CN102008763A - Automatic fluid preparation system for blood purification and use method thereof - Google Patents
Automatic fluid preparation system for blood purification and use method thereof Download PDFInfo
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- CN102008763A CN102008763A CN2010105796635A CN201010579663A CN102008763A CN 102008763 A CN102008763 A CN 102008763A CN 2010105796635 A CN2010105796635 A CN 2010105796635A CN 201010579663 A CN201010579663 A CN 201010579663A CN 102008763 A CN102008763 A CN 102008763A
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- 239000012530 fluid Substances 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 36
- 239000008280 blood Substances 0.000 title claims abstract description 25
- 210000004369 blood Anatomy 0.000 title claims abstract description 25
- 238000000746 purification Methods 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000001514 detection method Methods 0.000 claims abstract description 61
- 239000007788 liquid Substances 0.000 claims abstract description 51
- 230000005540 biological transmission Effects 0.000 claims description 32
- 101100321938 Arabidopsis thaliana AAPT2 gene Proteins 0.000 claims description 16
- 101100078998 Arabidopsis thaliana MWL2 gene Proteins 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 12
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 101100078997 Arabidopsis thaliana MWL1 gene Proteins 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 238000001223 reverse osmosis Methods 0.000 abstract description 9
- 239000012141 concentrate Substances 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract 4
- 239000011259 mixed solution Substances 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 238000001631 haemodialysis Methods 0.000 abstract 1
- 230000000322 hemodialysis Effects 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 51
- 239000000385 dialysis solution Substances 0.000 description 18
- 238000000502 dialysis Methods 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 239000002699 waste material Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920000554 ionomer Polymers 0.000 description 2
- 238000010338 mechanical breakdown Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000700 radioactive tracer Substances 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 230000004087 circulation Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000005662 electromechanics Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
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- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
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Abstract
The invention provides an automatic fluid preparation system for blood purification and a use method thereof. The system is provided with a fluid absorption pump, wherein concentrate is pumped by the fluid absorption pump from a concentrate vessel, is delivered to a liquid pipeline through a pipeline so as to mix with reverse osmosis water to form a mixed solution; the ion concentration of the mixed solution is detected by an ion concentration sensor, and is compared with a concentration target parameter value, if the concentration exceeds the standard, an alarm is given out, otherwise the rotating speed of the fluid absorption pump is regulated to control concentration pumping flow rate; and meanwhile, the rotating speed is compared with an alarm threshold value, an alarm is given out if the rotating speed is abnormal, otherwise, a liquid loop is detected in real time continuously. The invention has the advantages that the system has the function of ion concentration online detection and feedback control, can regulate the rotating speed of the fluid absorption pump in real time, effectively avoids safety risks of hemodialysis, avoids mechanical failures of a motor, and has high fluid preparation speed, accurate concentration proportion, high stability and high reliability.
Description
Technical field
The invention belongs to the blood purification automatic liquid mixing system, relate to dialysis solution that a kind of blood cleaning equipment the uses system and the using method thereof of preparation and security monitoring automatically.
Background technology
In the blood purification process, patient's blood flows out the extracorporeal circulation that constitutes via pipeline in the body to be got back in the body, in this blood circulation, mainly comprises bloody path, liquid road and three parts of monitoring system.Outside the intravital blood lead body of patient, enter extracorporeal circuit such as dialyser or filter, after purifying, pass back into human body, constitute the bloody path system; In the liquid-way system, the dialysis solution of standard ionomer concentration enters processes such as dialyser and dialyzer membrane offside blood samples of patients generation disperse, convection current, ultrafiltration, and removes redundant moisture in patient's body with suitable speed.Monitoring system is monitored each parts of blood cleaning equipment, parameter, index etc., and sends and report to the police and security control.
Under the normal condition, the dialysis solution that enters dialyser is the liquid that contains standard ionomer concentration and formula proportion, with processes such as blood samples of patients generation disperse, convection current, ultrafiltration, reaches the purpose of blood purification in dialyser.Reverse osmosis water after water treatment facilities purify enters in the machine by the influidic pipe road, is mixed in proportion from the concentrated solution B that concentrated solution B container sucks from the concentrated solution A and second suction pumps that concentrated solution A container sucks with first suction pumps respectively, and preparation becomes dialysis solution.Because prescription is improper or dialysis solution preparation fault will cause dialysis solution intermediate ion deviation of concentration standard value range, thereby make ion concentration monitor send warning, the dialysis solution bypass enters the waste liquid passing away, and the dialysis solution of avoiding exceeding standard enters in dialyser or the filter and causes security incident.
Traditional dialysis solution process for preparation is divided into two steps: the first step is A and two kinds of dialysis powders of B of selection standard prescription, adds reverse osmosis water by strict dilution ratio then, gets up with different container splendid attires respectively; Second step was the parameter setting by the user, according to configuration proportion under the control of computer program, make two suction pumps that have a function of measuring according to fixed setting speed separately, concentrated solution is incorporated in the equipment liquid-way system with reverse osmosis water after the heating mixes generation normal dialysis liquid.In this process, the concentrated solution process for preparation of the first step is because the manual operation reason can be introduced certain concentration error; The reasons such as metering suction pumps rotating speed flow error, wearing and tearing or mechanical breakdown in second step also can cause the ion concentration of dialysis solution to exceed standard, thereby cause the warning of monitoring device, make treatment interrupt even take place security incident.
