CN101991548A - Reduced glutathione freeze-dried powder injection and preparation method thereof - Google Patents
Reduced glutathione freeze-dried powder injection and preparation method thereof Download PDFInfo
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- CN101991548A CN101991548A CN2009100908006A CN200910090800A CN101991548A CN 101991548 A CN101991548 A CN 101991548A CN 2009100908006 A CN2009100908006 A CN 2009100908006A CN 200910090800 A CN200910090800 A CN 200910090800A CN 101991548 A CN101991548 A CN 101991548A
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- folic acid
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Abstract
The invention discloses a reduced glutathione freeze-dried powder injection and a preparation method thereof. The powder injection is mainly made of the reduced glutathione and other proper accessories with specifications of 0.3 g (2 mL) per injection, 0.6 g (4 mL) per injection, 0.9 g (6 mL) per injection, 1.2 g (8 mL) per injection, 1.5 g (10 mL) per injection, and 1.8 g (12 mL) per injection. As the reduced glutathione freeze-dried powder injection of the invention uses folic acid as an antioxidant, a toxic side effect on human body caused by using sodium sulfite and sodium metabisulfite as the antioxidant can be avoided. Simultaneously, the folic acid can enhance human immunity so as to play a better efficacy. The reduced glutathione freeze-dried powder injection of the invention has good safety and efficacy. The preparation process thereof is simple, and good in quality controllability and stability.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of lyophilized powder injection of glutathione agent and preparation method thereof.
Background technology
Reduced glutathion (GSH) is a synthetic naturally peptide species in human cell's matter, is made up of glutamic acid, cysteine and glycine, contains thin base and (SH), is distributed widely in each organ of body, plays an important role for keeping the cell biological function.
Glutathion is the prothetic group of Triose phosphate dehydrogenase, is again the coenzyme of aldoketonutase and phosphotriose dehydrogenase, participates in Rhizoma Sparganii circulation and carbohydrate metabolism in the body, makes human body obtain high-energy.Sulfydryl on the glutathion cysteine is its active group (so glutathion often be abbreviated as G-SH), easily and heavy metallic salt complexations such as iodoacetic acid, mustard gas (a kind of poison), lead, hydrargyrum, arsenic, and has had the integration Detoxication.Glutathion (the especially glutathion in the hepatocyte) has very important physiological action and integrates Detoxication exactly, can combine with some drugs (as acetaminophen), toxin (as free radical, heavy metal) etc., participate in biotransformation, thereby deleterious poisonous substance in the body is converted into harmless material, excretes external.Another major physiological effect of glutathion is as a kind of important antioxidants in the body, and it can dispose the intravital free radical of people, and cleaning and purification human internal environment pollute, thereby has promoted people's physical and mental health.Because reduced glutathion itself is subject to some material oxidation,, thereby allow protein and enzyme equimolecular bring into play its physiological function so it can protect sulfydryl in numerous protein and the enzyme equimolecular not by as harmful substance oxidations such as free radicals in vivo.The content of glutathion is a lot of in the human erythrocyte; this is in reducing condition to proteinic coloured glaze base on the protection erythrocyte membrane; prevent that haemolysis is significant; but also can protect hemoglobin not to be subjected to oxidations such as hydrogen peroxide or free radical, thereby make it continue normally to transport the ability of oxygen in performance.At present, manually developed the glutathion medicine, be widely used in clinical, except that utilizing its sulfydryl with the toxin poisonings such as sequestration heavy metal, fluoride, mustard gas, also be used in hepatitis, hemolytic disease and keratitis, cataract and retinal diseases etc., as the medicine of auxiliary treatment.
Following disease is treated and prevented to the clinical practice glutathion.
(1) detoxifcation: the poisoning to acrylonitrile, fluoride, mustard gas, carbon monoxide, heavy metal, organic solvent, arsenical (adjoining frost, male sulphur etc. as Chinese medicine), lead, hydrargyrum, sulfur, phosphorism etc. all has Detoxication.
