CN102028740A - Medicament for treating coronary heart disease and preparation process thereof - Google Patents
Medicament for treating coronary heart disease and preparation process thereof Download PDFInfo
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- CN102028740A CN102028740A CN2009100706803A CN200910070680A CN102028740A CN 102028740 A CN102028740 A CN 102028740A CN 2009100706803 A CN2009100706803 A CN 2009100706803A CN 200910070680 A CN200910070680 A CN 200910070680A CN 102028740 A CN102028740 A CN 102028740A
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Abstract
The invention relates to a medicament for treating coronary heart disease and a preparation process thereof. The preparation process comprises the steps of ethanol extraction of root of red rooted salvia and root of pseudo-ginseng, water extraction of the decoction dregs of the root of red rooted salvia and the root of pseudo-ginseng, and the like. The preparation process has the advantages that: the process can realize industrialization, and the quality is stable and controllable. Related experiments show that: the medicament has high curative effect compared with the prior art; the medicament has high purity, good absorption, stable quality and novel application; and meanwhile, the preparation process is simple and convenient for operation, has low cost, and is suitable for industrialized production.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease, belong to the field of Chinese medicines.
Background technology
Along with the rejuvenation of growth in the living standard, world population aging and morbidity colony, cardiovascular and cerebrovascular vessel patient increases year by year, has become the second largest disease of harm humans health.Angina pectoris is a kind of caused by the temporary transient ischemia of cardiac muscle, anoxia, serves as the clinical syndrome of main performance with ictal chest pain or chest discomfort.Angina pectoris is meant because coronary atherosclerosis or spasm cause myocardial ischemia, the caused angina pectoris of anoxia, accounts for 90% of patient with angina pectoris.
The anginal method of treatment is based on blood vessel dilating, reduction blood viscosity, anti-platelet aggregation, anticoagulation at present.Traditional Western medicine of using is nitrate, nitrous acid ester, beta-blocker, calcium antagonist etc., but all has bigger toxic and side effects, should not take for a long time, mostly is symptomatic treatment and course of disease progress is not had bigger effect.For example take occur sometimes behind the nitroglycerin beating in feeling of fullness in the head, the head, palpitating speed, even faint [referring to 264 pages of new pharmacologies (the 14th edition)], find again in recent years to cause severe hypotension [referring to contemporary Chinese medical journal 1997; 7 (4): 42; Shaanxi medical journal 1996; 25 (5): 315], easily produce toleration [referring to southern nursing magazine 1996; 3 (5): 7～9] etc. problem has hindered its application clinically.
Though the anginal Chinese patent medicine of many treatments is also arranged, wherein ball, loose, cream, pellet, decoction becomes old historical already, the modern seldom uses.There are preparations such as common FUFANG DANSHEN PIAN and capsule to sell in the market, but conventional tablet, capsule manufacture technology fall behind, active constituent content is low, no quality control index, need oral through gastrointestinal absorption, go into blood at liver generation first pass effect post-absorption, bioavailability is low, absorbs slow. can not be fit to the need of angina pectoris patient's first aid.
FUFANG DANSHEN DIWAN is fast, the eutherapeutic therapeutic drug of coronary heart disease of a kind of special effect, is subjected to patient's welcome clinically deeply.In order to improve the preparation technology of FUFANG DANSHEN DIWAN, the inventor furthers investigate from the extraction process aspect, from saving the herb resource aspect, has improved product yield, the comprehensive utilization ratio of the contained effective ingredient of medical material.
Summary of the invention
The invention provides a kind of medicine for the treatment of coronary heart disease.
The medicine of treatment coronary heart disease of the present invention, described medicine is prepared from by following raw materials by weight percent medicine, Radix Salviae Miltiorrhizae 19.8%-97%, Radix Notoginseng 2%-80%, Borneolum Syntheticum 0.2%-3%, described preparation is earlier crude drug to be prepared into active constituents of medicine through following steps, further is prepared into medicine again.
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add alcohol, extract, and extracting solution is concentrated, dry, obtains the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add alcohol extraction, filter, and extracting solution concentrates, drying. and be dissolved in water, add alcohol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Radix Salviae Miltiorrhizae after step 2 alcohol extraction and Radix Notoginseng medicinal residues, aqueous alkali are or/and water extraction, and extracting solution concentrates, and adds alcohol, leaves standstill, and supernatant concentration obtains the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, the Salvia miltiorrhiza and Panax notoginseng ethanol extract of step 1, the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol of step 2, the Salvia miltiorrhiza and Panax notoginseng extract and the Borneolum Syntheticum of step 3 are further made drop pill.
