CN101984989A - Gastrointestinal harmonizing oral liquid for treating gastrointestinal diseases - Google Patents
Gastrointestinal harmonizing oral liquid for treating gastrointestinal diseases Download PDFInfo
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- CN101984989A CN101984989A CN2010105009983A CN201010500998A CN101984989A CN 101984989 A CN101984989 A CN 101984989A CN 2010105009983 A CN2010105009983 A CN 2010105009983A CN 201010500998 A CN201010500998 A CN 201010500998A CN 101984989 A CN101984989 A CN 101984989A
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Abstract
The invention belongs to the technical field of Chinese patent medicines, and in particular relates to a gastrointestinal harmonizing oral liquid for treating gastrointestinal diseases. The gastrointestinal harmonizing oral liquid is prepared from the following raw materials by weight: 3 to 8g of vanilla flavour concentrate, 100 to 140g of baical skullcap root, 150 to 250g of large-head atractylodes rhizome, 100 to 180g of costustoot, 100 to 140g of giant knotweed rhizome, 100 to 140g of patchouli, 100 to 140g of corydalis tuber, 60 to 100g of Indian buead and 60 to 100g of liquoric root. The oral liquid is prepared by the following steps of: extracting volatile oil and aqueous solution from the large-head atractylodes rhizome, the costustoot and the patchouli for later use by a steam distillation method; performing reflux extraction on the baical skullcap root, the giant knotweed rhizome and the corydalis tuber with 70 percent ethanol; decocting the Indian buead and the liquoric root in water and extracting; removing impurities from each extract part; and combining the extract part with the vanilla flavour concentrate to prepare the oral liquid. The oral liquid is used for treating the gastrointestinal diseases caused by stagnation of dampness and heat, such as chronic gastritis, chronic enteritis, duodenal ulcer, irritable bowel syndrome and the like.
Description
Technical field
The invention belongs to Chinese patent drug technique field, be specially a kind of safe oral liquid of gastrointestinal for the treatment of gastroenteropathy.
Background technology
Gastroenteropathy is the common frequently-occurring disease of a class, and the sickness rate in the crowd is quite high because its cause of disease complexity, outbreak repeatedly, thus obstinate usually, have in addition initiation gastric cancer, intestinal cancer and threat to life.At present, the medicine that is used for the treatment of gastroenteropathy mainly contains Western medicine and Chinese patent medicine two big classes, because the general toxic and side effects of Western medicine is more, the patient usually is subjected to the restriction of some symptom when selecting medication, add that the medication cycle is long, have that many patients occur that ALT raises, dizzy, headache, feel sick, untoward reaction such as vomiting, constipation, diarrhoea, metal abnormal flavour and have no alternative but stopped treatment.Though and the Chinese patent medicine toxic and side effects is less, present product mostly is solid preparation, exists to absorb shortcomings such as slow, that drug effect concentration is low, effect is not obvious.Specially control the Chinese medicine preparation of gastric disease and manufacture method thereof, 93,110,022 1 kinds of " Weikang " capsules for the treatment of gastric ulcer of patent and preparation method thereof etc. as 96,112,372 1 kinds of patents.
Summary of the invention
Order of the present invention is in order to remedy the deficiency that prior art exists, a kind of safe oral liquid of gastrointestinal for the treatment of gastroenteropathy is provided, extract its active ingredient Rhizoma et radix valerianae oil (basil oil) by Rhizoma et radix valerianae (Herba Ocimi (Herba Ocimi Pilosi)) through scientific method and be primary raw material, be equipped with eight flavor purification of tcm such as Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae and form.Product need not dissolve and can directly act on gastrointestinal disease position and absorption once more, has the advantages that effect is fast, curative effect is high, toxic and side effects is few, is better than general similar solid preparation.
