CN102018738B - Application of scandent schefflera stem and leaf in preparation of radiation-proof health care products - Google Patents
Application of scandent schefflera stem and leaf in preparation of radiation-proof health care products Download PDFInfo
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- CN102018738B CN102018738B CN2009101924307A CN200910192430A CN102018738B CN 102018738 B CN102018738 B CN 102018738B CN 2009101924307 A CN2009101924307 A CN 2009101924307A CN 200910192430 A CN200910192430 A CN 200910192430A CN 102018738 B CN102018738 B CN 102018738B
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Abstract
The invention discloses novel application of scandent schefflera stem and leaf in preparation of radiation-proof health care products. The scandent schefflera stem and leaf is the common traditional Chinese medicine, so the scandent schefflera stem and leaf can be prepared into the health care products for patients who work in a radiation environment for a long term or suffer from cancers before or after radiotherapy.
Description
Technical field
The raw material that the present invention relates to is the Chinese medicine Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), is the purposes in the preparation radiation protection health products specifically.
Technical background
The social technology development, various radioactivity factors constantly increase, and from eighties of last century till now just, radiation has been penetrated into the social life every field.
In the daily life, mobile phone, computer progressively are human lives and work necessary, and a lot of staff reach the harm that each link of a few hours nuclear energy production and application etc. all will cause human body every day in the face of computer;
In medical range, radiodiagnosis and treatment are widely used, such as radiation x-ray, CT diagnosis etc.; Radiotherapy has become one of three big means of traditional treatment malignant tumor, radiotherapy is to utilize the ionizing radiation of (as 60 Co60 radiotherapy unit 60s, head, body knife,s) such as gamma-radiations that X ray, electron ray, neutron ray, proton ray and the radioactive source of the different-energy that all kinds of accelerator produces discharge to kill tumor cell, for tumor patient has brought hope; But in killing tumor cell, also normal tissue cell there are certain damaging action, i.e. radiation injury.Except that the patient, particularly the doctors and nurses of acceptance diagnosis and radiotherapy etc. is gone up in medical treatment, usually all is to be directly exposed under the radiation, and radiation protection is difficulty further, and radiation damage also aggravates.
Except medical application, nuclear energy is progressively accelerated to use in China, the foundation of large quantities of nuclear power stations, and contact the radiation worker increase gradually, and large quantities of practitioners is badly in need of feasible health protection.
Chinese invention patent publication number CN101095515A discloses a kind of health food to the radiation hazradial bundle protective effect, is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Radix Rhodiolae, Radix Ophiopogonis, is suitable for contacting the radiation crowd.Chinese invention patent publication number CN1660389A discloses a kind of radiation-resistant oral preparation of Chinese traditional medicinal and preparation method, is Ganoderma and rhodiola root composition, reaches radiation protection from the angle of human body immunity improving.Chinese invention patent grant number CN1282455C authorizes the antiradiation drug of a kind of ginkgetin and tea polyphenols combination, being all to contain identical benzene ring structure and polyhydric phenols hydroxyl structure from two raw materials, is two kinds of proportioning raw materials combination backs to be embodied improve radiation-resistant effect.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) is Araliaceae schefflera platymiscium schefflera arboricola Scheffleva arboricola Hayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (Wight et Arn.) Harms, is used as medicine with stem and leaf; This medicine property of medicine hardship, sweet, temperature.Has the pain relieving dissipating blood stasis, the repercussive effect.Be used for traumatic injury, rheumatic arthritis, gastric and duodenal ulcers pain.Yet there are no bibliographical information but whether Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) has radiation protection.
Summary of the invention
The object of the invention provides Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) or the application of its extract in the preparation radiation protection health products.
Adopt Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) or its extract as raw material, can be prepared into the health product that are fit to oral any dosage form.
The present invention is the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) that screening obtains having clear and definite radiation protection from Chinese medicine, by improving leucocytes reduction and the removing interior free yl of radiation to body damage, reaches the effect of control radiation damage; Be suitable for long-term work and take for a long time, also be suitable for tumor radiotherapy front and back patient the radiation environment crowd.
The specific embodiment
Experimental example 1 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) is tested the systematic influence of radiation damage mouse blood
1 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract is to the influence of radiation damage mice peripheral white blood cell
1.1 experimental technique
60 cleaning level Male Kunming strain mice are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 12 every group.Except that the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.Each dosage group mice of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) in
60The previous day is irritated the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated stomach and give isodose normal saline, and each organizes administration and normal saline is irritated stomach once every day, continuous seven days.Each treated animal is adopted tail tip blood the 7th day twice respectively at pre-irradiation, irradiation back, surveys leukocyte count.
1.2 experimental result
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract the results are shown in following table 1 to the influence of radiation damage mice peripheral white blood cell.
