CN1883383A - Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure - Google Patents
Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure Download PDFInfo
- Publication number
- CN1883383A CN1883383A CNA2006100612338A CN200610061233A CN1883383A CN 1883383 A CN1883383 A CN 1883383A CN A2006100612338 A CNA2006100612338 A CN A2006100612338A CN 200610061233 A CN200610061233 A CN 200610061233A CN 1883383 A CN1883383 A CN 1883383A
- Authority
- CN
- China
- Prior art keywords
- signal
- module
- sampling
- blood flow
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000004087 circulation Effects 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 44
- 230000033228 biological regulation Effects 0.000 title claims abstract description 26
- 230000003727 cerebral blood flow Effects 0.000 title claims description 72
- 230000002490 cerebral effect Effects 0.000 title claims description 55
- 238000005070 sampling Methods 0.000 claims abstract description 118
- 230000004872 arterial blood pressure Effects 0.000 claims abstract description 39
- 238000012545 processing Methods 0.000 claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims description 59
- 230000000747 cardiac effect Effects 0.000 claims description 56
- 230000017531 blood circulation Effects 0.000 claims description 44
- 230000036772 blood pressure Effects 0.000 claims description 44
- 230000001360 synchronised effect Effects 0.000 claims description 42
- 230000006870 function Effects 0.000 claims description 26
- 239000008280 blood Substances 0.000 claims description 23
- 230000011664 signaling Effects 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 11
- 238000004891 communication Methods 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 7
- 102100028570 Drebrin-like protein Human genes 0.000 claims description 6
- 101710167313 Drebrin-like protein Proteins 0.000 claims description 6
- 238000012417 linear regression Methods 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 6
- 230000001020 rhythmical effect Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 abstract description 13
- 230000010456 cerebrovascular autoregulation Effects 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 230000009711 regulatory function Effects 0.000 description 14
- 238000012544 monitoring process Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 101000885321 Homo sapiens Serine/threonine-protein kinase DCLK1 Proteins 0.000 description 7
- 102100039758 Serine/threonine-protein kinase DCLK1 Human genes 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000003728 cerebral autoregulation Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000011946 reduction process Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006442 vascular tone Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
A cerebrovascular regulation function monitor system and a method for detection of cerebrovascular circulation critical closing pressure, wherein the cerebrovascular regulation function monitor system includes a signal collection system for in-phase sampling analog signal of transcranial doppler (TCD) signal and continuous artery pressure signal and further converting the analog signals into correspondent digital signals and a signal processing/displaying system connected with the signal collection system via interfaces for processing the digital signals to obtain the cerebrovascular critical closing signal and displaying them. The method and system realize a non-invasion detection and monitor of cerebrovascular autoregulation function in clinical practice.
Description
Technical field
The present invention relates to field of medical, relate in particular to the automatic regulatory function detection/monitor system of a kind of noinvasive cerebral blood flow, and the method that detects cerebral circulation critical closing pressure in real time, and then the realization cerebral blood flow is regulated clinical noinvasive detection of lower limit and monitoring automatically.
Background technology
The automatic regulatory function of human body cerebral blood flow, most important in generation, development and the diagnoses and treatment of cerebrovascular, so the accurately practical automatic regulatory function detection/monitor of the noinvasive cerebral blood flow equipment of urgent clinical needs.The tradition physiological theory thinks that cerebral blood flow depends on pressure reduction and the cerebrovascular total resistance of blood flow between mean arterial pressure and intracranial pressure (or venous pressure), and cerebral blood flow is automatically regulated by regulating the resistance vessel bore, changes resistance of blood flow and realizes.For this reason, the evaluation methodology of the automatic regulatory function of cerebral blood flow has three classes at present: the automatic adjustment curve method of 1. classical cerebral blood flow: by means of medicine or various operation, classification changes arteriotony artificially, observe cerebral blood flow or arteria basilaris blood flow rate, draw the automatic adjustment curve of cerebral blood flow, manual observation determines that cerebral blood flow regulates the lower limit and the upper limit automatically, and corresponding modification scope.2. utilize coherence, the position phasic property analytic process of fluctuation between the perfusion of blood pressure and brain: the undulatory property of record arteriotony and cerebral blood flow signal, observation is that between the two coherence and position changes mutually when fluctuating the spontaneous fluctuation of arteriotony or people, and then estimates the automatic regulatory function of cerebral blood flow.3. the dynamic automatic regulatory function assessment method of cerebral blood flow: the people for a change behind the arteriotony, observes degree and time that cerebral blood flow recovers, and then calculates the corresponding index of regulating automatically.And existing theory thinks that effective downstream pressure of cerebral circulation was not an IJP when intracranial pressure was high, but the critical closing pressure of cerebral circulation.Cerebral circulation critical closing pressure is the mean arterial pressure when blood flow stops in the arteriotony reduction process, the vascular tone of essence reflection dynamic adjustments.Therefore in the cerebral blood flow self-regulating process, the contraction of vascular smooth muscle or diastole, but dynamic adjustments cerebrovascular tensity, raise or the reduction critical closing pressure, thereby change effective perfusion pressure of tremulous pulse part and realize stablizing cerebral blood flow, rather than realize stablizing cerebral blood flow by changing the resistance vessel bore, with the pressure independent of blood capillary and vein segment.Therefore, for the self-regulating classical notion of cerebral blood flow, the mean arterial pressure when critical closing pressure is zero is that cerebral blood flow is regulated lower limit automatically.
Though existing method 1. to be cerebral blood flow automatic classical way that regulatory function estimates is applied to animal experiment for many years, is difficult to clinical practice.Because necessary artificial arteriotony lifting on the methodology, severe complications takes place in the cerebrovascular patient that can cause automatic regulatory function to be on the verge of borderline state.Make measurement result reliable in colony again though change blood pressure with time stage, concrete patient's mensuration precision is greatly affected, even regulates bound automatically with the very difficult objective judgement of classical way sometimes for some patient.2. and 3. existing method, there is the human intervention arteriotony equally except that having, is unfavorable for being used for the shortcoming of clinical practice, all exist the measurement result people to be classification, the mensuration dissatisfactory deficiency of degree of accuracy (only being divided into 0～9 grade) as automatic adjusting index, can't satisfy clinical, the actual needs of diagnosis and treatment of cerebrovascular diseases treatment particularly.Because the cerebrovascular treatment, especially the regulating blood pressure of individuation is starved of the accurate numerical value that cerebral blood flow is regulated lower limit automatically, to determine the effective perfusion pressure of suitable cerebral circulation.
Summary of the invention
Technical problem to be solved by this invention is: provide cerebral blood flow automatic regulatory function detection/monitor system, this system realizes detecting and the monitoring cerebral circulation critical closing pressure by synchronous acquisition transcranial doppler (TCD-Transcranial Doppler) cerebral blood flow signal and continuous arteriotony (BP-Blood Pressure) signal.
Another purpose of the present invention is that the method for real-time detection and monitoring cerebral circulation critical closing pressure is provided.
