CN100460023C - Ion concentration monitor for purifying blood - Google Patents
Ion concentration monitor for purifying blood Download PDFInfo
- Publication number
- CN100460023C CN100460023C CNB200610054322XA CN200610054322A CN100460023C CN 100460023 C CN100460023 C CN 100460023C CN B200610054322X A CNB200610054322X A CN B200610054322XA CN 200610054322 A CN200610054322 A CN 200610054322A CN 100460023 C CN100460023 C CN 100460023C
- Authority
- CN
- China
- Prior art keywords
- circuit
- outfan
- resistance
- ion concentration
- conductivity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008280 blood Substances 0.000 title claims abstract description 38
- 210000004369 blood Anatomy 0.000 title claims abstract description 38
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 238000007493 shaping process Methods 0.000 claims abstract description 20
- 238000001514 detection method Methods 0.000 claims abstract description 15
- 229910002804 graphite Inorganic materials 0.000 claims description 32
- 239000010439 graphite Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 27
- 238000005070 sampling Methods 0.000 claims description 26
- 239000003990 capacitor Substances 0.000 claims description 12
- 238000004140 cleaning Methods 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 239000004020 conductor Substances 0.000 abstract 1
- 239000000385 dialysis solution Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000010355 oscillation Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000000746 purification Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000000502 dialysis Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 238000012806 monitoring device Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229920000554 ionomer Polymers 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Images
Abstract
The present invention relates to an ion concentration monitoring apparatus for purifying blood. It includes detection control circuit, electroconductivity sensor and temperature sensor. The output end of the described temperature sensor is connected with collecting and processing circuit in the described detection control circuit. It is characterized by that the described detection control circuit also includes: the input end of elecroconductivity/frequency conversion circuit is connected with output end of electroconductivity sensor, the output end of said electroconductivity/frequency conversion circuit is connected with frequency signal shaping circuit, the output end of frequency signal shaping circuit is connected with input end of the described collecting and processing circuit. The described electroconductivity sensor is formed from first and second graphite rings and first and second electrodes, the described first and second electrodes are respectively fixed on outer walls of first and second graphite rings, said first and second electrodes are also connected with electroconductivity/frequency conversion circuit conductor.
Description
Technical field
The invention belongs to ion concentration monitor for purifying blood, relate to the monitor of the monitoring dialysis solution intermediate ion concentration safety range that a kind of blood purification uses.
Background technology
In blood cleaning equipment, patient's blood flows out the extracorporeal circulation that constitutes via pipeline in the body to be got back in the body, in this blood circulation, mainly comprises bloody path, liquid road and three parts of monitoring system.Outside the intravital blood lead body of patient, enter extracorporeal circuit such as dialyser or filter, pass back into human body, constitute the bloody path system; In the liquid-way system, the dialysis solution of standard ionomer concentration enters processes such as dialyser and dialyzer membrane offside blood samples of patients generation disperse, convection current, ultrafiltration, and removes redundant moisture in patient's body with suitable speed.Monitoring system is monitored each parts of blood cleaning equipment, parameter, index etc., and sends and report to the police and security control.
Accompanying drawing 1 is the block diagram of dialysis solution path in the blood cleaning equipment, and wherein the concentration monitor device is used to detect the dialysis solution electrical conductivity exactly obtaining total ion concentration, and compares with standard value, in time sends alarm signal and takes safety precautions.When monitor is reported to the police, make the dialysis circuit bypass, shown in accompanying drawing 1 dotted line, dialysis solution does not enter dialyser and the blood of human body generation is got in touch, and directly discharges from leakage fluid dram by the waste liquid loop.
Under the normal condition, the dialysis solution that enters dialyser is the liquid that contains standard ionomer concentration and formula proportion, with processes such as blood samples of patients generation disperse, convection current, ultrafiltration, realizes the purpose of blood purification in dialyser.Since the prescription improper or artificial, when the automatic liquid matching operating trouble causes dialysis solution intermediate ion deviation of concentration standard value range, ion concentration monitor sends alarm signal makes the dialysis solution bypass enter the waste liquid passing away, avoid dialysis solution to enter in dialyser or the filter and cause that with processes such as blood generation disperse, convection current, ultrafiltration patient's body fluid is unbalance, cause security incident.
Traditional blood purification ion concentration monitoring device, conductivity sensor and temperature sensor in the liquid-way system that generally comprise and detect control circuit, is installed on blood cleaning equipment, wherein conductivity sensor adopts the electrode contact method, be that electrode is immersed in the solution and measures, temperature sensor is immersed in the solution equally and measures, and conductivity sensor and temperature sensor transmit signal respectively and give the detection control circuit; Traditional detection control circuit, often by isoperibol or by the correction of temperature-compensation circuit realization to conductivity measurements, because resistor network can't make the temperature characterisitic of its equivalent temperature characterisitic and conductivity sensor cancel out each other fully in whole range, adopts this temperature compensation can only really realize temperature-compensating on several points.
Traditional blood purification is that the product manufacturing need be checked on by the mounting process and the material technology of regulation strictness, is difficult to guarantee consistency of product and stability with the shortcoming of ion concentration monitoring device.