Therefore, traditional blood purification with the shortcoming of dialysis solution compound method is, need by strict ratio preparation and accurate Electromechanical Control, just can reach the treatment requirement, and in case produce fluctuation of concentration, the adjusting time that needs are long just can be carried out normal therapeutic, and its stability, safety and reliability are poor.
Summary of the invention
The purpose of this invention is to provide a kind of blood purification with the automatic compounding system of dialysis solution, possess ion concentration on-line monitoring and feedback control function, can effectively avoid the security risk that causes because of the preparation of concentrated solution concentration deviation and suction pumps fixed rotating speed ratio, it is fast to have dosing speed, concentration proportioning is accurate, the remarkable advantage that reliability is high.
For achieving the above object, a kind of blood purification automatic liquid mixing system of the present invention, comprise concentrated solution A container, concentrated solution B container, first suction pumps, second suction pumps and fluid pipeline, wherein, described concentrated solution A container communicates with the upstream liquid feeding end of described fluid pipeline, and described first suction pumps is arranged in the liquor charging pipeline of this concentrated solution A container; Described concentrated solution B container communicates with the downstream liquid feeding end of described fluid pipeline, and this second suction pumps is arranged in the liquor charging pipeline of this concentrated solution B container;
Concentrated solution A container and concentrated solution B container value are equipped with concentrated solution A and concentrated solution B respectively, and they are a kind of formula components of dialysis solution, and the position of concentrated solution A container and concentrated solution B container can exchange.First suction pumps and second suction pumps all are the liquor pumps with function of measuring.First suction pumps (second suction pumps) pumps out concentrated solution A (concentrated solution B) respectively from concentrated solution A container (concentrated solution B container), and mixes with reverse osmosis water in fluid pipeline via line transportation.Reverse osmosis water flows into through the upstream of fluid pipeline, when flowing through the upstream liquid feeding end of fluid pipeline, mix formation first mixed liquor with concentrated solution A, when first mixed liquor is flowed through the downstream liquid feeding end of fluid pipeline, mix formation second mixed liquor with concentrated solution B, second mixed liquor flows out through the downstream of fluid pipeline, with blood of human body the dialysis reaction takes place in dialyser.
Comprise that also first ion concentration sensor, second ion concentration sensor, detection control circuit and parameter are provided with warning circuit, wherein, the detecting electrode of described first ion concentration sensor detects the ion concentration at the liquid feeding end place, upstream of described fluid pipeline, the data transmission terminal group of this first ion concentration sensor connects the first data transmission terminal group of described detection control circuit, and the first control end group of this detection control circuit connects the control signal input group of described first suction pumps; First ion concentration sensor is delivered to the ion concentration value of detected first mixed liquor to detect in the control circuit and is analyzed comparison, and the motor speed of first suction pumps is adjusted by detecting control circuit, realization is controlled in real time to the flow of concentrated solution A aspiration, reaches the real-time adjustment to the first mixed liquor ion concentration.
The detecting electrode of described second ion concentration sensor detects the ion concentration at the liquid feeding end place, downstream of described fluid pipeline, the data transmission terminal group of this second ion concentration sensor connects the second data transmission terminal group of described detection control circuit, and the second control end group of this detection control circuit connects the control signal input group of described second suction pumps; Second ion concentration sensor is delivered to the ion concentration value of detected second mixed liquor to detect in the control circuit and is analyzed comparison, and the motor speed of second suction pumps is adjusted by detecting control circuit, realization is controlled in real time to the flow of concentrated solution B aspiration, reaches the real-time adjustment to the second mixed liquor ion concentration.
First data terminal of described detection control circuit connects the parameter outfan that described parameter is provided with warning circuit, and second data terminal of this detection control circuit connects the alarm control signal input that this parameter is provided with warning circuit.Through detecting the control circuit analysis, if finding ion concentration value or motor speed has unusually, then detecting control circuit controls parameter immediately and warning circuit is set carries out Realtime Alerts, and make the dialysis circuit bypass, dialysis solution does not enter dialyser and blood of human body effect, directly discharge from the waste liquid mouth, avoid patient's life is worked the mischief by the waste liquid loop.
Described detection control circuit is provided with microcontroller IC1, interface modular converter IC3, and the first data transmission terminal group UART2_TX, the UART2_RX of described microcontroller IC1 is connected with data transmission terminal group TXD2, the RXD2 of the detection module COND1 of described first ion concentration sensor respectively; The second data transmission terminal group UART3_TX, the UART3_RX of this microcontroller IC1 is connected with data transmission terminal group TXD3, the RXD3 of the detection module COND2 of described second ion concentration sensor respectively; Ion concentration sensor is delivered to the ion concentration value of detected mixed liquor to detect in the control circuit and is analyzed comparison, judges whether the mixed liquor ion concentration exceeds standard, if exceed standard, will in time report to the police.
The first control end group PC0 of described microcontroller IC1, PC1, PC2, PC3 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER1 of the motor M 1 of described first suction pumps respectively; The second control end group PC6 of this microcontroller IC1, PC7, PC8, PC9 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER2 of the motor M 2 of described second suction pumps respectively; By detecting control circuit the rotating speed of motor of suction pumps is adjusted, realized the concentrated solution suction flow is controlled in real time, reach real-time adjustment the mixed liquor ion concentration.
The parameter input UART1_RX of described microcontroller IC1 connects the data sending terminal TXD1 of described interface modular converter IC3, the controlling alarm end UART1_TX of this microcontroller IC1 connects the data receiver RXD1 of this interface modular converter IC3, and the transmitting-receiving control end PA8 of this microcontroller IC1 connects the transmitting-receiving control signal input R/D of this interface modular converter IC3; The first data terminal A of this interface modular converter IC3 connects the parameter outfan that described parameter is provided with warning circuit, and the second data terminal B of this interface modular converter IC3 connects the alarm control signal input that this parameter is provided with warning circuit.