The present invention solves the problems of the technologies described above the technical scheme that is adopted to be:
A kind of cerebral blood flow regulation function monitor system comprises:
One signal acquiring system, described signal acquiring system is used for the analogue signal that synchronized sampling obtains transcranial doppler signal and continuous arterial blood pressure signal, and the analog signal conversion of described transcranial doppler signal and continuous arterial blood pressure signal is become corresponding digital signal;
Through one signal processing/display system that interface is connected with described signal acquiring system, described signal processing/display system comprises signal processing module and display module; Described signal processing/display system is used for transcranial doppler that obtains synchronously and continuous arteriotony digital signal are handled, and obtains the cerebral circulation critical closing pressure signal, and the cerebral circulation critical closing pressure signal is shown.
Described cerebral blood flow regulation function monitor system, wherein: first kind of signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit one with the control of the synchronous sampling control signal of clock pulses under, to each gather path output signal carry out synchronized sampling;
Multichannel or multi-disc A/D converter, described A/D converter are gone into end and are linked to each other with the sampling hold circuit outfan respectively, be used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation inform that A/D changes completed A/D EOC signal;
One control module that is connected with interface communication, this module utilizes main clock pulse to produce the A/D conversion start signal and A/D reads control signal, described A/D conversion start signal control A/D converter begins to carry out the A/D conversion, when A/D converts and after control module received that A/D converts signal, the A/D that described control module is sent read control signal control A/D converter dateout.
Described cerebral blood flow regulation function monitor system, wherein: described sampling control signal is produced by control module.
Described cerebral blood flow regulation function monitor system, wherein: second kind of signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit one with the control of the synchronous sampling control signal of clock pulses under, to each gather path output signal carry out synchronized sampling;
One A/D converter be used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation informs that A/D changes completed A/D EOC signal;
One multiple signals selector, described multiple signals selector are gone into end and are connected with each sampling hold circuit outfan respectively, and the outfan of described multiple signals selector links to each other with the end of going into of A/D converter;
One control module that is connected with interface communication, this module utilize main clock pulse to produce the A/D conversion start signal, A/D reads control signal and channel selecting control signal; Described channel selecting control signal control multiple signals selector is realized the signal selection, and the analogue signal of sampling output is delivered to A/D converter successively; Described A/D conversion start signal control A/D converter begins to carry out the A/D conversion, when A/D converts and after control module received that A/D converts signal, the A/D that described control module is sent read control signal control A/D converter dateout successively
Described cerebral blood flow regulation function monitor system, wherein: described sampling control signal is produced by control module.
Described cerebral blood flow regulation function monitor system, wherein: the third signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit to each gather path output signal carry out synchronized sampling;
Multichannel or multi-disc A/D converter, described A/D converter are gone into end and are linked to each other with the sampling hold circuit outfan respectively, are used for the analog signal conversion of sampling output is become digital signal;
One control module that is connected with interface communication, this module are used to produce master clock signal and A/D changeover control signal, and described master clock signal and A/D changeover control signal act on A/D converter, control this A/D converter and carry out analog digital conversion; This module also produces sampling control signal, and described sampling control signal is used to control the sampled point that each sampling hold circuit obtains transcranial doppler signal and continuous arterial blood pressure signal synchronously.
Described cerebral blood flow regulation function monitor system, wherein: the 4th kind of signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arteriotony, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit to each gather path output signal carry out synchronized sampling;
One A/D converter is used for the analog signal conversion of sampling output is become digital signal;
One multiple signals selector, described multiple signals selector are gone into end and are connected with each sampling hold circuit outfan respectively, and the outfan of described multiple signals selector links to each other with the end of going into of A/D converter;
One control module that is connected with interface communication, this module are used to produce master clock signal and A/D changeover control signal, and described master clock signal and A/D changeover control signal act on A/D converter, control this A/D converter and carry out analog digital conversion; This module also produces sampling control signal, and described sampling control signal is used to control the sampled point that each sampling hold circuit obtains transcranial doppler signal and continuous arterial blood pressure signal synchronously; And also producing the channel selecting control signal, described channel selecting control signal control multiple signals selector is realized the signal selection, the analogue signal of sampling output is delivered to A/D converter successively carry out analog digital conversion.
Above-described cerebral blood flow regulation function monitor system, wherein: described signals collecting/control module adopts complex programmable logic device (CPLD)-Complex Programmable Logic Device to realize.
Described cerebral blood flow regulation function monitor system, wherein: described A/D converter outfan is connected with CPLD, and the digital signal of A/D converter output exports processing/display system to behind the CPLD buffer memory.
Described cerebral blood flow regulation function monitor system, wherein: described processing/display system adopts the PC system.
A kind of method that detects cerebral circulation critical closing pressure comprises the steps:
A, synchronous acquisition transcranial doppler signal and continuous arterial blood pressure signal make the sampled point of each signalling channel identical;
B, the transcranial doppler signal that synchronized sampling is obtained and continuous arterial blood pressure signal carry out the A/D conversion, obtain buffer memory output behind the corresponding digital signal;
C, according to transcranial doppler digital signal and continuous arteriotony digital signal, obtain according to rhythmic blood flow signal envelope of cardiac cycle and blood pressure signal curve;
D, select the cardiac cycle of M continuous whole in the same period, wherein M is the positive integer more than or equal to 1;
E, in the cardiac cycle of a described M continuous whole, choose the big high correlation cardiac cycle of N blood flow signal envelope and blood pressure signal curve correlation coefficient respectively, 1≤N≤M wherein, N is a positive integer;
F, in each high correlation cardiac cycle, be taken to few two time points, and find out the value of blood flow signal envelope correspondence on the same time point and the value of blood pressure signal curve correspondence, in the coordinate system of reflection flow velocity-blood pressure corresponding relation, obtain at least two blood flows-blood pressure and close mooring points;
G, blood flow-blood pressure is closed mooring points do linear regression, obtain the straight line of match, calculated line is cut square on the blood pressure axle, obtain cerebral circulation critical closing pressure.
Described method, wherein: described step e comprises following processing:
E1, translation blood flow signal envelope or blood pressure signal curve, the blood flow signal envelope of correspondence and the correlation coefficient maximum of blood pressure signal curve in a cardiac cycle, this cardiac cycle is the high correlation cardiac cycle;
E2, repeating step E1 are until finding out N high correlation cardiac cycle.
Described method, wherein: described M equals 6, and described N equals 4, and described step G comprises following processing:
G1, respectively the blood flow of each high correlation cardiac cycle-blood pressure is closed mooring points and do linear regression, obtain first to fourth straight line of match;
G2, calculate first to fourth straight line respectively and on the blood pressure axle, cut square, obtain first to fourth cerebral circulation critical closing pressure;
G3, first to fourth cerebral circulation critical closing pressure is averaged, obtain cerebral circulation critical closing pressure.
