CN102008567A - Novel decoction preparation (novel drug delivery system) for discharging blood clots and preparation method thereof - Google Patents

Abstract

The invention discloses a novel decoction preparation (novel drug delivery system) for discharging blood clots and a preparation method thereof, belonging to the field of biomedicines. The novel decoction preparation is prepared by the following steps of: with an extract of a composition of rheum officinale, peach seed and thelepus as a main raw material, extracting and separating; properly adding pharmaceutic adjuvants; and finally preparing the novel decoction preparation according to the conventional processes of sprays, ointments (or sirup), pills, aerosols, orally disintegrating tablets, target preparations, sustained-release preparations and other dosage forms. By using the improved technology, the curative effect of the traditional compound preparation can be further improved, the quality-controllable technical requirement of the modern traditional Chinese medicine can be met, side effects can be reduced and the compliance for clinically pharmacy can be improved. The novel preparation has the unique efficacies of treating lower abdominal pain caused by postpartum blood stasis internal stagnation of women, appendagitis, amenorrhea, uterine myoma, lumbar disc herniation, chronic prostatitis, hepaticfibrosis, liver cirrhosis, other gynecological diseases and other difficult and baffling diseases and particularly has unique clinical application value for treating liver cancer change, cervical cancer, breast cancer, endometriosis and other aspects.

Description

Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) and preparation method thereof

Technical field

The present invention belongs to biomedicine field for a kind of Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) (novel drug-supplying system) for the treatment of liver cirrhosis and preparation method thereof.

Background technology

The research and development of the modernization of Chinese medicine and herbal species occupy very important strategic position in China's medicinal industry layout.And modernized dosage form will become the emphasis of new drug development and old product transformation.

In recent years, the research and development of Chinese medicine novel form is very rapid, continuous progress along with pharmaceuticals industry and new drug development, China's Chinese medicine preparation level progressively rises to science pharmacy level from rule-of-thumb approach, the introduction of modern pharmaceutical equipment and The application of new technique make a collection of modern Chinese medicine novel form show huge potential applicability in clinical practice.

Novel formulation has comprised such as a series of novel drug-supplying systems such as spray, fast disintegrating tablet, sustained-release preparation, targeting preparation, intelligent administrations.

As developing more spray both at home and abroad at present, it is not contain propellant, and only the power that produces by compressed air by atomising device makes a kind of novel form of medical liquid atomizing and ejection, because it does not contain propellant, do not use pressure vessel, use more and more widely at present.Its advantage is that the droplet of ejection is thinner, in nasal cavity or oral cavity, be evenly distributed, be difficult for run off, absorb fast, bioavailability is high.Simultaneously, spray has little, the characteristics such as fast, easy to use that are evenly distributed, prove effective of dosage, can reduce gastrointestinal side effect during suction, but also stimulation to wound surface is avoided in external, and it controls dosage with quantitative valve, and positioning action has immediate effect.Medicinal herb spray is widely used in the treatment of emergency cases such as angina pectoris, asthma, epilepsy clinically, effectively changed the traditional view that Chinese medicine preparation can only treatment of chronic diseases.

And drop pill belongs to the new application of old technology.Modern drop pill is to utilize new solid dispersion technology, adopt the pill of the method preparation of the system of dripping, soon solid or liquid medicine dissolve suspendible or are emulsified in the substrate, splash into then with the immiscible liquid coolant of drug matrices in, be condensed into the pill of ball-type or oblate spheroid type through contraction, can be for usefulness such as for oral administration, tract or preparation solution.The maximum technical advantage of drop pill is: the bioavailability height, onset is rapid, production operation is simple, cost is lower etc.Because drops can improve the bioavailability of insoluble drug, but sublingual administration is just onset in 3 minutes, difficult problems such as the Chinese medicine onset is slow, quality control instability have been solved, thereby curative effect is better than conventional dosage forms, thereby drop pill will be a following important developing direction that realizes the modernization of Chinese medicine.

