CN101986071A - Lyophilizer - Google Patents
Lyophilizer Download PDFInfo
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- CN101986071A CN101986071A CN 201010570513 CN201010570513A CN101986071A CN 101986071 A CN101986071 A CN 101986071A CN 201010570513 CN201010570513 CN 201010570513 CN 201010570513 A CN201010570513 A CN 201010570513A CN 101986071 A CN101986071 A CN 101986071A
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- drying box
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- water vessel
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Abstract
The invention relates to a lyophilizer, comprising a lyophilisation box with lifting board layers inside, a condensing water catcher connected with the lyophilisation box by a middle separating valve and a compressor. The lyophilizer is characterized in that air inlets of the lyophilisation box and the condensing water catcher are connected with an air supply pipe; washing openings of the lyophilisation box and the condensing water catcher are connected with a washing pipe; and discharge outlets of the lyophilisation box and the condensing water catcher are connected with a discharge pipe by discharge angle seat valves. The lyophilizer has good integrity and good lyophilisation effect and is convenient to control in the production process.
Description
Technical field
The present invention relates to a kind of freeze dryer, can be applicable to fields such as bioengineering, medical industry, food industry, material science and agricultural byproducts deep processing.
Background technology
After the Vacuum Freezing ﹠ Drying Technology that freeze dryer originates from the twenties in 19th century has experienced the fluctuating of decades and paces up and down, in last 20 years, make significant progress.Enter 21 century, vacuum freeze drying technology relies on the incomparable advantage of other drying means, more and more be subjected to people's favor, except being used widely in medicine, biological products, food, blood product, active material field, its application scale and field are also in constantly enlarging.But existing freeze dryer is most of bulky, complex structure, and complex operation, and device association is poor.Therefore, how addressing the above problem is research purpose of the present invention.
Summary of the invention
The object of the present invention is to provide a kind of freeze dryer, this equipment good integrity, drying property is good, and it is abundant to catch water, and production process is convenient to control.
The invention is characterized in: a kind of freeze dryer, comprise that inside has the freeze drying box of liftable flaggy, the condensation water vessel that is connected with freeze drying box every valve in the warp, compressor, it is characterized in that: be connected with supply air line on the air inlet of described freeze drying box and condensation water vessel, be connected with detergent line on the Butterworth Hatch of described freeze drying box and condensation water vessel, the discharge outlet of described freeze drying box and condensation water vessel is connected with discharge pipe line through the discharge angle seat valve.
Advantage of the present invention: good integrity of the present invention, freeze drying is effective, and production process is convenient to control.
Description of drawings
Fig. 1 is an embodiment of the invention process chart.
The specific embodiment
With reference to figure 1, a kind of freeze dryer, comprise that inside has the freeze drying box 1 of liftable flaggy 1-6, the condensation water vessel 3 that is connected with freeze drying box 1 every valve 2 in the warp, compressor 10, be connected with supply air line 4 on air inlet 1-1, the 3-1 of described freeze drying box 1 and condensation water vessel 3, be connected with detergent line 5 on Butterworth Hatch 1-2, the 3-2 of described freeze drying box 1 and condensation water vessel 3, discharge outlet 1-3, the 3-3 of described freeze drying box 1 and condensation water vessel 3 is connected with discharge pipe line 6 through discharge angle seat valve 6-1.
Above-mentioned freeze drying box 1 also is connected with silicone oil case 7, be respectively arranged with in the described silicone oil case 7 in order to refrigeration pipe 11 that low-temperature receiver is provided to silicone oil and the heater 8 that heat is provided, the oil-out 7-1 of described silicone oil case 7 is connected with the liftable flaggy 1-6 oil-in 1-4 of freeze drying box 1 through circulating pump 9, and the liftable flaggy 1-6 oil-out 1-5 of described freeze drying box is connected with the oil-in 7-2 of silicone oil case.
The low pressure inlet end 10-1 of above-mentioned compressor 10 is connected in an end of refrigeration pipe 11, the other end of described refrigeration pipe 11 is connected with the high-pressure outlet end 10-2 of compressor through cooling angle pedestal valve 11-1, described refrigeration pipe 11 one tunnel is arranged in silicone oil case 7 bodies, and another road is arranged in the condensed water water vessel 3.
The outlet side 3-4 of above-mentioned condensed water water vessel 3 is connected with vavuum pump 13 through butterfly valve 12.