Microcontroller IC1 sends " receiving/transmit control signal " to interface modular converter IC3, is used to control the data transfer direction of IC1 and IC3.When interface modular converter IC3 receives " transmitting control signal ", interface modular converter IC3 sends to microcontroller IC1 with the aimed concn that parameter is provided with warning circuit, be used for comparing analysis, judge whether ion concentration exceeds standard with the ion concentration signal that detects in real time; When interface modular converter IC3 received " reception control signal ", the alarm control signal that interface modular converter IC3 sends microcontroller IC1 was exported to parameter warning circuit is set, and the control parameter is provided with warning circuit and reports to the police.
The blood purification using method of automatic liquid mixing system, described detection control circuit carries out work according to following steps:
Obtain aimed concn and alarm threshold value: be provided with from described parameter and obtain the first mixed liquor aimed concn CondT1 the warning circuit, the second mixed liquor aimed concn CondT2, first mixed liquid concentration alarm threshold value CondW1 that exceeds standard, second mixed liquid concentration alarm threshold value CondW2 that exceeds standard, the first mixed liquor minimum speed alarm threshold value MWL1, the first mixed liquor maximum speed alarm threshold value MWH1, the second mixed liquor minimum speed alarm threshold value MWL2 and the second mixed liquor maximum speed alarm threshold value MWL2;
The user is provided with parameter according to concrete needs aimed concn in the warning circuit is set, and detects control circuit aimed concn and measurement parameter are in real time compared, and analyzes the dialysis solution ion concentration whether in safety range, avoids malpractice to take place.
Definition detects the initial value i=1 of number of times i;
Determine the motor initial speed:
Determine rotating speed initial value Mv1 (i-1)=j1 * CondT1 of the motor M 1 of described first suction pumps, wherein j1 is the initial speed adjustment coefficient of this motor M 1;
Determine rotating speed initial value Mv2 (i-1)=j2 * CondT2 of the motor M 2 of described second suction pumps, wherein j2 is the initial speed adjustment coefficient of this motor M 2;
Obtain the motor speed initial value according to the aimed concn value, can guarantee that liquid mixing system carries out the dialysate concentration proportioning in strict accordance with customer requirements, guarantees the dosing precision.
Parameter initialization:
Define the rotation speed change amount initial value Vx1 (i-1)=0 of described motor M 1, the speed regulation k1 of M1;
Define the rotation speed change amount initial value Vx2 (i-1)=0 of described motor M 2, the speed regulation k2 of M2;
Wherein, the speed regulation k1=2 of motor M 1, the speed regulation k2=3 of motor M 2.
Define the real-time ion concentration initial value CondV1 (i-1)=0 of described first mixed liquor, the real-time ion concentration initial value CondV2 (i-1)=0 of second mixed liquor;
The rotation of control motor:
The motor M 1 of controlling described first suction pumps is rotated by rotating speed initial value Mv1 (i-1);
The motor M 2 of controlling described second suction pumps is rotated by rotating speed initial value Mv2 (i-1);
Motor speed initial value by the aimed concn value is determined can guarantee that motor is rotated in strict accordance with customer requirements, guarantees the flow of suction pumps suction concentrated solution, guarantees the dialysis solution matched proportion density.
Obtain the real-time ion concentration when detecting for the i time:
Read the real-time ion concentration CondV1 (i) of first mixed liquor of described first ion concentration sensor acquisition;
Read the real-time ion concentration CondV2 (i) of second mixed liquor of described second ion concentration sensor acquisition;
Detecting electrode on the ion concentration sensor can accurately record the ion concentration in the mixed liquor, has guaranteed the accuracy that subsequent parameter is adjusted, and guarantees the accurate proportioning of dialysate concentration, the reliability height.
Whether the real-time concentration when judging the i time detection exceeds standard:
If CondV1 (i)＜CondW1, and CondV2 (i)＜CondW2, then real-time concentration does not exceed standard, and enters the flow process of the rotating speed adjustment amount when determining the i time detection;
Otherwise real-time concentration exceeds standard, and controls described parameter the warning circuit warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
If ion concentration exceeds standard, then control Realtime Alerts, and make dialysis circuit bypass, dialysis solution not enter dialyser and blood of human body effect, directly discharge from the waste liquid mouth by the waste liquid loop, avoid patient's life is worked the mischief, guarantee that therapeutic process is safe and reliable.
The flow process of described rotating speed adjustment amount when determining the i time detection is:
Determine rotating speed adjustment amount Vx1 (i)=k1 * [CondV1 (i)-CondT1] of first mixed liquor;
Determine rotating speed adjustment amount Vx2 (i)=k2 * [CondV2 (i)-CondT2] of second mixed liquor;
Motor speed when determining the i time detection:
Determine rotating speed Mv1 (i)=Mv1 (the i-1)+Vx1 (i) of the motor M 1 of described first suction pumps;
Determine rotating speed Mv2 (i)=Mv2 (the i-1)+Vx2 (i) of the motor M 2 of described second suction pumps;
Adjust the suction pumps rotating speed according to the mixed liquor ion concentration, adjust the concentrated solution discharge that enters reverse osmosis water in real time, effectively control mixed liquid concentration and satisfy goal setting value scope, the realization dialysis solution is prepared automatically.