Medicine of the present invention is for oral medicine, the preparation of galenic pharmacy routine techniques is adopted in its preparation, comprise the blended step of the adjuvant of active constituents of medicine and oral drugs, wherein the adjuvant of oral drug preparation be selected from starch, amylum pregelatinisatum, dextrin, Icing Sugar, lactose, mannitol, calcium sulfate two water things, calcium hydrogen phosphate, magnesium oxide, calcium carbonate, magnesium carbonate, water, ethanol, starch slurry, syrup, liquid glucose, maltose, refined honey, cane sugar powder, citric acid, essence, mucialga of arabic gummy,
GelatinSlurry, polyvinylpyrrolidone (PVP), rubber cement, crystallite
Fine Dimension is plain,
Sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose,
Magnesium stearate,
Stearic acid, zinc stearate, calcium stearate, Pulvis Talci, Macrogol 4000, polyethylene glycol 6000, micropowder silica gel, vegetable oil, sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, insect wax, hydrogenated oil and fat one or several combinations.
Oral formulations of the present invention is selected from: all acceptable dosage forms on tablet, dispersible tablet, hard capsule, soft capsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, syrup, oral liquid, soft extract and the extractum pharmaceutics.
Its preferred manufacturing procedure of medicine that confession of the present invention is oral, step is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol or the isobutanol of 2-12 times of 70-100%, and reflux, extract, is filtered, and extracting solution concentrating under reduced pressure, drying obtain the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 20-60% alcohol reflux 1-3 time that 2-8 doubly measures, and each 1-3hr filters, extracting solution concentrates, drying. and be dissolved in water, add ethanol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, the Salvia miltiorrhiza and Panax notoginseng medicinal residues after the alcohol extraction of step 2 add the aqueous alkali of 2-12 times of pH value 7-10, extract 1-3 time, add 2-12 times of water again, extract 1-3 time, filter, filtrate concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 50-80%, leaves standstill, separation of supernatant, reclaim ethanol, receive cream to pol 50%-90%, concentrated, dry, pulverizing obtain the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, with the Salvia miltiorrhiza and Panax notoginseng ethanol extract of step 1, Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol, the Salvia miltiorrhiza and Panax notoginseng extract mixes with adjuvant with Borneolum Syntheticum, add any or more than one adjuvants, the adjuvant addition is 1-6 a times of active component, makes any oral formulations.
The preferred drop pill of medicine of the present invention, the preparation of galenic pharmacy routine techniques is adopted in its preparation, comprises that described adjuvant is selected from fat-soluble substrate and water-soluble base with the blended step of adjuvant of active constituents of medicine and drop pill medicine, and medicine is assisted than being 1: 1-6.Wherein said fat-soluble substrate is selected from: stearic acid, glyceryl monostearate, insect wax, Cera Flava, paraffin, hydrogenated vegetable oil, semi-synthetic fatty acid ester; Water-soluble base is selected from Polyethylene Glycol, polyoxyethylene monostearate, poloxamer, sodium stearate, glycerin gelatine etc.; Xylitol and composites of starch, erythritol; Preferred medicine is auxilliary than being 1: 1.76.
Drop pill preferred manufacturing procedure of the present invention, step is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-5 times of 70-100% ethanol, reflux, extract, 1-3 time, and each 1-3 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 20-60% alcohol reflux 1-3 time that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, add for the first time the aqueous alkali that 2-12 doubly measures pH7-8 and decocted 1-3 hour, add 2-12 times of water gaging for the second time and decocted 0.5-2 hour, obtain extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 50%-80%, left standstill separation of supernatant 12-36 hour, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%-80%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously is made drop pill.
The preferred preparation method of drop pill of the present invention, step is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-5 and doubly measure 95% ethanol, reflux, extract, 1-3 time, and each 1-3 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40-60% alcohol reflux 1-3 time that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2 for the first time add 6-12 and doubly measure PH7-8, aqueous alkali decocted 1-3 hour, adding for the second time 6-12 times of water gaging decocted 0.5-2 hour, obtain extracting solution, extracting solution concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 50%-75%, leave standstill more than 12 hours, separation of supernatant reclaims ethanol, receives cream to pol 55%-75%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 0-10 ℃, makes drop pill.
The particularly preferred preparation method of drop pill of the present invention, step is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-3 and doubly measure 95% ethanol, reflux, extract, 2 times, and each 1-2 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add the 40-60% alcohol reflux 2 times that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain alcohol amount and reach 60-70%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The present invention also comprises the application of medicinal dropping ball in the medicine of cardiovascular disease such as a kind of resisting coronary heart disease of preparation, angina pectoris with treatment coronary heart disease of the present invention.
