CN101987069B - Thermally stable oil-in-water microemulsion - Google Patents
Thermally stable oil-in-water microemulsion Download PDFInfo
- Publication number
- CN101987069B CN101987069B CN 200910161462 CN200910161462A CN101987069B CN 101987069 B CN101987069 B CN 101987069B CN 200910161462 CN200910161462 CN 200910161462 CN 200910161462 A CN200910161462 A CN 200910161462A CN 101987069 B CN101987069 B CN 101987069B
- Authority
- CN
- China
- Prior art keywords
- oil
- polyoxyethylene
- polyoxypropylene
- fatty acid
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention relates to oil-in-water microemulsion. The oil-in-water microemulsion comprises the following components based on the total weight: A) 75 to 94 weight percent of aqueous phase, B) 0.5 to 5 weight percent of oil phase, C) 2 to 20 weight percent of oil-in-water nonionic emulsifier serving as a surfactant, and D) 0.2 to 2 weight percent of auxiliary nonionic surfactant or auxiliary zwitterionic surfactant with the hydrophile-lipophile balance (HLB) value more than or equal to 17, wherein the weight ratio of the component C to the component D is 5 to 20. The oil-in-water microemulsion of the invention has thermal stability, can maintain the transparent property of the oil-in-water microemulsion at room temperature in the condition of high temperature, and has no phenomenon of turbidity, emulsion breaking or demixing; moreover, the microemulsion has a simple formula and is easy to prepare; in addition, the microemulsion can remove cosmetics rapidly, has a cleaning effect of being washed easily, also can be used as a resident product, and provides a moisture feeling different from a common water aqua product.
Description
Technical field
The present invention relates to a kind of heat-staple oil-in-water microemulsion.
Background technology
If two or more non soluble liquids is behind mixing and emulsifying, the average diameter of dispersant liquid drop or emulsified particles is between 5～100nm, and then this system is called microemulsion.Microemulsion normally mixes formed system by components such as water, oil, surfactant and cosurfactants, and this system is homogeneous phase in macroscopic view.Because the fine droplet that disperses is to the scattering of light ability, so microemulsion is translucent usually to transparence.Decentralized photo is called oil-in-water microemulsion for microemulsion oily, that disperse medium is water, otherwise then is called water-in-oil microemulsion.On thermodynamics, microemulsion is stabilising system, can spontaneously form, and need not special production equipment and technology.Microemulsion outward appearance uniqueness, performance is special, and its application in daily chemical industry more and more is subject to people's attention.
The size droplet diameter of conventional emulsions is usually greater than 1 μ m, owing to light scattering is opaque milky white shape.Emulsion is unstable on thermodynamics, needs to produce by extraneous work done, so can be separated by the generation profit after leaving standstill a period of time.But in commercial Application, emulsion can realize long stability by means of modes such as electrostatic repulsions, i.e. stability on the kinetics.Than emulsion, microemulsion has the following advantages when being used for producing cosmetics: 1. optical clear, and any inhomogeneities or sedimentary existence are all realized easily; 2. microemulsion can spontaneously form, thereby has the characteristics of efficient energy-saving; 3. good stability can store for a long time, and is not stratified; 4. good solubilization is arranged, can make the oil composition high product, and product does not have greasy feeling, by the lyotropy of microemulsion, can also improve active component and stability of drug and effectiveness; 5. the micelle particle is tiny, easily infiltrates skin; 6. microemulsion can also wrap up TiO
2With nanoparticles such as ZnO, these particles are added on to have brightening, absorbs characteristics such as ultraviolet and infra-red-emitting in the cosmetics.Therefore, microemulsion cosmetics development in recent years is very fast, has obtained good application in a plurality of fields of cosmetics, and market prospect is boundless.
In order to obtain microemulsion, in most cases can use nonionic surfactant, and use polar organic matter-be generally small molecule alcohol-as cosurfactant, but, so the microemulsion cloud point that obtains is lower, produces wild effects such as muddiness, layering down at high temperature (45 ℃ or higher temperature).For this reason, CN1751679A has proposed a solution, this scheme requires to use the combination of six kinds of components, these components comprise specific water-miscible organic solvent, this solvent be have in the molecule 2 above oxypropylene groups (PO) and hydroxyl (OH) and its quantity than (PO/OH) less than 5 chemical compound and/or contain monobasic or the polyhydric alcohol of 2-6 carbon atom.The prescription complexity of CN1751679A, loaded down with trivial details is unfavorable for the practical operation preparation.
Summary of the invention
In view of above-mentioned prior art situation, the inventor has carried out research extensively and profoundly aspect heat-staple oil-in-water microemulsion, found that: auxiliary non-ionic surface active agent or the auxiliary zwitterionic surfactant that will have higher HLB value combine with the oil-in-water nonionic emulsifier of routine, can make heat-staple oil-in-water microemulsion.This oil-in-water microemulsion can spontaneously form, and muddiness, breakdown of emulsion and lamination do not take place the character in the time yet keeping it in room temperature under high temperature (45 ℃ or the higher temperature) condition; And the prescription of this microemulsion is simple, prepares simple and easy to do; In addition, microemulsion of the present invention is the removal color make-up promptly, and has the cleaning effect that is easy to wash, and can also use as resident type product, and the moisture feeling that is different from general aqua product is provided.
Therefore, the purpose of this invention is to provide a kind of heat-staple oil-in-water microemulsion.
Above-mentioned purpose is achieved by a kind of oil-in-water microemulsion as described below, and this oil-in-water microemulsion comprises following component based on its gross weight:
A) water of 75-94wt%;
B) oil phase of 0.5-5wt%;
C) the oil-in-water nonionic emulsifier as surfactant of 2-20wt%; And
D) the HLB value of 0.2-2wt% is more than or equal to 17 auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant,
Wherein the weight ratio of component C and component D is 5-20.
Component A
In microemulsion of the present invention, comprised the water that accounts for the overwhelming majority, this water is as continuous phase.
The water of microemulsion of the present invention mainly comprises water, and water content accounts for the 50wt% at least of water, 60wt%, 70wt%, 80wt%, 90wt% or 95wt% at least at least at least at least at least usually.
According to the present invention, aqueous phase also can add low-molecular-weight alcohols material except water, as an example, can mention ethanol, glycerol, propylene glycol, 1,3 butylene glycol etc. to this.The consumption of low-molecular-weight alcohols material is generally 0-30wt% based on the gross weight of microemulsion of the present invention.
According to the present invention, aqueous phase also can add other functional additive, such as hyaluronic acid, lactic acid etc.
In addition, aqueous phase of the present invention also can add cithrol class material and carry out thickening, such as Polyethylene Glycol-120 methyl glucoside dioleate.The addition of thickening agent is generally 0-10wt% based on the gross weight of microemulsion of the present invention.
In microemulsion of the present invention, be generally 75-94wt% based on the microemulsion gross weight, preferred 85-94wt% as the consumption of the water of component A.
B component
In microemulsion of the present invention, comprised oil phase, this oil phase is as decentralized photo, is present in the microemulsion with the form of dispersant liquid drop.
Common hydrophobicity composition or oil-phase component, or the whole oil phase component that allow in the cosmetics to use can be used in the oil phase of the present invention.These oil-phase components can be at least a oils and fatss that is selected from vegetable oil, mineral oil, silicone oil and the artificial oil that uses traditionally, can also be the various waxes that use traditionally.
Be applicable to that silicone oil oils and fats of the present invention for example is polydimethylsiloxane and ring first siloxanes, and also have aryl-, alkyl-or the polymethyl siloxane of alkoxyl-replacements and encircle the first siloxanes.
Be applicable to that oils and fats of the present invention also comprises straight chain and/or side chain monobasic and/or the dicarboxylic acids with 2-44 carbon atom and has the saturated or undersaturated straight chain of 1-22 carbon atom and/or monobasic and the binary esters of branched-chain alcoho.Similarly, as being used for oils and fats of the present invention, also can using the difunctionality aliphatic alcohol with 2-36 carbon atom and the ester with simple function aliphatic carboxylic acid of 1-22 carbon atom.