The another kind of method that detects cerebral circulation critical closing pressure comprises the steps:
A, synchronous acquisition transcranial doppler signal and continuous arterial blood pressure signal make the sampled point of each signalling channel identical;
B, the transcranial doppler signal that synchronized sampling is obtained and continuous arterial blood pressure signal carry out the A/D conversion, obtain buffer memory output behind the corresponding digital signal;
C, according to transcranial doppler digital signal and continuous arteriotony digital signal, obtain according to rhythmic blood flow signal envelope of cardiac cycle and blood pressure signal curve;
D, choose a cardiac cycle, calculate the amplitude of first harmonic of blood pressure in this cardiac cycle and the amplitude of first harmonic of blood flow velocity ripple with the Fourier transform method; And calculate the time average of blood pressure time average and blood flow velocity ripple in this cardiac cycle;
E, employing following formula calculate the cycle cerebral circulation critical closing pressure of this cardiac cycle:
CCPf＝ABP0-CBFV0×ABP1/CBFV1
Wherein: CCPf is the cycle cerebral circulation critical closing pressure of a cardiac cycle, and ABP1 is the amplitude of first harmonic of blood pressure, and CBFV1 is the amplitude of first harmonic of blood flow velocity ripple, and ABP0 is the blood pressure time average, and CBFV0 is the time average of blood flow velocity ripple.
Described method also comprises the steps:
F, choose M cardiac cycle, repeating step D calculates M cycle cerebral circulation critical closing pressure to step e, M 〉=3 wherein, G, the highest and minimum cycle cerebral circulation critical closing pressure of rejecting are averaged remaining cycle cerebral circulation critical closing pressure, are cerebral circulation critical closing pressure.
Above-described two kinds of methods, wherein: described steps A comprises the steps:
A1, collection transcranial doppler signal and continuous arterial blood pressure signal are provided with and the synchronous sampling control signal of a clock pulses;
A2, control each signalling channel with described sampling control signal transcranial doppler signal and continuous arterial blood pressure signal are carried out synchronized sampling, make the sampled point of each signalling channel identical.
Above-described method, wherein: after obtaining described cerebral circulation critical closing pressure, calculate cerebral blood flow with following formula and regulate lower limit automatically
Cerebral blood flow is regulated lower limit=mean arterial pressure-cerebral circulation critical closing pressure automatically.
Beneficial effect of the present invention is: adopt system and method for the present invention, need not manually utilize medicine or adopt other various operational means to change tester's arteriotony, only need synchronously monitoring TCD cerebral blood flow signal and continuously arterial blood pressure signal just can detect cerebral circulation critical closing pressure, and can monitor cerebral blood flow smoothly by cerebral circulation critical closing pressure and regulate lower limit automatically, realized that noinvasive detects the automatic regulatory function of cerebral blood flow; And owing to the perfect number value representation of measurement result with mean arterial blood pressure, the automatic adjustment curve method of form and classical cerebral blood flow is similar, eliminated artificial fractionated defective, so the result accurately and reliably, and clinical practice is strong.
Description of drawings
Fig. 1 is a cerebral blood flow regulation function monitor system functional-block diagram of the present invention;
Fig. 2 is first kind of technical scheme signal acquiring system block diagram;
Fig. 3 is first kind of technical scheme signals collecting control sequential chart;
Fig. 4 is second kind of technical scheme signal acquiring system block diagram;
Fig. 5 is second kind of technical scheme signals collecting control sequential chart;
Fig. 6 is the third technical scheme signal acquiring system block diagram;
Fig. 7 is the third technical scheme signals collecting control sequential chart;
Fig. 8 is the 4th a kind of technical scheme signal acquiring system block diagram;
Fig. 9 is the 4th a kind of technical scheme signals collecting control sequential chart;
Figure 10 is signal acquiring system one an embodiment circuit diagram;
The envelope of Figure 11 blood flow signal and the curve synoptic diagram of blood pressure signal;
Figure 12 is that blood flow velocity-blood pressure concerns sketch map.
The specific embodiment
With embodiment the present invention is described in further detail with reference to the accompanying drawings below:
Detection and monitoring to the automatic regulatory function of cerebral blood flow, come down to detect and to guard the accurate numerical value that cerebral blood flow is regulated lower limit automatically, the present invention is by synchronous acquisition and monitoring transcranial doppler (TCD-Transcranial Doppler) cerebral blood flow signal and continuous arteriotony (BP-BloodPressure) signal, thereby obtain cerebral circulation critical closing pressure, and can monitor cerebral blood flow smoothly by cerebral circulation critical closing pressure and regulate lower limit automatically.The automatic regulatory function detection/monitor system of cerebral blood flow of the present invention as shown in Figure 1, comprise a signal acquiring system, described signal acquiring system is used for the analogue signal that synchronized sampling obtains TCD cerebral blood flow signal and BP signal, and synchronized sampling is obtained the corresponding digital signal of analog signal conversion one-tenth of TCD cerebral blood flow signal and BP signal; Also comprise an interface, and the one signal processing/display system that is connected with signal acquiring system through interface, this signal processing/display system comprises signal processing module and display module, signal processing module is used for TCD cerebral blood flow signal that obtains synchronously and BP digital signal are handled and computing, obtain cerebral circulation critical closing pressure CCP and cerebral blood flow and regulate lower limit (Lower limit of cerebralautoregulation automatically, LLCA), display module shows CCP and LLCA, realizes detection and monitoring to the automatic regulatory function of cerebral blood flow.Wherein, processing/display system adopts the PC system to realize usually; Adopt the PC interface to connect between signal acquiring system and the PC system, and the PC interface adopt the USB controller usually.
Signal acquiring system of the present invention has adopted several different technical schemes, but several scheme essence all are by adopting same collection, switching signal to control TCD cerebral blood flow signal, the continuously synchronized sampling and the analog digital conversion (A/D) of arterial blood pressure signal, thereby realize the function of signal synchronous collection.
First kind of signal acquiring system scheme as shown in Figure 2, comprise that at least one is used to gather the TCD module of transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, BP module can be to have wound to gather the BP module, also can be that noinvasive is gathered the BP module; TCD module and BP module respectively comprise one or more signals collecting paths, and for example the TCD module comprises 4 signal sampling channels, and the BP module comprises a signals collecting path;
According to the signal sampling channel sum a plurality of sampling hold circuits are set, sampling hold circuit links to each other with each signals collecting path outfan, be used for to each gather path output signal carry out synchronized sampling; Sampling hold circuit can adopt general circuit structure, comprise an analog switch, an operational amplifier and an electric capacity, the outfan of going into end connection signal acquisition circuit of analog switch, the in-phase input end of the outfan concatenation operation amplifier of analog switch, electric capacity is connected between the in-phase input end and ground of operational amplifier, the outfan concatenation operation amplifier's inverting input of operational amplifier; Control end at each analog switch all applies a sampling control signal S/H, the S/H signal is synchronized with same clock pulses, the S/H signal is used to control the sampled point that each sampling hold circuit obtains TCD signal and BP signal synchronously, thereby realizes each is gathered obtaining synchronously of path output signal.The output of sampling hold circuit connects multi-channel a/d converter (or multi-disc A/D conversion transducer), A/D converter is used for the analog signal conversion of sampling output is become digital signal, the signalling channel sum of A/D conversion this moment transducer must be more than or equal to the signal sampling channel sum of signal acquisition module, just can will carry out the A/D conversion simultaneously through the analogue signal of sampling hold circuit synchronized sampling output, and the output of the digital signal serial or parallel after will changing.