The present invention is more more superior than prior art because of the change of technology causes the present invention to treat the medicinal dropping ball of coronary heart disease.
Below data declaration the present invention treats the beneficial effect of the medicinal dropping ball of coronary heart disease by experiment.
Add the medicinal dropping ball of treatment coronary heart disease of the present invention before the myocardial cell anoxia, the intracellular calcium fluorescence intensity obviously descends, and proves that the medicinal dropping ball of treatment coronary heart disease has antagonism myocardial cell calcium overload, the effect of protecting myocardial cell.
Behind the myocardial ischemia-reperfusion, high-energy phosphate compound obviously reduces in the tissue, and the lipid peroxide contents showed increased causes reperfusion injury.The medicinal dropping ball that adds treatment coronary heart disease when pouring into again when before ischemia, pouring in advance and behind the ischemia, high-energy phosphate compound all is higher than ischemic reperfusion notes group in the tissue, two groups of adenosine triphosphate (ATP), cardiac muscular tissue's gland nucleoside total amount (TAN) are all near normal level, and the lipid peroxide level is lower than ischemic reperfusion notes group.This result proves, before ischemia during pre-perfusion with ischemia after treat coronary heart disease when pouring into again medicinal dropping ball all can be by increasing the cardiac energy deposit, the generation of inhibition lipid peroxide and protecting myocardial cell.
Cardiomyocyte cell death is a damage type the most serious in the myocardial ischemia-reperfusion, comprises necrocytosis and apoptosis.The apoptotic regulation and control that expressed by several genes.Myocardial infarction rear section myocardial cell generation apoptosis, relevant with the cell calcium overload due to the ischemia probably with the oxygen-derived free radicals effect.The medicinal dropping ball of treatment coronary heart disease can obviously reduce apoptosis of cardiac muscle quantity behind the myocardial ischemia-reperfusion, dwindles the myocardial infarct size of ischemia-reperfusion rat, significantly alleviates the pathology damage degree, and stronger with the medicinal dropping ball dosage increasing effect of treatment coronary heart disease.Carrying out the anoxia experiment in cardiac muscle cells shows, the medicinal dropping ball intervention of treatment coronary heart disease can obviously be reduced apoptotic proteins Fas and be expressed, slight upregulation of apoptosis Profilin Bcl-2 expresses, and shows that further the protein expression of apoptosis-related genes in the medicinal dropping ball pair cell for the treatment of coronary heart disease has certain influence.
The medicinal dropping ball of treatment coronary heart disease improves blood capillary circulation albumin outside leakage and mast cell degranulation is one of important symbol of microcirculation disturbance.The medicinal dropping ball of treatment coronary heart disease is to the improvement effect of endotoxin and the caused microcirculation disturbance of ischemia-reperfusion, the medicinal dropping ball that confirms treatment coronary heart disease improves significantly to the rat mesentery microcirculation disturbance that ischemia-reperfusion causes, shows: 1. can suppress the early stage albumin outside leakage of ischemia that Radix Salviae Miltiorrhizae can not play a role; 2. effectively suppress mast cell degranulation; 3. suppress the generation of vascular endothelial cell and leukocyte oxide; 4. suppress sticking of leukocyte and vascular endothelial cell; 5. also influential to the interaction of the cell adhesion factor, peroxidating and leukocyte behind the ischemia-reperfusion and endotheliocyte.
The medicinal dropping ball of treatment coronary heart disease has more obviously influence to patient's bulbar Conjunctiva Microcirculation, thrombelastogram, patient's arteriole vessel diameter broadening after the medication, and fine vein blood vessel narrow diameter, arteriole blood flow rate and blood flow have more significantly to be increased.
Medicinal dropping ball antioxidation, antiinflammatory, the protection blood vessel endothelium of treatment coronary heart disease, the balance between the formation of inhibition atherosclerotic plaque and neointimal hyperplasia vascular endothelial cell associated media nitric oxide (NO) and the vasoconstrictive factor endothelin-1 (ET-1) etc. is being kept the stability of blood vessel.The medicinal dropping ball of the treatment coronary heart disease of damage back variable concentrations all obviously alleviates human vascular endothelial damage due to the LPS, illustrate that the medicinal dropping ball for the treatment of coronary heart disease has obvious protective effect to vascular endothelial cell.The medicinal dropping ball of variable concentrations being treated coronary heart disease is used for the culture fluid that hydrogen peroxide damages the modeling front and back, discovery can generate by balance NO at the medicinal dropping ball of prevention and treatment group treatment coronary heart disease, significantly increase cytoactive, endothelial injury due to the hydrogen peroxide is had obvious antagonism.