Judge the motor speed safety whether when detecting for the i time:
If MWL1＜Mv1 (i)＜MWH1, and MWL2＜Mv2 (i)＜MWL2, motor speed safety then, i adds 1, returns the flow process of described control motor rotation;
Otherwise motor speed is dangerous, controls described parameter the warning circuit warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
If motor speed surpasses the rotating speed alarm threshold value, then cause the electromechanics fault easily, serious security incident may take place, answer the control system Realtime Alerts in the case, avoid security incident to take place.
Remarkable result of the present invention is: possess ion concentration on-line monitoring and feedback control function, adjust the suction pumps rotating speed in real time according to mixed liquor ion concentration in the fluid loop, effectively avoid the security risk that causes because of the preparation of concentrated solution concentration deviation and suction pumps fixed rotating speed ratio, can effectively avoid simultaneously the mechanical breakdown and the mechanical wear that cause unusually because of the suction pumps motor speed, it is fast to have dosing speed, concentration proportioning is accurate, good stability, safe and reliable remarkable advantage.
Description of drawings
Fig. 1 is the structure chart of blood purification with automatic liquid mixing system;
Fig. 2 is a circuit connection diagram of the present invention;
Fig. 3 is the flow chart of using method of the present invention.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
As shown in Figure 1, comprise concentrated solution A container 7, concentrated solution B container 8, first suction pumps 3, second suction pumps 5 and fluid pipeline 9, wherein, described concentrated solution A container 7 communicates with the upstream liquid feeding end of described fluid pipeline 9, and described first suction pumps 3 is arranged in the liquor charging pipeline of this concentrated solution A container 7; Described concentrated solution B container 8 communicates with the downstream liquid feeding end of described fluid pipeline 9, and this second suction pumps 5 is arranged in the liquor charging pipeline of this concentrated solution B container 8; The position of concentrated solution A container 7 and concentrated solution B container 8 can exchange.
Comprise that also first ion concentration sensor 4, second ion concentration sensor 6, detection control circuit 2 and parameter are provided with warning circuit 1, wherein, the detecting electrode of described first ion concentration sensor 4 detects the ion concentration at the liquid feeding end place, upstream of described fluid pipeline 9, the data transmission terminal group of this first ion concentration sensor 4 connects the first data transmission terminal group of described detection control circuit 2, and the first control end group of this detection control circuit 2 connects the control signal input group of described first suction pumps 3; The detecting electrode of described second ion concentration sensor 6 detects the ion concentration at the liquid feeding end place, downstream of described fluid pipeline 9, the data transmission terminal group of this second ion concentration sensor 6 connects the second data transmission terminal group of described detection control circuit 2, and the second control end group of this detection control circuit 2 connects the control signal input group of described second suction pumps 5; First data terminal of described detection control circuit 2 connects the parameter outfan that described parameter is provided with warning circuit 1, and second data terminal of this detection control circuit 2 connects the alarm control signal input that this parameter is provided with warning circuit 1.
As shown in Figure 2, described detection control circuit 2 is provided with microcontroller IC1, interface modular converter IC3, and the first data transmission terminal group UART2_TX, the UART2_RX of described microcontroller IC1 is connected with data transmission terminal group TXD2, the RXD2 of the detection module COND1 of described first ion concentration sensor 4 respectively; The second data transmission terminal group UART3_TX, the UART3_RX of this microcontroller IC1 is connected with data transmission terminal group TXD3, the RXD3 of the detection module COND2 of described second ion concentration sensor 6 respectively;
The first control end group PC0 of described microcontroller IC1, PC1, PC2, PC3 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER1 of the motor M 1 of described the-suction pumps 3 respectively; The second control end group PC6 of this microcontroller IC1, PC7, PC8, PC9 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER2 of the motor M 2 of described second suction pumps 5 respectively;
The parameter input UART1_RX of described microcontroller IC1 connects the data sending terminal TXD1 of described interface modular converter IC3, the controlling alarm end UART1_TX of this microcontroller IC1 connects the data receiver RXD1 of this interface modular converter IC3, and the transmitting-receiving control end PA8 of this microcontroller IC1 connects the transmitting-receiving control signal input R/D of this interface modular converter IC3; The first data terminal A of this interface modular converter IC3 connects the parameter outfan that described parameter is provided with warning circuit 1, and the second data terminal B of this interface modular converter IC3 connects the alarm control signal input that this parameter is provided with warning circuit 1.