For achieving the above object, the technical scheme taked of the present invention is: the safe oral liquid of the gastrointestinal of this treatment gastroenteropathy is made by the raw material of following weight ratio:
Rhizoma et radix valerianae oil 3～8g Radix Scutellariae 100～140g Rhizoma Atractylodis Macrocephalae 150～250g
The Radix Aucklandiae 100～180g Rhizoma Polygoni Cuspidati 100～140g Herba Pogostemonis 100～140g
Rhizoma Corydalis 100～140g Poria 60～100g Radix Glycyrrhizae 60～100g;
Preparation method:
(1) get the fresh branch and leaf of Rhizoma et radix valerianae,, collect volatile oil, leave standstill, separate oil reservoir with steam distillation 2 hours, by anhydrous sodium sulfate pull-up water, Rhizoma et radix valerianae oil;
(2) taking by weighing Radix Scutellariae, Rhizoma Corydalis and Rhizoma Polygoni Cuspidati concentration in proportion is 70% alcohol reflux 4 times, each 1.5 hours, merge backflow, and filter filtrate for later use;
(3) take by weighing the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae and Herba Pogostemonis in proportion and add water distillation extraction in 6 hours volatile oil, the medicinal liquid after the distillation is standby; Medicinal residues and Poria, Radix Glycyrrhizae merge, and decoct with water 2 times each 2 hours, and collecting decoction leaves standstill, filter, filtrate and medicinal liquid merge, and being concentrated into relative density is 1.15 (70 ℃), puts cold, add ethanol and make it precipitation, leave standstill, filter, filtrate and step (2) gained ethanol extract merges, reclaim ethanol, leave standstill, filter, filtrate adds Rhizoma et radix valerianae oil and volatile oil, adding water to 1000ml, is 40% sodium hydroxide solution adjust pH to 5.0 with concentration, filters, packing, sterilization promptly gets product.
The safe oral liquid of the gastrointestinal of described treatment gastroenteropathy, wherein the weight ratio of each raw material is:
Rhizoma et radix valerianae oil 5g Radix Scutellariae 120g Rhizoma Atractylodis Macrocephalae 200g
Radix Aucklandiae 160g Rhizoma Polygoni Cuspidati 120g Herba Pogostemonis 120g
Rhizoma Corydalis 120g Poria 80g Radix Glycyrrhizae 80g.
Described Rhizoma et radix valerianae is the labiate Rhizoma et radix valerianae, also claims Herba Ocimi (Herba Ocimi Pilosi).
Effect of the present invention is to draft according to pharmacodynamics and pharmacological achievement in research.Pharmacodynamic study shows that this product has antiulcer, regulates gastrointestinal motility, suppresses gastric secretion, reduces gastric acidity, suppresses pepsin activity, and analgesia, antiinflammatory and bacteriostatic effect.Pharmacology's acute toxicity test and long term toxicity test research prompting, this product safety non-toxic can be for clinical use.
Purposes of the present invention is the treatment gastroenteropathy, and product has heat clearing and damp drying, promoting the circulation of QI to relieve pain, the effect of invigorating the spleen and regulating the stomach.Be used for because of the gastralgia due to the damp-heat accumulation, distension and fullness in the abdomen, the xerostomia mouth if, belch acid regurgitation, anorexia, diseases such as yellowish fur; Chronic superficial gastritis, gastric and duodenal ulcers are seen above-mentioned patient.Have the advantages that effect is fast, curative effect is high, toxic and side effects is few, especially be fit to cureless patient and use.
Usage and dosage of the present invention is: oral, and a 20ml, 2-3 time on the one, (medicine) being taken before meal is used.The careful usefulness of anemia of pregnant woman.
Comprehensive therapeutic effect of the present invention: through first phase clinical observation case 60 examples, 20 examples of fully recovering, produce effects 25 examples, effective 11 examples, invalid 4 examples, clinical recovery rate are 33.3%, total effective rate is 93.3%.Be 90-98% wherein to syndromic improvement rate; Effective percentage to chronic superficial gastritis is 95.0%; Effective percentage to gastric ulcer is 95.0%; Effective percentage to duodenal ulcer is 90.0%.The result shows, the oral liquid of this treatment gastroenteropathy is to the gastric abscess being chronic superficial gastritis, the gastric and duodenal ulcers of primary symptom, the patient that Chinese medical discrimination belongs to the disease of burnt stomach in the damp and hot retardance has definite clinical efficacy, can effectively improve patient's clinical symptoms, reduce inflammation and the ulcer pathological changes, improve patient's quality of life, be worth further exploitation, so that apply.
The specific embodiment
The safe oral liquid of gastrointestinal that the present invention treats gastroenteropathy is to be made by the raw material of following weight ratio:
Rhizoma et radix valerianae oil 5g, Radix Scutellariae 120g, Rhizoma Atractylodis Macrocephalae 200g, Radix Aucklandiae 160g, Rhizoma Polygoni Cuspidati 120g, Herba Pogostemonis 120g, Rhizoma Corydalis 120g, Poria 80g, Radix Glycyrrhizae 80g;
Preparation method:
(1) get the fresh branch and leaf of Herba Ocimi (Herba Ocimi Pilosi) (Ocimum basilicum Lnn),, collect volatile oil, leave standstill, separate oil reservoir with steam distillation 2 hours, by anhydrous sodium sulfate pull-up water, Rhizoma et radix valerianae oil;
(2) taking by weighing Radix Scutellariae, Rhizoma Corydalis and Rhizoma Polygoni Cuspidati concentration in proportion is 70% alcohol reflux 4 times, each 1.5 hours, merge backflow, and filter filtrate for later use;
(3) take by weighing the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae and Herba Pogostemonis in proportion and add water distillation extraction in 6 hours volatile oil, the medicinal liquid after the distillation is standby; Medicinal residues and Poria, Radix Glycyrrhizae merge, and decoct with water 2 times each 2 hours, and collecting decoction leaves standstill, filter, filtrate and medicinal liquid merge, and being concentrated into relative density is 1.15 (70 ℃), puts cold, add ethanol and make it precipitation, leave standstill, filter, filtrate and step (2) gained ethanol extract merges, reclaim ethanol, leave standstill, filter, filtrate adds Rhizoma et radix valerianae oil and volatile oil, adding water to 1000ml, is 40% sodium hydroxide solution adjust pH to 5.0 with concentration, filters, packing, sterilization promptly gets product.