Atherosclerotic lesion is that a kind of protectiveness inflammation-fiber proliferative to local damage is responded.In the speckle forming process, lipidosis is most important factor.But the medicinal dropping ball treatment hypercholesterolemia reducing (TC) and low density lipoprotein, LDL (LDL) cholesterol levels of treatment coronary heart disease, high density lipoprotein increasing (HDL) cholesterol levels.Ma Xiao waits quietly observing the influence of the medicinal dropping ball of treatment coronary heart disease to film healing situation in damaging with similar method modeling, the medicinal dropping ball group postoperative NO concentration of finding treatment coronary heart disease is apparently higher than matched group, the neointimal hyperplasia degree obviously alleviates than matched group, new intima medium vessels smooth muscle cell and fibrous tissue obviously reduce than matched group, so think that the medicinal dropping ball of treatment coronary heart disease can promote to damage the reparation of inner membrance, reduces neointimal hyperplasia.
The medicinal dropping ball coronary blood flow increasing of treatment coronary heart disease improves the hemorheology hyperlipemia and can cause vascular endothelial injury, come off, platelet adhesion reaction and gathering.The medicinal dropping ball of treatment coronary heart disease can significantly increase the rat coronary flow but not increase heart rate, helps to improve the supply of heart oxygen and nutrient substance.The medicinal dropping ball of treatment coronary heart disease obviously reduces rabbit anteserum TC, triglyceride (TG), LDL, very low density lipoprotein (VLDL) (VLDL) concentration and TC/HDL ratio, and HDL concentration obviously raises.
The medicinal dropping ball inhibition platelet adhesion reaction and the gathering endothelial function for the treatment of coronary heart disease lacked of proper care, endothelium integrity destruction can trigger a series of molecules and biochemical reaction makes the blood flow stagnation, and blood vessel wall reparation, inhibition or antagonism platelet adhesion reaction and gathering are to prevent thrombotic key link.The medicinal dropping ball antiplatelet activation of treatment coronary heart disease and gathering be from the multi-section position, stage construction and many target spots play a role.
The medicinal dropping ball of treatment coronary heart disease all has obvious inhibitory action to adenosine diphosphate (ADP) (ADP), thrombin and collagen-induced rat platelet aggregation, and is dose-dependence.The medicinal dropping ball of treatment coronary heart disease can suppress high fat and feed dog platelet overactivity.The specificity molecular marker of plasma A membrane granulosa protein-140 (GMP-140) when being platelet activation.Before the treatment, treatment group and matched group GMP-140 level are organized apparently higher than healthy people, after the medicinal dropping ball associating aspirin for treatment of treatment coronary heart disease, treatment group angina pectoris symptom, electrocardiogram ischemia improve, blood plasma GMP-140 level significantly reduces than matched group (single clothes aspirin), organize no significant difference with healthy people.To the aspirin resistance person, the medicinal dropping ball that adds with treatment coronary heart disease can obviously improve the aspirin resistance state, reduces platelet aggregation rate, and total effective rate is 85%, and the average range of decrease is 51.57%.
Because the medicinal dropping ball of treatment coronary heart disease has above-mentioned many target spots effect, it is to all kinds coronary heart disease, comprises that the peri-operation period treatment etc. of stable or unstable angina pectoris, myocardial infarction, heart failure, silent ischemia and intervention all has remarkable result.
Following experimental data is used to illustrate effect of the present invention: experimental drug is the medicine of the embodiment of the invention 1.
The comparison of medicinal dropping ball aspect the angina pectoris treatment effect of table 1 treatment coronary heart disease
| Group | n | Produce effects | Effectively | Invalid | Increase the weight of | Total effective rate/% |
| The treatment group | 51 | 20 | 28 | 3 | 0 | 94.1① |
| Matched group | 51 | 8 | 29 | 13 | 1 | 72.5 |
Annotate: 1. compare, analyze U=3.039, P＜0.01 through Radit with matched group.
The comparison of medicinal dropping ball aspect ECG curative effect of table 2 treatment coronary heart disease
| Group | n | Produce effects | Effectively | Invalid | Increase the weight of | Total effective rate/% |
| The treatment group | 51 | 12 | 18 | 21 | 0 | 58.9① |
| Matched group | 51 | 1 | 18 | 30 | 2 | 37.3 |
Annotate: 1. compare, analyze U=2.685, P＜0.01 through Radit with matched group.