Simultaneously, should see that the application of sustained-release preparation technology in secondary exploitation for Chinese materia medica will be the development focus in following 20 years.Slow releasing preparation can continue to discharge the class preparation that medicine reaches the prolongation drug effect after meaning medication in a long time, and controlled release preparation means that medicine discharges within the predetermined time automatically at a predetermined velocity, makes the long-time constant preparation that maintains the valid density scope of blood drug level.The former drug release mainly is a first-order rate process, and the latter then discharges with zero level speed or is controlled in the effect organ and waits specific part release.China enters after the WTO, Western medicine imitated difficult day by day, and thereupon, the exploitation in Chinese medicine market is extremely urgent, though prepare the Chinese medicine sustained-release preparation at present many difficulties is arranged still, and its prospect is still very optimistic.(especially honeyed pill and wax pill) relaxes lastingly its release because of containing a large amount of adjuvants in the medicine pill, is a kind of durative action preparation the earliest in fact.Compare with Western medicine slow/controlled release preparation research, the research of Chinese medicine sustained-release preparation still is in the starting stage, but delayed effect of development is very sufficient.

Targeting preparation (TDDS) is called targeting drug delivery system again, and selectivity concentrates and is positioned the drug-supplying system of target tissue, target organ, target cell or cell inner structure by the circulation of topical or systemic blood with medicine to be meant carrier.At present, according to the target site branch, targeting drug delivery system research both at home and abroad mainly concentrates on positions such as liver, spleen, lung, brain, kidney, lymph, bone.Targeting preparation is by carrier drug selectivity to be concentrated in the drug-supplying system of diseased region, and targeting preparation not only requires medicine to arrive diseased region, and requires to have two fun gi polysaccharides at these target sites delay certain hours.Targeting preparation should possess the location and concentrate, controls key elements such as release, nontoxic and biodegradability.With injection, ordinary preparations such as tablet compare, and targeting preparation can improve curative effect of medication, reduce poisonous side effect of medicine, improve safety, effectiveness and the reliability of medication.The motive force of development of targeting preparation technology at first derives from the demand of clinical application, the deficiency of conventional medicament dosage form aspect curative effect, toxic and side effects, frequency of usage and accumulating, need the new pharmaceutical dosage form of exploitation to solve, the appearance of various functional excipient substances in recent years then provides condition for developing new targeting preparation.Targeting preparation has overcome the trouble of the frequent medications of conventional formulation needs, and release is steady, curative effect is obvious, toxic and side effects is little, develops the novel pharmaceutical formulation small investment simultaneously, the lead time is short, difficulty is little, so targeting preparation has vast potential for future development more.

And the compositions of Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga three flavor medical materials, [source] in Eastern Han Dynasty's last years of a dynasty or reign famous physician be it is called to curing holy Zhang Zhongjing classical works " Medical Treasures of the Golden Chamber " (volume down), it consists of Radix Et Rhizoma Rhei 9 and restrains 20 pieces of 20 Mei female ground beetles of Semen Persicae (endure, remove foot); Former method for making is that three flavors of will adding medicine to are end, refined honey and be 4 balls.With 200 milliliters of wine, fry in shallow oil 1 ball, get 160 milliliters, decoction being taken at a draught it; Its function cures mainly: puerpera's stasis of blood resistance stomachache, and stagnation of blood stasis, menstrual disorders, disease piece etc. in the abdomen.Its essential ideas is compatibility: go into blood system with Radix Et Rhizoma Rhei in the side, swing hot removing blood stasis, push away Chen Zhixin; The Semen Persicae blood circulation promoting and blood stasis dispelling is moisturized the kind blood stasis of attacking of ， female ground beetle, broken knot removing blood stasis; Three flavors share, and the power of removing blood stasis is high violent, just hindering for anti-, and be ball with honey, moisturize with emergency.With the wine ball of boiling medicine, can go into the through sick institute of blood system by priming, can play merit again with blood.

This side is through offspring and modern clinical verification, and we really belong to high dose of eliminating blood stasis by catharsis, swing hot removing blood stasis, and broken knot is moisturized.It is to take after mixing it with water or be decocted in water for oral dose and control the tympanitis due to blood stasis enlarged abdomen in the end that errors in Medicine Corrected adds Radix Kansui." abdomen card very look at " then thinks under the umbilicus blood stasis is arranged, and lower abdomen is unbearably painful, and very then the near person of hands is the card that we are led, and it is that fingertip has hard thing under the umbilicus that its abdomen is demonstrate,proved.Modern times are faced card, and we are used for diseases such as the hepatosplenomegaly, traumatic injury, intestinal adhesion, pelvic inflammatory disease of lochiostasis, amenorrhea, chronic hepatitis, liver cirrhosis and see the pathogenesis person of stagnation of blood stasis and heat.