As shown in Figure 3, the blood purification using method of automatic liquid mixing system, described detection control circuit 2 carries out work according to following steps:
Obtain aimed concn and alarm threshold value: be provided with from described parameter and obtain the first mixed liquor aimed concn CondT1 the warning circuit 1, the second mixed liquor aimed concn CondT2, first mixed liquid concentration alarm threshold value CondW1 that exceeds standard, second mixed liquid concentration alarm threshold value CondW2 that exceeds standard, the first mixed liquor minimum speed alarm threshold value MWL1, the first mixed liquor maximum speed alarm threshold value MWH1, the second mixed liquor minimum speed alarm threshold value MWL2 and the second mixed liquor maximum speed alarm threshold value MWL2;
Definition detects the initial value i=1 of number of times i;
Determine the motor initial speed:
Determine rotating speed initial value Mv1 (i-1)=j1 * CondT1 of the motor M 1 of described first suction pumps 3, wherein j1 is the initial speed adjustment coefficient of this motor M 1;
Determine rotating speed initial value Mv2 (i-1)=j2 * CondT2 of the motor M 2 of described second suction pumps 5, wherein j2 is the initial speed adjustment coefficient of this motor M 2;
Parameter initialization:
Define the rotation speed change amount initial value Vx1 (i-1)=0 of described motor M 1, the speed regulation k1=2 of M1;
Define the rotation speed change amount initial value Vx2 (i-1)=0 of described motor M 2, the speed regulation k2=3 of M2;
Define the real-time ion concentration initial value CondV1 (i-1)=0 of described first mixed liquor, the real-time ion concentration initial value CondV2 (i-1)=0 of second mixed liquor;
The rotation of control motor:
The motor M 1 of controlling described first suction pumps 3 is rotated by rotating speed initial value Mv1 (i-1);
The motor M 2 of controlling described second suction pumps 5 is rotated by rotating speed initial value Mv2 (i-1);
Obtain the real-time ion concentration when detecting for the i time:
Read the real-time ion concentration CondV1 (i) of first mixed liquor of described first ion concentration sensor 4 acquisitions;
Read the real-time ion concentration CondV2 (i) of second mixed liquor of described second ion concentration sensor 6 acquisitions;
Whether the real-time concentration when judging the i time detection exceeds standard:
If CondV1 (i)＜CondW1, and CondV2 (i)＜CondW2, then real-time concentration does not exceed standard, and enters the flow process of the rotating speed adjustment amount when determining the i time detection;
Otherwise real-time concentration exceeds standard, and controls described parameter warning circuit 1 warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
The flow process of described rotating speed adjustment amount when determining the i time detection is:
Determine rotating speed adjustment amount Vx1 (i)=k1 * [CondV1 (i)-CondT1] of first mixed liquor;
Determine rotating speed adjustment amount Vx2 (i)=k2 * [CondV2 (i)-CondT2] of second mixed liquor;
Motor speed when determining the i time detection:
Determine rotating speed Mv1 (i)=Mv1 (the i-1)+Vx1 (i) of the motor M 1 of described first suction pumps 3;
Determine rotating speed Mv2 (i)=Mv2 (the i-1)+Vx2 (i) of the motor M 2 of described second suction pumps 5;
Judge the motor speed safety whether when detecting for the i time:
If MWL1＜Mv1 (i)＜MWH1, and MWL2＜Mv2 (i)＜MWL2, motor speed safety then, i adds 1, returns the flow process of described control motor rotation;
Otherwise motor speed is dangerous, controls described parameter warning circuit 1 warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
Its working condition is as follows: suction pumps aspirates concentrated solution from concentrate container, and mixes with reverse osmosis water in the fluid pipeline via line transportation and to form mixed liquor; Ion concentration sensor is by the ion concentration of mixed liquor in the detecting electrode tracer liquid pipeline, and the ion concentration signal outputed to detect in the control circuit analyzes; Detecting control circuit compares concentration target component value and the real-time detected value of mixed liquor that parameter is provided with in the warning circuit, if the mixed liquor ion concentration exceeds standard, then control parameter the warning circuit warning is set, otherwise adjust the suction pumps motor speed, realization reaches the real-time adjustment to the mixed liquor ion concentration to the control of concentrated solution suction flow; Simultaneously, detect control circuit also adjusted rotating speed and parameter are provided with in the warning circuit the rotating speed alarm threshold value relatively, if motor speed is unusual, then controls parameter warning circuit, warning are set, otherwise continuation detects in real time to fluid loop.
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
As shown in Figure 1, comprise concentrated solution A container 7, concentrated solution B container 8, first suction pumps 3, second suction pumps 5 and fluid pipeline 9, wherein, described concentrated solution A container 7 communicates with the upstream liquid feeding end of described fluid pipeline 9, and described first suction pumps 3 is arranged in the liquor charging pipeline of this concentrated solution A container 7; Described concentrated solution B container 8 communicates with the downstream liquid feeding end of described fluid pipeline 9, and this second suction pumps 5 is arranged in the liquor charging pipeline of this concentrated solution B container 8; The position of concentrated solution A container 7 and concentrated solution B container 8 can exchange.
Comprise that also first ion concentration sensor 4, second ion concentration sensor 6, detection control circuit 2 and parameter are provided with warning circuit 1, wherein, the detecting electrode of described first ion concentration sensor 4 detects the ion concentration at the liquid feeding end place, upstream of described fluid pipeline 9, the data transmission terminal group of this first ion concentration sensor 4 connects the first data transmission terminal group of described detection control circuit 2, and the first control end group of this detection control circuit 2 connects the control signal input group of described first suction pumps 3; The detecting electrode of described second ion concentration sensor 6 detects the ion concentration at the liquid feeding end place, downstream of described fluid pipeline 9, the data transmission terminal group of this second ion concentration sensor 6 connects the second data transmission terminal group of described detection control circuit 2, and the second control end group of this detection control circuit 2 connects the control signal input group of described second suction pumps 5; First data terminal of described detection control circuit 2 connects the parameter outfan that described parameter is provided with warning circuit 1, and second data terminal of this detection control circuit 2 connects the alarm control signal input that this parameter is provided with warning circuit 1.
