CN102028706A - Flushing liquid for liver-cancer surgical incisions - Google Patents
Flushing liquid for liver-cancer surgical incisions Download PDFInfo
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- CN102028706A CN102028706A CN2009101964183A CN200910196418A CN102028706A CN 102028706 A CN102028706 A CN 102028706A CN 2009101964183 A CN2009101964183 A CN 2009101964183A CN 200910196418 A CN200910196418 A CN 200910196418A CN 102028706 A CN102028706 A CN 102028706A
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- liver
- otch
- flushing liquid
- surgical incisions
- iodine
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Abstract
The invention discloses a novel flushing liquid for liver-cancer surgical incisions, which is prepared by mixing III type non-alcohol Anerdian and flushing water in a proportion of 1 to 10. The recurrence and the metastasis of tumors are the difficulty and the key of treatment of liver cancer, and the novel flushing liquid can be used for reducing implantation metastasis of surgical incisions and is beneficial to improving the prognosis and the life quality of patients.
Description
Technical field
The present invention relates to the medicine and pharmacology field, more particularly, relate to a kind of flushing liquor that is used for operative incision.
Background technology
Primary hepatocarcinoma is second tumor cause of death of China.In recent years, raising and popularization along with surgical technic and local ablation techniques, part patient's curative effect is greatly improved, even but radical excision postoperative, still have 5 years relapse rates of nearly 80%, 1.03% the otch plantation of also having an appointment is shifted, thereby the overall and disease free survival of this part liver cancer patient of appreciable impact.Further reducing operative incision plantation transfer is one of problem of needing badly clinically solution.
III type no-alcohol type An Er iodine is to be the disinfectant solution of main effective ingredient with iodine, chlorhexidine acetate, ethanol, and available iodine content is 0.2% ± 0.02%, and chlorhexidine acetate is 0.45% ± 0.045%, and ethanol content is 65% ± 5% (V/V).Can kill pathogenic entero becteria, pyococcus, pathogenic yeast and hospital infection common bacteria.In the prior art, III type no-alcohol type An Er iodine is applicable to the operative site skin degerming, sterilization before the skin penetratings such as muscle, vein, the sterilization of changing dressings of handwashing disinfection before the surgery art, surgery.Especially, it is a kind of mucosa disinfectant sterilization that can be used for.
Behind the operation of liver cancer, when closing abdomen, routine is washed otch (adopted name: sterilized water for injection with water for injection; Composition: water for injection; Chemical structural formula H
2O), use 0.9% normal saline flushing otch under the certain situation is also arranged.Because operate in the art, to the extruding of tumor, move, have cancerous cell after the excision and be scattered in the operative field territory.Though through big water gaging flushing, do not get rid of the possibility that the cancerous cell plantation of being scattered is shifted, otch also is like this.
Summary of the invention
The object of the present invention is to provide a kind of novel flushing liquor that is used for the operation of liver cancer otch.
For achieving the above object, the invention discloses the prescription of novel flushing liquor: III type no-alcohol type An Er iodine adds wash water according to 1: 10 mixed.
The present invention also discloses the new purposes of III type no-alcohol type An Er iodine solution in reducing operation of liver cancer otch plantation transfer.
The present invention has following beneficial effect:
The recurrence of tumor and transfer are the difficult point and the emphasis of liver cancer treatment, and the plantation of using novel flushing liquor of the present invention can reduce operative incision is shifted, and helps patient's prognosis and the improvement of quality of life.
The specific embodiment
After operation of liver cancer is finished, when closing abdomen, use III type no-alcohol type An Er iodine to add wash water (sterilized water for injection) according to 1: 10 mixed, forms a new compositions, 500-1000ml washes otch first.For the second time a large amount of wash water (sterilized water for injection) flushing otch.Close abdomen again and then successively.