As being used for oils and fats of the present invention, can also specifically preferably use the esters of the fatty acid with 12-22 carbon atom, as methyl ester and isopropyl ester, for example methyl laurate, methyl stearate, methyl oleate, methyl erucate, isopropyl palmitate, isopropyl myristate, isopropyl stearate and/or acid isopropyl.
In addition, as being used for oils and fats of the present invention, go back concrete preferred n-butyl stearate, the just own ester of lauric acid, oleic acid ester in the positive last of the ten Heavenly stems, the different monooctyl ester of stearic acid, Palmic acid ester in the different ninth of the ten Heavenly Stems, isononyl isononanoate, Palmic acid 2-ethyl hexyl ester, lauric acid 2-ethyl hexyl ester, stearic acid 2-hexyl decyl ester, Palmic acid 2-octyl group dodecyl ester, oleic oil alkene ester, erucic acid oil alkene ester and/or oleic acid mustard ester.
As being used for oils and fats of the present invention, also especially suitable is the dicarboxylic acids esters, for example Di-n-butyl Adipate, n-butyl sebacate, adipic acid two (2-ethylhexyl) ester, succinic acid two (2-hexyl decyl) ester and/or Azelaic Acid two isotridecyl esters.As being used for oils and fats of the present invention, also especially suitable is diol-lipid, for example two oleic acid glycol esters, two different tridecanoic acid glycol esters, two (2 ethyl hexanoic acid) propylene glycol ester, two isostearic acid butanediol esters and/or two sad DOPCP.
As being used for oils and fats of the present invention, can also use the carbonic diester class, as carbonic acid two (2-ethylhexyl) ester.
It is same that what be suitable for is the triglyceride of relative long-chain, i.e. triple esters of glycerol and three acid molecules, and at least one is the acid molecule of a relative long-chain in these acid molecules.What can mention by way of example here is the fatty acid triglycercide class, and this comprises the triglyceride of the mixture of synthetic caprylic/capric, the triglyceride of industrial oleic acid, the triglyceride of isostearic acid and the triglyceride of Petiolus Trachycarpi/oleic acid mixture.Operable in addition is the straight or branched aliphatic alcohols, for example oleyl alcohol or octyldodecanol, and also have the aliphatic alcohol ethers, for example dicaprylyl ether etc.
As being used for oils and fats of the present invention, what be suitable for equally is crude vegetal, for example olive oil, Oleum Helianthi, soybean oil, Oleum Arachidis hypogaeae semen, rapeseed oil, almond oil, Petiolus Trachycarpi oil and/or Jojoba oil, and also has the liquid part of Oleum Cocois or palm shell oil, and also have animal oil, for example as the liquid part of sperm oil, neat's foot oil or Adeps Bovis seu Bubali.
As being used for oils and fats of the present invention, can also use hydro carbons oils and fats, particularly liquid paraffin and isoparaffin.The example of operable hydro carbons oils and fats is paraffin oil, white mineral oil, 2-Methylpentadecane, poly decene, petroleum jelly, light liquid paraffin and/or squalane.In addition, the esters of aryl carboxylic acid also is suitable, as benzoic esters, for example have the saturated or undersaturated straight or branched alcohol of 1-22 carbon atom and the benzoate of benzoic acid formation, for example benzoic acid iso stearyl ester and benzoic acid 2-octyl group dodecyl ester, preferred benzoic acid C12-15 Arrcostab.
In a preferred embodiment of oil-in-water microemulsion of the present invention, can also comprise at least a lubricant component that contains polyoxypropylene chains in the oil phase.As the described lubricant component that contains polyoxypropylene chains, can mention polyoxypropylene fatty alcohol ether, polyoxypropylene fatty acid ester and polyoxypropylene copolymerization dimethyl siloxane etc.
According to the present invention, as polyoxypropylene fatty alcohol ether quasi-grease, the aliphatic alcohol that preferably wherein forms this polyoxypropylene fatty alcohol ether is saturated or unsaturated and has 4-22, preferred 8-18 carbon atom and polyoxypropylene structure division and on average comprise 2-60, the preferred polyoxypropylene fatty alcohol ether of 2-18 propylene oxide repetitive.As the example, can mention polyoxypropylene-3 myristyl ether (
APM), polyoxypropylene-11 stearyl ether (
APS), polyoxypropylene-11 iso stearyl ether, polyoxypropylene-14 butyl ether (
PVE), polyoxypropylene-15 stearyl ether (
E), polyoxypropylene-15 iso stearyl ether, polyoxypropylene-7 lauryl ether, polyoxypropylene-10 oleyl ether etc.The aliphatic alcohol that especially preferably wherein forms this polyoxypropylene fatty alcohol ether is saturated or unsaturated and has 8-18 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty alcohol ether of 8-16 propylene oxide repetitive, especially wherein the aliphatic alcohol that forms this polyoxypropylene fatty alcohol ether is saturated or unsaturated and has 12-18 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty alcohol ether of 10-16 propylene oxide repetitive, for example polyoxypropylene-11 stearyl ether (
APS) and/or polyoxypropylene-15 stearyl ether (
E).
According to the present invention, as polyoxypropylene fatty acid ester quasi-grease, the fatty acid that preferably wherein forms this polyoxypropylene fatty acid ester is saturated or unsaturated and has 8-22, preferred 8-18 carbon atom and polyoxypropylene structure division and on average comprise 2-60, the preferred polyoxypropylene fatty acid ester of 6-26 propylene oxide repetitive.As the example, can mention that polyoxypropylene-15 stearate, polyoxypropylene-15 isostearate, polyoxypropylene-26 oleate (being provided by BASF), polyoxypropylene-9 laurate are (by A﹠amp; E Connock provides), polyoxypropylene-6 ricinoleate ester etc.The fatty acid that especially preferably wherein forms this polyoxypropylene fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty acid ester of 8-16 propylene oxide repetitive, especially wherein the fatty acid that forms this polyoxypropylene fatty acid ester is saturated or unsaturated and has 12-16 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty acid ester of 8-12 propylene oxide repetitive that for example polyoxypropylene-9 laurate is (by A﹠amp; EConnock provides).
According to the present invention, as polyoxypropylene copolymerization dimethyl siloxane quasi-grease, preferably polyoxypropylene structure division wherein on average comprises the polyoxypropylene copolymerization dimethyl siloxane of individual, preferred 2-30 the propylene oxide repetitive of 2-60.As the example, can mention polyoxypropylene-2 copolymerization dimethyl siloxane (PPG-2Dimethicone, provided by Dow-Corning), polyoxypropylene-12 copolymerization dimethyl siloxane (PPG-12Dimethicone is provided by GE), polyoxypropylene-27 copolymerization dimethyl siloxane (being provided by ShinEtsu) etc.The polyoxypropylene copolymerization dimethyl siloxane of 2-6 propylene oxide repetitive, for example polyoxypropylene-2 copolymerization dimethyl siloxane (being provided by Dow-Corning) on average are provided preferred especially polyoxypropylene structure division wherein.
In microemulsion of the present invention, as the described lubricant component that contains polyoxypropylene chains, can or use the polyoxypropylene fatty alcohol ether, perhaps use the polyoxypropylene fatty acid ester, perhaps use polyoxypropylene copolymerization dimethyl siloxane; In addition, can also use two or more the combination in any that is selected from polyoxypropylene fatty alcohol ether, polyoxypropylene fatty acid ester and the polyoxypropylene copolymerization dimethyl siloxane, for example can use polyoxypropylene-2 copolymerization dimethyl siloxane (being provided by Dow-Corning) and polyoxypropylene-11 stearyl ether (
APS) combination.
In a particularly preferred embodiment of the present invention, oil phase comprise be selected from down the group in one or more oil components: the oils and fats that contains polyoxypropylene chains as indicated above (as polyoxypropylene-11 stearyl ether (
APS)), the cetyl polydimethylsiloxane (
WAX9801), Palmic acid 2-ethyl hexyl ester (
OP), carbonic acid two (2-ethylhexyl) ester (
DEC), cyclohexyl methyl siloxanes, polydimethylsiloxane (
350), white oil and cyclohexyl methyl siloxanes/dimethyl-silicon alkanol (
OSW5).