Hemorheology index variation before and after the medicinal dropping ball treatment of table 3 treatment coronary heart disease (x ± s)
The medicinal dropping ball medication left ventricular contractile function comparison of table 4 treatment coronary heart disease (x ± s)
Annotate: 1. compare P＞0.05 before and after the medication; 2. compare P＜0.05 before and after the medication.
Efficient, quick-acting, the multi-purpose pure Chinese medicine dripping pills preparation that the present invention adopts the modern pharmacy technology to develop, prevent and treat the coronary heart disease determined curative effect, and can improve the blood capillary circulation,, comprise that diabetic renal papillary necrosis and diabetic nephropathy all have good preventive and therapeutic effect the diabetes microvascular complication.
The invention has the advantages that: this process route can be realized industrialization, and is stable and controllable for quality.Relevant test shows, the present invention is than prior art curative effect height, the product purity height, and good absorbing, steady quality, the purposes novelty, preparation method technology is simple, easy to operate, with low cost simultaneously, is fit to suitability for industrialized production.
The specific embodiment
Specify the present invention with embodiment below, embodiment is for the ease of understanding the present invention, and claim that does not limit the present invention in any way and core content.
The preparation of the medicinal dropping ball of embodiment 1 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 82.87%, Radix Notoginseng 16.21%, Borneolum Syntheticum 0.92%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 3 times of amount 95% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 2 times of amount 95% ethanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1.5hr of 5 times of amounts, filter; Last medicinal residues add 50% alcohol reflux 1hr of 4 times of amounts, filter the extracting solution concentrating under reduced pressure, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill more than 12 hours, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The preparation of the medicinal dropping ball of embodiment 2 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 78.2%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2 times of amount 85% ethanol, reflux, extract, 1 time, and each 1 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 85% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1.5hr of 5 times of amounts, filter; Last medicinal residues add 50% alcohol reflux 1hr of 4 times of amounts, filter the extracting solution concentrating under reduced pressure, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill more than 12 hours, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 3 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 5 times of amount 95% ethanol, reflux, extract, 3 times, and each 3 hours, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1.5hr of 5 times of amounts, filter; Last medicinal residues add 50% alcohol reflux 1hr of 4 times of amounts, filter the extracting solution concentrating under reduced pressure, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill more than 12 hours, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds to fit to press starch, mixing; Make tablet.
The preparation of the medicine of embodiment 4 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 95%, Radix Notoginseng 2%, Borneolum Syntheticum 3%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2 times of amount 75% ethanol, reflux, extract, twice, and each 2 hours, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 75% ethanol extract.
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1.5hr of 5 times of amounts, filter; Last medicinal residues add 50% alcohol reflux 1hr of 4 times of amounts, filter the extracting solution concentrating under reduced pressure, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill more than 12 hours, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 5 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient: Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 5 times of amount 95% ethanol, and reflux, extract, twice is filtered, and extracting solution concentrating under reduced pressure, drying obtain the Salvia miltiorrhiza and Panax notoginseng ethanol extract.
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1.5hr of 6 times of amounts, filter; Last medicinal residues add 50% alcohol reflux 1hr of 4 times of amounts, filter the extracting solution concentrating under reduced pressure, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill more than 12 hours, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 6 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 97%, Radix Notoginseng 2%, Borneolum Syntheticum 1%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 3 times of amount 95% methanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 2 times of amount 95% methanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40% alcohol reflux 1 time of 2 times of amounts, each 1hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40%, add ethanol and make and contain alcohol amount and reach 50%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 6 times of amount PH7-8 decocted 1 hour, added 6 times of water gagings for the second time and decocted 0.5 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 50%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%%;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds an amount of Cera Flava, paraffin, mixing; Make pill.
The preparation of the medicinal dropping ball of embodiment 7 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 19.8%, Radix Notoginseng 80%, Borneolum Syntheticum 0.2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 3 times of amount 95% normal propyl alcohols, and reflux, extract, 2 hours is filtered; Medicinal residues add 2 times of amount 95% normal propyl alcohols, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 2 times of amounts, each 3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 60%, add ethanol and make and contain alcohol amount and reach 80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 6 times of amount PH7-8 decocted 1 hour, added 6 times of water gagings for the second time and decocted 0.5 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 75%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 0-10 ℃, makes drop pill.
The preparation of the medicament pellet of embodiment 8 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 60%, Radix Notoginseng 37%, Borneolum Syntheticum 3%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 12 times of amount 95% n-butyl alcohol, and reflux, extract, 2 hours is filtered; Medicinal residues add 2 times of amount 95% n-butyl alcohol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 2 times of amounts, each 3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 60%, add ethanol and make and contain alcohol amount and reach 80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 6 times of amount PH7-8 decocted 1 hour, added 6 times of water gagings for the second time and decocted 2 hours, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 75%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 75%;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds an amount of calcium stearate, Pulvis Talci, Macrogol 4000, mixing; Make micropill.