Above-mentioned freeze drying box air inlet 1-1 also is connected with air cleaner 14, and described detergent line 5 comprises water for injection pipeline 5-2 and pure moise-heat sterilization pipeline 5-1, also is provided with water ring pump 15 on the described discharge pipe line 6.
The discharge outlet 3-3 of the oil-in 1-4 of above-mentioned freeze drying box, oil-out 1-5 and discharge outlet 1-3 and condensation water vessel is provided with temp probe 16, be provided with temp probe 16 in described freeze drying box 1 and condensation water vessel 3 bodies, the outlet side 3-4 of described condensation water vessel is provided with pressure probe 17.
The inlet end of above-mentioned supply air line 4 is provided with air feed angle pedestal valve 4-1, and the admission end of described pure moise-heat sterilization pipeline 5-1 is provided with inlet angles seat valve 5-1-1, and the water inlet end of described water for injection pipeline 5-2 is provided with flooding angle seat valve 5-2-1.
Above-mentioned pressure probe 16, temp probe 17, compressor 10, vavuum pump 13, heater 8, circulating pump 9, water ring pump 15, in every valve 2, butterfly valve 12, valve 11-1 is sat at the cooling angle, and inlet angles are sat valve 5-1-1, and flow inlet angle is sat valve 4-1, flooding angle is sat valve 5-2-1, and discharge angle is sat valve 6-1 and is connected with the PLC control system respectively.
Butterworth Hatch 1-2, the 3-2 of above-mentioned freeze drying box and the condensation water vessel spray head 18 interior with being located at its body is communicated with.
Before freeze-drying work is finished, unpacked, can will descend the pipe bottle bottle stopper of flaggy carrying to compress into the pipe bottle when flaggy is descended, thereby keep the vacuum and the moisture content of medicine in the bottle.
Freeze-drying program of the present invention is:
1. pre-freeze stage
Behind the product inlet, the freeze drying box temperature descends below the plait point rapidly, and keeps a period of time.Generally after reaching the pre-freeze minimum temperature, sample temperature can begin to vacuumize distillation in 1-2 hour.
2. the phase I heats up (lyophilization stage)
1) the temperature controlling lyophilization stage must suitably heat product, but can not make product temperature surpass himself temperature of eutectic point.If it is too much to be lower than temperature of eutectic point during the product distillation, then rate of sublimation reduces, the sublimation stage time lengthening, if be higher than temperature of eutectic point, then product can melt.
2) the control pressure of vacuum will be controlled at certain scope, generally is the 0.1-0.3 millibar.Pressure is low to help water sublimed in the product, but unfavorable to conducting heat, and product is owing to be difficult for obtaining heat, and rate of sublimation reduces.Pressure is too high, and the product moisture distillation is slowed down, and product absorbs heat will be reduced, so the temperature of product self rises, when being higher than temperature of eutectic point, product melts.
3. second stage heats up (adsorption stripping and dry stage)
Ice distillation in the product finishes, and also has the residual moisture about 10% in the product, reduces in order to make moisture, must continue further dry to product.In the adsorption stripping and dry stage, product temperature can rise to the maximum permissible temperature of this product rapidly, and is maintained to the freeze-drying end.General temperature is 25-30 ℃, and pressure is the 0.15-0.3 millibar.
The above only is preferred embodiment of the present invention, and all equalizations of being done according to the present patent application claim change and modify, and all should belong to covering scope of the present invention.
Claims (9)
1. freeze dryer, comprise that inside has the freeze drying box of liftable flaggy, the condensation water vessel that is connected with freeze drying box every valve in the warp, compressor, it is characterized in that: be connected with supply air line on the air inlet of described freeze drying box and condensation water vessel, be connected with detergent line on the Butterworth Hatch of described freeze drying box and condensation water vessel, the discharge outlet of described freeze drying box and condensation water vessel is connected with discharge pipe line through the discharge angle seat valve.
2. freeze dryer according to claim 1, it is characterized in that: described freeze drying box also is connected with the silicone oil case, be respectively arranged with in the described silicone oil case in order to the refrigeration pipe of low-temperature receiver and the heater of heat to be provided to silicone oil, the oil-out of described silicone oil case is connected with the liftable flaggy oil-in of freeze drying box through circulating pump, and the liftable flaggy oil-out of described freeze drying box is connected with the oil-in of silicone oil case.
3. freeze dryer according to claim 1 and 2, it is characterized in that: the low pressure inlet end of described compressor is connected in an end of refrigeration pipe, the other end of described refrigeration pipe is connected with the high-pressure outlet end of compressor through the cooling angle pedestal valve, described refrigeration pipe one tunnel is arranged in the silicone oil casing, and another road is arranged in the condensed water water vessel.