In microemulsion of the present invention, be generally 0.5-5wt% as the consumption of the oil phase of B component based on the microemulsion gross weight, be preferably 0.5-4wt%.
Component C
In microemulsion of the present invention, also comprised surfactant or emulsifying agent, it is the oil-in-water nonionic emulsifier.Be applicable to that oil-in-water nonionic emulsifier of the present invention is to be selected from the following three class oil-in-water nonionic emulsifiers one or more:
The first kind: the emulsifying agent with polysiloxanes+hydrophilic group+alkyl group molecular chain structure, wherein hydrophilic group is the polyether polyol base, preferred polyoxyethylene groups, the polyoxypropylene base, polyglyceryl or polyoxyethylene sorbitan base, such emulsifying agent comprises polysiloxane group, the block copolymer emulsifying agent that polyether polyol base and fatty alkyl are connected with covalent bond, be main chain with the polysiloxane group, the polyether polyol base is the emulsifying agent that side group is connected with the polysiloxane group chain with covalent bond respectively with fatty alkyl, and is main chain with the polysiloxane group, the polyether polyol base of modifying with fatty alkyl is the emulsifying agent that side group is connected with the polysiloxane group chain with covalent bond;
Second class: the emulsifying agent with polysiloxanes+hydrophilic group molecular chain structure, wherein hydrophilic group is the polyether polyol base, preferred polyoxyethylene groups, polyoxypropylene base, polyglyceryl or polyoxyethylene sorbitan base, such emulsifying agent comprises the block copolymer emulsifying agent that polysiloxane group and polyether polyol base are connected with covalent bond, is that main chain, polyether polyol base are the emulsifying agent that side group is connected with the polysiloxane group main chain with covalent bond with the polysiloxane group; Preferred polyoxyethylene polydimethylsiloxane, polyglycereol polydimethylsiloxane, for example: the PEG/PPG-14/4 polydimethylsiloxane is (with trade name
B8851 is provided by EVONIK), two-the PEG/PPG-20/20 polydimethylsiloxane (
B8843), the PEG/PPG-4/12 polydimethylsiloxane (
B8852), the PEG/PPG-20/20 polydimethylsiloxane (
B8863) etc.; And
The 3rd class: the following group of oil-in-water nonionic emulsifier that is different from the first kind and second class: have polyoxyethylene chain as hydrophilic non-ionic surfactant, polyglyceryl fatty acid ester, polyglycereol fat alcohol ether, sucrose fatty acid ester and the alkyl polysaccharide glycosides of hydrophilic group.
In a preferred embodiment of the invention, be the bi-component composite type emulsifying agent that is constituted by emulsifying agent X and emulsifying agent Y that is selected from above-mentioned the 3rd class oil-in-water nonionic emulsifier as the surfactant of component C or oil-in-water nonionic emulsifier, wherein emulsifying agent X has polyoxyethylene chain as the hydrophilic non-ionic surfactant of hydrophilic group, and component Y is the hydrophilic non-ionic surfactant that is selected from polyglyceryl fatty acid ester, polyglycereol fat alcohol ether, sucrose fatty acid ester or alkyl polysaccharide glycosides.
According to the present invention, under the situation of using compound emulsifying agent, based on the total amount of this compound emulsifying agent, the consumption of emulsifying agent X is 50-90wt%, and the consumption of emulsifying agent Y is 10-50wt%, preferably, the consumption of emulsifying agent X is 65-90wt%, and the consumption of emulsifying agent Y is 10-35wt%.
In a preferred embodiment of the invention, described have polyoxyethylene chain and be selected from down group as the hydrophilic non-ionic surfactant of hydrophilic group: polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty acid monoglyceride, polyoxyethylene hydrogenated Oleum Ricini and polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester.
More specifically, as above-mentioned polyoxyethylene fatty acid ester, the fatty acid that preferably wherein forms this polyoxyethylene fatty acid ester is saturated or unsaturated and has 8-22 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene fatty acid esters of 4-20 ethylene oxide repetitive.As the example, can mention: polyoxyethylene caprylate, polyoxyethylene 2-ethylhexanoate, polyoxyethylene decanoin, polyoxyethylene laurate, polyoxyethylene myristinate, polyoxyethylene cetylate, polyoxyethylene isostearate, Myrj 45, polyoxyethylene oleate, Ju oxygen ethylene behenic acid ester etc.The fatty acid that especially preferably wherein forms this polyoxyethylene fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene fatty acid esters of 4-12 ethylene oxide repetitive, for example polyoxyethylene-6 caprylic/capric ester (
GMC 6), polyoxyethylene-6 laurate, polyoxyethylene-8 laurate and/or polyoxyethylene-12 cetylate.Especially wherein the fatty acid that forms this polyoxyethylene fatty acid ester is saturated or unsaturated and has 8-12 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene fatty acid esters of 4-8 ethylene oxide repetitive, for example polyoxyethylene-6 caprylic/capric ester (
GMC 6).
More specifically, as above-mentioned polyoxyethylene aliphatic alcohol ether, the aliphatic alcohol that preferably wherein forms this polyoxyethylene aliphatic alcohol ether is saturated or unsaturated and has 8-22 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene aliphatic alcohol ether of 4-60 ethylene oxide repetitive.As the example, can mention: polyoxyethylene Octyl Ether, polyoxyethylene decyl ethers, polyoxyethylene lauryl ether, polyoxyethylene myristyl ether, polyoxyethylene palmityl ether, polyoxyethylene iso stearyl ether, polyoxyethylene stearyl base ether, polyoxyethylene oleyl ether, Ju oxygen ethylene Shan Yu base ether etc.The aliphatic alcohol that especially preferably wherein forms this polyoxyethylene aliphatic alcohol ether is saturated or unsaturated and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene aliphatic alcohol ether of 4-12 ethylene oxide repetitive, for example polyoxyethylene-8 lauryl ether and/or polyoxyethylene-5 Octyl Ether.Especially wherein the aliphatic alcohol that forms this polyoxyethylene aliphatic alcohol ether is saturated or unsaturated and has 10-14 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene aliphatic alcohol ether of 6-10 ethylene oxide repetitive, for example polyoxyethylene 8-lauryl ether.
More specifically, as above-mentioned polyoxyethylene fatty acid monoglyceride, the fatty acid that preferably wherein forms this polyoxyethylene fatty acid monoglyceride is saturated or unsaturated and has 8-22 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene fatty acid monoglycerides of 4-60 ethylene oxide repetitive.As the example, can mention: polyoxyethylene Monooctamoin, polyoxyethylene monocaprin, polyoxyethylene glyceryl monolaurate, polyoxyethylene monomyristin, polyoxyethylene glycerol monopalmitate, polyoxyethylene glycerol list isostearate, polyoxyethylene glyceryl monostearate, TMGO 5, polyoxyethylene glycerol Dan behenic acid ester etc.The fatty acid that especially preferably wherein forms this polyoxyethylene fatty acid monoglyceride is saturated or unsaturated and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene fatty acid monoglycerides of 4-12 ethylene oxide repetitive.
More specifically, as above-mentioned polyoxyethylene hydrogenated Oleum Ricini, preferred polyoxyethylene structure division wherein on average comprises those polyoxyethylene hydrogenated Oleum Ricini of individual, preferred 30-60 the ethylene oxide repetitive of 20-80.
More specifically, as above-mentioned polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester, the fatty acid that preferably wherein forms this polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester is saturated or unsaturated and has 8-22 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene hydrogenated Oleum Ricini mono fatty acid esters of 4-60 ethylene oxide repetitive.As the example, can mention: polyoxyethylene hydrogenated Oleum Ricini list caprylate, polyoxyethylene hydrogenated Oleum Ricini monkey cell, polyoxyethylene hydrogenated Oleum Ricini monolaurate, polyoxyethylene hydrogenated Oleum Ricini list myristinate, polyoxyethylene hydrogenated Oleum Ricini monopalmitate, polyoxyethylene hydrogenated Oleum Ricini list isostearate, polyoxyethylene hydrogenated Oleum Ricini monostearate, polyoxyethylene hydrogenated Oleum Ricini monoleate, polyoxyethylene hydrogenated Oleum Ricini Dan behenic acid ester etc.The fatty acid that especially preferably wherein forms this polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene hydrogenated Oleum Ricini mono fatty acid esters of 4-12 ethylene oxide repetitive.