The various product of Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga goods and modern exploitation that China is traditional, nothing more than decoction (oral liquid), pill or granule tablet etc., one side is because of the influence of processing technique, make in Radix Et Rhizoma Rhei, Semen Persicae, the Eupolyphaga Seu Steleophaga main effective ingredient can not get sufficient extraction, simultaneously, oral back can not effectively be absorbed in human body.In order to solve the clinical demand of Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga compositions deep development, the invention provides a kind of technical scheme of new Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) (novel drug-supplying system).

Summary of the invention

The purpose of this invention is to provide Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) of a kind of effective treatment liver cirrhosis and preparation method thereof, it is characterized in that by Radix Et Rhizoma Rhei, Semen Persicae, the extract or the crude drug of Eupolyphaga Seu Steleophaga three flavor medicinal material composition, be equipped with (also can be unworthy of) pharmaceutic adjuvant, that makes at last has a lochiostasis, amenorrhea, chronic hepatitis, the hepatosplenomegaly of liver cirrhosis, traumatic injury, intestinal adhesion, pelvic inflammatory disease etc., and prevention or treatment liver cirrhosis, malignant liver, cervical cancer, the novel formulation of uterus carcinoma promptly can be brought into play Radix Et Rhizoma Rhei, Semen Persicae, the novel drug-supplying system of Eupolyphaga Seu Steleophaga combination optimum curative effect.

The present invention is based on the pharmacological function and the modern novel drug-supplying system of traditional Chinese Chinese medicine Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga, compound preparation " Xiayuxue Tang, Decoction for Dischanging Blood clots " by Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga has nearly 1500 applicating history in China, Ming Dynasty well-known doctor Zhao Yide estimates: the drying of blood is coagulated the author, non-moisturizing cleansed, and can not go also; Radix Paeoniae, Fructus Aurantii Immaturus can not be controlled, and must swing by it with Radix Et Rhizoma Rhei; Semen Persicae is moisturized, broken knot in delaying; The female ground beetle hematochezia; Use sweet tonifying for the deficiency, pain relieving and medicine, slow Radix Et Rhizoma Rhei is anxious, particularly moistens also (" the deficient beautiful letter of gold is annotated through two ").The well-known doctor of Qing Dynasty You Zaijing is discussed: stomachache clothes Fructus Aurantii Immaturus Radix Paeoniae and person more, and blood stasis to be arranged under umbilicus, and do not go, be that the agent of the non-removing mass of assaulting fortified position can not remove.The power of Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle hematochezia is quite violent, the person that uses the honeyed pill, and slow its property does not make rapid sending out, and probably hinders upper and middle portions of the body cavity yet.Wine fries in shallow oil decoction being taken at a draught person, quick-acting prescriptions being used for treating diseases in the lower part, and go disease lest not to the utmost also (" Medical Treasures of the Golden Chamber heart allusion quotation ").Especially the well-known doctor of Qing Dynasty Wu Qian gives more deep evaluation: puerpera's stomachache, belong to the stagnation of both QI and blood person, and the Fructus Aurantii Immaturus Radix Paeoniae looses to transfer it.In case not healing behind the clothes, this be that the heat blood that burns is done, work in umbilicus down and bitterly, the institute of non-Fructus Aurantii Immaturus Radix Paeoniae can control also, should descend blood stasis.Master's Xiayuxue Tang, Decoction for Dischanging Blood clots attack hot blood stasis down also, and main warp water is obstructed, also does event also (" Yizong Jinjian is corrected the Medical Treasures of the Golden Chamber notes ") because of the bright blood of heat.