The preparation of the medicinal dropping ball of embodiment 9 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 80%, Radix Notoginseng 18%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 8 times of amount 80% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 4 times of amount 80% ethanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 80% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 6 times of amounts, each 1hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, add for the first time 6 times of amount PH7-8 solution and decocted 1 hour, add 6 times of water gagings for the second time and decocted 0.5 hour, obtain extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 75%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 0-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 10 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 65%, Radix Notoginseng 33%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 5 times of amount 75% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 3 times of amount 75% ethanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 75% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 6 times of amounts, each 1hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, add for the first time 6 times of amount PH7-8 solution and decocted 1 hour, add 6 times of water gagings for the second time and decocted 0.5 hour, obtain extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 75%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%%;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds an amount of polyvinylpyrrolidone (PVP), rubber cement, crystallite
Cellulose,
Sodium carboxymethyl cellulose, mixing; Make controlled release preparation.
The preparation of the medicine of embodiment 11 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 78%, Radix Notoginseng 21%, Borneolum Syntheticum 1%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 10 times of amount 70% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 5 times of amount 70% ethanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 70% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 45% alcohol reflux 2 times of 3 times of amounts, each 3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 50%, add ethanol and make and contain alcohol amount and reach 60%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2 add 6-12 for the first time and doubly measure PH7-8, and aqueous slkali decocted 1 hour, adding for the second time 6 times of water gagings decocted 0.5 hour, obtain extracting solution, extracting solution concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 75%, leave standstill more than 12 hours, separation of supernatant reclaims ethanol, receives cream to pol 65%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 8-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 12 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 28%, Radix Notoginseng 70%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 7 times of amount 95% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 4 times of amount 95% ethanol, and reflux, extract, 1 hour is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 45% alcohol reflux 2 times of 3 times of amounts, each 3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 50%, add ethanol and make and contain alcohol amount and reach 60%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2 add 6-12 for the first time and doubly measure PH7-8, and aqueous slkali decocted 1 hour, adding for the second time 6 times of water gagings decocted 1 hour, obtain extracting solution, extracting solution concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 75%, leave standstill more than 12 hours, separation of supernatant reclaims ethanol, receives cream to pol 65%, obtains the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
The preparation of the medicine of embodiment 13 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 85%, Radix Notoginseng 12%, Borneolum Syntheticum 3%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 6 times of amount 95% ethanol, and reflux, extract, 3 hours is filtered; Medicinal residues add 4 times of amount 95% ethanol, and reflux, extract, 1.5 hours is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 20% alcohol reflux 1 time of 2 times of amounts, and each 1hr filters, extracting solution concentrates, drying. and be dissolved in water, add ethanol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, the Salvia miltiorrhiza and Panax notoginseng medicinal residues after the alcohol extraction of step 2 add the aqueous alkali of 2 times of pH value 7, extract 1 time, add 2 times of water again, extract 1 time, filter, filtrate concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 50%, leaves standstill, separation of supernatant, reclaim ethanol, receive cream to pol 50%, concentrated, dry, pulverizing obtain the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds an amount of maltose, hydroxypropyl emthylcellulose, mixing, and drying is pulverized, and makes powder.
The preparation of the medicine of embodiment 14 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 50%, Radix Notoginseng 48%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 9 times of amount 95% ethanol, and reflux, extract, 4 hours is filtered; Medicinal residues add 7 times of amount 95% ethanol, and reflux, extract, 2 hours is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 2 times of amounts, and each 3hr filters, extracting solution concentrates, drying. and be dissolved in water, add ethanol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, the Salvia miltiorrhiza and Panax notoginseng medicinal residues after the alcohol extraction of step 2 add the aqueous alkali of 12 times of pH value 10, extract 3 times, add 12 times of water again, extract 3 times, filter, filtrate concentrates, add ethanol to medicinal liquid and contain alcohol amount 80%, leave standstill separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 90% or concentrated, dry, pulverizing;
Step 4 is got Salvia miltiorrhiza and Panax notoginseng ethanol extract, the dried cream of step 2 Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, step 3 Salvia miltiorrhiza and Panax notoginseng extract, Borneolum Syntheticum that step 1 obtains, adds an amount of vegetable oil, mixing; Make soft capsule according to the soft capsule conventional method.
