CN101987145B - Traditional Chinese medicine composite for born muscle antiphlogosis - Google Patents
Traditional Chinese medicine composite for born muscle antiphlogosis Download PDFInfo
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- CN101987145B CN101987145B CN200910161873XA CN200910161873A CN101987145B CN 101987145 B CN101987145 B CN 101987145B CN 200910161873X A CN200910161873X A CN 200910161873XA CN 200910161873 A CN200910161873 A CN 200910161873A CN 101987145 B CN101987145 B CN 101987145B
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Abstract
The invention relates to the field of traditional medicines and provides a traditional Chinese medicine composite for born muscle antiphlogosis. The traditional Chinese medicine composite for born muscle antiphlogosis comprises the following preferred components according to mass ratio: 1-5 of five claw grass, 1-5 of winter cherry, 1-10 of garment button grass and 1-10 of sweet vernal grass. In the invention, the traditional Chinese medicine composite can promote the absorption of the wound surface, improve wound blood circulation and increase skin and muscle cell regeneration. The clinical verification shows that the efficiency ratio of the traditional Chinese medicine composite for treating the scalding, knife wound, skin ulcer, and the like is up to 95 percent.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of Chinese medicine composition of composite for born muscle antiphlogosis.
Background technology
Acute epidermis wound is the surgical clinical commonly encountered diseases, is also the frequently-occurring disease in people's daily life.Due to the position of wound and the difference of light and heavy degree, the near water of wound after the drug of topical application simultaneously, be difficult to cure and consume greatly, affect people and work normally and live.Simultaneously, come from the various infection that acute epidermis injury causes, thereby finally form the skin ulcer of multi-infection, of common occurrence especially.
Skin ulcer is the skin chronic infection ulcer that a variety of causes causes, skin or the Mucosa Defect that causes due to tissue ischemia, necrosis, because the local organization nutritional status is poor, disturbance of blood circulation and lower for the resistance, occur that on this basis repeated infection forms vicious cycle.Characteristics such as recurrence very easily because of its protracted course of disease and more, become a difficult problem rather thorny in clinical medicine.
The infected skin ulcer and the scald that cause for acute epidermis wound in the market, the western medicines that adopt more, additional surgery skin grafting, it is long that this class is treated first treatment time, second medical expense is high especially, therefore can not meet the lower patient family of income and use,, so develop the medical herbs compound recipe of evident in efficacy, cheap dephlogistication and promoting nuscle growth, promotion wound healing, become the focus of research.
Summary of the invention
, in order to overcome the defect that the prior art western medicine time is long and expense is high, the invention provides a kind of Chinese medicine composition of evident in efficacy, cheap promotion dephlogistication and promoting nuscle growth.
Realize the foregoing invention purpose, the present invention by the following technical solutions:
A kind of Chinese medicine composition of dephlogistication and promoting nuscle growth, its component comprise five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani.
Four kinds of medical herbs that relate in the present invention are respectively " China's book on Chinese herbal medicine " through investigating its Species origin:
(1) five pawl grass is the leaf (" China's book on Chinese herbal medicine " numbering 4260, name is called five leaf wall rattans) of the green parthenocissus of Vitaceae Parthenocissus plant, and the effect of removing blood stasis with potent drugs blood, detumescence poison is arranged.
(2) clothing button grass is spent the stem and branch with leaf (" China's book on Chinese herbal medicine " numbering 6304, name is called Herba solani photeinocarpi) of Herba Solani Nigri, clearing away heat-damp and promoting diuresis for oral administration, removing pathogenic heat from blood and toxic substance from the body less for plant of Solanaceae.The externally applied anti-inflammation detumescent.
(3) Fructus Seu Herba Pubescentis is the herb (" China's book on Chinese herbal medicine " numbering 6279, name is called Fructus Seu Herba Pubescentis) of Solanaceae monkey flower Fructus Seu Herba Pubescentis, has clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, the effect of hard masses softening and resolving.