(2) Radiation sickness and radiation protection: be used for radiation cure, radiopharmaceutical or owing to use leukopenia that tumour medicine causes and because the myeloid tissue inflammation that lonizing radiation cause.
(3) the liver protecting: comprise the liver injury that viral, drug toxicity, ethanol toxicity and other chemical substance toxicity cause.
(4) antiallergic: can correct the imbalance of acetylcholine, acetylcholine esterase, thereby eliminate because the caused allergic symptom of this imbalance.Can be used for the treatment of autoimmune diseasees such as lupus erythematosus, scleroderma, dermatomyositis, arthritis.
(5) improve the course of disease and the symptom of some disease: to leukopenia, various hypoxemia (as acute anemia, adult respiratory distress syndrome, septicemia etc.), nausea and vomiting, painful abdominal mass symptom and because other symptoms that hepatic disease causes all have the improvement effect such as itch.Simultaneously, to diabetic complication such as retinal diseases, peripheral nerve disease etc., the improvement effect is arranged all.
(6) peptide is protected in skin maintenance: since glutathion can the intravital free radical of sequestration, extracellular toxin in the heavy metal etc., prevent skin peptide pigmentation, preventing that new melanin from forming and reducing its oxidation, still is that external all has good skin care, the effect of beauty treatment so use in it.
(7) increase vision and ophthalmic diseases: promote the metabolism of ocular tissue, can suppress the instability of crystal proteins sulfydryl, thereby can be used for keratitis, cornea wound etc., and can prevent the development of cataract and retinal diseases.
(8) anti-aging effects: when body aging, free radical of all kinds generates and increases in the body, and free radical is one of endotoxin important in the human body as human body waste.Because glutathion can be removed extracellular toxin in free radical, the heavy metal etc., thereby this product is applicable to slow down aging and has good effect.
At present, the glutathione for injection dosage form is an injectable powder, and the powder pin mainly contains sterilized powder and freeze-dried powder.Because there is more problem in sterilized powder in preparation process, as, content uniformity, dissolubility and clarity be relatively poor, pollute easily, when particularly relating to biochemical drug, requires higher to preparation technology.And freeze-dried powder generally needs to add antioxidant in the preparation process, in Chinese patent (CN200510123876.6, lyophilized powder injection of glutathione preparation and preparation technology thereof), has used sodium sulfite, sodium pyrosulfite etc.But the research report is arranged, and sodium sulfite, sodium pyrosulfite etc. can bring bio-toxicity to human body as antioxidant.Sodium pyrosulfite has bio-toxicity, can damage erythrocyte membrane, changes the micro structure of cell membrane, cause erythrocytic haemolysis (Zhang Rongxin, the research of food preservative sodium pyrosulfite bio-toxicity, " Maoming College's journal ", in June, 2008, Vol 18 (3): 23-25,29.); And influential (Wei Cailing, sodium pyrosulfite was to the influence of rat Dorsal root ganglion neuron film ion channel,, University Of Shanxi, master's thesis, 2006-08-24 in 2006 to rat Dorsal root ganglion neuron film ion channel for sodium pyrosulfite.)。Sodium sulfite has tangible teratogenesis to mouse sperm, can cause tire Mus dysplasia (Wang Ping, the bleach sodium sulfite is to mouse propagation toxicity and teratogenecity research, the 5th national environment of joint and occupational medicine postgraduate scientific seminar collection of thesis, 2006.); And the HL-7702 normal liver cell is had damaging action, and (former good fortune wins for Wang Mingheng, Bai Jianying, and the food additive sodium sulfite is to the hepatocellular toxic action of HL-7702, Mountain Western Medicine S University's journal, in January, 2008, Vol39 (1): 21-23.)。
Because medicine is directly connected to people's life security, the medicine of therefore researching and developing, produce the better high quality standards of safety is those skilled in the art's research emphasis always.