Summary of the invention
The purpose of this invention is to provide a kind of blood purification ion concentration monitoring device, can reduce the difficulty requirement that product is made mounting process and material technology.
For achieving the above object, ion concentration monitor for purifying blood of the present invention, comprise conductivity sensor and temperature sensor in the liquid-way system that detects control circuit, is installed on blood cleaning equipment, wherein, detect control circuit and comprise collection and treatment circuit, described temperature sensor is arranged in described liquid-way system, the outfan of this temperature sensor is connected with collection and treatment circuit in the described detection control circuit, this collection and treatment circuit are provided with alarm signal output ends O, and its key is:
Described detection control circuit also comprises electric conductance/frequency-conversion circuit and frequency signal shaping circuit, the input of wherein said electric conductance/frequency-conversion circuit is connected with the outfan of described conductivity sensor, the outfan of this electric conductance/frequency-conversion circuit is connected with described frequency signal shaping circuit input, and the outfan of described frequency signal shaping circuit is connected with the input of described collection and treatment circuit;
Described conductivity sensor is made up of first, second graphite annulus and first, second electrode, wherein the internal ring wall of first, second graphite annulus directly contacts with liquid in the described liquid-way system, described first, second electrode is separately fixed at the outer wall of first, second graphite annulus, and this first, second electrode also is connected with the electric conductance/frequency-conversion circuit lead of described detection control circuit.
The two ends of first graphite annulus and second graphite annulus are bonded with shading ring respectively in the described conductivity sensor, described shading ring is connected by conduit with liquid-way system in the described blood cleaning equipment, and described first graphite annulus, second graphite annulus, shading ring and liquid road conduit constitute fluid pipeline.
Described temperature sensor is an integrated digital temperature sensor, and this integrated digital temperature sensor is installed in the inner-walls of duct of described fluid pipeline, and the outfan of described temperature sensor connects described collection and treatment circuit.
Conductivity sensor is made up of graphite annulus, the annular isolation material of outer engaged column electrode, and dialysis solution flows through from the pipeline that looping pit constitutes.The terminal embedded temperature sensor of isolated material, temperature sensor temperature-sensitive end directly contacts with dialysis solution.The conductivity sensor extraction electrode is connected to electric conductance/frequency-conversion circuit.
Contain the electric conductance liquid of various formula proportion and the water for dialysis that water treatment facilities come, flow through the graphite annulus that in inwall, is embedded with electrode and the aperture at interval insulant center after the mixing, understand equivalent resistance Rs different when generation is passed through with pure water between two electrodes, this equivalence resistance R s is an oscillation circuit element in described electric conductance/frequency-conversion circuit, cooperates with other element in the circuit to produce pulse signal output.
Described electric conductance/frequency-conversion circuit is a triangular-wave generator, and it is by amplifier U1A, resistance R 1, resistance R 2 and integrator U1B, resistance R 3, resistance R 4, and capacitor C 1 is formed; The backward end crosstalk resistance R1 ground connection of described amplifier U1A, hold and the described resistance R 2 of outfan cross-over connection in the same way, this is held in the same way also with first electrode 5 in described first graphite annulus 4 and is connected, the described resistance R 3 of the outfan string of described amplifier U1A connects the backward end of described integrator U1B, the crosstalk of the end in the same way resistance R4 ground connection of this integrator U1B, the outfan of this integrator U1B and described frequency signal shaping circuit 7 are connected with second electrode 5 ' in described second graphite annulus 4 ', between the outfan of this integrator U1B and the backward end also string described capacitor C 1 is arranged.
When the ion concentration of water for dialysis changed, resistivity was also different, and its equivalent resistance (Rs) also changes thereupon, and this variation causes the respective change of circuit oscillation frequency, and its electric conductance/frequency transformation formula is: and f=R2/ (4 * Rs * R3 * C1).
Described frequency signal shaping circuit is made up of reshaper U2A, capacitor C 2, resistance R 5, resistance R 6, stabilivolt Z3, wherein capacitor C 2 one ends connect the outfan of described integrator U1B, the other end connects the end in the same way of described reshaper U2A, the end in the same way of this reshaper U2A has also been gone here and there resistance R 5 ground connection, the backward end ground connection of this reshaper U2A, the outfan crosstalk resistance R6 of this reshaper U2A connects positive supply, and the outfan reversal connection stabilivolt Z3 of this reshaper U2A plough.
Frequency of oscillation is delivered to the waveform shaping circuit of being made up of C2, R5, U2A, R6, Z3 with the signal that ion concentration changes, and produces the digital signal level of a standard by the effect of comparator U2A.This signal is delivered to the frequency sampling circuit in collection and the treatment circuit.
Described collection and treatment circuit are the single chip circuits of a tape storage, the first input end I1 of this single chip circuit connects the outfan of described reshaper U2A, the second input I2 of this single chip circuit connects the outfan of described temperature sensor, and the 3rd input I3 and the alarm signal output ends O of this single chip circuit are circumscribed with keyboard/display circuit.