More specifically, as above-mentioned polyglyceryl fatty acid ester, the preferred fatty acid that wherein forms this polyglyceryl fatty acid ester is saturated or unsaturated and has 8-22 carbon atom and the polyglycereol structure division on average comprises those polyglyceryl fatty acid esters of 2-60 glycerol repetitive, this polyglyceryl fatty acid ester both can be the mono fatty acid ester of polyglycereol, also can be the many fatty acid ester of polyglycereol.As the example, can mention: the list of polyglycereol-and the list of many caprylates, polyglycereol-and the list of many 2-ethylhexanoate, polyglycereol-and the list of many decanoins, polyglycereol-and the list of many laurates (as polyglycereol-10 cinnamic acid in May ester), polyglycereol-and the list of fleshiness myristate, polyglycereol-and the list of many cetylates, polyglycereol-and the list of many isostearates, polyglycereol-and the list of many stearates (as polyglycereol-3 distearate), polyglycereol-and the list of heavy wool acid esters (as polyglycereol-2 dioleate), polyglycereol-and Duo behenic acid ester etc.The fatty acid that especially preferably wherein forms this polyglyceryl fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyglycereol structure division on average comprises polyglycereol list and/or the many fatty acid ester of 3-15 glycerol repetitive, for example: polyglycereol-3 monkey cell (
PC31), polyglycereol-4 monkey cell (
PC41), the single caprylate of polyglycereol-3 (
COSMO P813) and/or polyglycereol-4 monolaurate (
CARE PL 4).Especially wherein the fatty acid that forms this polyglyceryl fatty acid ester is saturated or unsaturated and has 8-12 carbon atom and the polyglycereol structure division on average comprises the polyglycereol list of 3-6 glycerol repetitive-and/or many fatty acid ester, for example polyglycereol-3 monkey cell (
PC31) and/or polyglycereol-4 monkey cell (
PC41).
More specifically, as above-mentioned polyglycereol fat alcohol ether, the aliphatic alcohol that preferably wherein forms this polyglycereol fat alcohol ether is saturated or unsaturated and has 8-22 carbon atom and the polyglycereol structure division on average comprises the fatty alcohol ether of polyglycereol of 2-60 glycerol repetitive.As the example, can mention: polyglycereol Octyl Ether, polyglycereol decyl ethers, polyglycereol lauryl ether, polyglycereol myristyl ether, polyglycereol palmityl ether, polyglycereol iso stearyl ether, polyglycereol stearyl ether, polyglycereol oleyl ether, polyglycereol Shan Yu base ether etc.The aliphatic alcohol that especially preferably wherein forms this polyglycereol fat alcohol ether is saturated or unsaturated and has 8-18 carbon atom and the polyglycereol structure division on average comprises the fatty alcohol ether of polyglycereol of 3-15 glycerol repetitive, especially wherein the aliphatic alcohol that forms this polyglycereol fat alcohol ether is saturated or unsaturated and has 10-14 carbon atom and the polyglycereol structure division on average comprises polyglycereol fatty alcohol ether, for example polyglycereol-4 lauryl ether of 3-5 glycerol repetitive.
More specifically, as above-mentioned sucrose fatty acid ester, the preferred fatty acid that wherein forms this sucrose fatty acid ester is saturated or unsaturated and has those sucrose fatty acid ester of 8-22 carbon atom, this sucrose fatty acid ester both can be the mono fatty acid ester of sucrose, also can be the many fatty acid ester of sucrose, as two of sucrose-, three-, four-, five-and six fatty acid esters.As the example, can mention: the list of sucrose-and the list of many caprylates, sucrose-and the list of many 2-ethylhexanoate, sucrose-and the list of many decanoins, sucrose-and the list of many laurates (as sucrose dilaurate), sucrose-and the list of fleshiness myristate, sucrose-and the list of many cetylates (as sucrose six cetylates), sucrose-and the list of many isostearates, sucrose-and the list of many stearates, sucrose-and the list of heavy wool acid esters, sucrose-and Duo behenic acid ester etc.The fatty acid that especially preferably wherein forms this sucrose fatty acid ester is saturated or unsaturated and has the sucrose list of 8-18 carbon atom-and/or many fatty acid ester, especially wherein the fatty acid that forms this sucrose fatty acid ester is saturated or unsaturated and has the sucrose list of 12-18 carbon atom-and/or many fatty acid ester, for example sucrose list-and/or dilaurate and/or sucrose list-and/or distearate.
More specifically, as above-mentioned alkyl polysaccharide glycosides, preferred alkyl wherein is that saturated or unsaturated, straight chain or branching and average condensation degree that have 8-22 carbon atom and glucosides unit are the alkyl polysaccharide glycosides of 1-7, and more preferably alkyl wherein is that saturated or unsaturated, straight chain or branching and average condensation degree that have 8-22 carbon atom, glucosides unit are that 1-7 and glucosides are the alkyl poly glucoside of glucoside.As the example, can mention: octyl group many (Portugal) glucosides, 2-ethylhexyl many (Portugal) glucosides, decyl many (Portugal) glucosides, lauryl many (Portugal) glucosides, myristyl many (Portugal) glucosides, palmityl many (Portugal) glucosides, iso stearyl many (Portugal) glucosides, stearyl many (Portugal) glucosides, oil base many (Portugal) glucosides, Shan Yu Quito (Portugal) glucosides etc.Preferred especially alkyl wherein is that saturated or unsaturated, straight chain or branching and average condensation degree that have 8-11 carbon atom, glucosides unit are that 1-1.4 and glucosides are that the alkyl poly glucoside of glucoside and/or alkyl wherein are that saturated or unsaturated, straight chain or branching and average condensation degree that have 12-14 carbon atom, glucosides unit are that 1.5-4.0 and glucosides are the alkyl poly glucoside of glucoside.
The bi-component composite type emulsifying agent that is applicable to microemulsion of the present invention is preferably the mixed emulsifier that polyoxyethylene fatty acid ester and polyglyceryl fatty acid ester constitute, for example polyoxyethylene-6 caprylic/capric ester (
GMC 6) and polyglycereol-3 monkey cell (
PC31) or with polyglycereol-4 monkey cell (
PC41) mixed emulsifier of Gou Chenging.In addition, be applicable to that the bi-component composite type emulsifying agent of microemulsion of the present invention also is preferably the mixed emulsifier of polyoxyethylene aliphatic alcohol ether and polyglycereol fat alcohol ether formation, for example mixed emulsifier of polyoxyethylene-8 lauryl ether and polyglycereol-4 lauryl ethers formation.
In microemulsion of the present invention, be generally 2-20wt% as the surfactant of component C or the consumption of oil-in-water nonionic emulsifier based on the microemulsion gross weight, be preferably 5-10wt%.
Component D
In microemulsion of the present invention, also comprised the cosurfactant as component D, its at least a HLB value more than or equal to 17, be preferably greater than and equal 20 auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant.
According to the present invention preferably, be to be selected from down in the group one or more as the auxiliary non-ionic surface active agent of component D or auxiliary zwitterionic surfactant: number-average molecular weight is 500-20,000, is preferably 500-5,000 polyoxyethylene (EO)/polyoxypropylene (PO) block copolymer, C
8-C
24Alkyl betaine, C
8-C
24Alkyl amido betaine and polyoxyethylene sorbitan fatty acid ester.