4. freeze dryer according to claim 1 is characterized in that: the outlet side of described condensed water water vessel is connected with vavuum pump through butterfly valve.
5. freeze dryer according to claim 1 is characterized in that: described freeze drying box air inlet also is connected with air cleaner, and described detergent line comprises water for injection pipeline and pure moise-heat sterilization pipeline, also is provided with water ring pump on the described discharge pipe line.
6. according to claim 1 or 2 or 4 described freeze dryers, it is characterized in that: the discharge outlet of the oil-in of described freeze drying box, oil-out and discharge outlet and condensation water vessel is provided with temp probe, be provided with temp probe in described freeze drying box and the condensation water vessel body, the outlet side of described condensation water vessel is provided with pressure probe.
7. freeze dryer according to claim 1 or 5, it is characterized in that: the inlet end of described supply air line is provided with the air feed angle pedestal valve, the admission end of described pure moise-heat sterilization pipeline is provided with the inlet angles seat valve, and the water inlet end of described water for injection pipeline is provided with the flooding angle seat valve.
8. according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 described freeze dryers, it is characterized in that: described pressure probe, temp probe, compressor, vavuum pump, heater, circulating pump, water ring pump, in every valve, butterfly valve, valve is sat at the cooling angle, and inlet angles are sat valve, and flow inlet angle is sat valve, flooding angle is sat valve, and discharge angle is sat valve and is connected with the PLC control system respectively.
9. freeze dryer according to claim 1 is characterized in that: the Butterworth Hatch of described freeze drying box and the condensation water vessel spray head interior with being located at its body is communicated with.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010570513 CN101986071A (en) | 2010-12-02 | 2010-12-02 | Lyophilizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010570513 CN101986071A (en) | 2010-12-02 | 2010-12-02 | Lyophilizer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101986071A true CN101986071A (en) | 2011-03-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010570513 Pending CN101986071A (en) | 2010-12-02 | 2010-12-02 | Lyophilizer |
Country Status (1)
| Country | Link |
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| CN (1) | CN101986071A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102628645A (en) * | 2012-04-24 | 2012-08-08 | 无锡凯夫制药有限公司 | Water outlet structure of freeze dryer |
| CN107120957A (en) * | 2017-05-16 | 2017-09-01 | 太极集团四川太极制药有限公司 | Injection solvent collection system and the freeze-drying system for including this system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407140A (en) * | 1979-07-04 | 1983-10-04 | Kyowa Vacuum Engineering, Ltd. | Vacuum apparatus |
| CN2352909Y (en) * | 1998-08-28 | 1999-12-08 | 张祯儒 | Freezing type drying machine |
| CN2416463Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Vacuum freezing dryer |
| CN2416462Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Cleaning structure for vacuum freezing dryer |
| CN2695888Y (en) * | 2004-04-29 | 2005-04-27 | 上海远东制药机械总厂 | Vacuum freezing drier |
| JP2010054064A (en) * | 2008-08-26 | 2010-03-11 | Kyowa Shinku Gijutsu Kk | Freeze drying method and freeze drying apparatus |
-
2010
- 2010-12-02 CN CN 201010570513 patent/CN101986071A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407140A (en) * | 1979-07-04 | 1983-10-04 | Kyowa Vacuum Engineering, Ltd. | Vacuum apparatus |
| CN2352909Y (en) * | 1998-08-28 | 1999-12-08 | 张祯儒 | Freezing type drying machine |
| CN2416463Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Vacuum freezing dryer |
| CN2416462Y (en) * | 2000-04-11 | 2001-01-24 | 北京天利医药设备有限公司 | Cleaning structure for vacuum freezing dryer |
| CN2695888Y (en) * | 2004-04-29 | 2005-04-27 | 上海远东制药机械总厂 | Vacuum freezing drier |
| JP2010054064A (en) * | 2008-08-26 | 2010-03-11 | Kyowa Shinku Gijutsu Kk | Freeze drying method and freeze drying apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102628645A (en) * | 2012-04-24 | 2012-08-08 | 无锡凯夫制药有限公司 | Water outlet structure of freeze dryer |
| CN107120957A (en) * | 2017-05-16 | 2017-09-01 | 太极集团四川太极制药有限公司 | Injection solvent collection system and the freeze-drying system for including this system |
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Application publication date: 20110316 |