CN101990577A - 鉴定肺病药物开发的新途径 - Google Patents
鉴定肺病药物开发的新途径 Download PDFInfo
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- CN101990577A CN101990577A CN2008801147951A CN200880114795A CN101990577A CN 101990577 A CN101990577 A CN 101990577A CN 2008801147951 A CN2008801147951 A CN 2008801147951A CN 200880114795 A CN200880114795 A CN 200880114795A CN 101990577 A CN101990577 A CN 101990577A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99464307P | 2007-09-19 | 2007-09-19 | |
| US60/994,643 | 2007-09-19 | ||
| PCT/US2008/077136 WO2009039457A1 (en) | 2007-09-19 | 2008-09-19 | Identification of novel pathways for drug development for lung disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101990577A true CN101990577A (zh) | 2011-03-23 |
Family
ID=40468411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801147951A Pending CN101990577A (zh) | 2007-09-19 | 2008-09-19 | 鉴定肺病药物开发的新途径 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20090186951A1 (enExample) |
| EP (1) | EP2193211A4 (enExample) |
| JP (2) | JP2010538680A (enExample) |
| CN (1) | CN101990577A (enExample) |
| AU (1) | AU2008302076B2 (enExample) |
| CA (1) | CA2700200A1 (enExample) |
| WO (1) | WO2009039457A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005047451A2 (en) * | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| EP1874962A2 (en) * | 2005-04-14 | 2008-01-09 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| EP2605018A1 (en) * | 2006-03-09 | 2013-06-19 | The Trustees of the Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| CN101990577A (zh) | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
| WO2009121070A1 (en) * | 2008-03-28 | 2009-10-01 | The Trustees Of Boston University | Multifactorial methods for detecting lung disorders |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| CN103396487A (zh) | 2008-12-12 | 2013-11-20 | 贝林格尔.英格海姆国际有限公司 | 抗igf抗体 |
| JP6078339B2 (ja) | 2009-05-07 | 2017-02-08 | ベラサイト インコーポレイテッド | 甲状腺状態の診断のための方法および組成物 |
| WO2011133867A2 (en) * | 2010-04-23 | 2011-10-27 | The Regents Of The University Of Colorado, A Body Corporate | Vaccines, methods of administering vaccines, methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration |
| WO2012130720A2 (en) * | 2011-03-28 | 2012-10-04 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | PREDICTION OF RESPONSIVENESS TO PIK3/mTOR INHIBITORS |
| WO2012135651A1 (en) | 2011-03-31 | 2012-10-04 | The Procter & Gamble Company | Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis |
| WO2013177060A2 (en) * | 2012-05-20 | 2013-11-28 | Trustees Of Boston University | Methods and systems for monitoring, diagnosing, and treating chronic obstructive polmonary disease |
| US9920357B2 (en) | 2012-06-06 | 2018-03-20 | The Procter & Gamble Company | Systems and methods for identifying cosmetic agents for hair/scalp care compositions |
| WO2013190092A1 (en) | 2012-06-21 | 2013-12-27 | Philip Morris Products S.A. | Gene signatures for copd diagnosis |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| WO2016011068A1 (en) | 2014-07-14 | 2016-01-21 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3770274A1 (en) | 2014-11-05 | 2021-01-27 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688582A (zh) * | 2002-09-30 | 2005-10-26 | 拜尔药品公司 | 稠合吡咯-嘧啶衍生物 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3640268A (en) * | 1965-10-23 | 1972-02-08 | Hugh J Davis | Method and device for biopsy specimen collecting and handling |
| US4641662A (en) * | 1984-09-28 | 1987-02-10 | Jaicks John R | Endocervical curette system |
| US4800896A (en) * | 1985-11-08 | 1989-01-31 | Jalowayski Alfredo A | Cell sample collector probe |
| US5726060A (en) | 1991-09-17 | 1998-03-10 | Bridges; Michael Anthony | Method for culturing mammalian respiratory epithelial cells |
| US5422273A (en) * | 1993-03-23 | 1995-06-06 | Baal Medical Products, Inc. | Cell collection apparatus |
| US5876978A (en) | 1993-04-06 | 1999-03-02 | Medical College Of Ohio | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5477863A (en) * | 1993-04-14 | 1995-12-26 | Grant; Michael A. | Collection kit with a sample collector |
| US5440942A (en) * | 1994-02-02 | 1995-08-15 | Hubbard; Stephen H. | Biological sample collecting and holding device |