One signals collecting/the control module that is connected with the communication of USB controller, during this module can be used, small scale integration (gate circuit, enumerator, latch) makes up, also can utilize programming device (PLD, CPLD, FPGA) to realize, present embodiment adopts CPLD (CPLD one Complex Programmable Logic Device).This CPLD is connected with a clock pulses signal, the clock signal of a 2M for example, CPLD carries out frequency division with the clock signal of 2M, produce sampling control signal (S/H signal), A/D conversion start signal (SMP signal) and A/D and read control signal (RD signal), wherein: the frequency of S/H signal is that several kHz are to tens kHz, each sampling hold circuit of the unified control of S/H signal is sampled to signal, has realized obtaining synchronously transcranial doppler signal and the continuous arterial blood pressure signal sampled point in the identical moment; SMP signal controlling A/D converter begins to carry out the A/D conversion, after A/D converts, A/D converter sends informs that A/D changes completed A/D EOC signal (INT signal), and CPLD receives and produces and send the RD signal behind the INT signal, control A/D converter dateout.Its signals collecting control sequential is referring to Fig. 3, as seen from Figure 3, when the S/H signal effectively after, TCD, BP signal be sampled/holding circuit preserves, the S/H signal uprises post-sampling and finishes, the SMP signal arrives afterwards, and A/D begins signal is changed, after A/D converts, produce the INT signal, CPLD sends the RD signal after receiving the INT signal, reads the data of the 1st, 2,3,4,5 passages of A/D successively, and the every step-down of RD signal once reads a passage.
Scheme one shown in Figure 2 has been used multi-channel synchronous conversion A/D converter, therefore, only need sample to signal, changes, read and get final product.If use single channel A/D, after then needing signal sampled, give A/D with signal successively by the multiple signals selector again and change.Need to adopt technical scheme two as shown in Figure 4 thus.The signal acquisition module of this technical scheme and sampling hold circuit and technical scheme one are identical, different with technical scheme one is: A/D converter is the single channel A/D converter, and increased by a multiple signals selector (MUX), MUX goes into end and is connected with each sampling hold circuit outfan respectively, its outfan links to each other with the end of going into of A/D converter, CPLD is except producing sampling control signal (S/H signal) simultaneously, A/D conversion start signal (SMP signal) and A/D read control signal (RD signal), also produce channel selecting control signal MPX0, MPX1, MPX2 (the unified MPX[2...0 that is expressed as), MPX[2...0] selection of signal controlling multiple signals selector realization signal, the analogue signal of sampling output is delivered to A/D converter successively carry out analog digital conversion, its signals collecting control sequential is referring to Fig. 5.As seen from Figure 5, after the S/H signal is effective, TCD, the BP signal is sampled/and holding circuit preserves, the S/H signal uprises post-sampling and finishes, afterwards at MPX[2...0] signal is from 000,001,010,011,100 conversion, successively with 1 of multiplexer (MUX), 2,3,4,5 passages are preserved the signal that gets off and are sent into A/D converter, A/D converter is changed signal under the control of SMP signal, after A/D converts, produce the INT signal, CPLD sends the RD signal after receiving the INT signal, reads the 1st of A/D, 2,3,4, the data of 5 passages, the every step-down of RD signal once reads a passage.
In the above technical scheme one and two, A/D converter has adopted the conversion regime of the formula of replying, that is: control module sends conversion start signal SMP notice A/D conversion beginning, A/D conversion finishing back transmission one converts signal INT and informs that the control module conversion finishes, control module receives that conversion finishes and sends read signal RD behind the signal, obtains data DATA from the data output end of A/D converter.If A/D converter adopts synchronous conversion regime, that is: offer change over clock DCLK of A/D converter and conversion start signal CS, A/D converter can be finished the output of conversion and data synchronous time of clock, and need not the intervention of external control module (CPLD).When adopting this mode, following two kinds of schemes can be arranged.
Technical scheme three as shown in Figure 6, basic identical with the circuit structure form of technical scheme one, and adopt identical signal acquisition module and sampling hold circuit, and multichannel or multi-disc A/D converter, different is that CPLD is except producing sampling control signal (S/H signal), provide master clock signal DCLK and A/D changeover control signal CS to A/D converter, DCLK signal and this A/D converter of CS signal controlling carry out analog digital conversion, A/D converter need not produce and inform that A/D changes completed INT signal this moment, A/D converter is in the output of finishing conversion and data synchronously down of clock DCLK, and the signals collecting control sequential of this scheme is referring to Fig. 7.
Technical scheme four is similar to scheme three, referring to Fig. 8, the signal acquisition module of this technical scheme and sampling hold circuit and technical scheme three are identical, different with technical scheme three is: A/D converter is the single channel A/D converter, and increased by a multiple signals selector (MUX), MUX goes into end and is connected with each sampling hold circuit outfan respectively, its outfan links to each other with the end of going into of A/D converter, CPLD is except producing the S/H signal simultaneously, master clock signal DCLK and A/D changeover control signal CS, also produce channel selecting control signal MPX0, MPX1, MPX2 (the unified MPX[2...0 that is expressed as]), MPX[2...0] selection of signal controlling multiple signals selector realization signal, the analogue signal of sampling output is delivered to A/D converter successively carry out analog digital conversion, its signals collecting control sequential is referring to Fig. 9.Before this sequential chart is described, need be as follows to relevant signal instruction:
TCD/BP: expression transcranial doppler cerebral blood flow signal, arterial blood pressure signal continuously, be analogue signal, TCD is 4 the tunnel, BP is 1 the tunnel, totally 5 the tunnel.
S/H: sampling control signal, be digital signal, switch closure during low level is sampled; Switch opens during high level enters hold mode.
The CS:A/D changeover control signal is digital signal, and A/D begins conversion during low level.
DCLK: the master clock signal of signals collecting, conversion.
The dateout of DOUT:A/D transducer.
MPX[2...0]: the channel selecting control signal, be used for the MUX0-MUX3 signalling channel and select, be digital signal, signal selection mode such as following table:
| MPX[2] | MPX[1] | MPX[0] | |
| 0 | 0 | 0 | 1 |
| 0 | 0 | 1 | 2 |
| 0 | 1 | 0 | 3 |
| 0 | 1 | 1 | 4 |
| 1 | 0 | 0 | 5 |
The signal that collects from TCD module, BP module is at first through a sample/hold circuit, sampling control signal S/H is obtained through the CPLD frequency division by the clock signal of 2M, the frequency of S/H signal is that several kHz are to tens kHz, by each sample/hold circuit of the unified control of S/H signal signal is sampled, realized obtaining synchronously signal.Simultaneously, CPLD also carries out frequency division with the 2M signal, obtains MPX[2...0] and the CS signal, by MPX[2...0] control the multiple signals selector, signal is delivered to A/D successively, A/D changes under the control of CS and DCLK.As seen from the figure, after the S/H signal arrives, at MPX[2...0] under the control of signal, give A/D with the signal that keeps successively, A/D is converted to DOUT to signal.For example, after first S/H signal arrives, MPX[2...0] change according to 000,001,010,011,100 orders, choose the passage 1,2,3,4,5 of MUX successively, signal is delivered to A/D converter, simultaneously, whenever choose a channel C S effectively once, so just the signal of choosing is changed by A/D.
