Summary of the invention
The present invention is directed to the deficiency of prior art; Chinese medicine of a kind of liver-protecting fat-dropping treatment cardiovascular disease and preparation method thereof is provided; Repairing hepatic injury, activating hepatocyte, strengthening on the basis of liver function the purpose of synchronous therapeutic hepatic disease and cardiovascular system diseases to reach.
The technical scheme that the present invention solves the problems of the technologies described above is following: a kind of Chinese medicine of liver-protecting fat-dropping treatment cardiovascular disease, said Chinese medicine is made up of each raw material of following parts by weight: 12~18 parts of Bulbus Liliies, 25~30 parts of Herba Taraxacis, 25~35 parts of Radix Puerariaes, 12~18 parts of Semen Ziziphi Spinosaes, 30~34 parts of Rhizoma Polygonatis, 38~45 parts of Fructus Hippophaes, 30~35 parts of Flos Chrysanthemis, 10~12 parts of Semen Sesami Nigrums, 24~30 parts of Flos Loniceraes, 15~20 parts of Fructus Crataegis, 14~30 parts of Semen Glyciness.
On the basis of technique scheme, the present invention can also do following improvement.
Further, said Chinese medicine is made up of each raw material of following parts by weight: 15 parts of Bulbus Liliies, 30 parts of Herba Taraxacis, 30 parts of Radix Puerariaes, 15 parts of Semen Ziziphi Spinosaes, 30 parts of Rhizoma Polygonatis, 45 parts of Fructus Hippophaes, 30 parts of Flos Chrysanthemis, 10 parts of Semen Sesami Nigrums, 30 parts of Flos Loniceraes, 15 parts of Fructus Crataegis, 20 parts of Semen Glyciness.
Adopt the beneficial effect of above-mentioned further scheme to be, strengthen blood fat reducing emphatically and repair the hepatic injury function.
Further, said Chinese medicine is tablet or pill.
The another technical scheme that the present invention solves the problems of the technologies described above is following: a kind of preparation method of Chinese medicine of liver-protecting fat-dropping treatment cardiovascular disease may further comprise the steps:
1) takes by weighing 12~18 parts of following each raw material Bulbus Liliies, 25~30 parts of Herba Taraxacis, 25~35 parts of Radix Puerariaes, 12~18 parts of Semen Ziziphi Spinosaes, 30~34 parts of Rhizoma Polygonatis, 38~45 parts of Fructus Hippophaes, 30~35 parts of Flos Chrysanthemis, 10~12 parts of Semen Sesami Nigrums, 24~30 parts of Flos Loniceraes, 15~20 parts of the Fructus Crataegis of parts by weight; After its pretreatment, grind to form 100~120 purpose powder;
2) soak of 2 times of 14~30 parts of usefulness of Semen Glycines of parts by weight is soaked pull out, dry after 24 hours, be ground into 100~120 purpose powder again;
3) with ground drug powder, insert stir in the agitator after, add water equiponderant with it, stir once more and process stock, leaving standstill became half-dried medicine embryo in 24 hours;
4) half-dried medicine embryo is put into make-up machine, process tablet or pill, with its oven dry, promptly get again
Further, the pretreatment in the said step 1) is that its roguing is cleaned, and concocts according to traditional method.
Further, said step 2) soak in is an edible white vinegar, and the weight of said soak is 2 times of Semen Glycines.
Further, the water in the said step 3) is deionized water.
The instructions of taking of Chinese medicine of the present invention: every day 3 times, each 3g, 30 days is a course of treatment.