| US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6085907A (en) * | 1998-05-08 | 2000-07-11 | Institute Of Legal Medicine, University Of Bern | Foldable cardboard box for contact-free drying and long-term storage of biological evidence recovered on cotton swabs and forensic evidence collection kit including same |
| CA2328138A1 (en) | 1998-05-21 | 1999-11-25 | Diadexus Llc | A novel method of diagnosing, monitoring, and staging lung cancer |
| US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| US20040241728A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of lung disease related gene transcripts in blood |
| US6746846B1 (en) * | 1999-06-30 | 2004-06-08 | Corixa Corporation | Methods for diagnosing lung cancer |
| AU7808500A (en) | 1999-10-18 | 2001-04-30 | Denis Marshall-Fraser | Sample taking device |
| US6383804B1 (en) | 2000-07-13 | 2002-05-07 | International Bioproducts, Inc. | Sampling device with snap-off head and method of use |
| AU2001281136A1 (en) | 2000-08-04 | 2002-02-18 | Board Of Regents, The University Of Texas System | Detection and diagnosis of smoking related cancers |
| US20020160388A1 (en) | 2000-11-20 | 2002-10-31 | Roberto Macina | Compositions and methods relating to lung specific genes and proteins |
| WO2002044331A2 (en) | 2000-11-29 | 2002-06-06 | Cangen International | Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer |
| US6972181B2 (en) | 2001-01-12 | 2005-12-06 | Mount Sinai School Of Medicine Of New York University | Differential diagnosis of cancer and other conditions based on expression of p63 |
| WO2003040325A2 (en) | 2001-02-01 | 2003-05-15 | Curagen Corporation | Novel proteins and nucleic acids encoding same |
| IL157872A0 (en) * | 2001-03-12 | 2004-03-28 | Monogen Inc | A panel for detecting a generic disease state containing a plurality of probes and using cell-based diagnosis |
| AU2002250285A1 (en) * | 2001-03-14 | 2002-09-24 | Medical College Of Ohio | Method for quantitative measurement of gene expression for identifying individuals at risk for bronchogenic carcinoma |
| AU2002309583A1 (en) | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| US7332590B2 (en) | 2001-08-16 | 2008-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular characteristics of non-small cell lung cancer |
| AU2002343443A1 (en) * | 2001-09-28 | 2003-04-14 | Whitehead Institute For Biomedical Research | Classification of lung carcinomas using gene expression analysis |
| US20040005294A1 (en) * | 2002-02-25 | 2004-01-08 | Ho-Young Lee | IGFBP-3 in the diagnosis and treatment of cancer |
| US8722331B2 (en) * | 2002-03-28 | 2014-05-13 | University Of Toledo | Method for selecting a treatment for non-small cell lung cancer using gene expression profiles |
| DE10219117C1 (de) | 2002-04-29 | 2003-10-30 | Adnagen Ag | Verfahren zur Stabilisierung von RNS und Verwendungen von Stabilisierungspuffern |
| US20040063120A1 (en) * | 2002-07-10 | 2004-04-01 | The Regents Of The University Of Michigan | Expression profile of lung cancer |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| US20040241725A1 (en) * | 2003-03-25 | 2004-12-02 | Wenming Xiao | Lung cancer detection |
| WO2004091511A2 (en) | 2003-04-10 | 2004-10-28 | Genzyme Corporation | Compositions and methods to diagnose and treat lung cancer |
| WO2005000098A2 (en) | 2003-06-10 | 2005-01-06 | The Trustees Of Boston University | Detection methods for disorders of the lung |
| WO2004111197A2 (en) | 2003-06-10 | 2004-12-23 | Trustees Of Boston University | Gene expression signatures, methods and compositions for diagnosing disorders of the lung |
| WO2005047451A2 (en) * | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| EP1753873A4 (en) * | 2004-03-05 | 2008-11-05 | Ohio Med College | METHOD AND COMPOSITIONS FOR THE ASSESSMENT OF NUCLEIC ACIDS AND ALLELES |
| WO2006056080A1 (en) | 2004-11-29 | 2006-06-01 | Diagnocure Inc. | Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis |
| ES2356830T3 (es) * | 2004-12-03 | 2011-04-13 | Schering Corporation | Biomarcadores para preselección de pacientes para terapia de anti-igf-1r. |
| US7862995B2 (en) * | 2004-12-10 | 2011-01-04 | Targeted Molecular Diagnostics | Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor |
| EP1851334A4 (en) * | 2005-01-21 | 2010-05-26 | Gene Express Inc | DATABASES FOR EVALUATING NUCLEIC ACIDS |
| EP1874962A2 (en) | 2005-04-14 | 2008-01-09 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| EP1940860B1 (en) * | 2005-09-02 | 2012-08-08 | The University of Toledo | Methods for identifying biomarkers useful in diagnosis and/or treatment of biological states |
