thereby can accurately monitor PaCO
2Variation.
Should be understood that application of the present invention is not limited to above-mentioned giving an example, concerning those of ordinary skills, can improve or conversion that all these improvement and conversion all should belong to the protection domain of accompanying claims of the present invention according to above-mentioned explanation.
Claims (6)
1. a cerebrovascular reserve function monitor system is characterized in that, comprising:
From body CO
2Suck rising PaCO
2Device, the examinee's that is used to raise PaCO
2
The breath harvester is used to gather examinee's ETCO
2Signal;
Signal pickup assembly is used for cerebral blood flow signal and ETCO
2Signal carries out synchronized sampling, and with cerebral blood flow signal and ETCO
2Conversion of signals becomes corresponding digital signal;
Signal processing apparatus is used for cerebral blood flow signal and ETCO to obtaining synchronously
2Signal is handled, and obtains serial CVR index;
Display device is used to show the CVR index;
Wherein, breath harvester, signal pickup assembly, communication interface module, signal processing apparatus, display device connect successively;
SaidSignal pickup assembly comprises: at least one is used to gather the transcranial doppler module of cerebral blood flow signal; At least one is used to gather ETCO
2The CO of signal
2Gas analysis module;
Each transcranial doppler module and CO
2Gas analysis module comprises that respectively at least one signals collecting path and sampling keep path;
The outfan of each signals collecting path connects a sampling hold circuit; Sampling hold circuit is under the control with the synchronous sampling control signal of clock pulses; Signal to each signals collecting path output carries out synchronized sampling, and sampling control signal is produced by control module;
The outfan of sampling hold circuit is connected with the input of multi-channel a/d converter, and A/D converter is used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation informs that A/D changes completed A/D EOC signal; The outfan of A/D converter is connected with control module;
Control module is connected with communication interface module; Control module utilizes main clock pulse to produce the A/D conversion start signal and A/D reads control signal; The A/D conversion start signal is used to control A/D converter and begins to carry out the A/D conversion; When A/D converts and after control module received that A/D converts signal, control module was sent A/D and read control signal control A/D converter dateout.
2. cerebrovascular reserve function monitor system according to claim 1 is characterized in that, from body CO
2Suck rising PaCO
2Device by the noinvasive Ventilation mask be connected in the vertical respirator circuit ventilation of face shield pipe and form.
3. cerebrovascular reserve function monitor system according to claim 2 is characterized in that, adopts and closes face shield replacement noinvasive Ventilation mask.
4. ETCO
2Signal pickup assembly is characterized in that, comprising:
From body CO
2Suck rising PaCO
2Device, the examinee's that is used to raise PaCO
2
Be arranged on from body CO
2Suck rising PaCO
2Breath harvester on the device is used to gather examinee's ETCO
2Signal;
Said breath harvester comprises CO
2A gas collecting pipe and a CO
2Gas analysis module, CO
2One end of gas collecting pipe is arranged in the noinvasive Ventilation mask, CO
2The other end of gas collecting pipe and said CO
2Gas analysis module connects, through CO
2Gas collecting pipe continuous acquisition examinee's breath imports to CO
2Gas analysis module obtains ETCO
2Signal.
5. ETCO according to claim 4
2Signal pickup assembly is characterized in that, from body CO
2Suck rising PaCO
2Device by the noinvasive Ventilation mask be connected in the vertical respirator circuit ventilation of face shield pipe and form.
6. ETCO according to claim 4
2Signal pickup assembly is characterized in that, adopts and closes face shield replacement noinvasive Ventilation mask.
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CN1883383A (en) * | 2006-06-21 | 2006-12-27 | 深圳市德力凯电子有限公司 | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure |
CN101214151A (en) * | 2007-12-29 | 2008-07-09 | 广州医学院第一附属医院 | Method and device for pressure dividing monitoring and estimating arterial blood CO2 by using respiratory gas CO2 |
CN201905888U (en) * | 2010-12-23 | 2011-07-27 | 高庆春 | Brain blood vessel reserve function monitoring system and ETCO2 signal acquisition device |
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CN1883383A (en) * | 2006-06-21 | 2006-12-27 | 深圳市德力凯电子有限公司 | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure |
CN101214151A (en) * | 2007-12-29 | 2008-07-09 | 广州医学院第一附属医院 | Method and device for pressure dividing monitoring and estimating arterial blood CO2 by using respiratory gas CO2 |
CN201905888U (en) * | 2010-12-23 | 2011-07-27 | 高庆春 | Brain blood vessel reserve function monitoring system and ETCO2 signal acquisition device |
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高庆春.《经颅多普勒超声在脑血管储备功能评价中的应用》.《中国卒中杂志》.2008,第3卷(第1期),39-44. * |
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