Described collection and treatment circuit are by discerning the input signal of the described first input end I1 and the second input I2 with lower device, and generate alarm signal by alarm signal output ends O output:
Be used to start the device of ion concentration monitor;
The device that is used for parameter initialization;
Be used to judge whether the device of external connection keyboard/display circuit;
When described collection and treatment circuit are circumscribed with keyboard/display circuit, be used for calling the device of the keyboard scan program that is circumscribed with keyboard/display circuit; Be used to the device that judges whether that keyboard is pressed, have, then, be used to set up electrical conductivity linear correction value table subprogram mechanism, return the device that is used for calling the keyboard scan program that is circumscribed with keyboard/display circuit; No, then, be used for the initialized device of electrical conductivity sampling timing;
Obtained new electrical conductivity linear correction value table this moment and deposit in gather and the memorizer of treatment circuit in,
When described collection and treatment circuit are not circumscribed with keyboard/display circuit, then, be used for the initialized device of electrical conductivity sampling timing;
The electrical conductivity linear correction value table that obtain this moment be deposit in advance gather and the memorizer of treatment circuit in,
Be used to judge that the electrical conductivity sampling timing is to device not;
Timing is less than, and then returns to be used to judge that the electrical conductivity sampling timing is to device not;
Be timed to, then read the frequency signal Fv of described first input end I1, be used to make frequency signal Fv to equal the device of current conductivity sample frequency value fx;
This is used to judge that the electrical conductivity sampling timing is preset with the sampling period to device not, arrives when the sampling period, promptly is timed to, and then enters the described frequency signal Fv that is used for and equals current conductivity sample frequency value fx device;
Be used for searching for the device of Fv in the interval position of electrical conductivity linear correction value table;
Be used to set f
0Equal interval lower bound, f
1Equal the device in the interval upper bound; For
f
0For in the linear correction value table less than the maximum that equals Fv, f
1For in the linear correction value table greater than the minima of Fv,
Be used to look into electrical conductivity linear correction value table and get f
0Corresponding electric conductivity value S
0, f
1Corresponding electric conductivity value S
1Device;
Be used to draw intervals linear correction slope K=(S
1-S
0)/(f
1-f
0) device;
Be used to draw Current Temperatures electric conductivity value Sx=K (fx-f
0)+S
0Device;
Be used to call the device of temperature-compensating subprogram;
Be used to draw the device of the real-time electric conductivity value Sv on current liquid road; When drawing 25 ℃ at this moment, the electric conductivity value S on current liquid road
25=Sx/ (1+a * Tx), and with this S
25Give Sv;
Be used for Sv and alarm limit relatively, judge the device whether Sv transfinites:
Do not transfinite, then return and be used for the initialized device of electrical conductivity sampling timing;
Transfinite, be used to send the device of alarm signal; Return and be used for the initialized device of electrical conductivity sampling timing;
This alarm limit is preset in the memorizer of described collection and treatment circuit.
Described electrical conductivity linear correction value table is: when ambient temperature is 25 ℃, and the conductivity table of standard K CL solution in liquid-way system.
The described device that is used to call the temperature-compensating subprogram is made of following:
Be used to call the mechanism of temperature survey program;
Be used to obtain the mechanism of liquid road current temperature value t;
Be used to obtain the mechanism of temperature difference Tx=t-25.0;
Be used to obtain the mechanism of liquid road Current Temperatures electric conductivity value Sx;
When being used to draw 25 ℃, the electric conductivity value S on current liquid road
25=Sx/ (the device of 1+ α * Tx).
Described α is a temperature compensation coefficient, α=0.0207.
Remarkable result of the present invention is: a kind of blood purification ion concentration monitoring device is provided, can have reduced the difficulty requirement that product is made mounting process and material technology, can guarantee consistency of product and stability.
Description of drawings
Accompanying drawing 1: the block diagram of dialysis solution path in the blood cleaning equipment;
Accompanying drawing 2: structure principle chart of the present invention;
Accompanying drawing 3: detection control circuit schematic diagram of the present invention;
Accompanying drawing 4: conductivity sensor structural representation of the present invention;
Accompanying drawing 5: conductivity temperature compensation program flow diagram of the present invention;
Accompanying drawing 6: main program flow block diagram of the present invention.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Shown in accompanying drawing 2, accompanying drawing 3: a kind of ion concentration monitor for purifying blood, comprise conductivity sensor 2 and temperature sensor 3 in the liquid-way system that detects control circuit 1, is installed on blood cleaning equipment, wherein, detect control circuit 1 and comprise collection and treatment circuit 8, described temperature sensor 3 is arranged in described liquid-way system, the outfan of this temperature sensor 3 is connected with collection and treatment circuit 8 in the described detection control circuit 1, this collection and treatment circuit 8 are provided with alarm signal output ends O, wherein:
Described detection control circuit 1 also comprises electric conductance/frequency-conversion circuit 6 and frequency signal shaping circuit 7, the input of wherein said electric conductance/frequency-conversion circuit 6 is connected with the outfan of described conductivity sensor 2, the outfan of this electric conductance/frequency-conversion circuit 6 is connected with described frequency signal shaping circuit 7 inputs, and the outfan of described frequency signal shaping circuit 7 is connected with the input of described collection and treatment circuit 8;
As shown in Figure 4: described conductivity sensor 2 is by first, second graphite annulus 4,4 ' and first, second electrode 5,5 ' forms, wherein the internal ring wall of first, second graphite annulus 4,4 ' directly contacts described first, second electrode 5 with liquid in the described liquid-way system, 5 ' is separately fixed at first, second graphite annulus 4,4 ' outer wall, this first, second electrode 5,5 ' also is connected with electric conductance/frequency-conversion circuit 6 leads of described detection control circuit 1.