| EP2605018A1 (en) | 2006-03-09 | 2013-06-19 | The Trustees of the Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| US7832459B2 (en) | 2007-08-30 | 2010-11-16 | Phillips Plastics Corporation | Methods, tools, and products for molded ordered porous structures |
| CN101990577A (zh) | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
| US20090246779A1 (en) | 2008-02-15 | 2009-10-01 | University Of Washington | Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh |
| WO2009121070A1 (en) | 2008-03-28 | 2009-10-01 | The Trustees Of Boston University | Multifactorial methods for detecting lung disorders |
| WO2010054233A1 (en) | 2008-11-08 | 2010-05-14 | The Wistar Institute Of Anatomy And Biology | Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers |
| US8735074B2 (en) | 2009-08-28 | 2014-05-27 | Asuragen, Inc. | MiRNA biomarkers of lung disease |
| US20130303826A1 (en) | 2011-01-11 | 2013-11-14 | University Health Network | Prognostic signature for oral squamous cell carcinoma |
| US20120288860A1 (en) | 2011-05-12 | 2012-11-15 | George Mason University | Differential gene expression for detecting and/or differentiating lung disease |
| WO2013033640A1 (en) | 2011-09-01 | 2013-03-07 | Allegro Diagnostics Corp. | Methods and compositions for detecting cancer based on mirna expression profiles |
| WO2013049152A2 (en) | 2011-09-26 | 2013-04-04 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| WO2013134786A2 (en) | 2012-03-09 | 2013-09-12 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarker compositions and methods |
| WO2013163568A2 (en) | 2012-04-26 | 2013-10-31 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| WO2013177060A2 (en) | 2012-05-20 | 2013-11-28 | Trustees Of Boston University | Methods and systems for monitoring, diagnosing, and treating chronic obstructive polmonary disease |
| US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
| EP2971128B1 (en) | 2013-03-15 | 2023-03-01 | Veracyte, Inc. | Biomarkers for diagnosis of lung diseases and methods of use thereof |
| WO2016011068A1 (en) | 2014-07-14 | 2016-01-21 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| US20190292600A1 (en) | 2016-05-12 | 2019-09-26 | Trustees Of Boston University | Nasal epithelium gene expression signature and classifier for the prediction of lung cancer |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| AU2017324949B2 (en) | 2016-09-07 | 2024-05-23 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
-
2008
- 2008-09-19 CN CN2008801147951A patent/CN101990577A/zh active Pending
- 2008-09-19 JP JP2010526034A patent/JP2010538680A/ja active Pending
- 2008-09-19 WO PCT/US2008/077136 patent/WO2009039457A1/en not_active Ceased
- 2008-09-19 EP EP20080832403 patent/EP2193211A4/en not_active Withdrawn
- 2008-09-19 CA CA2700200A patent/CA2700200A1/en not_active Abandoned
- 2008-09-19 US US12/234,588 patent/US20090186951A1/en not_active Abandoned
- 2008-09-19 AU AU2008302076A patent/AU2008302076B2/en not_active Ceased
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2014
- 2014-07-31 JP JP2014155833A patent/JP2014204737A/ja active Pending
- 2014-09-29 US US14/500,475 patent/US10570454B2/en active Active
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2020
- 2020-01-23 US US16/751,145 patent/US20200232045A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688582A (zh) * | 2002-09-30 | 2005-10-26 | 拜尔药品公司 | 稠合吡咯-嘧啶衍生物 |
Non-Patent Citations (3)
| Title |
|---|
| ERIN A. BOHULA等: "The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 * |
| STEPHEN LAM等: "A Phase I Study of myo-Inositol for Lung Cancer Chemoprevention", 《CANCER EPIDEMIOL BIOMARKERS PREV》 * |
| 林彦等: "地塞米松对急性肺损伤大鼠细胞信号转导系统ERK和PI3-K的影响", 《解放军医学杂志》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008302076A1 (en) | 2009-03-26 |
| EP2193211A4 (en) | 2010-12-08 |
| CA2700200A1 (en) | 2009-03-26 |
| EP2193211A1 (en) | 2010-06-09 |
| US20200232045A1 (en) | 2020-07-23 |
| JP2010538680A (ja) | 2010-12-16 |
| JP2014204737A (ja) | 2014-10-30 |
| US20150232945A1 (en) | 2015-08-20 |
| AU2008302076B2 (en) | 2015-06-11 |
| US20090186951A1 (en) | 2009-07-23 |
| US10570454B2 (en) | 2020-02-25 |
| WO2009039457A1 (en) | 2009-03-26 |
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