For this reason, we have developed a kind of with the lyophilized powder injection of glutathione agent of folic acid as antioxidant through exploring repeatedly.Thisly be with the advantage of folic acid as the lyophilized powder injection of glutathione agent of antioxidant: avoided using sodium sulfite, sodium pyrosulfite etc. as antioxidant the bio-toxicity brought to human body, thereby the safety of medicine is improved greatly; The folic acid that adds simultaneously participates in making erythrocyte and leukocyte, stimulating immune system ability, can enhancing immunity, and in the fight of human immune system and pathogen such as virus, antibacterial, the meaning of lifting autoimmunity is very great.
Show through relevant patent and prior art literature search result, there is no with the relevant report of folic acid class material as lyophilized powder injection of glutathione agent of antioxidant and preparation method thereof.
Summary of the invention
In order to overcome the defective that present lyophilized powder injection of glutathione agent and preparation technology thereof exist, the invention provides a kind of with folic acid as lyophilized powder injection of glutathione agent of antioxidant and preparation method thereof.Thisly be with the advantage of folic acid as the lyophilized powder injection of glutathione agent of antioxidant: avoided using sodium sulfite, sodium pyrosulfite etc. as antioxidant the bio-toxicity brought to human body, thereby the safety of medicine is improved greatly; The folic acid that adds participates in making erythrocyte and leukocyte simultaneously, stimulating immune system ability, energy enhancing immunity; And its preparation technology is simple, quality controllability and good stability.
The object of the present invention is to provide a kind of lyophilized powder injection of glutathione agent and preparation method thereof.
Technical scheme of the present invention is: a kind of lyophilized powder injection of glutathione agent, form by reduced glutathion, proppant, pH regulator agent and antioxidant, it is characterized in that: the used antioxidant of this injectable powder is a folic acid class antioxidant, the specification of injectable powder be 0.3g (2mL)/, 0.6g (4mL)/, 0.9g (6mL)/, 1.2g (8mL)/, 1.5g (10mL)/and 1.8g (12mL)/prop up.
Reduced glutathion of the present invention can adopt the technology of this area routine to be prepared, and also can buy from the market, but should meet the requirement to this material medicine of standards of pharmacopoeia, relative national standards or industry standard.
Proppant described in the present invention can be selected the medicinal proppant of this area routine for use, concrete a kind of, two or more combination as mannitol, dextran, gelatin hydrolysate, HP-, glucose, sorbitol, sucrose, lactose, sulfobutyl ether cyclodextrin, poloxamer, Polyethylene Glycol, glycine etc.It is prerequisite that the selection of proppant reacts, do not influence curative effect of medication with active component among discord the present invention; Proppant of the present invention is a kind of, two or more combination of mannitol, dextran, HP-, glycine, gelatin hydrolysate, poloxamer etc. more preferably.The concentration range of proppant is 1%～10%, and can to select as concentration according to the actual needs be 1%, 2%, 4%, 5%, 6%, 8%, even as required working concentration greater than 10% or less than 1% proppant, as 15%, 20%, 0.6% etc., the present invention is not limited to cited concentration.