The preparation of the medicine of embodiment 15 treatment coronary heart disease, each component consists of in the weight percent of crude drug effective ingredient:
Radix Salviae Miltiorrhizae 90%, Radix Notoginseng 8%, Borneolum Syntheticum 2%;
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 4 times of amount 95% ethanol, and reflux, extract, 2 hours is filtered; Medicinal residues add 3 times of amount 95% ethanol, and reflux, extract, 2 hours is filtered, and extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 60% alcohol reflux 3 times of 5 times of amounts, and each 3hr filters, extracting solution concentrates, drying. and be dissolved in water, add ethanol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, the Salvia miltiorrhiza and Panax notoginseng medicinal residues after the alcohol extraction of step 2 add the aqueous alkali of 9 times of pH value 8, extract 3 times, add 10 times of water again, extract 3 times, filter, filtrate concentrates, add ethanol to medicinal liquid and contain alcohol amount 80%, leave standstill separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 90% or concentrated, dry, pulverizing;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
Claims (10)
1. medicine for the treatment of coronary heart disease, described medicine is prepared from by following raw materials by weight percent medicine, Radix Salviae Miltiorrhizae 19.8%-97%, Radix Notoginseng 2%-80%, Borneolum Syntheticum 0.2%-3%, described preparation is earlier crude drug to be prepared into active constituents of medicine through following steps, further be prepared into medicine again
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add alcohol, extract, and extracting solution is concentrated, dry, obtains the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add alcohol extraction, filter, and extracting solution concentrates, drying. and be dissolved in water, add alcohol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Radix Salviae Miltiorrhizae after step 2 alcohol extraction and Radix Notoginseng medicinal residues, aqueous alkali are or/and water extraction, and extracting solution concentrates, and adds alcohol, leaves standstill, and supernatant concentration obtains the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, the Salvia miltiorrhiza and Panax notoginseng ethanol extract of step 1, the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol of step 2, the Salvia miltiorrhiza and Panax notoginseng extract and the Borneolum Syntheticum of step 3 are further made drop pill.
2. the medicine of the treatment coronary heart disease of claim 1 is for oral medicine, it is characterized in that preparation process is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol or the isobutanol of 2-12 times of 70-100%, and reflux, extract, is filtered, and extracting solution concentrating under reduced pressure, drying obtain the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 20-60% alcohol reflux 1-3 time that 2-8 doubly measures, and each 1-3hr filters, extracting solution concentrates, drying. and be dissolved in water, add ethanol, leave standstill, separation of supernatant, reclaim under reduced pressure alcohol, drying obtains Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, the Salvia miltiorrhiza and Panax notoginseng medicinal residues after the alcohol extraction of step 2 add the aqueous alkali of 2-12 times of pH value 7-10, extract 1-3 time, add 2-12 times of water again, extract 1-3 time, filter, filtrate concentrates, and adds ethanol to medicinal liquid and contains alcohol amount 50-80%, leaves standstill, separation of supernatant, reclaim ethanol, receive cream to pol 50%-90%, concentrated, dry, pulverizing obtain the Salvia miltiorrhiza and Panax notoginseng extract;
Step 4, with the Salvia miltiorrhiza and Panax notoginseng ethanol extract of step 1, Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol, the Salvia miltiorrhiza and Panax notoginseng extract mixes with adjuvant with Borneolum Syntheticum, add any or more than one adjuvants, the adjuvant addition is 1-6 a times of active component, makes any oral formulations.
3. the medicine of the treatment coronary heart disease of claim 2 is drop pills, it is characterized in that, preparation process is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-5 times of 70-100% ethanol, reflux, extract, 1-3 time, and each 1-3 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain the Salvia miltiorrhiza and Panax notoginseng ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 20-60% alcohol reflux 1-3 time that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, add for the first time the aqueous alkali that 2-12 doubly measures pH7-8 and decocted 1-3 hour, add 2-12 times of water gaging for the second time and decocted 0.5-2 hour, obtain extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 50%-80%, left standstill separation of supernatant 12-36 hour, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%-80%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously is made drop pill.
4. the medicine of the treatment coronary heart disease of claim 3: it is characterized in that preparation process is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-5 and doubly measure 95% ethanol, reflux, extract, 1-3 time, and each 1-3 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add 40-60% alcohol reflux 1-3 time that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 40-60%, add ethanol and make and contain alcohol amount and reach 50-80%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, add for the first time the aqueous alkali that 6-12 doubly measures PH7-8 and decocted 1-3 hour, add 6-12 times of water gaging for the second time and decocted 0.5-2 hour, obtain extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 50%-75%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 55%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 0-10 ℃, makes drop pill.