For first and third kind of technical scheme, collection/control module among Fig. 1 comprises sampling hold circuit, A/D converter and control module, and for second, four kind of technical scheme, the collection/control module among Fig. 1 comprises sampling hold circuit, A/D converter, control module and multiple signals selector.The digital signal of A/D converter output can be directly be sent to the PC system through a buffer memory and PC interface and processs and displays, simultaneously in order to make full use of the FPGA resource, the A/D converter outfan also can be connected with CPLD, and the digital signal of A/D converter output is exported behind the CPLD buffer memory.In the specific implementation process of scheme, satisfying under the prerequisite of signal quality, can select multiple different analog switch, operational amplifier, sampling capacitance to realize sample/hold circuit according to practical situation, all do not influence the function of sample/hold circuit; A/D converter also can according to circumstances be selected a slice or multi-disc, if use multi-disc A/D, and can guarantee that the total number of channels that the A/D converter signal is imported can satisfy the TCD signal, the BP signal is changed simultaneously, does not then need to use MUX; Otherwise, need to use MUX to give A/D successively and change, and MUX also can according to circumstances be selected different models signal; The output of A/D can be adopted serial or parallel mode.
Figure 10 is a specific embodiment of the present invention, and this embodiment has adopted A/D converter chip AD787, and integrated sampling hold circuit, multiple signals are selected and the A/D translation function in this chip, and signals collecting control sequential utilizes CPLD to produce.Because the input of AD7874 carries sample/hold circuit, multiple signals selector, so not extra sample/hold circuit and multiple signals selector of using in circuit is realized, and additionally produce sampling control signal S/H, only according to the instructions for use of AD7874, provide SMP, RD signal by CPLD, AD7874 inside produces corresponding sampling control signal S/H by the SMP signal.Because every AD787 only has 4 to go into end and gather path and link to each other, therefore needs two AD787 realizations.
Four kinds of technical schemes to sum up, the present invention detects cerebral circulation critical closing pressure, and then realizes that cerebral blood flow regulates the method for lower limit Clinical detection and monitoring automatically and be summarized as follows:
A1, collection transcranial doppler signal and continuous arterial blood pressure signal are provided with and the synchronous sampling control signal of a clock pulses;
A2, control each signalling channel with described sampling control signal transcranial doppler signal and continuous arterial blood pressure signal are carried out synchronized sampling, make the sampled point of each signalling channel identical.
B, the transcranial doppler signal that synchronized sampling is obtained and continuous arterial blood pressure signal carry out the A/D conversion, obtain buffer memory output behind the corresponding digital signal;
When acquisition system finish to the synchronous acquisition of TCD and BP signal and export TCD and the BP digital signal after, the PC system handles and calculates TCD and BP digital signal, the steps include:
C, at first utilize image processing method (for example Edge extraction algorithm) to obtain according to the rhythmic blood flow signal envelope of cardiac cycle and blood pressure signal curve as shown in figure 11, wherein curve 1 is the blood flow envelope, and unit is cm/s; Curve 2 is a blood pressure curve, and unit is mmHg; The blood flow signal envelope of each cardiac cycle and blood pressure signal curve present a triangle;
Obtain after blood flow signal envelope and the blood pressure signal curve, (critical closing pressure, CCP), and then the realization cerebral blood flow is regulated clinical noinvasive detection of lower limit and monitoring automatically can to adopt two kinds of diverse ways to obtain cerebral circulation critical closing pressure.First method
D, select the cardiac cycle of M continuous whole in the same period, wherein M is the positive integer more than or equal to 1.For example select M to equal 6, promptly select the cardiac cycle of 6 continuous whole;
E, in 6 complete cardiac cycles, choose blood flow signal envelope and N high high correlation cardiac cycle of blood pressure signal curve correlation coefficient, 1≤N≤M wherein, N is a positive integer, for example N equals 4.Can adopt following concrete processing method to realize selecting 4 high correlation cardiac cycle: E1, translation blood flow signal envelope or blood pressure signal curves (scope of translation is no more than a cardiac cycle), in the process of translation, calculate the correlation coefficient of blood flow signal envelope and blood pressure signal curve in (for example adopting product moment method) cardiac cycle, until the cardiac cycle that finds the two correlation coefficient maximum, this cardiac cycle is the high correlation cardiac cycle; E2, repeating step E1 are until finding out 4 high correlation cardiac cycles.
F, in each high correlation cardiac cycle, get several time points, and find out same time point (the identical point of abscissa among Figure 11) and go up corresponding value of blood flow signal envelope (curve 1) and the corresponding value of blood pressure signal curve (curve 2), with the value of blood flow envelope is that the value of abscissa, blood pressure curve is a vertical coordinate, set up the coordinate system of flow velocity-blood pressure corresponding relation, and with blood flow-blood pressure pass mooring points (blood flow value, pressure value) is depicted in flow velocity-blood pressure coordinate, obtains flow velocity-blood pressure graph as shown in figure 12;
G, these blood flows-blood pressure are closed mooring points do linear regression, obtain the straight line of match, calculate this straight line and cut square on blood pressure axle (X-axis), this intercept is the cerebral circulation critical closing pressure CCPr of a cardiac cycle.
For the accuracy of data, step G comprises following processing:
G1, respectively the blood flow of each high correlation cardiac cycle-blood pressure is closed mooring points and do linear regression, obtain first to fourth straight line of match;
G2, calculate first to fourth straight line respectively and on the blood pressure axle, cut square, obtain first to fourth cerebral circulation critical closing pressure;
G3, first to fourth cerebral circulation critical closing pressure is averaged, obtain cerebral circulation critical closing pressure CCP.
After C obtained blood flow signal envelope and blood pressure signal curve, second method comprised the steps: according to steps A
D, choose a cardiac cycle, calculate the amplitude of first harmonic of blood pressure in this cardiac cycle and the amplitude of first harmonic of blood flow velocity ripple with the Fourier transform method; And calculate the time average of blood pressure time average and blood flow velocity ripple in this cardiac cycle;
E, employing following formula calculate the cycle cerebral circulation critical closing pressure of this cardiac cycle:
CCPf＝ABP0-CBFV0×ABP1/CBFV1
Wherein: CCPf is the cycle cerebral circulation critical closing pressure of a cardiac cycle, and ABP1 is the amplitude of first harmonic of blood pressure, and CBFV1 is the amplitude of first harmonic of blood flow velocity ripple, and ABP0 is the blood pressure time average, and CBFV0 is the time average of blood flow velocity ripple;
F, choose M cardiac cycle, repeating step D calculates M (for example 6) CCPf to step e,
G, the highest and minimum CCPf of rejecting average remaining CCPf, are cerebral circulation critical closing pressure CCP.
After utilizing first and second kind method to obtain cerebral circulation critical closing pressure CCP, utilize following formula just can calculate again to obtain cerebral blood flow regulate automatically lower limit (Lower limit of cerebra1autoregulation, LLCA),
LLCA=mean arterial pressure-CCP
The PC system will finally show critical closing pressure and automatically regulate lower limit, so the inventive method and system have realized the clinical noinvasive of the automatic regulatory function of cerebral blood flow is detected and monitoring.