The pH regulator agent can be adopted the basic medicinally pH regulator agent of pharmacy routine among the present invention, can select a kind of, two or more combination in organic base, inorganic base, basic amino acid, strong base-weak acid salt or their alkaline buffer solution for use; Concrete as: can select a kind of, two or more combination in diamidogen, natrium carbonicum calcinatum, sal soda, monohydrated sodium carbonate, isopropanolamine, monoethanolamine, sodium hydroxide, potassium hydroxide, sodium citrate, potassium citrate, D-sodium potassium tartrate tetrahydrate, potassium metaphosphate, Kurrol's salt, Polymeric sodium metaphosphate., sodium bicarbonate, potassium bicarbonate, ammonium carbonate, sodium hydrogen phosphate, dipotassium hydrogen phosphate, smart aminoacid, the lysine of diethanolamine, monoethanolamine, diisopropylamine, diisopropanolamine (DIPA), triethanolamine, 1,2.Alkaline buffer solution as phosphate buffered solution, buffered with amino acid solution etc., is not limited to the alkaline matter that the present invention carries.But the selected alkaline matter of the present invention with discord generation chemical reaction of the present invention, not influence curative effect of medication be prerequisite.More preferably a kind of, two or more combination in ethanolamine, sodium carbonate, sodium hydroxide, potassium hydroxide, sodium citrate, D-sodium potassium tartrate tetrahydrate, Polymeric sodium metaphosphate., sodium bicarbonate, sodium hydrogen phosphate and the dipotassium hydrogen phosphate of pH regulator agent among the present invention.
For preventing the active component reduced glutathion generation oxidation in the lyophilized powder injection of glutathione agent of the present invention, the lyophilized powder injection of glutathione agent of preparation generally will add antioxidant.The more antioxidant of utilization is sodium sulfite, sodium pyrosulfite etc. at present.But the research report is arranged, and sodium sulfite, sodium pyrosulfite etc. can bring bio-toxicity to human body as antioxidant.Sodium pyrosulfite has bio-toxicity, can damage erythrocyte membrane, changes the micro structure of cell membrane, cause erythrocytic haemolysis (Zhang Rongxin, the research of food preservative sodium pyrosulfite bio-toxicity, " Maoming College's journal ", in June, 2008, Vol 18 (3): 23-25,29.); And influential (Wei Cailing, sodium pyrosulfite was to the influence of rat Dorsal root ganglion neuron film ion channel,, University Of Shanxi, master's thesis, 2006-08-24 in 2006 to rat Dorsal root ganglion neuron film ion channel for sodium pyrosulfite.)。Sodium sulfite has tangible teratogenesis to mouse sperm, can cause tire Mus dysplasia (Wang Ping, the bleach sodium sulfite is to mouse propagation toxicity and teratogenecity research, the 5th national environment of joint and occupational medicine postgraduate scientific seminar collection of thesis, 2006.); And the HL-7702 normal liver cell is had damaging action, and (former good fortune wins for Wang Mingheng, Bai Jianying, and the food additive sodium sulfite is to the hepatocellular toxic action of HL-7702, Mountain Western Medicine S University's journal, in January, 2008, Vol39 (1): 21-23.)。
Folic acid (Folic acid) is by pteridine, and a kind of water solublity vitamin B group that para-amino benzoic acid and glutaminic acid residue are formed also is called Folie Acid or vitamin(e) M; For body cell growth with breed necessary material.It helps proteinic metabolism; And with common erythrocytic generation and the maturation of promoting of vitamin B12, be to make the indispensable material of erythrocyte.Folic acid works with the form of tetrahydrofolic acid in vivo, and tetrahydrofolic acid participates in the synthetic of purine nucleic acid and pyrimidine nucleotide in vivo and transforms; Playing the part of important role on manufacturing nucleic acid (ribonucleic acid, DNA (deoxyribonucleic acid)), is the necessary material of human body when utilizing sugar and aminoacid.
In recent years, Chinese scholars had found successively that folic acid had the new purposes of much making us feeling act, comprising:
1, antitumor action;
2, neurocyte and the brain cell development to infant has facilitation;
3, other effects: research worker is found both at home and abroad, and folic acid can be used as schizophrenia patient's auxiliary therapeutical agent, and it has significant mitigation to this disease; In addition, folic acid also can be used for treating chronic atrophic gastritis, suppresses the bronchus squamous transforms and control causes because of hyperhomocysteinemiainjury coronary sclerosis, myocardial damage and myocardial infarction etc.