(4) Herba Malvastri Coromandeliani is the herb (" China's book on Chinese herbal medicine " numbering 2304, name is called Radix hemerocalis plicatae) of Capparidaceae (also claiming Capparaceae) plant Radix hemerocalis plicatae, has heat-clearing and toxic substances removing, the effect of nebula removing.
Above four flavor medical herbs are all take " China's book on Chinese herbal medicine " middle medicinal part of putting down in writing as standard.
Preferably, the weight ratio of described five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani is 1～5: 1～5: 1～10: 1～10.
Preferred, the weight ratio of described five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani is 1: 1: 1: 1.
Chinese medicine composition of the present invention, also comprise pharmaceutically acceptable adjuvant.
Chinese medicine composition of the present invention directly or indirectly adds pharmaceutically acceptable adjuvant to make lotion, liniment, cataplasma, liniment, external spraying agent through conventional machining.
The present invention also provides the application of described Chinese medicine composition on the medicine of preparation treatment scald, skin ulcer.The Chinese medicine composition of composite for born muscle antiphlogosis provided by the invention, can improve the blood circulation of wound skin, promote wound skin and muscle cell regeneration, be used for the treatment of various wounds, dermatopathy, as scald, knife injury, skin and muscular decay, dark and see the surgical wound etc. of bones of the dead and the infected skin ulcer that causes thus, can improve the wound blood circulation, promote skin and muscle cell regeneration, promote wound healing, the wound surface skin smooth.Its prescription is simple, and drug effect is remarkable, and is easy to use, safe without toxic side effect, and through clinical verification curative effect highly significant, total effective rate reaches 95%.
The specific embodiment
, below in conjunction with embodiment, further set forth the present invention:
Embodiment 1: the preparation of the compound recipe lotion of Chinese medicine composition of the present invention
Take dry product medical herbs five pawl grass, Fructus Seu Herba Pubescentis, Herba Malvastri Coromandeliani and each 50g of clothing button grass, add for the first time 12 times of amounts of water, soaked 30 minutes, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, and then merged decoction liquor, filter, after standing 24 hours, get supernatant concentration to relative density 0.8～1.0 (60 ℃), spray drying, obtain dry extract.Add wherein more appropriate azone, glycerol or propylene glycol, sodium benzoate, be diluted with water to 1000ml, get final product to obtain herbal recurrence due to taking drug side lotion.
Wherein azone is as cutaneous permeable agent, consumption 0.25～0.5% (g/ml); Glycerol or propylene glycol be as solubilizing agent, 2～10% (ml/ml); Sodium benzoate is as antiseptic, 0.25～0.5% (g/ml).
Embodiment 2: the compound recipe liniment preparation of Chinese medicine composition of the present invention
Take medical herbs five pawl grass 25g, Fructus Seu Herba Pubescentis 25g, Herba Malvastri Coromandeliani 250g, clothing button grass 250g, add for the first time 12 times of amounts of water, soaked 30 minutes, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, then merge decoction liquor, filter, after standing 24 hours, get supernatant concentration to relative density 0.8～1.0 (60 ℃), obtain concentrated solution.With 75% ethanol extraction concentrated solution, centrifugal filtering, the filtrate spray drying obtains dry extract, add wherein again polyvinyl alcohol (W25,140) 50g and appropriate glycerol, propylene glycol, after mix homogeneously, add dehydrated alcohol to 800ml, obtain herbal recurrence due to taking drug side liniment.
Wherein polyvinyl alcohol is as filmogen, and consumption is 5%～10% (g/ml); Glycerol, propylene glycol are plasticizer, and consumption is 2%～5% (ml/ml); Dehydrated alcohol is made organic solvent.
Embodiment 3: the preparation of the described Chinese medicine composition compound liniment of this medical herbs
Take medical herbs five pawl grass 250g, Fructus Seu Herba Pubescentis 250g, Herba Malvastri Coromandeliani and clothing button grass (dry product) each 50g, 75% ethanol that adds 10 times of weight, soaked 30 minutes, twice of reflux, extract,, each 2 hours, then merge extractive liquid,, filtered, decompression filtrate recycling ethanol is concentrated into 200ml, obtains herbal recurrence due to taking drug side liniment.