The two ends of first graphite annulus 4 and second graphite annulus 4 ' are bonded with shading ring respectively in the described conductivity sensor 2, described shading ring 9 is connected by conduit with liquid-way system in the described blood cleaning equipment, and described first graphite annulus 4, second graphite annulus 4 ', shading ring 9 constitute fluid pipeline with liquid road conduit.
As shown in Figure 3: described temperature sensor 3 is integrated digital temperature sensors, its model is DS18B20, this integrated digital temperature sensor is installed in the inner-walls of duct of described fluid pipeline, and the outfan of described temperature sensor 3 connects described collection and treatment circuit 8.
Conductivity sensor is made up of graphite annulus, the annular isolation material of outer engaged column electrode, and dialysis solution flows through from the pipeline that looping pit constitutes.The terminal embedded temperature sensor of isolated material, temperature sensor temperature-sensitive end directly contacts with dialysis solution.The conductivity sensor extraction electrode is connected to electric conductance/frequency-conversion circuit.
Contain the electric conductance liquid of various formula proportion and the water for dialysis that water treatment facilities come, flow through the graphite annulus that in inwall, is embedded with electrode and the aperture at interval insulant center after the mixing, understand equivalent resistance Rs different when generation is passed through with pure water between two electrodes, this equivalence resistance R s is an oscillation circuit element in described electric conductance/frequency-conversion circuit 6, cooperates with other element in the circuit to produce pulse signal output.
As shown in Figure 3: described electric conductance/frequency-conversion circuit 6 is triangular-wave generators, and it is by amplifier (U1A), resistance R 1, resistance R 2 and integrator U1B, resistance R 3, resistance R 4, and capacitor C 1 is formed; The backward end crosstalk resistance R1 ground connection of described amplifier U1A, hold and the described resistance R 2 of outfan cross-over connection in the same way, this is held in the same way also with first electrode 5 in described first graphite annulus 4 and is connected, the described resistance R 3 of the outfan string of described amplifier U1A connects the backward end of described integrator U1B, the crosstalk of the end in the same way resistance R4 ground connection of this integrator U1B, the outfan of this integrator U1B and described frequency signal shaping circuit 7 are connected with second electrode 5 ' in described second graphite annulus 4 ', between the outfan of this integrator U1B and the backward end also string described capacitor C 1 is arranged.
When the ion concentration of water for dialysis changed, resistivity was also different, and its equivalent resistance Rs also changes thereupon, and this variation causes the respective change of circuit oscillation frequency, and its electric conductance/frequency transformation formula is: and f=R2/ (4 * Rs * R3 * C1).
As shown in Figure 3: described frequency signal shaping circuit 7 is made up of reshaper U2A, capacitor C 2, resistance R 5, resistance R 6, stabilivolt Z3, wherein capacitor C 2 one ends connect the outfan of described integrator U1B, the other end connects the end in the same way of described reshaper U2A, the end in the same way of this reshaper U2A has also been gone here and there resistance R 5 ground connection, the backward end ground connection of this reshaper U2A, the outfan crosstalk resistance R6 of this reshaper U2A connects positive supply, and the outfan reversal connection stabilivolt Z3 of this reshaper U2A plough.
Frequency of oscillation is delivered to the waveform shaping circuit of being made up of C2, R5, U2A, R6, Z3 with the signal that ion concentration changes, and produces the digital signal level of a standard by the effect of comparator U2A.This signal is delivered to the frequency sampling circuit in collection and the treatment circuit.
As shown in Figure 3: described collection and treatment circuit 8 are single chip circuits of a tape storage, its model is P89LPC915, the first input end I1 of this single chip circuit connects the outfan of described reshaper U2A, the second input I2 of this single chip circuit connects the outfan of described temperature sensor 3, and the 3rd input I3 and the alarm signal output ends O of this single chip circuit are circumscribed with keyboard/display circuit.