Particularly importantly: folic acid also participates in making erythrocyte and leukocyte, stimulating immune system ability, can enhancing immunity, and in the fight of human immune system and pathogen such as virus, antibacterial, the meaning of lifting autoimmunity is very great.
So we add folic acid as antioxidant when the prepared lyophilized powder injection of glutathione agent of the present invention, folic acid participates in making erythrocyte and leukocyte, stimulating immune system ability, energy enhancing immunity play collaborative effect with reduced glutathion on drug effect.
Folic acid class antioxidant described in the lyophilized powder injection of glutathione agent of the present invention, it is characterized in that comprising in the salt, folic acid derivatives of folic acid, folic acid a kind of, two or more, wherein preferred folic acid.Described folic acid class antioxidant is characterized in that the salt of antioxidant folic acid, folic acid, the addition of folic acid derivatives are 0.02%～0.4% (in folic acid).Described folic acid class antioxidant is characterized in that the salt of antioxidant folic acid, folic acid, the addition of folic acid derivatives are 0.04%～0.2% (in folic acid).
The preparation method of lyophilized powder injection of glutathione agent of the present invention can adopt the preparation technology of this area routine to be prepared, but answer the requirement to this product according to the invention, preferred for preparation method wherein of the present invention is: reduced glutathion, lyophilizing proppant, the folic acid class antioxidant of getting recipe quantity place sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with the PH regulator, add water for injection to the volume capacity of writing out a prescription, stir evenly, detect intermediate, filter, sterile filling, lyophilization gets product.
The advantage of lyophilized powder injection of glutathione agent of the present invention is: avoided using sodium sulfite, sodium pyrosulfite etc. as antioxidant the bio-toxicity brought to human body, thereby the safety of medicine is improved greatly; The folic acid that adds participates in making erythrocyte and leukocyte simultaneously, and stimulating immune system ability, energy enhancing immunity play collaborative effect with reduced glutathion on drug effect; And its preparation technology is simple, quality controllability and good stability.
The specific embodiment
Embodiment 1
Get reduced glutathion 30.00g, mannitol 12.00g, folic acid 0.20g places sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with 10% sodium hydroxide, add the injection water to 200ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 2ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 2
Get reduced glutathion 60g, mannitol 16g, folic acid 0.20g places sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with the 1M sodium carbonate liquor, add the injection water to 400ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 4ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 3
Reduced glutathion 90g, dextran 30g, folic acid 0.60g place sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with 10% potassium hydroxide, add the injection water to 600ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 6ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 4
Reduced glutathion 30g, glycine 6g, folic acid 0.10g place sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with 10% sodium hydroxide, add the injection water to 200ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 2ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 5
Reduced glutathion 120g, poloxamer 24g, folic acid 0.40g place sterile chamber, after adding an amount of water for injection stirring and dissolving, sodium carbonate/bicarbonate buffer solution with 0.1M is regulated pH value to 5.0～6.5, add the injection water to 800ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 8ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 6
Reduced glutathion 150g, 40g cysteine, folic acid 1.2g place sterile chamber, after adding an amount of water for injection stirring and dissolving, Polymeric sodium metaphosphate. solution with 0.1M is regulated pH value to 5.0～6.5, add the injection water to 1000ml, detect intermediate, with 0.22 μ m filtering with microporous membrane, filtrate is sub-packed in the cillin bottle aseptic condition down, every bottle of 10ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Embodiment 7
Reduced glutathion 180g, mannitol 96g folic acid, 1.2g place sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with 10% sodium hydroxide, add the injection water to 1200ml, detect intermediate, aseptic condition uses filtering with microporous membrane, filtrate to be sub-packed in the cillin bottle down, every bottle of 12ml, then promptly with the goods lyophilization.
Zhi Bei lyophilized powder injection of glutathione agent as stated above meets the requirement of the coherent detection project of regulation among the glutathione for injection lyophilized injectable powder tentative standard WS-900 (X-665)-2002 (1).