Modern age, well-known doctor Ran Xuefeng thought then special blood medicine of we, miscellaneous QI medicine not, reason person, this side must with deficient bar of gold above the Fructus Aurantii Immaturus Radix Paeoniae loose to close and see.Lid stomachache, excessive thirst must not crouch, and is that the institute of two side's adaptations is same.The edema caused by disorder of QI of asking is person more, the blood system of asking again.Former the meaning of one's words is very obvious, is to close two sides to control, divide one control be two sides and branch it, meaning is respectively arranged, the scholar works as and has in mind.The same usefulness of Semen Persicae and Radix Et Rhizoma Rhei, former is Taoren Chengqi Tang system, but Taoren Chengqi Tang, control is blood-retention, this Fang Suozhi is a blood stasis, after the clothes Semen Persicae holds gas, when little and, behind the clothes we, blood stasis is down as the globefish liver, effect is levied also variant.We card is controlled, and Semen Persicae holds the gas button not, and the system of Radix Et Rhizoma Rhei Eupolyphaga Seu Steleophaga worm ball of holding concurrently of having to, and add Eupolyphaga Seu Steleophaga becomes soup again and is ball, drives straight on to the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, multiple with ball for frying in shallow oil, the blending of matter gas, emergency is helped mutually, the wine of borrowing the brave meeting of water paddy to be agitating it, square uniform method, trial of strength is essence extremely.(" successive dynasties well-known doctor good recipe note ").

The modern pharmacology drug efficacy study proves: cirrhosis, liver ascites, hepatocarcinoma, hysteromyoma, cervical cancer and cerebral thrombosis apoplexy sequela or the like are had very sure curative effect.

And novel drug-supplying system, comprise solid dispersions technique, mucosa delivery technology, sustained-release preparation technology, self-emulsifying drug delivery technology, target administration technology or the like, in development of new Chinese medicine, shown great application prospect, therefore using above-mentioned new formulation technology carries out secondary development to Xiayuxue Tang, Decoction for Dischanging Blood clots, to obtain that curative effect is better, quality controllable, side effect reduces, the novel formulation more easily of taking medicine, and can satisfy pressing for clinically.

Concrete technical scheme of the present invention is as follows:

1. fill a prescription: Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) is by being made up of following three parts by mass ratio:

Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga make up in the ratio of 1-99% respectively: effective component extracting (or crude drug);

Solvent is above-mentioned three flavor medical material combinations: 1-12 doubly;

Pharmaceutic adjuvant: 0-55%;

2. preparation technology:

The first step, Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle are made up in the ratio of 1-99% respectively, to be pulverized after the medical material clean dry, put into pure water, also added the organic solvent immersion by a certain percentage 2-24 hour, then by conventional extracting method, or the applied microwave extractive technique, extract the effective ingredient in Radix Et Rhizoma Rhei, the Semen Persicae, female ground beetle compositions; In second step, the extract of Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle is concentrated and even is dried to solid particle; In the 3rd step,, add suitable pharmaceutic adjuvant and be prepared into novel formulation concentrating or dry good Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle compositions extract; The 4th step, above-mentioned novel formulation is carried out quality inspection by relevant quality index, qualified back.

Technical characterstic of the present invention or advantage are as follows:

1. Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga extract the method for effective part group: by improved extraction process and novel energy-conserving The Application of Technology, wherein tens compounds improve in extracting solution significantly; Especially can guarantee the extraction efficiency of some key component and unlikely degeneration in the volatile oil in Radix Et Rhizoma Rhei, Semen Persicae, the Eupolyphaga Seu Steleophaga.

2. the novel formulation of Xiayuxue Tang, Decoction for Dischanging Blood clots preparation, promptly novel drug-supplying system, emphasis is realized liver targeted drug delivery, cavity/canal drug administration and transmucosal administration.Not only the bioavailability that can realize effective ingredient significantly improves, the more important thing is the realization target administration, by our liver cirrhosis RESEARCH ON CELL-BIOLOGY, find that Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga effective ingredient can enter the liver reticuloendothelial system effectively, the concentration ratio ordinary preparation has improved more than 300 times in its liver.

3. the further research of target administration pharmacological model, to help us and find and explore target for modulation and the pathological changes mechanism that causes liver cirrhosis, this thinking and following its meaning of scientific achievement that can produce are outstanding: the pathological changes mechanism that discloses liver cirrhosis deeply with guidance prevent ahead of time, instruct newtype drug research and development, give full play to Chinese medicine is treated difficult miscellaneous diseases in the present age comprehensive advantage; Especially under the very urgent situation of the modernization of Chinese medicine, the science of Chinese medicine traditional theory is subjected under the serious situation about querying, with the science of case verification Chinese medicine traditional theory, and the road of realizing the modernization of Chinese medicine in conjunction with Modern New Technology!

The specific embodiment

Embodiment 1:

Prescription:

Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga: each 10g;

Yellow wine: 10ml;

Ethanol (75%): 10ML;

Mel: an amount of;

Pure water: 40ml.