Embodiment 4: the preparation of Chinese medicine composition compound ointment of the present invention agent
Take medical herbs five pawl grass 75g, Fructus Seu Herba Pubescentis 25g, Herba Malvastri Coromandeliani 25g and clothing button grass 50g (dry product), with 75% soak with ethanol percolation after 24 hours, filter, after the percolate decompression recycling ethanol, being concentrated into relative density is 0.8～1.0 (60 ℃), add wherein more appropriate white vaseline, triethanolamine, sodium benzoate, stir, obtain herbal recurrence due to taking drug side ointment.
Described sodium benzoate is antiseptic, consumption 0.25%～0.5% (g/ml); White vaseline is done ointment base, consumption 50%～70% (g/g).
Embodiment 5: the Clinical efficacy of Chinese medicine composition of the present invention
The Wang, man, 23 years old, on April 12nd, 2008 scalded, and with carrying out diagnosis and treatment, the skin ulcer face is larger, rinse with 2% hydrogen peroxide, normal saline cleans, after 75% ethanol disinfection, the compound ointment agent of external application embodiment 4 preparations, cover the skin ulcer face,, with the antiseptic gauze wrapping, change dressings every day 3 times, grew fresh granulation through 3 days, incrustation in 26 days comes off and heals.
Embodiment 6: Chinese medicine composition Clinical efficacy of the present invention
Zhang, female, 63 years old, JIUYUE in 2006 traumatic injury on the 02nd, during diagnosis and treatment, patient skin is rubescent, the large wound surface of its palm is infection suppurates, and wound is difficult to healing, with 2% hydrogen peroxide, rinses, normal saline cleans, and after 75% ethanol disinfection, coats the compound liniment of embodiment 3 preparations, cover the skin ulcer face, and defeated injection of antibiotic liquid changes dressings 2 times with prevention infection every day, 32 days afterwards incrustation come off and heal.
Embodiment 7: Chinese medicine composition Clinical efficacy of the present invention
Ma, the man, 41 years old, scalded on November 14th, 2006, during diagnosis and treatment, according to patient main suit: after scalding, be coated with erythromycin ointment smear every day, but have no improvement, rubescent on the contrary.On inspection, be to enclose owing to not clearing up good wound, cause that the skin ulcer face infects, skin is rotten to the corn, through with 2% hydrogen peroxide, rinsing, normal saline cleans, and after 75% ethanol disinfection, coats the compound recipe liniment of embodiment 2 preparations, cover the skin ulcer face, change dressings every day 3 times, formed a scab and come off and heal afterwards in 28 days, wound surface is smooth.
Embodiment 8: Chinese medicine composition of the present invention is controlled Clinical efficacy
Lee, man, 36 years old, on August 17th, 2007, arm was by the sharp weapon scratch, during diagnosis and treatment, and outside skin ulcer, its wound surface is suppurated, and have transudate to flow out, with 2% hydrogen peroxide, rinse, normal saline cleans, after 75% ethanol disinfection, affected part is cleaned with the compound recipe lotion of embodiment 1 preparation, washes every day 2 times, forms a scab and comes off and heal afterwards in 30 days.
Embodiment 9: traditional Chinese medicine composition for treating skin ulcer clinical data of the present invention
2006.3.14-2008.12.8 case observation is done by the People's Hospital in Tunchang County, result is as follows:
Clinical trial method: observe in 80 cases male 54 examples wherein, female's 26 examples; Minimum 21 years old of age, maximum 80 years old; Minimum 1.0cm * the 0.5cm of ulcer wound surface, maximum 12cm * 20cm, the darkest 3.0cm.64% ulcer wound surface＞6cm * 14cm; Wherein scald burn 36 examples, traumatic injury 21 examples, dermatosis infects ulceration, prolonged 12 examples that do not heal of the open sore part, operative incision infects 6 examples, soda acid burn 4 examples, insect bite dermatitis 1 example; Be divided at random two groups by medical sequencing: every group of each 40 examples, treatment group man 29 examples, female's 11 examples; Matched group man 26 examples, female's 15 examples.Two groups of wounds are all used the hydrogen peroxide soak, after normal saline flushing is clean, and 75% ethanol disinfection.One of the dosage form that treatment group prepares with Chinese medicine composition embodiment 1-4 of the present invention flap coverage, matched group are with common oil-sand flap coverage, and sterile gauze is wrapped up.Change dressings every day the last week 3 times, change dressings every day afterwards 1 time, until wound healing.