As shown in Figure 2, described detection control circuit 2 is provided with microcontroller IC1, interface modular converter IC3, and the first data transmission terminal group UART2_TX, the UART2_RX of described microcontroller IC1 is connected with data transmission terminal group TXD2, the RXD2 of the detection module COND1 of described first ion concentration sensor 4 respectively; The second data transmission terminal group UART3_TX, the UART3_RX of this microcontroller IC1 is connected with data transmission terminal group TXD3, the RXD3 of the detection module COND2 of described second ion concentration sensor 6 respectively;
The first control end group PC0 of described microcontroller IC1, PC1, PC2, PC3 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER1 of the motor M 1 of described first suction pumps 3 respectively; The second control end group PC6 of this microcontroller IC1, PC7, PC8, PC9 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER2 of the motor M 2 of described second suction pumps 5 respectively;
The parameter input UART1_RX of described microcontroller IC1 connects the data sending terminal TXD1 of described interface modular converter IC3, the controlling alarm end UART1_TX of this microcontroller IC1 connects the data receiver RXD1 of this interface modular converter IC3, and the transmitting-receiving control end PA8 of this microcontroller IC1 connects the transmitting-receiving control signal input R/D of this interface modular converter IC3; The first data terminal A of this interface modular converter IC3 connects the parameter outfan that described parameter is provided with warning circuit 1, and the second data terminal B of this interface modular converter IC3 connects the alarm control signal input that this parameter is provided with warning circuit 1.
As shown in Figure 3, the blood purification using method of automatic liquid mixing system, described detection control circuit 2 carries out work according to following steps:
Obtain aimed concn and alarm threshold value: be provided with from described parameter and obtain the first mixed liquor aimed concn CondT1 the warning circuit 1, the second mixed liquor aimed concn CondT2, first mixed liquid concentration alarm threshold value CondW1 that exceeds standard, second mixed liquid concentration alarm threshold value CondW2 that exceeds standard, the first mixed liquor minimum speed alarm threshold value MWL1, the first mixed liquor maximum speed alarm threshold value MWH1, the second mixed liquor minimum speed alarm threshold value MWL2 and the second mixed liquor maximum speed alarm threshold value MWL2;
Definition detects the initial value i=1 of number of times i;
Determine the motor initial speed:
Determine rotating speed initial value Mv1 (i-1)=j1 * CondT1 of the motor M 1 of described first suction pumps 3, wherein j1 is the initial speed adjustment coefficient of this motor M 1;
Determine rotating speed initial value Mv2 (i-1)=j2 * CondT2 of the motor M 2 of described second suction pumps 5, wherein j2 is the initial speed adjustment coefficient of this motor M 2;
Parameter initialization:
Define the rotation speed change amount initial value Vx1 (i-1)=0 of described motor M 1, the speed regulation k1=2 of M1;
Define the rotation speed change amount initial value Vx2 (i-1)=0 of described motor M 2, the speed regulation k2=3 of M2;
Define the real-time ion concentration initial value CondV1 (i-1)=0 of described first mixed liquor, the real-time ion concentration initial value CondV2 (i-1)=0 of second mixed liquor;
The rotation of control motor:
The motor M 1 of controlling described first suction pumps 3 is rotated by rotating speed initial value Mv1 (i-1);
The motor M 2 of controlling described second suction pumps 5 is rotated by rotating speed initial value Mv2 (i-1);
Obtain the real-time ion concentration when detecting for the i time:
Read the real-time ion concentration CondV1 (i) of first mixed liquor of described first ion concentration sensor 4 acquisitions;
Read the real-time ion concentration CondV2 (i) of second mixed liquor of described second ion concentration sensor 6 acquisitions;
Whether the real-time concentration when judging the i time detection exceeds standard:
If CondV1 (i)＜CondW1, and CondV2 (i)＜CondW2, then real-time concentration does not exceed standard, and enters the flow process of the rotating speed adjustment amount when determining the i time detection;
Otherwise real-time concentration exceeds standard, and controls described parameter warning circuit 1 warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
The flow process of described rotating speed adjustment amount when determining the i time detection is:
Determine rotating speed adjustment amount Vx1 (i)=k1 * [CondV1 (i)-CondT1] of first mixed liquor;
Determine rotating speed adjustment amount Vx2 (i)=k2 * [CondV2 (i)-CondT2] of second mixed liquor;
Motor speed when determining the i time detection:
Determine rotating speed Mv1 (i)=Mv1 (the i-1)+Vx1 (i) of the motor M 1 of described first suction pumps 3;
Determine rotating speed Mv2 (i)=Mv2 (the i-1)+Vx2 (i) of the motor M 2 of described second suction pumps 5;
Judge the motor speed safety whether when detecting for the i time:
If MWL1＜Mv1 (i)＜MWH1, and MWL2＜Mv2 (i)＜MWL2, then the motor speed peace is individual, and i adds 1, returns the flow process of described control motor rotation;
Otherwise motor speed is dangerous, controls described parameter warning circuit 1 warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
Its working condition is as follows: suction pumps aspirates concentrated solution from concentrate container, and mixes with reverse osmosis water in the fluid pipeline via line transportation and to form mixed liquor; Ion concentration sensor is by the ion concentration of mixed liquor in the detecting electrode tracer liquid pipeline, and the ion concentration signal outputed to detect in the control circuit analyzes; Detecting control circuit compares concentration target component value and the real-time detected value of mixed liquor that parameter is provided with in the warning circuit, if the mixed liquor ion concentration exceeds standard, then control parameter the warning circuit warning is set, otherwise adjust the suction pumps motor speed, realization reaches the real-time adjustment to the mixed liquor ion concentration to the control of concentrated solution suction flow; Simultaneously, detect control circuit also adjusted rotating speed and parameter are provided with in the warning circuit the rotating speed alarm threshold value relatively, if motor speed is unusual, then controls parameter warning circuit, warning are set, otherwise continuation detects in real time to fluid loop.