As shown in Figure 6: described collection and treatment circuit 8 are by discerning the input signal of the described first input end I1 and the second input I2 with lower device, and generate alarm signal by alarm signal output ends O output:
Be used to start the device of ion concentration monitor;
The device that is used for parameter initialization;
Be used to judge whether the device of external connection keyboard/display circuit;
When described collection and treatment circuit are circumscribed with keyboard/display circuit, be used for calling the device of the keyboard scan program that is circumscribed with keyboard/display circuit; Be used to the device that judges whether that keyboard is pressed, have, then, be used to set up electrical conductivity linear correction value table subprogram mechanism, return the device that is used for calling the keyboard scan program that is circumscribed with keyboard/display circuit; No, then, be used for the initialized device of electrical conductivity sampling timing;
Obtained new electrical conductivity linear correction value table this moment and deposit in gather and the memorizer of treatment circuit 8 in,
When described collection and treatment circuit are not circumscribed with keyboard/display circuit, then, be used for the initialized device of electrical conductivity sampling timing;
The electrical conductivity linear correction value table that obtain this moment be deposit in advance gather and the memorizer of treatment circuit (8) in,
Be used to judge that the electrical conductivity sampling timing is to device not;
Timing is less than, and then returns to be used to judge that the electrical conductivity sampling timing is to device not;
Be timed to, then read the frequency signal Fv of described first input end I1, be used to make frequency signal Fv to equal the device of current conductivity sample frequency value fx;
This is used to judge that the electrical conductivity sampling timing is preset with the sampling period to device not, arrives when the sampling period, promptly is timed to, and then enters the described device that frequency signal Fv equals current conductivity sample frequency value fx that is used for;
Be used for searching for the device of Fv in the interval position of electrical conductivity linear correction value table;
Be used to set f
0Equal interval lower bound, f
1Equal the device in the interval upper bound; For
f
0For in the linear correction value table less than the maximum that equals Fv, f
1For in the linear correction value table greater than the minima of Fv,
Be used to look into electrical conductivity linear correction value table and get f
0Corresponding electric conductivity value S
0, f
1Corresponding electric conductivity value S
1Device;
Be used to draw intervals linear correction slope K=(S
1-S
0)/(f
1-f
0) device;
Be used to draw Current Temperatures electric conductivity value Sx=K (fx-f
0)+S
0Device;
Be used to call the device of temperature-compensating subprogram;
Be used to draw the device of the real-time electric conductivity value Sv on current liquid road; When drawing 25 ℃ at this moment, the electric conductivity value S on current liquid road
25=Sx/ (1+a * Tx), and with this S
25Give Sv;
Be used for Sv and alarm limit relatively, judge the device whether Sv transfinites:
Do not transfinite, then return and be used for the initialized device of electrical conductivity sampling timing;
Transfinite, be used to send the device of alarm signal; Return and be used for the initialized device of electrical conductivity sampling timing;
This alarm limit is preset in the memorizer of described collection and treatment circuit.
Described electrical conductivity linear correction value table is: when ambient temperature is 25 ℃, and the conductivity table of standard K CL solution in liquid-way system.
As shown in Figure 5: the described device that is used to call the temperature-compensating subprogram is made of following:
Be used to call the mechanism of temperature survey program;
Be used to obtain the mechanism of liquid road current temperature value t;
Be used to obtain the mechanism of temperature difference Tx=t-25.0;
Be used to obtain the mechanism of liquid road Current Temperatures electric conductivity value Sx;
When being used to draw 25 ℃, the electric conductivity value S on current liquid road
25=Sx/ (the device of 1+ α * Tx).
Described α is a temperature compensation coefficient, α=0.0207.
Its operation principle is as follows:
The present invention is installed in the liquid-way system of blood cleaning equipment, conductivity sensor 2 is arranged in the dialysis solution pipeline of dialyser or filter front end, the dialysis solution of standard ionomer concentration flows through the aperture at the graphite annulus center that is embedded with electrode in inwall, flow through dispose various ionic dialysis solution can between two electrodes, produce with pure water by the time different equivalent resistance; When ion concentration changed, its resistivity was also different, and its equivalent resistance also changes thereupon.2 liang of electrodes of conductivity sensor are linked in electric conductance/frequency-conversion circuit 6, and the variation of this equivalence resistance value causes the respective change of circuit oscillation frequency; The output of electric conductance/frequency-conversion circuit 6 is connected to frequency signal shaping circuit 7 and puts in order, and delivering to the microcontroller is the collection and the treatment circuit 8 of core again.When in the liquid road because some factor is when causing ion concentration to exceed standard, gather and treatment circuit 8 detects frequency of oscillation exceptional value that concentration change causes and compares with setting alarm limit, send alarm signal.
Claims (9)
1. ion concentration monitor for purifying blood, comprise conductivity sensor (2) and temperature sensor (3) in the liquid-way system that detects control circuit (1), is installed on blood cleaning equipment, wherein, detect control circuit (1) and comprise collection and treatment circuit (8), described temperature sensor (3) is arranged in described liquid-way system, the outfan of this temperature sensor (3) is connected with collection and treatment circuit (8) in the described detection control circuit (1), this collection and treatment circuit (8) are provided with alarm signal output ends (0), it is characterized in that:
Described detection control circuit (1) also comprises electric conductance/frequency-conversion circuit (6) and frequency signal shaping circuit (7), the input of wherein said electric conductance/frequency-conversion circuit (6) is connected with the outfan of described conductivity sensor (2), the outfan of this electric conductance/frequency-conversion circuit (6) is connected with described frequency signal shaping circuit (7) input, and the outfan of described frequency signal shaping circuit (7) is connected with the input of described collection and treatment circuit (8);
Described conductivity sensor (2) is by first, second graphite annulus (4,4 ') and first, second electrode (5,5 ') form, wherein the internal ring wall of first, second graphite annulus (4,4 ') directly contacts described first, second electrode (5 with liquid in the described liquid-way system, 5 ') be separately fixed at first, second graphite annulus (4,4 ') outer wall, this first, second electrode (5,5 ') also are connected with electric conductance/frequency-conversion circuit (6) lead of described detection control circuit (1).