Be 500-20 as above-mentioned number-average molecular weight, 000 polyoxyethylene (EO)/polyoxypropylene (PO) block copolymer, it can be that the diblock copolymer (PEG-PPG type copolymer) of polyoxyethylene (EO)/polyoxypropylene (PO) also can be the triblock copolymer (PEG-PPG-PEG block copolymer or PPG-PEG-PPG block copolymer) of polyoxyethylene (EO)/polyoxypropylene (PO), for example oxirane (46) expoxy propane (16) oxirane (46) block copolymer (
PE/F 38 or
L 62D), oxirane (75) expoxy propane (30) oxirane (75) block copolymer (
PE/F 68 or
F 68), oxirane (98) expoxy propane (67) oxirane (98) block copolymer (
PE/F 127 or
F 127), oxirane (62) expoxy propane (39) oxirane (62) block copolymer (
F 87), oxirane (122) expoxy propane (47) oxirane (122) block copolymer (
F 98), oxirane (128) expoxy propane (54) oxirane (128) block copolymer (Hodag 1108-F) etc.
As above-mentioned C
8-C
24Alkyl betaine and C
8-C
24Alkyl amido betaine can be mentioned cocamidopropyl betaine, cocamidopropyl ethyl betanin, coco betaine, cocamidopropyl propyl hydroxy sulfobetaines (CAS:68139-30-0), Petiolus Trachycarpi oil amido propyl betaine, myristoyl amido CAB, myristyl betaine, stearoyl amido CAB, stearyl betaine, soybean oil amido propyl betaine, milk amido propyl betaine etc.
As above-mentioned polyoxyethylene sorbitan fatty acid ester, the preferred fatty acid that wherein forms this polyoxyethylene sorbitan fatty acid ester is saturated or unsaturated and has 8-22 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene sorbitan fatty acid esters of 4-60 ethylene oxide repetitive, for example the list of polyoxyethylene sorbitol acid anhydride-, two-and tri-fatty acid ester.As the example, can mention: polyoxyethylene sorbitol acid anhydride list-, two-and three caprylates, polyoxyethylene sorbitol acid anhydride list-, two-and three decanoins, polyoxyethylene sorbitol acid anhydride list-, two-and trilaurin, polyoxyethylene sorbitol acid anhydride list-, two-and three myristinates, polyoxyethylene sorbitol acid anhydride list-, two-and tripalmitate, polyoxyethylene sorbitol acid anhydride list-, two-and three isostearates, polyoxyethylene sorbitol acid anhydride list-, two-and tristearate, polyoxyethylene sorbitol acid anhydride list-, two-and trioleate, polyoxyethylene sorbitol acid anhydride list-, two-and San behenic acid ester etc.The fatty acid that especially preferably wherein forms this polyoxyethylene sorbitan fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises those polyoxyethylene sorbitan fatty acid esters of 4-12 ethylene oxide repetitive, for example the list of polyoxyethylene sorbitol acid anhydride-, two-and tri-fatty acid ester.Especially can mention tween 20, tween-21, Tween-40, Tween-60, tween-61, Tween-65, tween 80 etc., preferred tween 20.
In microemulsion of the present invention, be generally 0.2-2wt% as the auxiliary non-ionic surface active agent of component D or the consumption of auxiliary zwitterionic surfactant based on the microemulsion gross weight, be preferably 0.5-1.6wt%.
Add an amount of HLB value more than or equal to 17, be preferably greater than and equal the cloud point that 20 auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant help to improve microemulsion of the present invention, make the heat stability of microemulsion increase.For this reason, as the oil-in-water nonionic emulsifier of component C be generally 5-20 as the auxiliary non-ionic surface active agent of component D or the weight ratio of auxiliary zwitterionic surfactant, be preferably 5-10.
In the present invention, the algorithm of the HLB value of surfactant or emulsifying agent can be with reference to Davies algorithm (people such as " cosmetic chemistry and Technology complete works " QiuBing Yi, China Light Industry Press, in May, 1997, front page, the 786th page).
In oil-in-water microemulsion of the present invention, can also suitably comprise the cosmetics universaling component, for example viscosifier, antibacterial, wetting agent, wetting agent, coloring agent, antiseptic, the agent of lifting sense of touch, spice, anti-inflammatory agent, whitening agent, antiperspirant, UV absorbent etc.
As not having other explanation, the percentage composition of addressing among the present invention is weight percentage.
Microemulsion prescription of the present invention is simple, prepares simple and easy to do.Oil-in-water microemulsion of the present invention can prepare by conventional method.Usually, each component in the microemulsion prescription of the present invention is added in the container, under heating, mix and to obtain oil-in-water microemulsion of the present invention in case of necessity.
Oil-in-water microemulsion of the present invention has transparent or semitransparent outward appearance, and with the DELSA NANO S type particle size distribution instrument test of BECKMANCOULTER company, its mean diameter is about 20-100nm.
Set forth the present invention below by embodiment, but these embodiment should not be construed as limitation of the scope of the invention.
Embodiment
Embodiment 1
The prescription of embodiment 1 is as shown in table 1 below.
Table 1
To go up that each component mixes in the table 1 under 40 ℃, be cooled to room temperature then, and obtain product 1, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 1 usefulness BECKMAN COULTER company records forms microemulsion about 40nm.
Embodiment 2
The prescription of embodiment 2 is as shown in table 2 below.
Table 2
To go up that each component mixes in the table 2 under 40 ℃, be cooled to room temperature then, and obtain product 2, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 2 usefulness BECKMAN COULTER companies records forms microemulsion about 89nm.
Embodiment 3
The prescription of embodiment 3 is as shown in table 3 below.
Table 3
To go up that each component mixes in the table 3 under 40 ℃, be cooled to room temperature then, and obtain product 3, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 3 usefulness BECKMAN COULTER companies records forms microemulsion about 80nm.
Embodiment 4
The prescription of embodiment 4 is as shown in table 4 below.
Table 4
To go up that each component mixes in the table 4 under 40 ℃, be cooled to room temperature then, and obtain product 4, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 4 usefulness BECKMAN COULTER companies records forms microemulsion about 35nm.
Embodiment 5
The prescription of embodiment 5 is as shown in table 5 below.
Table 5
To go up that each component mixes in the table 5 under 40 ℃, be cooled to room temperature then, and obtain product 5, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 5 usefulness BECKMAN COULTER companies records forms microemulsion about 90nm.
Embodiment 6
The prescription of embodiment 6 is as shown in table 6 below.
Table 6
To go up that each component mixes in the table 6 under 40 ℃, be cooled to room temperature then, and obtain product 6, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 6 usefulness BECKMAN COULTER companies records forms microemulsion about 85nm.
Embodiment 7
The prescription of embodiment 7 is as shown in table 7 below.
Table 7
To go up that each component mixes in the table 7 under 40 ℃, be cooled to room temperature then, and obtain product 7, its outward appearance is transparent fully.The mean diameter that the DELSA NANOS type particle size distribution instrument of product 7 usefulness BECKMAN COULTER companies records forms microemulsion about 90nm.
Comparative Examples 1
The prescription of Comparative Examples 1 is as shown in table 8 below.
Table 8
To go up that each component mixes in the table 8 under 40 ℃, be cooled to room temperature then, obtain contrasting product 1, its appearance transparent.The mean diameter that the DELSANANO S type particle size distribution instrument of contrast product 1 usefulness BECKMAN COULTER company records forms microemulsion about 40nm.
Heat stabilization test
Product 1-7 and contrast product 1 that above-described embodiment 1-7 and Comparative Examples 1 are obtained respectively carry out heat resistant test separately.This heat resistant test refers to the sample that respectively is in room temperature is directly put into 45 ℃ baking oven, leave standstill wait for that sample reaches hygral equilibrium after, observe sample and variable color, muddiness, lamination whether occur.As a result, variable color, muddiness and lamination do not appear in the complete pellucidity when outward appearance still keeps testing beginning under 45 ℃ of conditions after the above-mentioned heat resistant test of product 1-7 process.Show that thus product 1-7 has good heat stability.Yet contrast product 1 presents the White-opalescent shape through become muddy after the above-mentioned heat resistant test under 45 ℃ of conditions, and this shows that its heat stability is relatively poor.