Preparation method:

At first that clean dry is good Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga are pulverized, and the pure water an amount of with adding soaks 8h, can add an amount of yellow wine during immersion;

In second step, soaked medical material uses microwave-assisted to extract, and 50 ℃ decocted about 60--100 minute, and it is standby that medicinal liquid is collected in filtration then;

The 3rd step concentrated the medicinal liquid of collecting, and it is stand-by to get thick paste;

In the 4th step, in thick paste, add ethanol, proper honey dissolving homogenizing, filtration, quality inspection, fill and become spray.

Embodiment 2:

Prescription:

Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga: be respectively 9g, 10g, 10g;

Ethanol: an amount of;

Polyethylene Glycol: 6g

Fabaceous lecithin: 1g

Polypropylene glycol: 0.1g;

Cholesterol: 0.5g.

Preparation method:

At first that clean dry is good Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga are pulverized, the 35% soak with ethanol 8h an amount of with adding;

In second step, soaked medical material uses ultrasonic method, and decocts about 100--120 minute at 65 ℃, and it is standby to filter the collection medicinal liquid then;

In the 3rd step, that the medicinal liquid of collecting is concentrated, dry that solid particle is stand-by;

The 4th goes on foot, and earlier with the Polyethylene Glycol heating and melting, adds above-mentioned thick paste while hot and stirs, and cooling back adding fabaceous lecithin, cholesterol, polypropylene glycol are gone and stirred slightly, and cross the drop pill machine and make drop pill, cooling, check.

Embodiment 3:

Prescription:

Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga: each 30g;

Ethanol: an amount of;

Refined honey: an amount of.

Preparation method:

At first that clean dry is good Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga are pulverized, and add the water logging bubble 8h of an amount of ethanol and 6 times of amounts;

In second step, soaked medical material uses circumfluence method, and decocts about 4-8 hour at 100 ℃, and it is standby to filter the collection medicinal liquid then;

The 3rd step, the medicinal liquid of collecting is added concentrated, thick paste is stand-by;

The 4th step earlier with the refined honey heating and melting, added above-mentioned thick paste while hot and stirs, cooling, check, fill.

Claims (10)

1. effectively treatment hepatic fibrosis, liver cirrhosis, and the Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation (novel drug-supplying system) of all kinds of gynaecopathias etc. and preparation method thereof, it is characterized in that by Radix Et Rhizoma Rhei, the extract of Semen Persicae female ground beetle three flavor medicinal material composition, be equipped with (also can be unworthy of) pharmaceutic adjuvant, having in the treatment women postnatal blood stasis of making at last stops causing few abdomen pain, adnexitis, amenorrhea, hysteromyoma, hepatocarcinogenesis, cervical cancer, breast carcinoma, prolapse of lumbar intervertebral disc, chronic prostatitis, and treatment hepatic fibrosis, liver cirrhosis, and the novel formulation of other gynaecopathia etc., promptly can bring into play by Radix Et Rhizoma Rhei, the novel drug-supplying system of the optimum curative effect of the Chinese medicine tradition compound recipe prescription that Semen Persicae female ground beetle etc. are formed.

2. the described novel formulation of claim 1 is meant following novel drug-supplying system:

Spray;

Unguentum (or syrup);

Drop pill;

Aerosol;

Oral cavity quick disintegrating slice;

Sustained-release preparation;

Targeting drug administration preparation.

3. the described novel formulation of claim 1: each composition is by weight composed as follows:

The extract (or effective part group) of Radix Et Rhizoma Rhei, the three flavor medical material combinations of Semen Persicae, female ground beetle: 1-85%;

Pharmaceutic adjuvant: 0-55%;

Solvent: 1-12 doubly.

4. the described novel formulation of claim 2, its preparation method or technology are as follows: the first step, pulverized after the medical material clean dry that Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle are made up by a certain percentage, put into pure water and add certain organic solvent immersion 2-24 hour, then by conventional extracting method, or the applied microwave extractive technique, extract the effective ingredient in Radix Et Rhizoma Rhei, the Semen Persicae, female ground beetle compositions; In second step, the extract of Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle is concentrated and even is dried to solid particle; In the 3rd step,, add suitable pharmaceutic adjuvant and be prepared into novel formulation concentrating or dry good Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle compositions extract; In the 4th step, above-mentioned novel formulation is carried out quality inspection by relevant quality index; Qualified back.