Claims (3)
1. safe oral liquid of the gastrointestinal for the treatment of gastroenteropathy, make by the raw material of following weight ratio:
Rhizoma et radix valerianae oil 3～8g Radix Scutellariae 100～140g Rhizoma Atractylodis Macrocephalae 150～250g
The Radix Aucklandiae 100～180g Rhizoma Polygoni Cuspidati 100～140g Herba Pogostemonis 100～140g
Rhizoma Corydalis 100～140g Poria 60～100g Radix Glycyrrhizae 60～100g;
Preparation method:
(1) get the fresh branch and leaf of Rhizoma et radix valerianae,, collect volatile oil, leave standstill, separate oil reservoir with steam distillation 2 hours, by anhydrous sodium sulfate pull-up water, Rhizoma et radix valerianae oil;
(2) taking by weighing Radix Scutellariae, Rhizoma Corydalis and Rhizoma Polygoni Cuspidati concentration in proportion is 70% alcohol reflux 4 times, each 1.5 hours, merge backflow, and filter filtrate for later use;
(3) take by weighing the Radix Aucklandiae, the Rhizoma Atractylodis Macrocephalae and Herba Pogostemonis in proportion and add water distillation extraction in 6 hours volatile oil, the medicinal liquid after the distillation is standby; Medicinal residues and Poria, Radix Glycyrrhizae merge, and decoct with water 2 times each 2 hours, and collecting decoction leaves standstill, filter, filtrate and medicinal liquid merge, and being concentrated into relative density is 1.15, puts cold, add ethanol and make it precipitation, leave standstill, filter, filtrate and step (2) gained ethanol extract merges, reclaim ethanol, leave standstill, filter, filtrate adds Rhizoma et radix valerianae oil and volatile oil, adding water to 1000ml, is 40% sodium hydroxide solution adjust pH to 5.0 with concentration, filters, packing, sterilization promptly gets product.
2. according to the safe oral liquid of the gastrointestinal of the described treatment gastroenteropathy of claim 1, it is characterized in that: the weight ratio of each raw material is:
Rhizoma et radix valerianae oil 5g Radix Scutellariae 120g Rhizoma Atractylodis Macrocephalae 200g
Radix Aucklandiae 160g Rhizoma Polygoni Cuspidati 120g Herba Pogostemonis 120g
Rhizoma Corydalis 120g Poria 80g Radix Glycyrrhizae 80g.
3. according to the safe oral liquid of the gastrointestinal of claim 1 or 2 described treatment gastroenteropathys, it is characterized in that: described Rhizoma et radix valerianae is the labiate Rhizoma et radix valerianae, also claims Herba Ocimi (Herba Ocimi Pilosi).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105009983A CN101984989A (en) | 2010-09-26 | 2010-09-26 | Gastrointestinal harmonizing oral liquid for treating gastrointestinal diseases |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105009983A CN101984989A (en) | 2010-09-26 | 2010-09-26 | Gastrointestinal harmonizing oral liquid for treating gastrointestinal diseases |
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| CN101984989A true CN101984989A (en) | 2011-03-16 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825691A (en) * | 2015-05-30 | 2015-08-12 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating duodenal ulcer and application of traditional Chinese medicine composition |
| CN105250881A (en) * | 2015-11-18 | 2016-01-20 | 包莉丽 | Medicine for treating chronic superficial gastritis |
-
2010
- 2010-09-26 CN CN2010105009983A patent/CN101984989A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825691A (en) * | 2015-05-30 | 2015-08-12 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine composition for treating duodenal ulcer and application of traditional Chinese medicine composition |
| CN105250881A (en) * | 2015-11-18 | 2016-01-20 | 包莉丽 | Medicine for treating chronic superficial gastritis |
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Open date: 20110316 |