2. ion concentration monitor for purifying blood according to claim 1 is characterized in that:
The two ends of first graphite annulus (4) and second graphite annulus (4 ') are bonded with shading ring respectively in the described conductivity sensor (2), described shading ring (9) is connected by conduit with liquid-way system in the described blood cleaning equipment, and described first graphite annulus (4), second graphite annulus (4 '), shading ring (9) constitute fluid pipeline with conduit.
3. ion concentration monitor for purifying blood according to claim 2 is characterized in that:
Described temperature sensor (3) is an integrated digital temperature sensor, and this integrated digital temperature sensor is installed in the inner-walls of duct of described fluid pipeline, and the outfan of described temperature sensor (3) connects described collection and treatment circuit (8).
4. ion concentration monitor for purifying blood according to claim 1 is characterized in that:
Described electric conductance/frequency-conversion circuit (6) is a triangular-wave generator, and it is by amplifier (U1A), resistance R 1, resistance R 2 and integrator (U1B), resistance R 3, resistance R 4, and capacitor C 1 is formed; The backward end crosstalk resistance R1 ground connection of described amplifier (U1A), hold and the described resistance R 2 of outfan cross-over connection in the same way, this is held in the same way also with first electrode (5) in described first graphite annulus (4) and is connected, the described resistance R 3 of the outfan string of described amplifier (U1A) connects the backward end of described integrator (U1B), the crosstalk of the end in the same way resistance R4 ground connection of this integrator (U1B), the outfan of this integrator (U1B) and described frequency signal shaping circuit (7) are connected with second electrode (5 ') in described second graphite annulus (4 '), between outfan of this integrator (U1B) and the backward end also string described capacitor C 1 is arranged.
5. ion concentration monitor for purifying blood according to claim 4 is characterized in that:
Described frequency signal shaping circuit (7) is made up of reshaper (U2A), capacitor C 2, resistance R 5, resistance R 6, stabilivolt (Z3), wherein capacitor C 2 one ends connect the outfan of described integrator (U1B), the other end connects the end in the same way of described reshaper (U2A), the end in the same way of this reshaper (U2A) has also been gone here and there resistance R 5 ground connection, the backward end ground connection of this reshaper (U2A), the outfan crosstalk resistance R6 of this reshaper (U2A) connects positive supply, and the outfan reversal connection stabilivolt (Z3) of this reshaper (U2A) is ploughed.
6. ion concentration monitor for purifying blood according to claim 5 is characterized in that:
Described collection and treatment circuit (8) are the single chip circuits of a tape storage, the first input end of this single chip circuit (I1) connects the outfan of described reshaper (U2A), second input (I2) of this single chip circuit connects the outfan of described temperature sensor (3), and the 3rd input (I3) of this single chip circuit is circumscribed with keyboard/display circuit with alarm signal output ends (0).
7. ion concentration monitor for purifying blood according to claim 6 is characterized in that:
Described collection and treatment circuit (8) are by discerning the input signal of described first input end (I1) and second input (I2) with lower device, and generate alarm signal by alarm signal output ends (0) output:
Be used to start the device of ion concentration monitor;
The device that is used for parameter initialization;
Be used to judge whether the device of external connection keyboard/display circuit;
When described collection and treatment circuit (8) are circumscribed with keyboard/display circuit, be used for calling the device of the keyboard scan program that is circumscribed with keyboard/display circuit; Be used to the device that judges whether that keyboard is pressed, have, then, be used to set up electrical conductivity linear correction value table subprogram mechanism, return the device that is used for calling the keyboard scan program that is circumscribed with keyboard/display circuit; No, then, be used for the initialized device of electrical conductivity sampling timing;
When described collection and treatment circuit (8) are not circumscribed with keyboard/display circuit, then, be used for the initialized device of electrical conductivity sampling timing;
Be used to judge that the electrical conductivity sampling timing is to device not;
Timing is less than, and then returns to be used to judge that the electrical conductivity sampling timing is to device not;
Be timed to, then read the frequency signal Fv of described first input end (I1), be used to make frequency signal Fv to equal the device of current conductivity sample frequency value fx;
Be used for searching for the device of Fv in the interval position of electrical conductivity linear correction value table;
Be used to set f
0Equal interval lower bound, f
1Equal the device in the interval upper bound;
Be used to look into electrical conductivity linear correction value table and get f
0Corresponding electric conductivity value S
0, f
1Corresponding electric conductivity value S
1Device;
Be used to draw intervals linear correction slope K=(S
1-S
0)/(f
1-f
0) device;
Be used to draw Current Temperatures electric conductivity value Sx=K (fx-f
0)+S
0Device;
Be used to call the device of temperature-compensating subprogram;
Be used to draw the device of the real-time electric conductivity value Sv on current liquid road;
Be used for Sv and alarm limit relatively, judge the device whether Sv transfinites: do not transfinite, then return and be used for the initialized device of electrical conductivity sampling timing;
Transfinite, be used to send the device of alarm signal; Return and be used for the initialized device of electrical conductivity sampling timing.