Should be understood that; the method of cerebral blood flow regulation function monitor system of the present invention and detection cerebral circulation critical closing pressure; above-mentioned description at preferred embodiment is too concrete; can not therefore be interpreted as restriction to scope of patent protection of the present utility model; for those of ordinary skills; can be equal to replacement or change according to technical scheme of the present invention and inventive concept thereof, and all these changes or replacement all should belong to the protection domain of the appended claim of the present invention.
Claims (17)
1, a kind of cerebral blood flow regulation function monitor system is characterized in that: comprising:
One signal acquiring system, described signal acquiring system is used for the analogue signal that synchronized sampling obtains transcranial doppler signal and continuous arterial blood pressure signal, and the analog signal conversion of described transcranial doppler signal and continuous arterial blood pressure signal is become corresponding digital signal;
Through one signal processing/display system that interface is connected with described signal acquiring system, described signal processing/display system comprises signal processing module and display module; Described signal processing/display system is used for transcranial doppler that obtains synchronously and continuous arteriotony digital signal are handled, and obtains the cerebral circulation critical closing pressure signal, and the cerebral circulation critical closing pressure signal is shown.
2, cerebral blood flow regulation function monitor system according to claim 1 is characterized in that: described signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit one with the control of the synchronous sampling control signal of clock pulses under, to each gather path output signal carry out synchronized sampling;
Multichannel or multi-disc A/D converter, described A/D converter are gone into end and are linked to each other with the sampling hold circuit outfan respectively, be used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation inform that A/D changes completed A/D EOC signal;
One control module that is connected with interface communication, this module utilizes main clock pulse to produce the A/D conversion start signal and A/D reads control signal, described A/D conversion start signal control A/D converter begins to carry out the A/D conversion, when A/D converts and after control module received that A/D converts signal, the A/D that described control module is sent read control signal control A/D converter dateout.
3, cerebral blood flow regulation function monitor system according to claim 2 is characterized in that: described sampling control signal is produced by control module.
4, cerebral blood flow regulation function monitor system according to claim 1 is characterized in that: described signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit one with the control of the synchronous sampling control signal of clock pulses under, to each gather path output signal carry out synchronized sampling;
One A/D converter be used for the analogue signal of sampling output is carried out A/D conversion and dateout, and generation informs that A/D changes completed A/D EOC signal;
One multiple signals selector, described multiple signals selector are gone into end and are connected with each sampling hold circuit outfan respectively, and the outfan of described multiple signals selector links to each other with the end of going into of A/D converter;
One control module that is connected with interface communication, this module utilize main clock pulse to produce the A/D conversion start signal, A/D reads control signal and channel selecting control signal; Described channel selecting control signal control multiple signals selector is realized the signal selection, and the analogue signal of sampling output is delivered to A/D converter successively; Described A/D conversion start signal control A/D converter begins to carry out the A/D conversion, when A/D converts and after control module received that A/D converts signal, the A/D that described control module is sent read control signal control A/D converter dateout successively
5, cerebral blood flow regulation function monitor system according to claim 4 is characterized in that: described sampling control signal is produced by control module.
6, cerebral blood flow regulation function monitor system according to claim 1 is characterized in that: described signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arterial blood pressure signal, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit to each gather path output signal carry out synchronized sampling;
Multichannel or multi-disc A/D converter, described A/D converter are gone into end and are linked to each other with the sampling hold circuit outfan respectively, are used for the analog signal conversion of sampling output is become digital signal;
One control module that is connected with interface communication, this module are used to produce master clock signal and A/D changeover control signal, and described master clock signal and A/D changeover control signal act on A/D converter, control this A/D converter and carry out analog digital conversion; This module also produces sampling control signal, and described sampling control signal is used to control the sampled point that each sampling hold circuit obtains transcranial doppler signal and continuous arterial blood pressure signal synchronously.
7, cerebral blood flow regulation function monitor system according to claim 1 is characterized in that: described signal acquiring system comprises:
At least one TCD module that is used to gather the transcranial doppler signal, at least one BP module that is used to gather continuous arteriotony, described TCD module and BP module respectively comprise at least one signals collecting path;
A plurality of sampling hold circuits that link to each other with each signals collecting path outfan respectively, described sampling hold circuit to each gather path output signal carry out synchronized sampling;
One A/D converter is used for the analog signal conversion of sampling output is become digital signal;
One multiple signals selector, described multiple signals selector are gone into end and are connected with each sampling hold circuit outfan respectively, and the outfan of described multiple signals selector links to each other with the end of going into of A/D converter;
One control module that is connected with interface communication, this module are used to produce master clock signal and A/D changeover control signal, and described master clock signal and A/D changeover control signal act on A/D converter, control this A/D converter and carry out analog digital conversion; This module also produces sampling control signal, and described sampling control signal is used to control the sampled point that each sampling hold circuit obtains transcranial doppler signal and continuous arterial blood pressure signal synchronously; And also producing the channel selecting control signal, described channel selecting control signal control multiple signals selector is realized the signal selection, the analogue signal of sampling output is delivered to A/D converter successively carry out analog digital conversion.
8, according to the described cerebral blood flow regulation function monitor system of the arbitrary claim of claim 2 to 7, it is characterized in that: described control module adopts CPLD to realize.
9, cerebral blood flow regulation function monitor system according to claim 8 is characterized in that: described A/D converter outfan is connected with CPLD, and the digital signal of A/D converter output exports processing/display system to behind the CPLD buffer memory.
10, cerebral blood flow regulation function monitor system according to claim 9 is characterized in that: described processing/display system adopts the PC system.
11, a kind of method that detects cerebral circulation critical closing pressure comprises the steps:
A, synchronous acquisition transcranial doppler signal and continuous arterial blood pressure signal make the sampled point of each signalling channel identical;
B, the transcranial doppler signal that synchronized sampling is obtained and continuous arterial blood pressure signal carry out the A/D conversion, obtain buffer memory output behind the corresponding digital signal;
C, according to transcranial doppler digital signal and continuous arteriotony digital signal, obtain according to rhythmic blood flow signal envelope of cardiac cycle and blood pressure signal curve;
D, select the cardiac cycle of M continuous whole in the same period, wherein M is the positive integer more than or equal to 1;
E, in the cardiac cycle of a described M continuous whole, choose the big high correlation cardiac cycle of N blood flow signal envelope and blood pressure signal curve correlation coefficient respectively, 1≤N≤M wherein, N is a positive integer;
F, in each high correlation cardiac cycle, be taken to few two time points, and find out the value of blood flow signal envelope correspondence on the same time point and the value of blood pressure signal curve correspondence, in the coordinate system of reflection flow velocity-blood pressure corresponding relation, obtain at least two blood flows-blood pressure and close mooring points;
G, blood flow-blood pressure is closed mooring points do linear regression, obtain the straight line of match, calculated line is cut square on the blood pressure axle, obtain cerebral circulation critical closing pressure.