The effect of each component is following in the Chinese medicine of the present invention:
Bulbus Lilii: be rich in compositions such as colchicine, xanthin ester, carotene, vitamin, the effect of falling liver-fire, clearing away heart-fire for tranquillization is arranged;
Herba Taraxaci: be rich in compositions such as sterol, choline, inulin, pectin, antibacterial is arranged, effect such as detoxifcation, heat clearing away, diuresis;
Radix Puerariae: be rich in compositions such as puerarin, xyloside, cupreol, isoflavone, the blood circulation of improvement is arranged, effect such as yang invigorating expelling pathogenic factors from muscles, relieving restlessness are sobered up;
Semen Ziziphi Spinosae: be rich in effects such as compositions such as jujuboside, sterol, triterpenoid, influential cardiovascular, nourishing the liver, mind calming, calmness;
Rhizoma Polygonati: be rich in compositions such as aspartic acid, digitalis glucoside, azetidinecarboxylic acid, anthraquinone class, antibiotic, antifungal is arranged, effect such as blood pressure lowering, bone and muscle strengthening, invigorating the spleen and replenishing QI;
Fructus Hippophae: be rich in compositions such as multivitamin, flavone, triterpene olefin(e) acid, blood fat reducing, cholesterol reducing are arranged, improve effects such as unit secretion;
Flos Chrysanthemi: be rich in compositions such as volatile oil, chrysanthemum glycoside, choline, flavone, antipathogen is arranged, strengthen capillary resistance and effects such as permeability, wind and heat dispersing;
Semen Sesami Nigrum: be rich in compositions such as sesamin, oleic acid, linoleic acid, arachidic acid, sterol, vitamin E, effects such as the liver of increasing glycogen, invigorating the liver and kidney, moistening five ZANG-organs are arranged;
Flos Lonicerae: be rich in compositions such as luteolin, inositol, Saponin, effects such as antibiotic, heat-clearing and toxic substances removing are arranged;
Fructus Crataegi: be rich in compositions such as Crataegolic acid, tartaric acid, citric acid, flavone, lactone, vitamin C, antibiotic, blood pressure lowering is arranged, effect such as removing food stagnancy, dissipating blood stasis;
Semen Glycines: be rich in compositions (containing levulic acid after the hydrolysis) such as folic acid, folinic acid, vitamin B12, osajin, choline, Saponin; Effects such as spleen invigorating alleviating distention in middle-JIAO, activating blood and promoting diuresis are arranged.
These Chinese medicine high quality materials, compatibility rationally, preparation science, evident in efficacy, safe and reliable, steady quality, take convenient; To repair hepatic injury, activate hepatocyte, to strengthen liver function and be the basis, with blood fat reducing, cholesterol reducing for curing mainly direction, synchronous therapeutic hepatic disease and cardiovascular system diseases; Have effects such as QI and blood regulating, enhancing anti pathologic immunity ability concurrently; And it is good, without any side effects to take safety for a long time, and meets the Chinese medicine preparation modernization request.
After taking a course of treatment, sx, take three courses of treatment (taking five courses of treatment at most continuously) after, great majority are cured, cure rate is greater than 98%, and has no side effect for a long time, has no drug resistance.
The specific embodiment
Below principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Embodiment 1
Press following weight proportion weighing: Bulbus Lilii 15g, Herba Taraxaci 30g, Radix Puerariae 30g, Semen Ziziphi Spinosae 15g, Rhizoma Polygonati 30g, Fructus Hippophae 45g, Flos Chrysanthemi 30g, Semen Sesami Nigrum 10g, Flos Lonicerae 30g, Fructus Crataegi 15g, Semen Glycines 20g; Weighing eats brew white vinegar 40g separately, the special-purpose distilled water 270g of pharmacy;
20g puts into container with Semen Glycines, soaks with the edible brew white vinegar of 40g, after 24 hours, pulls, dries, is ground into 100 to 120 order fine powders out;
With Bulbus Lilii 15g, Herba Taraxaci 30g, Radix Puerariae 30g, Semen Ziziphi Spinosae 15g, Rhizoma Polygonati 30g, Fructus Hippophae 45g, Flos Chrysanthemi 30g, Semen Sesami Nigrum 10g, Flos Lonicerae 30g, Fructus Crataegi 15g; Its roguing is cleaned; After the traditional method process of preparing Chinese medicine, be ground into 100 to 120 order fine powders altogether after again it being mixed;
The powder of 10 flavor medicines such as analysis for soybean powder and Bulbus Lilii is put into container mix stirring, add the 270g deionized water again, it is the special-purpose distilled water of pharmacy that meets the Ministry of Public Health regulation, through stirring, leaves standstill 24 hours, processes half-dried medicine embryo;
The half-dried medicine embryo of gained is put into shaping mechanism and is become tablet, after oven dry, processes the Chinese medicine tablet again.