Table 1 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract is to the influence of radiation damage mice peripheral white blood cell
* model group compares P＜0.01 with blank group; * and model control group be P＜0.01 relatively
Model group and blank group compare,
607 days leukocyte counts obviously reduce behind the Co roentgenization, and significant differences (P＜0.01) is arranged, and this experiment modeling success is described.Each dosage group murine interleukin counting of the present invention all has rising in various degree, have significance meaning (P＜0.01) with the model group comparing difference, and each dosage group has tangible dose-effect relationship.By the explanation of above-mentioned experimental result, the present invention has and improves the effect that body peripheral blood leucocyte that radiation damage causes reduces.
2 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extracts are to the influence of radiation damage mouse bone marrow cells nucleated cell number and mouse Bone marrow cells micronucleus rate
2.1 experimental technique
60 cleaning level Male Kunming strain mice are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 12 every group.Except that the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.Each dosage group mice of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) in
60The previous day is irritated the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated stomach and give isodose normal saline.Irritate stomach every day once, continuous seven days.Last irritate stomach after 24 hours the cervical vertebra dislocation put to death mice, separate femur, use Hank ' s liquid to go out whole medullary cells in the femur.Mirror is counting down.Calculate the nucleated cell number in every milliliter of medullary cell.Take out breastbone, extrude bone marrow fluid and calf serum mixing, routine smear, methanol is fixed, Giemsa dyeing, distilled water flushing dries.Under the optical microscope, micronucleus cell number in 1000 polychromatic erythrocytes of every animal counting.
2.2 experimental result
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract to radiation damage after seven days the influence of mouse bone marrow cells nucleated cell number and bone marrow cell micronucleus rate see the following form 2.
Table 2 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract is to the influence of radiation damage mouse bone marrow cells nucleated cell number and bone marrow cell micronucleus rate after seven days
* model group compares P＜0.01 with blank group; * and model group be P＜0.01 relatively
After the radiation seven days, bone marrow nucleated cell number of model group mice and bone marrow cell micronucleus rate and blank group more all have significant difference (P＜0.01); Each dosage group mouse bone marrow cells nucleated cell number of the present invention has increase in various degree, and wherein high, middle dosage group and model group relatively have significant difference (P＜0.01); Each dosage group mouse Bone marrow cells micronucleus rate of the present invention has reduction in various degree, and wherein high and low dose group and model group relatively have significant difference (P＜0.01).Bone marrow nucleated cell number and bone marrow cell micronucleus rate all are reflection radiation sensitive indicators to body injury, the present invention can increase raying mouse bone marrow cells nucleated cell number, reduce bone marrow cell micronucleus rate, illustrating that the present invention has improves the bone marrow injury effect that radiation causes.
3 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extracts are to radiation damage mice blood and the active influence of liver organization superoxide dismutase (SOD)
3.1 experimental technique
60 cleaning level Male Kunming strain mice are divided into 5 groups at random: blank group, model group, the high, medium and low dosage group of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), 12 every group.Except that the blank group, all the other group mices are all used
60The Co ray carries out a subtotal body irradiation, and the irradiation total absorbed dose is 2.0Gy.Each dosage group mice of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) in
60The previous day is irritated the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) aqueous extract that stomach gives corresponding dosage in the Co radiation, and matched group and model group animal are irritated stomach and give isodose normal saline.Irritate stomach every day once, continuous seven days.In shining the back the 7th day, each treated animal is extractd eyeball and is got blood, surveys serum activity of SOD; Get liver 1g 0.9%NaCl solution on the rocks 5ml preparation 20% (w/v) liver tissue homogenate, the method that provides in the hydroxylamine assay testing cassete is provided is measured SOD vigor in the hepatic tissue.
3.2 experimental result
The Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract sees Table 3 to radiation damage mice blood and liver organization superoxide dismutase (SOD) activity influence.
Table 3 Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) water extract is to radiation damage mice blood and liver organization superoxide dismutase (SOD) activity influence
* model group compares P＜0.01 with blank group; * and model group be P＜0.05 relatively
Radiation is all significantly decline of model group mice serum regulating liver-QI tissue SOD vigor after seven days, has significant differences (P＜0.01) with blank group comparing difference, and animal modeling establishment is described.Each dosage group mice serum regulating liver-QI tissue SOD's vigor of the present invention and model group relatively have rising in various degree, and wherein high, middle dosage group increases obviously, with model group significant differences (P＜0.01) is arranged relatively.SOD is a kind of interior and closely-related protein of cellular oxidation metabolism of organism that extensively is present in, and the SOD vigor is the sensitive indicator of reflection radiation to body injury; Above-mentioned experimental result shows that the present invention is that the free radical vigor reaches the Antiradiation injury effect in the body by influencing.
Claims (2)
1. Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) or its water extract purposes in preparation radiation-proof healthcare product.
2. purposes according to claim 1 is characterized in that: described health product are oral formulations.
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| CN102018738B true CN102018738B (en) | 2011-11-23 |
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