12, method according to claim 11 is characterized in that: described step e comprises following processing:
E1, translation blood flow signal envelope or blood pressure signal curve, the blood flow signal envelope of correspondence and the correlation coefficient maximum of blood pressure signal curve in a cardiac cycle, this cardiac cycle is the high correlation cardiac cycle;
E2, repeating step E1 are until finding out N high correlation cardiac cycle.
13, method according to claim 12 is characterized in that: described M equals 6, and described N equals 4, and described step G comprises following processing:
G1, respectively the blood flow of each high correlation cardiac cycle-blood pressure is closed mooring points and do linear regression, obtain first to fourth straight line of match;
G2, calculate first to fourth straight line respectively and on the blood pressure axle, cut square, obtain first to fourth cerebral circulation critical closing pressure;
G3, first to fourth cerebral circulation critical closing pressure is averaged, obtain cerebral circulation critical closing pressure.
14, a kind of method that detects cerebral circulation critical closing pressure comprises the steps:
A, synchronous acquisition transcranial doppler signal and continuous arterial blood pressure signal make the sampled point of each signalling channel identical;
B, the transcranial doppler signal that synchronized sampling is obtained and continuous arterial blood pressure signal carry out the A/D conversion, obtain buffer memory output behind the corresponding digital signal;
C, according to transcranial doppler digital signal and continuous arteriotony digital signal, obtain according to rhythmic blood flow signal envelope of cardiac cycle and blood pressure signal curve;
D, choose a cardiac cycle, calculate the amplitude of first harmonic of blood pressure in this cardiac cycle and the amplitude of first harmonic of blood flow velocity ripple with the Fourier transform method; And calculate the time average of blood pressure time average and blood flow velocity ripple in this cardiac cycle;
E, employing following formula calculate the cycle cerebral circulation critical closing pressure of this cardiac cycle:
CCPf＝ABP0-CBFV0×ABP1/CBFV1
Wherein: CCPf is the cycle cerebral circulation critical closing pressure of a cardiac cycle, and ABP1 is the amplitude of first harmonic of blood pressure, and CBFV1 is the amplitude of first harmonic of blood flow velocity ripple, and ABP0 is the blood pressure time average, and CBFV0 is the time average of blood flow velocity ripple.
15, method according to claim 14 is characterized in that: described method comprises the steps:
F, choose M cardiac cycle, repeating step D calculates M cycle cerebral circulation critical closing pressure to step e, M 〉=3 wherein,
G, the highest and minimum cycle cerebral circulation critical closing pressure of rejecting are averaged remaining cycle cerebral circulation critical closing pressure, are cerebral circulation critical closing pressure.
16, according to the described method of the arbitrary claim of claim 11 to 15, it is characterized in that: described steps A comprises the steps:
A1, collection transcranial doppler signal and continuous arterial blood pressure signal are provided with and the synchronous sampling control signal of a clock pulses;
A2, control each signalling channel with described sampling control signal transcranial doppler signal and continuous arterial blood pressure signal are carried out synchronized sampling, make the sampled point of each signalling channel identical.
17, method according to claim 16 is characterized in that: after obtaining described cerebral circulation critical closing pressure, calculate cerebral blood flow with following formula and regulate lower limit automatically:
Cerebral blood flow is regulated lower limit=mean arterial pressure-cerebral circulation critical closing pressure automatically.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100612338A CN100399990C (en) | 2006-06-21 | 2006-06-21 | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100612338A CN100399990C (en) | 2006-06-21 | 2006-06-21 | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1883383A true CN1883383A (en) | 2006-12-27 |
| CN100399990C CN100399990C (en) | 2008-07-09 |
Family
ID=37581781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100612338A Active CN100399990C (en) | 2006-06-21 | 2006-06-21 | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100399990C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2111787A1 (en) * | 2008-04-25 | 2009-10-28 | UAB Vittamed Technologijos | Apparatus and method of non-invasive cerebrovascular autoregulation monitoring |
| CN102038496A (en) * | 2010-12-23 | 2011-05-04 | 高庆春 | Method for rising PaCO2, acquisition device, monitor system and medical treatment purpose |
| CN102274049A (en) * | 2011-05-09 | 2011-12-14 | 深圳市德力凯电子有限公司 | Intracranial and extracranial blood flow signal detection system, signal display method and signal processing system |
| CN103006334A (en) * | 2013-01-05 | 2013-04-03 | 中国科学院深圳先进技术研究院 | Individualized real-time measuring system for noninvasive cerebral blood flow automatic adjusting function |
| CN107194200A (en) * | 2017-07-14 | 2017-09-22 | 深圳市德力凯医疗设备股份有限公司 | A kind of selections method, storage medium and the ultrasonic device of ultrasonic system data |
| CN107296627A (en) * | 2017-07-14 | 2017-10-27 | 深圳市德力凯医疗设备股份有限公司 | Output intent, storage medium and the ultrasonic device of cerebral-vessel imaging index |
| CN108703773A (en) * | 2018-06-07 | 2018-10-26 | 深圳市德力凯医疗设备股份有限公司 | A kind of cerebral-vessel imaging monitoring device |
| CN108784742A (en) * | 2018-06-07 | 2018-11-13 | 深圳市德力凯医疗设备股份有限公司 | A kind of cerebral-vessel imaging monitoring device |
| CN109730668A (en) * | 2018-11-30 | 2019-05-10 | 上海浩聚医疗科技有限公司 | Signal processing method based on histogram estimation brain self-regulation ability |
| CN111631699A (en) * | 2020-05-18 | 2020-09-08 | 华南理工大学 | Arterial blood pressure target value range evaluation system for keeping cerebral blood flow stable |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599896B (en) * | 2011-12-16 | 2015-01-21 | 广州医学院第二附属医院 | System for measuring conduction time of pulse waves between cerebral arteries and cerebral veins |
| CN102551698B (en) * | 2011-12-16 | 2015-03-18 | 广州医学院第二附属医院 | Neck and brain arterial pulse wave speed measurement system |
| US11419558B2 (en) | 2017-05-24 | 2022-08-23 | Covidien Lp | Determining a limit of autoregulation |
| US10660530B2 (en) | 2018-04-25 | 2020-05-26 | Covidien Lp | Determining changes to autoregulation |
| US11026586B2 (en) | 2018-04-25 | 2021-06-08 | Covidien Lp | Determining changes to autoregulation |
| US10610164B2 (en) | 2018-04-25 | 2020-04-07 | Covidien Lp | Determining changes to autoregulation |
| US10674964B2 (en) | 2018-04-25 | 2020-06-09 | Covidien Lp | Determining changes to autoregulation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1056046A (en) * | 1991-05-24 | 1991-11-13 | 复旦大学 | Inspection and measuring instrument for cerebrovascular function |