5. the extract of the described Radix Et Rhizoma Rhei of claim 3, Semen Persicae, female ground beetle three flavor medicinal material composition: can be crude drug wherein, also can be the effective part group that Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle main component are formed, the part by weight of each medical material of compound recipe prescription of its composition be as follows:

Radix Et Rhizoma Rhei: 1-99%

Semen Persicae: 1-99%

Female ground beetle: 1-99%

6. the described pharmaceutic adjuvant of claim 3: by following a kind of or several form: Borneolum Syntheticum, Polyethylene Glycol (or polyethylene glycol monolaurate), polyvinylpyrrolidone (PVP), polyoxyethylene monostearate (S-40), sodium stearate, glycerol, stearic acid, glyceryl monostearate, insect wax, Cera Flava, hydrogenated vegetable oil, stearyl alcohol, spermol, semi-synthetic fatty acid ester, vegetable oil, dimethyl sulfoxide, glycerol, ethanol, propanol, propylene glycol, vegetable oil, ethyl acetate, polysorbate, dodecylbenzene sodium sulfonate, sodium laurate, sodium lauryl sulphate, poloxamer, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, polyvidone, carbomer, gelatin, 2,3-lauryl alcohol ester, benzalkonium chloride, capric acid, cetrimonium bromide, cetylpyridinium chloride, chitosan, chitosan-4-sulfo-butylamine, chitosan-4-thioglycolic acid, citric acid, cyclodextrin, dextran sulfate, azone, EDTA, ethylene glycol, phospholipid (lecithin, fabaceous lecithin), cholesterol, dipalmitoyl phosphatidyl choline, two palmityl PHOSPHATIDYL ETHANOLAMINE, distearoyl phosphatidylcholine, L-lysine, lysalbinic acid, LYSO-PHOSPHATIDYLCHOLINE LYSOPC, menthol, methyl oleate, oleic acid, poly-to ten polyglycereol stearates, polypropylene glycol, the water sorbitol ester, tween, sucrose ester, the succinic acid monoglyceride, the citric acid monoglyceride, oleic acid monoglyceride, polyoxyethylene (20) cetyl ether, poly-L-arginine, 5-methoxyl group sodium salicylate, sodium citrate, NaTDC, the EDTA sodium salt, dextrin (and related polymer), Oleum Caryophylli, glycyrrhizin, mannitol, sodium alginate, Herba Menthae (essence), synthetic essence (or natural essence), potassium sorbate, sodium benzoate, Mel, sucrose, fructose, lactose, glucose, xylitol, synthetic sweetener etc.

7. the first step in claim 4 described Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation its preparation method or the technology: comprise following basic step at least: immersion, extraction, filtration etc., wherein for the abundant extraction of effective ingredient, added organic solvent is meant following one or more: ethanol, yellow wine, Chinese liquor, wine, acetone, ether, petroleum ether etc.

8. the first step in claim 4 described Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation its preparation method or the technology: the conventional extracting method of Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle effective ingredient is meant: can be used alone solvent and extract, also can use a kind of solvent or compound solvent to extract respectively and remerge extract, and use infusion process, percolation, circumfluence method, ultrasonic method etc.

9. the first step in claim 4 described Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation its preparation method or the technology: the microwave extract method of Radix Et Rhizoma Rhei, Semen Persicae, female ground beetle effective ingredient is meant: when using conventional extraction method (promptly using infusion process, percolation, circumfluence method, ultrasonic method etc.), extract temperature and only need 35-80 ℃, add that the microwave-assisted extraction element of suitable power gets final product.The corresponding minimizing of solvent 20-60%, extraction time is corresponding to reduce to original 1/2nd to 1/10th.

10. the 3rd in claim 4 described Xiayuxue Tang, Decoction for Dischanging Blood clots novel formulation its preparation method or the technology goes on foot, the novel formulation of making is meant as required, by the common process of relevant preparation the suitable adjuvant of extract interpolation of Radix Et Rhizoma Rhei, Semen Persicae, Eupolyphaga Seu Steleophaga is made spray, unguentum (or syrup), drop pill, aerosol, oral cavity quick disintegrating slice, targeting drug administration preparation and sustained-release preparation respectively.