Embodiment 2
Press following weight proportion weighing: Bulbus Lilii 18g, Herba Taraxaci 25g, Radix Puerariae 35g, Semen Ziziphi Spinosae 18g, Rhizoma Polygonati 34g, Fructus Hippophae 38g, Flos Chrysanthemi 35g, Semen Sesami Nigrum 11g, Flos Lonicerae 24g, Fructus Crataegi 18g, Semen Glycines 14g; Weighing eats brew white vinegar 28g separately, the special-purpose distilled water 270g of pharmacy;
14g puts into container with Semen Glycines, soaks with the edible brew white vinegar of 28g, after 24 hours, pulls, dries, is ground into 100 to 120 order fine powders out;
With Bulbus Lilii 18g, Herba Taraxaci 25g, Radix Puerariae 35g, Semen Ziziphi Spinosae 18g, Rhizoma Polygonati 34g, Fructus Hippophae 38g, Flos Chrysanthemi 35g, Semen Sesami Nigrum 11g, Flos Lonicerae 24g, Fructus Crataegi 18g, be ground into 100 to 120 order fine powders after the mixing altogether;
The powder of 10 flavor medicines such as analysis for soybean powder and Bulbus Lilii is put into container mix stirring, add the 270g deionized water again, it is the special-purpose distilled water of pharmacy that meets the Ministry of Public Health regulation, through stirring, leaves standstill 24 hours, processes half-dried medicine embryo;
The half-dried medicine embryo of gained is put into shaping mechanism and is become tablet, after oven dry, processes the Chinese medicine tablet again.
Embodiment 3
Press following weight proportion weighing: Bulbus Lilii 12g, Herba Taraxaci 28g, Radix Puerariae 25g, Semen Ziziphi Spinosae 12g, Rhizoma Polygonati 32g, Fructus Hippophae 40g, Flos Chrysanthemi 32g, Semen Sesami Nigrum 12g, Flos Lonicerae 27g, Fructus Crataegi 20g, Semen Glycines 30g; Weighing eats brew white vinegar 60g separately, the special-purpose distilled water 270g of pharmacy;
30g puts into container with Semen Glycines, soaks with the edible brew white vinegar of 60g, after 24 hours, pulls, dries, is ground into 100 to 120 order fine powders out;
With Bulbus Lilii 12g, Herba Taraxaci 28g, Radix Puerariae 25g, Semen Ziziphi Spinosae 12g, Rhizoma Polygonati 32g, Fructus Hippophae 40g, Flos Chrysanthemi 32g, Semen Sesami Nigrum 12g, Flos Lonicerae 27g, Fructus Crataegi 20g, be ground into 100 to 120 order fine powders after the mixing altogether;
The powder of 10 flavor medicines such as analysis for soybean powder and Bulbus Lilii is put into container mix stirring, add the 270g deionized water again, it is the special-purpose distilled water of pharmacy that meets the Ministry of Public Health regulation, through stirring, leaves standstill 24 hours, processes half-dried medicine embryo;
The half-dried medicine embryo of gained is put into make-up machine and is processed pill, after oven dry, processes the Chinese medicine pill again.
Clinical trial
Case 1
Ma Shubin, man, 50 years old, Chinese culture art city president.Private prosecution has the moderate fatty liver.
Before taking medicine of the present invention, Yantai City worker's hospital biochemical investigation report (2005-6-23),
Triglyceride 2.51mmol/L (height)
T-CHOL 5.61mmol/L (height)
Low lipoprotein cholesterol 2.55mmol/L (height)
High lipoprotein cholesterol 1.59mmol/L (height)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
After taking the Chinese medicine one and a half months of the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes, Yantai City worker's hospital biochemical investigation report (2005-8-11),
Triglyceride 1.23mmol/L (normally)
T-CHOL 5.08mmol/L (normally)
Low lipoprotein cholesterol 2.35mmol/L (height)
High lipoprotein cholesterol 2.11mmol/L (height)
Adhere to taking again (totally two and half courses of treatment) after a course of treatment, cure.
Case 2
Liu Yunzhen, woman, 48 years old, Yantai Arts & Crafts Co..