8. ion concentration monitor for purifying blood according to claim 7 is characterized in that:
Described electrical conductivity linear correction value table is: when ambient temperature is 25 ℃, and the conductivity table of standard K CL solution in liquid-way system.
9. ion concentration monitor for purifying blood according to claim 7 is characterized in that:
The described device that is used to call the temperature-compensating subprogram is made of following:
Be used to call the mechanism of temperature survey program;
Be used to obtain the mechanism of liquid road current temperature value t;
Be used to obtain the mechanism of temperature difference Tx=t-25.0;
Be used to obtain the mechanism of liquid road Current Temperatures electric conductivity value Sx;
When being used to draw 25 ℃, the electric conductivity value S on current liquid road
25=Sx/ (the device of 1+ α * Tx);
Described α is a temperature compensation coefficient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610054322XA CN100460023C (en) | 2006-05-24 | 2006-05-24 | Ion concentration monitor for purifying blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610054322XA CN100460023C (en) | 2006-05-24 | 2006-05-24 | Ion concentration monitor for purifying blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1850305A CN1850305A (en) | 2006-10-25 |
| CN100460023C true CN100460023C (en) | 2009-02-11 |
Family
ID=37131816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610054322XA Active CN100460023C (en) | 2006-05-24 | 2006-05-24 | Ion concentration monitor for purifying blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100460023C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008763A (en) * | 2010-12-08 | 2011-04-13 | 重庆山外山科技有限公司 | Automatic fluid preparation system for blood purification and use method thereof |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2444509B (en) | 2006-12-06 | 2010-09-15 | Abb Ltd | Conductivity sensor |
| JP4573860B2 (en) * | 2007-08-22 | 2010-11-04 | 日機装株式会社 | Blood purification equipment |
| DE102009008554B3 (en) * | 2009-02-12 | 2010-08-26 | Schunk Kohlenstofftechnik Gmbh | Temperature measuring device |
| JP5423318B2 (en) * | 2009-10-29 | 2014-02-19 | ニプロ株式会社 | Dialysate concentration monitoring device and operating method thereof |
| CN101718608B (en) * | 2009-11-03 | 2011-07-20 | 重庆山外山科技有限公司 | Electromagnetic valve leak detection system for blood purification |
| US8906240B2 (en) * | 2011-08-29 | 2014-12-09 | Fresenius Medical Care Holdings, Inc. | Early detection of low bicarbonate level |
| CN114324489A (en) * | 2021-12-20 | 2022-04-12 | 中电科技集团重庆声光电有限公司 | Solution ion concentration measuring method based on conductivity measurement |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4553552A (en) * | 1984-02-21 | 1985-11-19 | Valdespino Joseph M | Hemodialysis meter |
| DE3639797C1 (en) * | 1986-11-21 | 1988-02-25 | Fresenius Ag | Method and device for monitoring the correct composition of dialysis solution, in particular for bicarbonate dialysis |
| CN2101871U (en) * | 1991-09-09 | 1992-04-15 | 聂金福 | Blood ion concentration tester |
| US5441049A (en) * | 1992-12-28 | 1995-08-15 | Automata Medical Instrumentation, Inc. | Conductivity meter |
| DE19702441C1 (en) * | 1997-01-24 | 1998-02-26 | Fresenius Medical Care De Gmbh | Dialysis recirculation monitoring |
| WO2005073701A1 (en) * | 2004-01-19 | 2005-08-11 | Baxter International Inc. | Conductive polymer materials and applications thereof including monitoring and providing effective therapy |
-
2006
- 2006-05-24 CN CNB200610054322XA patent/CN100460023C/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4553552A (en) * | 1984-02-21 | 1985-11-19 | Valdespino Joseph M | Hemodialysis meter |
| DE3639797C1 (en) * | 1986-11-21 | 1988-02-25 | Fresenius Ag | Method and device for monitoring the correct composition of dialysis solution, in particular for bicarbonate dialysis |
| CN2101871U (en) * | 1991-09-09 | 1992-04-15 | 聂金福 | Blood ion concentration tester |
| US5441049A (en) * | 1992-12-28 | 1995-08-15 | Automata Medical Instrumentation, Inc. | Conductivity meter |
| DE19702441C1 (en) * | 1997-01-24 | 1998-02-26 | Fresenius Medical Care De Gmbh | Dialysis recirculation monitoring |
| WO2005073701A1 (en) * | 2004-01-19 | 2005-08-11 | Baxter International Inc. | Conductive polymer materials and applications thereof including monitoring and providing effective therapy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008763A (en) * | 2010-12-08 | 2011-04-13 | 重庆山外山科技有限公司 | Automatic fluid preparation system for blood purification and use method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1850305A (en) | 2006-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100460023C (en) | Ion concentration monitor for purifying blood | |
| CN207317872U (en) | A kind of remote transmitting water meter based on the NB-IoT communication technologys | |
| CN105536105A (en) | Infusion set monitoring system and monitoring method | |
| CN104941036A (en) | Capacitance infusion monitoring method and device | |
| Zhou et al. | A design of high-level water tank monitoring system based on Internet of things | |
| CN202693518U (en) | Dissolved oxygen monitoring system based on polarographic electrode | |
