CN101990541A - 糖皮质激素受体、AP-1和/或NF-κB活性的稠合杂芳基调节剂及其用途 - Google Patents

糖皮质激素受体、AP-1和/或NF-κB活性的稠合杂芳基调节剂及其用途 Download PDF

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Publication number
CN101990541A
CN101990541A CN2009801124206A CN200980112420A CN101990541A CN 101990541 A CN101990541 A CN 101990541A CN 2009801124206 A CN2009801124206 A CN 2009801124206A CN 200980112420 A CN200980112420 A CN 200980112420A CN 101990541 A CN101990541 A CN 101990541A
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alkyl
aryl
substituted
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mmol
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段敬武
戴维·S·温斯坦
江斌
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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CN2009801124206A 2008-02-07 2009-02-05 糖皮质激素受体、AP-1和/或NF-κB活性的稠合杂芳基调节剂及其用途 Pending CN101990541A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2681608P 2008-02-07 2008-02-07
US61/026,816 2008-02-07
PCT/US2009/033134 WO2009100171A1 (en) 2008-02-07 2009-02-05 Fused heteroaryl modulators of glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof

Publications (1)

Publication Number Publication Date
CN101990541A true CN101990541A (zh) 2011-03-23

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CN2009801124206A Pending CN101990541A (zh) 2008-02-07 2009-02-05 糖皮质激素受体、AP-1和/或NF-κB活性的稠合杂芳基调节剂及其用途

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Country Link
US (1) US8304539B2 (enExample)
EP (1) EP2247597A1 (enExample)
JP (1) JP2011511085A (enExample)
CN (1) CN101990541A (enExample)
WO (1) WO2009100171A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108546246A (zh) * 2018-07-10 2018-09-18 湖南华腾制药有限公司 一种双吡啶基甲醇的制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013004322A2 (pt) * 2010-08-27 2016-06-21 Corcept Therapeutics Inc moduladores de azadecalin fundidos com piridil-aminas
WO2015077537A1 (en) * 2013-11-25 2015-05-28 Corcept Therapeutics, Inc. Heteroaryl-ether fused azadecalin glucocorticoid receptor modulators
ES2943542T3 (es) * 2013-11-25 2023-06-14 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro
CN113373466B (zh) * 2021-06-19 2023-07-21 安徽科技学院 一种β-乙酰氨基羰基化合物的电化学合成方法
AR127618A1 (es) 2021-11-29 2024-02-14 Bayer Ag Dihidropiranopiridinas sustituidas, sales o n-óxidos de las mismas y su uso como sustancias herbicidamente activas
WO2025057723A1 (ja) 2023-09-13 2025-03-20 石原産業株式会社 Ｎ－置換オキシアミド化合物又はその塩
AU2024400853A1 (en) 2023-12-15 2026-05-28 Ishihara Sangyo Kaisha, Ltd. N-substituted oxy-2-aminothiazolecarboxamide compound or salt thereof and agricultural and horticultural fungicide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1652786A (zh) * 2002-03-13 2005-08-10 麦克公司 作为雄激素受体调节剂的氟代4－氮杂甾体衍生物
WO2005072732A1 (en) * 2004-01-16 2005-08-11 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof
CN1741986A (zh) * 2003-01-24 2006-03-01 诺瓦提斯公司 酰胺衍生物及其作为11－β羟类固醇脱氢酶抑制剂的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5962440A (en) 1996-05-09 1999-10-05 Bristol-Myers Squibb Company Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method
US5827875A (en) 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5885983A (en) 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
AU2003296414A1 (en) 2002-12-12 2004-07-09 Pharmacia Corporation Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
US8034940B2 (en) * 2006-08-09 2011-10-11 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1652786A (zh) * 2002-03-13 2005-08-10 麦克公司 作为雄激素受体调节剂的氟代4－氮杂甾体衍生物
CN1741986A (zh) * 2003-01-24 2006-03-01 诺瓦提斯公司 酰胺衍生物及其作为11－β羟类固醇脱氢酶抑制剂的用途
WO2005072732A1 (en) * 2004-01-16 2005-08-11 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, ap-1, and/or nf-kb activity and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108546246A (zh) * 2018-07-10 2018-09-18 湖南华腾制药有限公司 一种双吡啶基甲醇的制备方法

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WO2009100171A1 (en) 2009-08-13
US20110002952A1 (en) 2011-01-06
US8304539B2 (en) 2012-11-06
JP2011511085A (ja) 2011-04-07
EP2247597A1 (en) 2010-11-10

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