One, novel flushing liquor is 1 bottle
III type no-alcohol type An Er iodine 50ml
Sterilized water for injection 500mg
Cumulative volume 550ml
Preparation method:
(1) gets commercially available III type no-alcohol type An Er iodine 50ml/ bottle, 1 bottle;
(2) get commercially available 500ml/ bottle sterilized water for injection, 1 bottle, rock rinsing bottle gently behind the adding III type no-alcohol type An Er iodine 50ml, mix fully;
(3) with 1 bottle of aforesaid liquid, as a flushing dosage;
Can use 1-2 flushing dosage flushing otch when (4) closing abdomen, in a large amount of subsequently wash water (sterilized water for injection) flushing otch, close abdomen again and then successively.
Two, the effect that plantation is shifted to the hepatocarcinoma otch
1,2003-2007, to use III type no-alcohol type An Er iodine to add common wash water (sterilized water for injection) according to 1: 10 mixed, form a new wash water, be used for operation of liver cancer patient 298 examples, select the same period similar surgical patient 195 examples to organize in contrast, and no obvious significant difference between the ordinary circumstance such as liver function before the two groups of patient's sexes, age, modus operandi, tumor size, art.Follow up a case by regular visits to more than at least 1 year, observing it has non-incision to shift.This research through the court (Eastern Hepatobiliary Hospital, the Second Military Medical University of Chines) Ethics Committee by and through patient's informed consent.
2, result of the test and discussion
To in June, 2009, otch takes place and shifts in none example of target group postoperative, and matched group generation otch shifts 3 examples, X
2=4.61, P＜0.05 sees Table 1.The patient does not all have other complication relevant with this experimental study.
Table 1 a liang group hepatocarcinoma patient uses the result of different flushing liquors to compare
The surgical oncology doctor must be noted that protection notching edge and wound surface, because of the easily plantation growth on wound sex organization wound surface of cancerous cell that comes off.Except reducing iatrogenic plantation, also have some complementary processing and treatments, the new prescription that adopts III type no-alcohol type An Er iodine to add sterilized water for injection can significantly reduce the hepatocarcinoma postoperative wound rate of transform.
Claims (2)
1. flushing liquor that is used for the operation of liver cancer otch, its prescription is: III type no-alcohol type An Er iodine and wash water were according to 1: 10 mixed.
2.III the new purposes of type no-alcohol type An Er iodine solution in reducing operation of liver cancer otch plantation transfer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910196418A CN102028706B (en) | 2009-09-25 | 2009-09-25 | Flushing liquid for liver-cancer surgical incisions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910196418A CN102028706B (en) | 2009-09-25 | 2009-09-25 | Flushing liquid for liver-cancer surgical incisions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102028706A true CN102028706A (en) | 2011-04-27 |
| CN102028706B CN102028706B (en) | 2012-09-05 |
Family
ID=43882516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910196418A Expired - Fee Related CN102028706B (en) | 2009-09-25 | 2009-09-25 | Flushing liquid for liver-cancer surgical incisions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102028706B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018202687A1 (en) * | 2017-05-02 | 2018-11-08 | Pierre Fabre Medicament | Antiseptic composition combining chlorhexidine and iodine |
| CN116421590A (en) * | 2023-06-14 | 2023-07-14 | 深圳市第二人民医院(深圳市转化医学研究院) | Application of chlorhexidine diacetate in preparing medicine for preventing or/and treating liver cancer |
-
2009
- 2009-09-25 CN CN200910196418A patent/CN102028706B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018202687A1 (en) * | 2017-05-02 | 2018-11-08 | Pierre Fabre Medicament | Antiseptic composition combining chlorhexidine and iodine |
| FR3065879A1 (en) * | 2017-05-02 | 2018-11-09 | Pierre Fabre Medicament | ANTISEPTIC COMPOSITION OF A CHLORHEXIDINE AND IODINE ASSOCIATION |
| CN116421590A (en) * | 2023-06-14 | 2023-07-14 | 深圳市第二人民医院(深圳市转化医学研究院) | Application of chlorhexidine diacetate in preparing medicine for preventing or/and treating liver cancer |
| CN116421590B (en) * | 2023-06-14 | 2023-08-29 | 深圳市第二人民医院(深圳市转化医学研究院) | Application of chlorhexidine diacetate in preparing medicine for preventing or/and treating liver cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102028706B (en) | 2012-09-05 |
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Granted publication date: 20120905 Termination date: 20130925 |