Before taking medicine of the present invention, Yantai City worker's hospital biochemical investigation report (2005-9-8),
Triglyceride 2.51mmol/L (height)
T-CHOL 5.69mmol/L (height)
Low lipoprotein cholesterol 2.15mmol/L (height)
High lipoprotein cholesterol 1.56mmol/L (height)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after 3 months, Yantai City worker's hospital biochemical investigation report (2005-12-16),
Triglyceride 1.76mmol/L (slightly high)
T-CHOL 5.12mmol/L (normally)
Low lipoprotein cholesterol 2.39mmol/L (normally)
High lipoprotein cholesterol 1.68mmol/L (normally)
After adhering to taking again a course of treatment, cure.
Case 3
Han Xiulan, woman, 79 years old, retirement.
Before taking medicine of the present invention, Yantai City worker's hospital biochemical investigation report (2005-8-8),
Triglyceride 2.51mmol/L (height)
T-CHOL 5.54mmol/L (height)
Low lipoprotein cholesterol 2.68mmol/L (height)
High lipoprotein cholesterol 1.51mmol/L (normally)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after 5 months, Yantai City worker's hospital biochemical investigation report (2006-1-9),
Triglyceride 1.09mmol/L (normally)
T-CHOL 2.41mmol/L (normally)
Low lipoprotein cholesterol 2.38mmol/L (normally)
High lipoprotein cholesterol 1.29mmol/L (normally)
Each item index is normal.
Case 4
By high post, the man, 44 years old, the pure screen in Xixia City district party and government did director.
Before taking medicine of the present invention, the People's Hospital, Xixia City biochemical investigation report (2004-11-7),
Glutamate pyruvate transaminase 275.0U/L (height)
GOT2 63.0U/L (height)
Glutamyl transpeptidase 110.7U/L (height)
Triglyceride 3.70mmo l/L (height)
T-CHOL 4.90mmol/L (normally)
Blood glucose 13.60mmol/L (height)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after half a year, the People's Hospital, Xixia City biochemical investigation report (2005-5-29),
Glutamate pyruvate transaminase 119.2U/L (falling 156)
Glutamic oxaloacetic transaminase, GOT 69.1U/L (falling 194)
Glutamyl transpeptidase 60.8U/L (falling 50)
Triglyceride 2.10mmol/L (normally)
T-CHOL 2.80mmol/L (normally)
Blood glucose 14.3mmol/L (not falling)
After adhering to taking again two courses of treatment, cure.
Case 5
Fan Minghui, man, Yantai cultural palace art troupe.
Before taking medicine of the present invention, Yantai Yantaishan Hospital's biochemical investigation report (2005-6-29),
Triglyceride 2.38mmol/L (height)
T-CHOL 7.87mmol/L (height)
Low lipoprotein cholesterol (not surveying)
High lipoprotein cholesterol (not surveying)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 2 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after 7 months, Yantai City's semi-annular jade pendant top hospital's biochemical investigation report (2006-1-26) of giving birth,
Triglyceride 0.98mmol/L (normally)
T-CHOL 3.35mmol/L (normally)
Low lipoprotein cholesterol 1.33mmol/L (normally)
High lipoprotein cholesterol 1.11mmol/L (normally)
Each item index is normal.
Case 6
Meet adopted ripple, man, 40 years old, Laishan District, Yantai Local Tax Bureau.
Before taking medicine of the present invention, Yantai City's semi-annular jade pendant top hospital's Laishan branch biochemical investigation report (2005-03-04) of giving birth,
Triglyceride 6.40mmol/L (height)
T-CHOL 6.00mmol/L (height)
Apolipoprotein B 1.23G/L (height)
Blood glucose 8.40mmol/L (height)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 3 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after 2 months, Yantai City's semi-annular jade pendant top hospital's Laishan branch biochemical investigation report (2005-05-01) of giving birth,
Triglyceride 4.40mmol/L (having fallen 2)
T-CHOL 5.30mmol/L (normally)
Apolipoprotein B 0.72G/L (normally)
Blood glucose 6.90mmol/L (falling, omit high)
After adhering to taking again a course of treatment, cure.
Case 7
Zhang Chunji, man, 36 years old, five metals station, Yantai.