Claims (5)
1. lyophilized powder injection of glutathione agent, form by reduced glutathion, proppant, pH regulator agent and antioxidant, it is characterized in that: the used antioxidant of this injectable powder is a folic acid class antioxidant, the specification of injectable powder be 0.3g (2mL)/, 0.6g (4mL)/, 0.9g (6mL)/, 1.2g (8mL)/, 1.5g (10mL)/and 1.8g (12mL)/prop up.
2. folic acid class antioxidant as claimed in claim 1, it is characterized in that comprising in the salt, folic acid derivatives of folic acid, folic acid a kind of, two or more, wherein preferred folic acid.
3. folic acid class antioxidant as claimed in claim 1 is characterized in that the salt of antioxidant folic acid, folic acid, the addition of folic acid derivatives are 0.02%～0.4% (in folic acid).
4. folic acid class antioxidant as claimed in claim 1 is characterized in that the salt of antioxidant folic acid, folic acid, the addition of folic acid derivatives are 0.04%～0.2% (in folic acid).
5. lyophilized powder injection of glutathione agent preparation method, the reduced glutathion, lyophilizing proppant, the folic acid class antioxidant that it is characterized in that getting recipe quantity place sterile chamber, after adding an amount of water for injection stirring and dissolving, regulate pH value to 5.0～6.5 with the pH regulator agent, add water for injection, stir evenly to the volume capacity of writing out a prescription, detect intermediate, filter, sterile filling, lyophilization gets product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356879A (en) * | 2011-10-21 | 2012-02-22 | 深圳市俪斯生物科技有限公司 | Functional peptide-reinforced healthcare food |
| CN108567970A (en) * | 2018-05-25 | 2018-09-25 | 福安药业集团湖北人民制药有限公司 | High stable glutathione for injection |
| CN111450025A (en) * | 2020-05-18 | 2020-07-28 | 重庆喜迈嘉美容服务有限公司 | Medical beauty product formula |
| CN112451653A (en) * | 2020-12-27 | 2021-03-09 | 西北农林科技大学 | Application of glutathione in preparation of medicine for preventing and treating intravascular hemolysis induced by puerarin injection |
| CN115137666A (en) * | 2022-07-29 | 2022-10-04 | 上海药坦药物研究开发有限公司 | Reduced glutathione freeze-dried powder and preparation method and application thereof |
-
2009
- 2009-08-11 CN CN2009100908006A patent/CN101991548A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356879A (en) * | 2011-10-21 | 2012-02-22 | 深圳市俪斯生物科技有限公司 | Functional peptide-reinforced healthcare food |
| CN102356879B (en) * | 2011-10-21 | 2014-08-06 | 深圳市俪斯生物科技有限公司 | Functional peptide-reinforced healthcare food |
| CN108567970A (en) * | 2018-05-25 | 2018-09-25 | 福安药业集团湖北人民制药有限公司 | High stable glutathione for injection |
| CN108567970B (en) * | 2018-05-25 | 2021-09-24 | 福安药业集团湖北人民制药有限公司 | Preparation method of reduced glutathione for injection |
| CN111450025A (en) * | 2020-05-18 | 2020-07-28 | 重庆喜迈嘉美容服务有限公司 | Medical beauty product formula |
| CN112451653A (en) * | 2020-12-27 | 2021-03-09 | 西北农林科技大学 | Application of glutathione in preparation of medicine for preventing and treating intravascular hemolysis induced by puerarin injection |
| CN115137666A (en) * | 2022-07-29 | 2022-10-04 | 上海药坦药物研究开发有限公司 | Reduced glutathione freeze-dried powder and preparation method and application thereof |
| CN115137666B (en) * | 2022-07-29 | 2023-10-13 | 上海药坦药物研究开发有限公司 | Reduced glutathione freeze-dried powder and preparation method and application thereof |
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Application publication date: 20110330 |