CN101983068B - N末端和c末端取代的人gh-rh拮抗类似物 - Google Patents

N末端和c末端取代的人gh-rh拮抗类似物 Download PDF

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Publication number
CN101983068B
CN101983068B CN200980111242.5A CN200980111242A CN101983068B CN 101983068 B CN101983068 B CN 101983068B CN 200980111242 A CN200980111242 A CN 200980111242A CN 101983068 B CN101983068 B CN 101983068B
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CN
China
Prior art keywords
boc
arg
peptide
ala
tyr
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CN200980111242.5A
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English (en)
Chinese (zh)
Other versions
CN101983068A (zh
Inventor
A·V·沙利
J·L·瓦格加
M·扎兰蒂
蔡仁治
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University of Miami
United States Department of Veterans Affairs
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University of Miami
United States Department of Veterans Affairs
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN200980111242.5A 2008-03-28 2009-03-26 N末端和c末端取代的人gh-rh拮抗类似物 Active CN101983068B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4041808P 2008-03-28 2008-03-28
US61/040,418 2008-03-28
PCT/US2009/038351 WO2009120831A2 (en) 2008-03-28 2009-03-26 Novel n-and c-terminal substituted antagonistic analogs of gh-rh

Publications (2)

Publication Number Publication Date
CN101983068A CN101983068A (zh) 2011-03-02
CN101983068B true CN101983068B (zh) 2014-12-24

Family

ID=40886425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980111242.5A Active CN101983068B (zh) 2008-03-28 2009-03-26 N末端和c末端取代的人gh-rh拮抗类似物

Country Status (11)

Country Link
US (1) US8227405B2 (cg-RX-API-DMAC10.html)
EP (1) EP2288374B1 (cg-RX-API-DMAC10.html)
JP (1) JP5588963B2 (cg-RX-API-DMAC10.html)
CN (1) CN101983068B (cg-RX-API-DMAC10.html)
AU (1) AU2009228244A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0910873A2 (cg-RX-API-DMAC10.html)
CA (1) CA2718146C (cg-RX-API-DMAC10.html)
IL (1) IL208099A0 (cg-RX-API-DMAC10.html)
MX (1) MX2010010642A (cg-RX-API-DMAC10.html)
WO (1) WO2009120831A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201006843B (cg-RX-API-DMAC10.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691942B2 (en) * 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
CN104582796A (zh) * 2012-06-27 2015-04-29 迈阿密大学 治疗阿尔茨海默病的组合物和方法
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
CA3129405A1 (en) * 2019-02-08 2020-08-13 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
WO2021011874A1 (en) 2019-07-18 2021-01-21 University Of Miami Ghrh antagonists for use in a method of treating sarcoidosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
WO1997042223A1 (en) * 1996-05-03 1997-11-13 The Administrators Of The Tulane Educational Fund hGH-RH(1-29)NH2 ANALOGUES HAVING ANTAGONISTIC ACTIVITY
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016923A1 (en) * 1990-05-04 1991-11-14 The Administrators Of The Tulane University Educational Fund Novel synthetic grf analogs
WO1997042223A1 (en) * 1996-05-03 1997-11-13 The Administrators Of The Tulane Educational Fund hGH-RH(1-29)NH2 ANALOGUES HAVING ANTAGONISTIC ACTIVITY
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Also Published As

Publication number Publication date
WO2009120831A2 (en) 2009-10-01
WO2009120831A8 (en) 2010-09-30
US8227405B2 (en) 2012-07-24
JP2011517675A (ja) 2011-06-16
ZA201006843B (en) 2012-03-28
WO2009120831A3 (en) 2009-12-23
CA2718146A1 (en) 2009-10-01
US20100092539A1 (en) 2010-04-15
CN101983068A (zh) 2011-03-02
IL208099A0 (en) 2010-12-30
MX2010010642A (es) 2011-03-29
CA2718146C (en) 2016-09-20
EP2288374A2 (en) 2011-03-02
JP5588963B2 (ja) 2014-09-10
BRPI0910873A2 (pt) 2015-10-06
AU2009228244A1 (en) 2009-10-01
EP2288374B1 (en) 2017-02-01

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