Claims (4)
1. blood purification automatic liquid mixing system, comprise concentrated solution A container (7), concentrated solution B container (8), first suction pumps (3), second suction pumps (5) and fluid pipeline (9), wherein, described concentrated solution A container (7) communicates with the upstream liquid feeding end of described fluid pipeline (9), and described first suction pumps (3) is arranged in the liquor charging pipeline of this concentrated solution A container (7); Described concentrated solution B container (8) communicates with the downstream liquid feeding end of described fluid pipeline (9), and this second suction pumps (5) is arranged in the liquor charging pipeline of this concentrated solution B container (8);
It is characterized in that: comprise that also first ion concentration sensor (4), second ion concentration sensor (6), detection control circuit (2) and parameter are provided with warning circuit (1), wherein, the detecting electrode of described first ion concentration sensor (4) detects the ion concentration at the liquid feeding end place, upstream of described fluid pipeline (9), the data transmission terminal group of this first ion concentration sensor (4) connects the first data transmission terminal group of described detection control circuit (2), and the first control end group of this detection control circuit (2) connects the control signal input group of described first suction pumps (3);
The detecting electrode of described second ion concentration sensor (6) detects the ion concentration at the liquid feeding end place, downstream of described fluid pipeline (9), the data transmission terminal group of this second ion concentration sensor (6) connects the second data transmission terminal group of described detection control circuit (2), and the second control end group of this detection control circuit (2) connects the control signal input group of described second suction pumps (5);
First data terminal of described detection control circuit (2) connects the parameter outfan that described parameter is provided with warning circuit (1), and second data terminal of this detection control circuit (2) connects the alarm control signal input that this parameter is provided with warning circuit (1).
2. blood purification automatic liquid mixing system according to claim 1, it is characterized in that: described detection control circuit (2) is provided with microcontroller IC1, interface modular converter IC3, and the first data transmission terminal group UART2_TX, the UART2_RX of described microcontroller IC1 is connected with data transmission terminal group TXD2, the RXD2 of the detection module COND1 of described first ion concentration sensor (4) respectively; The second data transmission terminal group UART3_TX, the UART3_RX of this microcontroller IC1 is connected with data transmission terminal group TXD3, the RXD3 of the detection module COND2 of described second ion concentration sensor (6) respectively;
The first control end group PC0 of described microcontroller IC1, PC1, PC2, PC3 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER1 of the motor M 1 of described first suction pumps (3) respectively; The second control end group PC6 of this microcontroller IC1, PC7, PC8, PC9 are connected with control signal input group A+, A-, B+, the B-of the driver module DRIVER2 of the motor M 2 of described second suction pumps (5) respectively;
The parameter input UART1_RX of described microcontroller IC1 connects the data sending terminal TXD1 of described interface modular converter IC3, the controlling alarm end UART1_TX of this microcontroller IC1 connects the data receiver RXD1 of this interface modular converter IC3, and the transmitting-receiving control end PA8 of this microcontroller IC1 connects the transmitting-receiving control signal input R/D of this interface modular converter IC3; The first data terminal A of this interface modular converter IC3 connects the parameter outfan that described parameter is provided with warning circuit (1), and the second data terminal B of this interface modular converter IC3 connects the alarm control signal input that this parameter is provided with warning circuit (1).
3. the blood purification as claimed in claim 1 or 2 using method of automatic liquid mixing system, it is characterized in that: described detection control circuit (2) carries out work according to following steps:
Obtain aimed concn and alarm threshold value: be provided with from described parameter and obtain the first mixed liquor aimed concn CondT1 the warning circuit (1), the second mixed liquor aimed concn CondT2, first mixed liquid concentration alarm threshold value CondW1 that exceeds standard, second mixed liquid concentration alarm threshold value CondW2 that exceeds standard, the first mixed liquor minimum speed alarm threshold value MWL1, the first mixed liquor maximum speed alarm threshold value MWH1, the second mixed liquor minimum speed alarm threshold value MWL2 and the second mixed liquor maximum speed alarm threshold value MWL2;
Definition detects the initial value i=1 of number of times i;
Determine the motor initial speed:
Determine rotating speed initial value Mv1 (i-1)=j1 * CondT1 of the motor M 1 of described first suction pumps (3), wherein j1 is the initial speed adjustment coefficient of this motor M 1;
Determine rotating speed initial value Mv2 (i-1)=j2 * CondT2 of the motor M 2 of described second suction pumps (5), wherein j2 is the initial speed adjustment coefficient of this motor M 2;
Parameter initialization:
Define the rotation speed change amount initial value Vx1 (i-1)=0 of described motor M 1, the speed regulation k1 of M1;
Define the rotation speed change amount initial value Vx2 (i-1)=0 of described motor M 2, the speed regulation k2 of M2;
Define the real-time ion concentration initial value CondV1 (i-1)=0 of described first mixed liquor, the real-time ion concentration initial value CondV2 (i-1)=0 of second mixed liquor;