Claims (25)
1. oil-in-water microemulsion, this oil-in-water microemulsion comprises following component based on its gross weight:
A) water of 75-94wt%;
B) oil phase of 0.5-5wt%;
C) the oil-in-water nonionic emulsifier as surfactant of 2-20wt%; And
D) the HLB value of 0.2-2wt% is more than or equal to 17 auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant,
Wherein
The weight ratio of component C and component D is 5-20;
Be to be selected from down in the group one or more as the auxiliary non-ionic surface active agent of component D or auxiliary zwitterionic surfactant: number-average molecular weight is 500-20,000 polyoxyethylene/polyoxypropylene block copolymers, C
8-C
24Alkyl betaine, C
8-C
24Alkyl amido betaine and polyoxyethylene sorbitan fatty acid ester;
Be to be selected from the following three class oil-in-water nonionic emulsifiers one or more as the described oil-in-water nonionic emulsifier of component C:
The first kind: the emulsifying agent with polysiloxanes+hydrophilic group+alkyl group molecular chain structure, wherein hydrophilic group is polyoxyethylene groups, the polyoxypropylene base, polyglyceryl or polyoxyethylene sorbitan base, such emulsifying agent comprises polysiloxane group, the block copolymer emulsifying agent that polyether polyol base and fatty alkyl are connected with covalent bond, be main chain with the polysiloxane group, the polyether polyol base is the emulsifying agent that side group is connected with the polysiloxane group chain with covalent bond respectively with fatty alkyl, and is main chain with the polysiloxane group, the polyether polyol base of modifying with fatty alkyl is the emulsifying agent that side group is connected with the polysiloxane group chain with covalent bond;
Second class: the emulsifying agent with polysiloxanes+hydrophilic group molecular chain structure, wherein hydrophilic group is polyoxyethylene groups, polyoxypropylene base, polyglyceryl or polyoxyethylene sorbitan base, such emulsifying agent comprises the block copolymer emulsifying agent that polysiloxane group and polyether polyol base are connected with covalent bond, is that main chain, polyether polyol base are the emulsifying agent that side group is connected with the polysiloxane group main chain with covalent bond with the polysiloxane group; And
The 3rd class: the following group of oil-in-water nonionic emulsifier that is different from the first kind and second class: have polyoxyethylene chain as hydrophilic non-ionic surfactant, polyglyceryl fatty acid ester, polyglycereol fat alcohol ether, sucrose fatty acid ester and the alkyl polysaccharide glycosides of hydrophilic group;
And
Described oil phase as B component comprises at least a oils and fats that is selected from down group: the silicone oil oils and fats, have straight chain and/or side chain monobasic and/or the dicarboxylic acids of 2-44 carbon atom and have the saturated or undersaturated straight chain of 1-22 carbon atom and/or monobasic and the binary esters of branched-chain alcoho, difunctionality aliphatic alcohol and the ester with simple function aliphatic carboxylic acid of 1-22 carbon atom with 2-36 carbon atom, the dicarboxylic ester quasi-grease, the carbonic diester quasi-grease, the triglyceride quasi-grease of relative long-chain, straight or branched aliphatic alcohols oils and fats, the fatty alcohol ether quasi-grease, the hydro carbons oils and fats, the esters of aryl carboxylic acid, and at least a lubricant component that contains polyoxypropylene chains, the wherein said lubricant component that contains polyoxypropylene chains is the polyoxypropylene fatty alcohol ether, the polyoxypropylene fatty acid ester, polyoxypropylene copolymerization dimethyl siloxane or their any mixture.
2. oil-in-water microemulsion as claimed in claim 1, the HLB value of wherein said auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant is more than or equal to 20.
3. oil-in-water microemulsion as claimed in claim 1, wherein the weight ratio of component C and component D is 5-10.
4. oil-in-water microemulsion as claimed in claim 1, this oil-in-water microemulsion comprises following component based on its gross weight:
A) water of 85-94wt%;
B) oil phase of 0.5-4wt%;
C) the oil-in-water nonionic emulsifier as surfactant of 5-10wt%; And
D) the auxiliary non-ionic surface active agent of 0.5-1.6wt% or auxiliary zwitterionic surfactant.
5. oil-in-water microemulsion as claimed in claim 4, the HLB value of wherein said auxiliary non-ionic surface active agent or auxiliary zwitterionic surfactant is more than or equal to 20.
6. oil-in-water microemulsion as claimed in claim 4, wherein the weight ratio of component C and component D is 5-10.
7. oil-in-water microemulsion as claimed in claim 1, wherein the number-average molecular weight of polyoxyethylene/polyoxypropylene block copolymers is 500-5 among the component D, 000.
8. oil-in-water microemulsion as claimed in claim 1 is wherein among the component D
Described number-average molecular weight is 500-20, and 000 polyoxyethylene/polyoxypropylene block copolymers is selected from down group: oxirane (98) expoxy propane (67) oxirane (98) block copolymer, oxirane (46) expoxy propane (16) oxirane (46) block copolymer, oxirane (75) expoxy propane (30) oxirane (75) block copolymer, oxirane (62) expoxy propane (39) oxirane (62) block copolymer, oxirane (122) expoxy propane (47) oxirane (122) block copolymer and oxirane (128) expoxy propane (54) oxirane (128) block copolymer;
Described C
8-C
24Alkyl betaine and C
8-C
24Alkyl amido betaine is selected from down group: cocamidopropyl betaine, cocamidopropyl ethyl betanin, coco betaine, cocamidopropyl propyl hydroxy sulfobetaines, Petiolus Trachycarpi oil amido propyl betaine, myristoyl amido CAB, myristyl betaine, stearoyl amido CAB, stearyl betaine, soybean oil amido propyl betaine and milk amido propyl betaine; And
Described polyoxyethylene sorbitan fatty acid ester is selected from down group: tween 20, tween-21, Tween-40, Tween-60, tween-61, Tween-65 and tween 80.
9. oil-in-water microemulsion as claimed in claim 8, wherein said polyoxyethylene sorbitan fatty acid ester is tween 20.
10. oil-in-water microemulsion as claimed in claim 1 is wherein in the B component
Described silicone oil oils and fats is selected from: polydimethylsiloxane and ring first siloxanes, and aryl-, alkyl-or the polymethyl siloxane of alkoxyl-replacements and encircle the first siloxanes;
Described dicarboxylic ester quasi-grease is selected from: Di-n-butyl Adipate, n-butyl sebacate, adipic acid two (2-ethylhexyl) ester, succinic acid two (2-hexyl decyl) ester and/or Azelaic Acid two isotridecyl esters, two oleic acid glycol esters, two different tridecanoic acid glycol esters, two (2 ethyl hexanoic acid) propylene glycol ester, two isostearic acid butanediol esters and/or two sad DOPCP;
Described carbonic diester quasi-grease is selected from: carbonic acid two (2-ethylhexyl) ester;
The triglyceride quasi-grease of described relative long-chain is selected from: triglyceride, the triglyceride of industrial oleic acid, the triglyceride of isostearic acid and the triglyceride of Petiolus Trachycarpi/oleic acid mixture of the mixture of synthetic caprylic/capric;
Described straight or branched aliphatic alcohols oils and fats is selected from: oleyl alcohol or octyldodecanol;
Described fatty alcohol ether quasi-grease is selected from: dicaprylyl ether;
Described hydro carbons oils and fats is selected from: paraffin oil, white mineral oil, 2-Methylpentadecane, poly decene, petroleum jelly, light liquid paraffin and/or squalane; And
The esters of described aryl carboxylic acid is selected from: have the saturated or undersaturated straight or branched alcohol of 1-22 carbon atom and the benzoate of benzoic acid formation.
11. oil-in-water microemulsion as claimed in claim 10, the esters of wherein said aryl carboxylic acid is selected from: benzoic acid C12-15 Arrcostab.
12. oil-in-water microemulsion as claimed in claim 11, the esters of wherein said aryl carboxylic acid is selected from: benzoic acid iso stearyl ester and benzoic acid 2-octyl group dodecyl ester.
13. oil-in-water microemulsion as claimed in claim 1, wherein said oil phase comprises the esters of the fatty acid with 12-22 carbon atom.