| CN209475348U (en) | A kind of ICU disease postoperative care drain age-tube device | |
| CN204864362U (en) | Capacitanc infusion monitoring device | |
| CN202078593U (en) | Automatic infusion alarm device | |
| CN206057467U (en) | A kind of high-precise synchronization harvester | |
| CN206324731U (en) | A kind of chair for closet for monitoring defecation condition | |
| CN206832324U (en) | A kind of new wireless water level transmitter based on NB IoT | |
| CN208985015U (en) | A kind of liquid level intelligent monitoring device | |
| CN207249000U (en) | A kind of conductivity of dialysate detector | |
| CN106419706A (en) | Potty chair capable of monitoring defecation condition and monitoring method of potty chair | |
| CN209147425U (en) | A kind of storage tank | |
| CN209332038U (en) | Low-power consumption milk cow health monitoring device | |
| CN207973590U (en) | A kind of water-level detecting device in water purifier or boiler | |
| CN208188198U (en) | New electric energy metering and equipment for monitoring power quality | |
| CN209193688U (en) | A kind of moving emergency Multifunctional water purifying device with big data | |
| CN201324402Y (en) | Pipeline blood monitoring device | |
| CN108414828A (en) | New electric energy metering and equipment for monitoring power quality and its monitoring method | |
| CN220170287U (en) | Intelligent monitoring integrated device for water treatment and system thereof | |
| CN206361980U (en) | A kind of solar water heater water-temperature based on fuzzy control automatically adjusts device | |
| CN107219141A (en) | A kind of moisture sample circuit and the condenser type moisture analyser for possessing the circuit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ion concentration monitor for purifying blood Effective date of registration: 20120802 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: Gao Guangyong|Chongqing Shanwaishan science and Technology Co Ltd Registration number: 2012990000422 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20130820 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: Gao Guangyong|Chongqing Shanwaishan science and Technology Co Ltd Registration number: 2012990000422 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ion concentration monitor for purifying blood Effective date of registration: 20130820 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: Gao Guangyong|Chongqing Shanwaishan science and Technology Co Ltd Registration number: 2013990000593 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20150203 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: Gao Guangyong|Chongqing Shanwaishan science and Technology Co Ltd Registration number: 2013990000593 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ion concentration monitor for purifying blood Effective date of registration: 20150205 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: Gao Guangyong|Chongqing Shanwaishan science and Technology Co Ltd Registration number: 2015990000104 |
|
| C56 | Change in the name or address of the patentee | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gao Guangyong Inventor before: Lin Jinchao Inventor before: Gao Guangyong Inventor before: Wang Zhigang Inventor before: Xiong Jianqiong Inventor before: Li Xihua |
|
| COR | Change of bibliographic data | ||
| CP03 | Change of name, title or address |
Address after: The 401121 northern New District of Chongqing municipality Mount Huangshan Road No. 5 South Building Mercury Technology Development Center Patentee after: SWS HEMODIALSIS CARE CO., LTD. Address before: 2, H building, No. three, No. 67, 400041 Garden Road, Chongqing hi tech Zone Patentee before: Chongqing Shanwaishan Science & Technology Co., Ltd. |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160531 Granted publication date: 20090211 Pledgee: Chongqing Sanxia bank Limited by Share Ltd New District Branch Pledgor: SWS HEMODIALSIS CARE CO., LTD. Registration number: 2015990000104 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20160531 Registration number: 2015990000104 Pledgor after: Chongqing Shanwaishan Science & Technology Co., Ltd. Pledgor before: Gao Guangyong Pledgor before: Chongqing Shanwaishan science and Technology Co Ltd |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ion concentration monitor for purifying blood Effective date of registration: 20170310 Granted publication date: 20090211 Pledgee: Export Import Bank of China Pledgor: SWS HEMODIALSIS CARE CO., LTD. Registration number: 2017980000035 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| CP02 | Change in the address of a patent holder |
Address after: 401123 Tzu Chi Road, Liangjiang New Area, Chongqing, No. 1 Patentee after: SWS HEMODIALSIS CARE CO., LTD. Address before: The 401121 northern New District of Chongqing municipality Mount Huangshan Road No. 5 South Building Mercury Technology Development Center Patentee before: SWS HEMODIALSIS CARE CO., LTD. |
|
| CP02 | Change in the address of a patent holder | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210129 Granted publication date: 20090211 Pledgee: Export Import Bank of China Pledgor: SWS HEMODIALYSIS CARE Co.,Ltd. Registration number: 2017980000035 |