The rotation of control motor:
The motor M 1 of controlling described first suction pumps (3) is rotated by rotating speed initial value Mv1 (i-1);
The motor M 2 of controlling described second suction pumps (5) is rotated by rotating speed initial value Mv2 (i-1);
Obtain the real-time ion concentration when detecting for the i time:
Read the real-time ion concentration CondV1 (i) of first mixed liquor of described first ion concentration sensor (4) acquisition;
Read the real-time ion concentration CondV2 (i) of second mixed liquor of described second ion concentration sensor (6) acquisition;
Whether the real-time concentration when judging the i time detection exceeds standard:
If CondV1 (i)＜CondW1, and CondV2 (i)＜CondW2, then real-time concentration does not exceed standard, and enters the flow process of the rotating speed adjustment amount when determining the i time detection;
Otherwise real-time concentration exceeds standard, and controls described parameter warning circuit (1) warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
The flow process of described rotating speed adjustment amount when determining the i time detection is:
Determine rotating speed adjustment amount Vx1 (i)=k1 * [CondV1 (i)-CondT1] of first mixed liquor;
Determine rotating speed adjustment amount Vx2 (i)=k2 * [CondV2 (i)-CondT2] of second mixed liquor;
Motor speed when determining the i time detection:
Determine rotating speed Mv1 (i)=Mv1 (the i-1)+Vx1 (i) of the motor M 1 of described first suction pumps (3);
Determine rotating speed Mv2 (i)=Mv2 (the i-1)+Vx2 (i) of the motor M 2 of described second suction pumps (5);
Judge the motor speed safety whether when detecting for the i time:
If MWL1＜Mv1 (i)＜MWH1, and MWL2＜Mv2 (i)＜MWL2, motor speed safety then, i adds 1, returns the flow process of described control motor rotation;
Otherwise motor speed is dangerous, controls described parameter warning circuit (1) warning is set, and returns the described flow process of obtaining aimed concn and alarm threshold value;
4. blood purification according to claim 3 is characterized in that: the speed regulation k1=2 of motor M 1, the speed regulation k2=3 of motor M 2 with the using method of automatic liquid mixing system.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010579663A CN102008763B (en) | 2010-12-08 | 2010-12-08 | Automatic fluid preparation system for blood purification and use method thereof |
| PCT/CN2011/074494 WO2012075782A1 (en) | 2010-12-08 | 2011-05-23 | Automatic liquid preparation system for purifying blood and its usage method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201010579663A CN102008763B (en) | 2010-12-08 | 2010-12-08 | Automatic fluid preparation system for blood purification and use method thereof |
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| CN102008763A true CN102008763A (en) | 2011-04-13 |
| CN102008763B CN102008763B (en) | 2012-10-24 |
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| CN201010579663A Active CN102008763B (en) | 2010-12-08 | 2010-12-08 | Automatic fluid preparation system for blood purification and use method thereof |
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| WO (1) | WO2012075782A1 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012075782A1 (en) * | 2010-12-08 | 2012-06-14 | 重庆山外山科技有限公司 | Automatic liquid preparation system for purifying blood and its usage method |
| CN103083745A (en) * | 2013-01-23 | 2013-05-08 | 荣维淳 | Distributor used for hematodialysis concentrated solutions |
| CN103823485A (en) * | 2014-02-24 | 2014-05-28 | 广东宝莱特医用科技股份有限公司 | System and method for automatically controlling and detecting ionic concentration |
| CN104379189A (en) * | 2013-04-25 | 2015-02-25 | 甘布罗伦迪亚股份公司 | System and method for preparation of a medical fluid |
| CN104587547A (en) * | 2015-01-07 | 2015-05-06 | 成都邦研科技有限公司 | Emergency water supply conveying device of water preparing equipment for hemodialysis |
| CN104907115A (en) * | 2015-05-15 | 2015-09-16 | 邢孝玲 | Comprehensive intravenous drug blending station |
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| CN110812557A (en) * | 2019-10-21 | 2020-02-21 | 广东宝莱特医用科技股份有限公司 | Self-correcting PID ion adjusting method for hemodialysis machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012075782A1 (en) * | 2010-12-08 | 2012-06-14 | 重庆山外山科技有限公司 | Automatic liquid preparation system for purifying blood and its usage method |
| CN103083745A (en) * | 2013-01-23 | 2013-05-08 | 荣维淳 | Distributor used for hematodialysis concentrated solutions |
| CN104379189A (en) * | 2013-04-25 | 2015-02-25 | 甘布罗伦迪亚股份公司 | System and method for preparation of a medical fluid |
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| CN103823485A (en) * | 2014-02-24 | 2014-05-28 | 广东宝莱特医用科技股份有限公司 | System and method for automatically controlling and detecting ionic concentration |
| CN104587547A (en) * | 2015-01-07 | 2015-05-06 | 成都邦研科技有限公司 | Emergency water supply conveying device of water preparing equipment for hemodialysis |
| CN104587547B (en) * | 2015-01-07 | 2016-08-10 | 成都邦研科技有限公司 | A kind of hemodialysis water making device Emergency water supply conveyer device |
| CN106137379A (en) * | 2015-03-26 | 2016-11-23 | 四川锦江电子科技有限公司 | Charge pump, the control method of charge pump and device |
| CN104907115A (en) * | 2015-05-15 | 2015-09-16 | 邢孝玲 | Comprehensive intravenous drug blending station |
| CN105900800A (en) * | 2016-06-06 | 2016-08-31 | 区登波 | Remote control method and system for water and fertilizer integrated irrigation |
| CN110812557A (en) * | 2019-10-21 | 2020-02-21 | 广东宝莱特医用科技股份有限公司 | Self-correcting PID ion adjusting method for hemodialysis machine |
| CN112843362A (en) * | 2020-12-31 | 2021-05-28 | 江苏关怀医疗科技有限公司 | Dialysate preparation and supply device for dialysate system |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012075782A1 (en) | 2012-06-14 |
| CN102008763B (en) | 2012-10-24 |
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