Before taking medicine of the present invention, Yantai City's Zhifu District hospital biochemical investigation report (2005-6-13),
Uric acid 462.0mmol/L (height)
Triglyceride 2.73mmol/L (height)
T-CHOL 7.06mmol/L (height)
Low lipoprotein cholesterol 3.18mmol/L (height)
High lipoprotein cholesterol 1.38mmol/L (normally)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
Zhang Chunji was once interrupted take the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes for three times after, three biochemical inspection reports of Yantai City's Zhifu District hospital are following,
Project |
Unit |
2005-10-9 |
2006-1-5 |
2006-3-30 |
Triglyceride |
mmol/L |
(1.80 height) |
(2.08 height) |
(1.62 normally) |
T-CHOL |
mmol/L |
(7.00 height) |
(7.03 height) |
(5.27 normally) |
Low lipoprotein cholesterol |
mmol/L |
(3.63 height) |
(3.24 height) |
(2.76 normally) |
High lipoprotein cholesterol |
mmol/L |
1.79 |
1.77 |
(1.80 normally) |
[0153]
ApoA |
G/L |
1.25 |
(1.71 height) |
(1.39 normally) |
Apolipoprotein B |
G/L |
1.00 |
(1.25 height) |
(0.99 normally) |
(annotate: Zhang Chunji during intermittently taking medicine of the present invention, the diet that never draws oneself up with drink.From in January, 2006, take medicine of the present invention continuously after three courses of treatment, it is normal that each item index is recovered.)
Case 8
Jiang Bin, woman, 34 years old, the auspicious rich biotechnology in Yantai company.
Before taking medicine of the present invention, Yantai City worker's hospital biochemical investigation report (2005-8-8),
Triglyceride 1.75mmol/L (height)
T-CHOL 5.21mmol/L (height)
Low lipoprotein cholesterol 2.26mmol/L (height)
High lipoprotein cholesterol 1.22mmol/L (normally)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
The Chinese medicine of taking the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes is after 4 months, Yantai City worker's hospital biochemical investigation report (2005-12-16),
Triglyceride 1.69mmol/L (normally)
T-CHOL 4.68mmol/L (normally)
Low lipoprotein cholesterol 2.15mmol/L (normally)
High lipoprotein cholesterol 1.35mmol/L (normally)
Each item index is normal, cures.
Case 9
Tang's fork celebrating, man, 51 years old, municipal administration environmental sanitation place, development zone, Yantai.Private prosecution was once taken depressor and lipid lowerers for a long time, but was not had positive effect, 2005 then take medicine of the present invention.
Before taking medicine of the present invention, the 107th hospital of PLA biochemical investigation report (2003-11-4),
Triglyceride 2.36mmol/L (height)
T-CHOL 7.15mmol/L (height)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
After taking the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that the embodiment of the invention 1 makes, the 107th hospital of PLA biochemical investigation report (2005-10-27),
Triglyceride 1.33mmol/L (normally)
T-CHOL 5.80mmol/L (normally)
Each item index is normally
Case 10
Jiang Wenzhong, man, 53 years old, Yantai TWB company limited.Private prosecution has symptoms such as hypertension, dizziness, and colitis is arranged.
Before taking medicine of the present invention, Yantai City worker's hospital biochemical investigation report (2005-3-21),
Triglyceride 2.10mmol/L (height)
T-CHOL 5.35mmol/L (height)
Low lipoprotein cholesterol 1.69mmol/L (height)
High lipoprotein cholesterol 1.22mmol/L (normally)
Prescription: the Chinese medicine of the liver-protecting fat-dropping treatment cardiovascular disease that embodiment 1 makes.
Take medicine of the present invention after course of treatment after, same hospital's biochemical investigation report (2005-5-24),
Triglyceride 1.68mmol/L (normally)
T-CHOL 5.56mmol/L (height)
Low lipoprotein cholesterol 2.35mmol/L (height)
High lipoprotein cholesterol 1.39mmol/L (normally)
Take medicine of the present invention after two courses of treatment after, same hospital's biochemical investigation report (2005-6-25),
Triglyceride 1.68mmol/L (normally)
T-CHOL 5.0mmol/L (normally)
Low lipoprotein cholesterol 1.50mmol/L (normally)
High lipoprotein cholesterol 1.45mmol/L (normally)
After this once intermittently took medicine of the present invention, the private prosecution blood pressure has bigger reduction, dizzy transference cure, and colitis alleviates, is tending towards to cure.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.