Curative effect determinate standard: cure: in 4 weeks, ulcer surface disappears fully, wound healing; Produce effects: in 4 weeks, clinical symptoms alleviates or disappears through treatment; Invalid: as to have no and reduce through the treatment ulcer surface in 4 weeks, even occur enlarging or infecting.
Cure rate %=cures number of cases/total number of cases * 100%
Effective percentage %=(curing number of cases+produce effects number of cases)/total number of cases * 100%
Obvious effective rate %=produce effects number of cases/total number of cases * 100%
The effective number of cases of effective percentage %=/total number of cases * 100%
The curative effect for the treatment of group, matched group is compared, the results are shown in following table 1:
Table 1, Chinese medicine composition of the present invention and common oil-sand treatment skin ulcer curative effect are relatively
Annotate: treatment group compares with matched group:
*P＜0.01
Above-mentioned result of study shows, compare with matched group, the various dosage forms of Chinese medicine composition of the present invention are all effective, for the cure rate 87.5% of acute epidermis wound, obvious effective rate 7.5%, total effective rate are 95.0%, its successful is better than matched group (p＜0.01), show that Chinese medicine composition of the present invention has good therapeutical effect to skin ulcer, have composite for born muscle antiphlogosis, promote the effect of wound healing.
Claims (3)
1. the Chinese medicine composition of a dephlogistication and promoting nuscle growth, directly or indirectly add pharmaceutically acceptable adjuvant to make lotion, liniment, cataplasma, liniment, external spraying agent by five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani through conventional machining, the weight ratio of described five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani is 1～5:1～5:1～10:1～10.
2. Chinese medicine composition according to claim 1, is characterized in that, the weight ratio of described five pawl grass, Fructus Seu Herba Pubescentis, clothing button grass, Herba Malvastri Coromandeliani is 1:1:1:1.
3. the application of the described Chinese medicine composition of claim 1～2 any one on the medicine of preparation treatment scald, skin ulcer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910161873XA CN101987145B (en) | 2009-08-05 | 2009-08-05 | Traditional Chinese medicine composite for born muscle antiphlogosis |
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| CN200910161873XA CN101987145B (en) | 2009-08-05 | 2009-08-05 | Traditional Chinese medicine composite for born muscle antiphlogosis |
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| CN101987145A CN101987145A (en) | 2011-03-23 |
| CN101987145B true CN101987145B (en) | 2013-11-20 |
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- 2009-08-05 CN CN200910161873XA patent/CN101987145B/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 樊晓霞等.藤类中药四气属性与成分和功效的关联性研究.《中国中医药信息杂志》.2008,第15卷(第10期),95-97. |
| 清肺汤治疗肛肠出血性疾病739例;相鲁闽;《中国民间疗法》;20060131;第14卷(第1期);36-37 * |
| 相鲁闽.清肺汤治疗肛肠出血性疾病739例.《中国民间疗法》.2006,第14卷(第1期),36-37. |
| 藤类中药四气属性与成分和功效的关联性研究;樊晓霞等;《中国中医药信息杂志》;20081031;第15卷(第10期);95-97 * |
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Owner name: HAINAN QUANXING PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: LIU QUANSHENG Effective date: 20141212 |
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Effective date of registration: 20141212 Address after: 570216 Haikou Free Trade Zone, Hainan, A06-2 Patentee after: HAINAN JINXING PHARMACEUTICAL CO., LTD. Address before: 570216 Haikou Free Trade Zone, Hainan, A06-2 Patentee before: Liu Quansheng |
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