14. oil-in-water microemulsion as claimed in claim 1, wherein said oil phase comprise the component that is selected from down group: methyl laurate, methyl stearate, methyl oleate, methyl erucate, isopropyl palmitate, isopropyl myristate, isopropyl stearate, acid isopropyl, n-butyl stearate, the just own ester of lauric acid, oleic acid ester in the positive last of the ten Heavenly stems, the different monooctyl ester of stearic acid, Palmic acid ester in the different ninth of the ten Heavenly Stems, isononyl isononanoate, Palmic acid 2-ethyl hexyl ester, lauric acid 2-ethyl hexyl ester, stearic acid 2-hexyl decyl ester, Palmic acid 2-octyl group dodecyl ester, oleic oil alkene ester, erucic acid oil alkene ester and/or oleic acid mustard ester.
15. oil-in-water microemulsion as claimed in claim 1 is wherein in the B component
Be that the aliphatic alcohol that wherein forms this polyoxypropylene fatty alcohol ether is saturated or unsaturated and has 8-18 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty alcohol ether of 2-18 propylene oxide repetitive as the polyoxypropylene fatty alcohol ether of the oils and fats that contains polyoxypropylene chains;
Be that the fatty acid that wherein forms this polyoxypropylene fatty acid ester is saturated or unsaturated and has 8-18 carbon atom and the polyoxypropylene structure division on average comprises the polyoxypropylene fatty acid ester of 6-26 propylene oxide repetitive as the polyoxypropylene fatty acid ester of the oils and fats that contains polyoxypropylene chains; And
Be the polyoxypropylene copolymerization dimethyl siloxane that wherein polyoxypropylene structure division on average comprises 2-30 propylene oxide repetitive as the polyoxypropylene copolymerization dimethyl siloxane of the oils and fats that contains polyoxypropylene chains.
16. oil-in-water microemulsion as claimed in claim 15, wherein
Polyoxypropylene fatty alcohol ether as the oils and fats that contains polyoxypropylene chains is: polyoxypropylene-3 myristyl ether, polyoxypropylene-11 stearyl ether, polyoxypropylene-11 iso stearyl ether, polyoxypropylene-14 butyl ether, polyoxypropylene-15 stearyl ether, polyoxypropylene-15 iso stearyl ether, polyoxypropylene-7 lauryl ether and/or polyoxypropylene-10 oleyl ether;
Polyoxypropylene fatty acid ester as the oils and fats that contains polyoxypropylene chains is: polyoxypropylene-15 stearate, polyoxypropylene-15 isostearate, polyoxypropylene-26 oleate, polyoxypropylene-9 laurate and/or polyoxypropylene-6 ricinoleate ester; And
Polyoxypropylene copolymerization dimethyl siloxane as the oils and fats that contains polyoxypropylene chains is: polyoxypropylene-2 copolymerization dimethyl siloxane, polyoxypropylene-12 copolymerization dimethyl siloxane and/or polyoxypropylene-27 copolymerization dimethyl siloxane.
17. as each described oil-in-water microemulsion among the claim 1-16, wherein oil-in-water nonionic emulsifier described in the component C comprises polyoxyethylene polydimethylsiloxane and/or polyglycereol polydimethylsiloxane.
18. oil-in-water microemulsion as claimed in claim 17, wherein said oil-in-water nonionic emulsifier is selected from: the PEG/PPG-14/4 polydimethylsiloxane, two-the PEG/PPG-20/20 polydimethylsiloxane, PEG/PPG-4/12 polydimethylsiloxane and PEG/PPG-20/20 polydimethylsiloxane.
19. as each described oil-in-water microemulsion among the claim 1-16, be the bi-component composite type emulsifying agent that is constituted by emulsifying agent X and emulsifying agent Y that is selected from the 3rd class oil-in-water nonionic emulsifier as the oil-in-water nonionic emulsifier of component C wherein, wherein emulsifying agent X has polyoxyethylene chain as the hydrophilic non-ionic surfactant of hydrophilic group, it is selected from down group: polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty acid monoglyceride, polyoxyethylene hydrogenated Oleum Ricini and polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester, and component Y is for being selected from polyglyceryl fatty acid ester, polyglycereol fat alcohol ether, the hydrophilic non-ionic surfactant of sucrose fatty acid ester or alkyl polysaccharide glycosides.
20. oil-in-water microemulsion as claimed in claim 19, wherein
Described polyoxyethylene fatty acid ester is saturated or unsaturated for the fatty acid that wherein forms this polyoxyethylene fatty acid ester and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene fatty acid ester of 4-12 ethylene oxide repetitive;
Described polyoxyethylene aliphatic alcohol ether is saturated or unsaturated for the aliphatic alcohol that wherein forms this polyoxyethylene aliphatic alcohol ether and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene aliphatic alcohol ether of 4-12 ethylene oxide repetitive;
Described polyoxyethylene fatty acid monoglyceride is saturated or unsaturated for the fatty acid that wherein forms this polyoxyethylene fatty acid monoglyceride and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene fatty acid monoglyceride of 4-12 ethylene oxide repetitive;
Described polyoxyethylene hydrogenated Oleum Ricini on average comprises the polyoxyethylene hydrogenated Oleum Ricini of 30-60 ethylene oxide repetitive for polyoxyethylene structure division wherein;
Described polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester is saturated or unsaturated for the fatty acid that wherein forms this polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester and has 8-18 carbon atom and the polyoxyethylene structure division on average comprises the polyoxyethylene hydrogenated Oleum Ricini mono fatty acid ester of 4-12 ethylene oxide repetitive;
Described polyglyceryl fatty acid ester is saturated or unsaturated for the fatty acid that wherein forms this polyglyceryl fatty acid ester and has 8-18 carbon atom and the polyglycereol structure division on average comprises polyglycereol list and/or the many fatty acid ester of 3-15 glycerol repetitive;
Described polyglycereol fat alcohol ether is saturated or unsaturated for the aliphatic alcohol that wherein forms this polyglycereol fat alcohol ether and has 8-18 carbon atom and the polyglycereol structure division on average comprises the fatty alcohol ether of polyglycereol of 3-15 glycerol repetitive;
Described sucrose fatty acid ester is saturated or unsaturated for the fatty acid that wherein forms this sucrose fatty acid ester and has the sucrose list of 8-18 carbon atom-and/or many fatty acid ester; And
Described alkyl polysaccharide glycosides is that saturated or unsaturated, straight chain or branching and average condensation degree that have 8-11 carbon atom, glucosides unit are that 1-1.4 and glucosides are that the alkyl poly glucoside of glucoside and/or alkyl wherein are that saturated or unsaturated, straight chain or branching and average condensation degree that have 12-14 carbon atom, glucosides unit are that 1.5-4.0 and glucosides are the alkyl poly glucoside of glucoside for wherein alkyl.
21. oil-in-water microemulsion as claimed in claim 20, wherein
Described polyoxyethylene fatty acid ester is polyoxyethylene-6 caprylic/capric ester, polyoxyethylene-6 laurate, polyoxyethylene-8 laurate and/or polyoxyethylene-12 cetylate;
Described polyoxyethylene aliphatic alcohol ether is polyoxyethylene-8 lauryl ether and/or polyoxyethylene-5 Octyl Ether;
Described polyglyceryl fatty acid ester is polyglycereol-3 monkey cell, polyglycereol-4 monkey cell, the single caprylate of polyglycereol-3 and/or polyglycereol-4 monolaurate; And
Described polyglycereol fat alcohol ether is polyglycereol-4 lauryl ether.
22. oil-in-water microemulsion as claimed in claim 19, wherein said bi-component composite type emulsifying agent are the mixed emulsifier of polyoxyethylene fatty acid ester and polyglyceryl fatty acid ester formation or are the mixed emulsifier that polyoxyethylene aliphatic alcohol ether and polyglycereol fat alcohol ether constitute.
23. oil-in-water microemulsion as claimed in claim 22, wherein said bi-component composite type emulsifying agent are polyoxyethylene-6 caprylic/capric ester and polyglycereol-3 monkey cell or the mixed emulsifier that constitutes with polyglycereol-4 monkey cell or polyoxyethylene-8 lauryl ether and the mixed emulsifier of polyglycereol-4 lauryl ether formation
24. oil-in-water microemulsion as claimed in claim 19, wherein based on the total amount of described compound emulsifying agent, the consumption of emulsifying agent X is 50-90wt%, and the consumption of emulsifying agent Y is 10-50wt%.