| US7547283B2 (en) * | 2000-11-28 | 2009-06-16 | Physiosonics, Inc. | Methods for determining intracranial pressure non-invasively |
| JP3785084B2 (en) * | 2001-11-09 | 2006-06-14 | フクダ電子株式会社 | Vascular endothelial function measuring device |
| CN1593333A (en) * | 2004-07-05 | 2005-03-16 | 上海德安生物医学工程有限公司 | Cerebral blood circulation dynamic analysis method and instrument |
| CN2728423Y (en) * | 2004-07-07 | 2005-09-28 | 无锡贝尔森影像技术有限公司 | Cerebrovascular hemodynamics detection instrument |
-
2006
- 2006-06-21 CN CNB2006100612338A patent/CN100399990C/en active Active
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2111787A1 (en) * | 2008-04-25 | 2009-10-28 | UAB Vittamed Technologijos | Apparatus and method of non-invasive cerebrovascular autoregulation monitoring |
| US7998075B2 (en) | 2008-04-25 | 2011-08-16 | Uab Vittamed Technologijos | Apparatus and method of non-invasive cerebrovascular autoregulation monitoring |
| CN102038496A (en) * | 2010-12-23 | 2011-05-04 | 高庆春 | Method for rising PaCO2, acquisition device, monitor system and medical treatment purpose |
| CN102038496B (en) * | 2010-12-23 | 2012-06-06 | 高庆春 | Acquisition device for rising PaCO2 and monitor system |
| CN102274049A (en) * | 2011-05-09 | 2011-12-14 | 深圳市德力凯电子有限公司 | Intracranial and extracranial blood flow signal detection system, signal display method and signal processing system |
| CN103006334A (en) * | 2013-01-05 | 2013-04-03 | 中国科学院深圳先进技术研究院 | Individualized real-time measuring system for noninvasive cerebral blood flow automatic adjusting function |
| CN103006334B (en) * | 2013-01-05 | 2014-11-26 | 中国科学院深圳先进技术研究院 | Individualized real-time measuring system for noninvasive cerebral blood flow automatic adjusting function |
| CN107296627A (en) * | 2017-07-14 | 2017-10-27 | 深圳市德力凯医疗设备股份有限公司 | Output intent, storage medium and the ultrasonic device of cerebral-vessel imaging index |
| CN107194200A (en) * | 2017-07-14 | 2017-09-22 | 深圳市德力凯医疗设备股份有限公司 | A kind of selections method, storage medium and the ultrasonic device of ultrasonic system data |
| WO2019010983A1 (en) * | 2017-07-14 | 2019-01-17 | 深圳市德力凯医疗设备股份有限公司 | Segment selecting method of ultrasonic system data, storage medium and ultrasonic equipment |
| CN108703773A (en) * | 2018-06-07 | 2018-10-26 | 深圳市德力凯医疗设备股份有限公司 | A kind of cerebral-vessel imaging monitoring device |
| CN108784742A (en) * | 2018-06-07 | 2018-11-13 | 深圳市德力凯医疗设备股份有限公司 | A kind of cerebral-vessel imaging monitoring device |
| CN108784742B (en) * | 2018-06-07 | 2024-03-12 | 深圳市德力凯医疗设备股份有限公司 | Cerebral blood flow automatic regulating and monitoring equipment |
| CN108703773B (en) * | 2018-06-07 | 2024-03-12 | 深圳市德力凯医疗设备股份有限公司 | Cerebral blood flow automatic regulating and monitoring device |
| CN109730668A (en) * | 2018-11-30 | 2019-05-10 | 上海浩聚医疗科技有限公司 | Signal processing method based on histogram estimation brain self-regulation ability |
| CN111631699A (en) * | 2020-05-18 | 2020-09-08 | 华南理工大学 | Arterial blood pressure target value range evaluation system for keeping cerebral blood flow stable |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100399990C (en) | 2008-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1883383A (en) | Cerebral blood flow regulation function monitor system and method for detecting cerebral circulation critical closing pressure | |
| CN106108877B (en) | A kind of survey meter of blood pressure | |
| EP3358485A1 (en) | General noninvasive blood glucose prediction method based on timing analysis | |
| CN103054562B (en) | Cardiovascular function detection method based on multi-channel pulse wave form analysis and device thereof | |
| CN105147269B (en) | A kind of noninvasive continuous BP measurement method | |
| EP2416270A3 (en) | Module-level analysis of peripheral blood leukocyte transcriptional profiles | |
| CN102579024A (en) | Adaptive time domain filtering for improved blood pressure estimation | |
| CN1348341A (en) | Method and apparatus for measuring cardiac flow output | |
| CN100344257C (en) | Cardiovascular dynamics checking checkup method | |
| CN1849998A (en) | Method and apparatus for continuously measuring blood pressure | |
| CN1244779A (en) | Method and apparatus for noninvasively determining hematocrit | |
| CN1732843A (en) | Blood pressure measuring system and method | |
| CN103932694A (en) | Method and device for accurately diagnosing FFR | |
| CN111000544B (en) | Method and system for constructing hybrid continuous blood pressure measurement model based on PPG waveform | |
| CN106991291B (en) | Computer simulation conversion method for real-time conversion of fetal electrocardiosignals into fetal sounds | |
| CN109567868A (en) | A kind of CTG fetal rhythm methods of marking and system | |
| CN86102378A (en) | Measure the method and apparatus of circulatory function | |
| CN1883380A (en) | Nerve intensive monitor system and method for realizing synchronous monitor of human multi-parameter signals | |
| CN106388867A (en) | Automatic identification measurement method for intima-media membrane in blood vessel and ultrasonic apparatus | |
| CN1872002A (en) | System for obtaining pulsant information | |
| CN106667474A (en) | Heart rate measuring method and device suitable for intelligent wearable device | |
| CN205964031U (en) | Blood pressure measuring instrument | |
| CN106473744A (en) | A kind of product axis computational methods based on plane cutting | |
| CN205964032U (en) | Blood pressure measuring system | |
| CN107184194A (en) | Based on numerically controlled blood pressure self-operated measuring unit and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Shenzhen City, Guangdong province Nanshan District 518054 board Nanyou Tian An Industrial Zone Liang Road Building 8 6C Patentee after: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. Patentee after: SHENZHEN University Address before: Shenzhen City, Guangdong province Nanshan District 518054 board Nanyou Tian An Industrial Zone Liang Road Building 8 6C Patentee before: Shenzhen Delicate Electronics Co.,Ltd. Patentee before: Shenzhen University |
|
| CP02 | Change in the address of a patent holder |
Address after: 518054 6 building, second industrial zone, Guan Long Cun, Xili street, Nanshan District, Shenzhen, Guangdong, China. 10 Co-patentee after: SHENZHEN University Patentee after: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. Address before: 518054 8 6C, South Oil Tianan Industrial Zone, Nanshan District, Shenzhen, Guangdong. Co-patentee before: Shenzhen University Patentee before: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder | ||
| CP03 | Change of name, title or address |
Address after: 518054 6 building, second industrial zone, Guan Long Cun, Xili street, Nanshan District, Shenzhen, Guangdong, China. 10 Patentee after: Shenzhen Delikai Medical Electronics Co.,Ltd. Country or region after: China Patentee after: SHENZHEN University Address before: 518054 6 building, second industrial zone, Guan Long Cun, Xili street, Nanshan District, Shenzhen, Guangdong, China. 10 Patentee before: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. Country or region before: China Patentee before: SHENZHEN University |
|
| CP03 | Change of name, title or address |