5. the medicine of the treatment coronary heart disease of claim 4: it is characterized in that preparation process is:
Step 1, Radix Salviae Miltiorrhizae, Radix Notoginseng add 2-3 and doubly measure 95% ethanol, reflux, extract, 2 times, and each 1-2 hour, to filter, extracting solution concentrating under reduced pressure, drying obtain Salvia miltiorrhiza and Panax notoginseng 95% ethanol extract;
Step 2, the Radix Salviae Miltiorrhizae that obtains after step 1 alcohol extraction, Radix Notoginseng medicinal residues add the 40-60% alcohol reflux 2 times that 2-6 doubly measures, each 1-3hr filters, and extracting solution concentrates, dry. be dissolved in water to pol 48-52%, add ethanol and make and contain alcohol amount and reach 60-70%, leave standstill more than 12 hours separation of supernatant, reclaim under reduced pressure alcohol, drying obtain Radix Salviae Miltiorrhizae, the dried cream of Radix Notoginseng alcohol extraction precipitate with ethanol;
Step 3, Salvia miltiorrhiza and Panax notoginseng medicinal residues behind the ethanol extraction of step 2, the aqueous alkali that adds for the first time 8 times of amount PH7-8 decocted 2 hours, added 8 times of water gagings for the second time and decocted 1 hour, obtained extracting solution, extracting solution concentrates, add ethanol to medicinal liquid and contain alcohol amount 60%-70%, leave standstill more than 12 hours separation of supernatant, reclaim ethanol, receive cream, obtain the Salvia miltiorrhiza and Panax notoginseng extract to pol 70%-75%;
Step 4, step 2 obtain the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol and add water-solubleization, and step 1 obtains the PEG-6000 that the Salvia miltiorrhiza and Panax notoginseng ethanol extract is suspended in pre-thawing; Add Salvia miltiorrhiza and Panax notoginseng extract and Borneolum Syntheticum behind the said two devices mix homogeneously, mix homogeneously, changing the material temperature is 60-100 ℃; The temperature of liquid paraffin is 5-10 ℃, makes drop pill.
6. the medicine of the arbitrary described treatment coronary heart disease of claim 1-5: it is characterized in that, step 4 is, Salvia miltiorrhiza and Panax notoginseng ethanol extract with step 1, the dried cream of Salvia miltiorrhiza and Panax notoginseng alcohol extraction precipitate with ethanol, the Salvia miltiorrhiza and Panax notoginseng extract mixes with adjuvant with Borneolum Syntheticum, add any or more than one adjuvants, described adjuvant is selected from fat-soluble substrate and water-soluble base, and wherein fat-soluble substrate is selected from: stearic acid, glyceryl monostearate, insect wax, Cera Flava, paraffin, hydrogenated vegetable oil, semi-synthetic fatty acid ester; Water-soluble base is selected from Polyethylene Glycol, polyoxyethylene monostearate, poloxamer, sodium stearate, glycerin gelatine; Xylitol and composites of starch, erythritol.
7. the medicine of the treatment coronary heart disease of claim 6: it is characterized in that wherein preparation process 4 Chinese medicines are auxilliary than being 1: 1-6.
8. the medicine of the treatment coronary heart disease of claim 7: it is characterized in that wherein step 3 medicine is auxilliary than being 1: 1.76
9. the medicine of the treatment coronary heart disease of claim 8: it is characterized in that wherein said Polyethylene Glycol is a Polyethylene Glycol-6000.
10. the application of the medicine of the treatment coronary heart disease of claim 1 in the medicine of cardiovascular disease such as a kind of resisting coronary heart disease of preparation, angina pectoris.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114470035A (en) * | 2022-03-23 | 2022-05-13 | 暨南大学 | A composition containing Chinese medicinal extract, its preparation method and application in preparing product with antioxidant effect |
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| CN1714819A (en) * | 2004-06-30 | 2006-01-04 | 天津天士力制药股份有限公司 | Medicinal composition for treating coronary heart disease |
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| CN1714819A (en) * | 2004-06-30 | 2006-01-04 | 天津天士力制药股份有限公司 | Medicinal composition for treating coronary heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114470035A (en) * | 2022-03-23 | 2022-05-13 | 暨南大学 | A composition containing Chinese medicinal extract, its preparation method and application in preparing product with antioxidant effect |
| CN114470035B (en) * | 2022-03-23 | 2023-02-21 | 暨南大学 | A composition containing Chinese medicinal extract, its preparation method and application in preparing product with antioxidant effect |
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Application publication date: 20110427 |