25. oil-in-water microemulsion as claimed in claim 24, wherein based on the total amount of described compound emulsifying agent, the consumption of emulsifying agent X is 65-90wt%, and the consumption of emulsifying agent Y is 10-35wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910161462 CN101987069B (en) | 2009-07-31 | 2009-07-31 | Thermally stable oil-in-water microemulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910161462 CN101987069B (en) | 2009-07-31 | 2009-07-31 | Thermally stable oil-in-water microemulsion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101987069A CN101987069A (en) | 2011-03-23 |
| CN101987069B true CN101987069B (en) | 2013-09-04 |
Family
ID=43743990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910161462 Expired - Fee Related CN101987069B (en) | 2009-07-31 | 2009-07-31 | Thermally stable oil-in-water microemulsion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101987069B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103157362A (en) * | 2011-12-09 | 2013-06-19 | 中国科学院广州地球化学研究所 | Preparation method of micro-emulsion absorption liquid used for processing organic exhaust gas |
| WO2013170419A1 (en) * | 2012-05-14 | 2013-11-21 | Evonik Degussa (China) Co., Ltd. | Emulsifier composition and the use thereof |
| CN103417389B (en) * | 2013-08-15 | 2015-03-04 | 上海应用技术学院 | O/W/O (oil/water/oil) multi-structure emulsion and method for manufacturing same |
| ES2717287T3 (en) * | 2013-10-31 | 2019-06-20 | Oreal | Composition in the form of an emulsion |
| CN105362278A (en) * | 2014-09-01 | 2016-03-02 | 苏州系统医学研究所 | Preparation containing 25-hydroxycholesterol and preparation method thereof and anti-virus application |
| EP3308766B1 (en) * | 2016-10-11 | 2019-12-25 | Ionia Azure AG | Cosmetic water-in-oil microemulsion |
| CN106420594A (en) * | 2016-11-30 | 2017-02-22 | 广州市花安堂生物科技有限公司 | Transparent smoothing toner and preparation method thereof |
| CN106511256A (en) * | 2016-11-30 | 2017-03-22 | 广州市花安堂生物科技有限公司 | Transparent mask and preparation method thereof |
| CN106420426A (en) * | 2016-11-30 | 2017-02-22 | 广州市花安堂生物科技有限公司 | Transparent mask and preparation method thereof |
| CN106420595A (en) * | 2016-11-30 | 2017-02-22 | 广州市花安堂生物科技有限公司 | Transparent smoothing toner and preparing method thereof |
| CN106727305A (en) * | 2016-12-10 | 2017-05-31 | 钦州学院 | A kind of microemulsion and preparation method thereof |
| JP7250725B2 (en) * | 2020-04-24 | 2023-04-03 | 信越化学工業株式会社 | Microemulsion composition and cosmetics containing the same |
| CN114515248B (en) * | 2020-11-19 | 2023-08-15 | 伽蓝（集团）股份有限公司 | Oil-in-water nanoemulsion and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124449A (en) * | 1993-03-23 | 1996-06-12 | 索尔维氟及其衍生物有限公司 | Low-viscosity cosmetic and pharmaceutical emulsions |
| CN1751679A (en) * | 2004-09-22 | 2006-03-29 | 花王株式会社 | Microemulsion |
| CN101011318A (en) * | 2006-01-30 | 2007-08-08 | 戈尔德施米特有限公司 | Cold-preparable, low-viscosity and prolonged-stability cosmetic emulsions |
| EP1852102A2 (en) * | 2006-04-28 | 2007-11-07 | Henkel Kommanditgesellschaft Auf Aktien | Method for manufacturing oil in water emulsions for roll-on applications |
| CN101181185A (en) * | 2006-10-06 | 2008-05-21 | 戈尔德施米特有限公司 | Cosmetic emulsions manufactured at low temperature, with low viscosity and long-term stability, with coemulgators containing cationic groups |
-
2009
- 2009-07-31 CN CN 200910161462 patent/CN101987069B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124449A (en) * | 1993-03-23 | 1996-06-12 | 索尔维氟及其衍生物有限公司 | Low-viscosity cosmetic and pharmaceutical emulsions |
| CN1751679A (en) * | 2004-09-22 | 2006-03-29 | 花王株式会社 | Microemulsion |
| CN101011318A (en) * | 2006-01-30 | 2007-08-08 | 戈尔德施米特有限公司 | Cold-preparable, low-viscosity and prolonged-stability cosmetic emulsions |
| EP1852102A2 (en) * | 2006-04-28 | 2007-11-07 | Henkel Kommanditgesellschaft Auf Aktien | Method for manufacturing oil in water emulsions for roll-on applications |
| CN101181185A (en) * | 2006-10-06 | 2008-05-21 | 戈尔德施米特有限公司 | Cosmetic emulsions manufactured at low temperature, with low viscosity and long-term stability, with coemulgators containing cationic groups |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101987069A (en) | 2011-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101987069B (en) | Thermally stable oil-in-water microemulsion | |
| CN101987070A (en) | Oil-in-water microemulsion with high oil-loading quantity | |
| CN101011318B (en) | Cold-preparable, low-viscosity and prolonged-stability cosmetic emulsions | |
| CN109152703B (en) | PEG-free stable low viscosity oil-in-water emulsions and uses thereof | |
| CN103945824B (en) | Water-in-oil emulsified sunscreen cosmetic composition | |
| EP1704848B1 (en) | Oily cleansing composition | |
| JP2008013554A (en) | Method for producing fine oil-in-water type emulsion | |
| CN107007481B (en) | Multiple emulsion composition and preparation method thereof | |
| CN102327199B (en) | Cosmetic composition comprising double-shell nano-structure | |
| KR101507893B1 (en) | Oil-in water emulsion type moisturizing cosmetic composition capable of spraying | |
| CN104284970B (en) | Emulsifier combination and application thereof | |
| CN108721132A (en) | A kind of suspension oil droplet toner and preparation method thereof containing Sucrose acetoisobutyrate | |
| CN102058493A (en) | Cosmetic composition | |
| CN104080440A (en) | Liquid cosmetic | |
| TW201538171A (en) | Oil-in-water type emulsified cosmetic | |
| JP5543069B2 (en) | Polyoxyalkylene-alkyl functional siloxane resins and aqueous compositions thereof | |
| WO2012090581A1 (en) | Oil-in-water emulsion sunscreen cosmetic | |
| JP6478186B2 (en) | Sunscreen cosmetics and method for producing the same | |
| CN104116650B (en) | A kind of cream preparation of high oil phase content and emulsifier-free and preparation method thereof | |
| JP4969773B2 (en) | Cosmetic composition and cosmetics | |
| CN103648470B (en) | Oil-in-water type topical agent | |
| CN111803427A (en) | Oil-in-water type cosmetic composition and preparation method thereof | |
| CN111449975A (en) | Microemulsion and preparation method thereof | |
| CZ315096A3 (en) | Cosmetic compositions based on oil-in-water emulsion intended for skin care | |
| JP6019024B2 (en) | High concentration emulsion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: EVONIK GOLDSCHMIDT GMBH Free format text: FORMER OWNER: EVONIK DEGUSSA (CHINA) CO., LTD. Effective date: 20110614 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201108 NO. 68, CHUNDONG ROAD, XINZHUANG INDUSTRIAL PARK, SHANGHAI TO: ESSEN, GERMANY |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20110614 Address after: essen Applicant after: Evonik Goldschmidt GmbH Address before: 201108 No. 68 East Spring Road, Xhenzhuang Industrial Park, Shanghai Applicant before: Evonik Degussa (China) Co., Ltd. |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: EVONIK DEGUSSA GMBH Free format text: FORMER OWNER: EVONIK GOLDSCHMIDT GMBH Effective date: 20140512 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20140512 Address after: essen Patentee after: Evonik Degussa GmbH Address before: essen Patentee before: Evonik Goldschmidt GmbH |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130904 Termination date: 20150731 |
|
| EXPY | Termination of patent right or utility model |