CN101982190A - External cream for treating wind cold by utilizing percutaneous absorption technology - Google Patents
External cream for treating wind cold by utilizing percutaneous absorption technology Download PDFInfo
- Publication number
- CN101982190A CN101982190A CN2010105218090A CN201010521809A CN101982190A CN 101982190 A CN101982190 A CN 101982190A CN 2010105218090 A CN2010105218090 A CN 2010105218090A CN 201010521809 A CN201010521809 A CN 201010521809A CN 101982190 A CN101982190 A CN 101982190A
- Authority
- CN
- China
- Prior art keywords
- cream
- external
- cold
- exogenous wind
- percutaneous absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006071 cream Substances 0.000 title claims abstract description 26
- 238000010521 absorption reaction Methods 0.000 title abstract description 10
- 238000005516 engineering process Methods 0.000 title abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 26
- 230000000694 effects Effects 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229940099259 vaseline Drugs 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims description 19
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 229960005489 paracetamol Drugs 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- -1 as vaseline Substances 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 8
- 206010037660 Pyrexia Diseases 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 3
- 208000011580 syndromic disease Diseases 0.000 abstract description 3
- 210000001061 forehead Anatomy 0.000 abstract description 2
- 239000003390 Chinese drug Substances 0.000 abstract 1
- 241001180876 Saposhnikovia Species 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
- 235000019477 peppermint oil Nutrition 0.000 abstract 1
- 239000001335 perilla frutescens leaf extract Substances 0.000 abstract 1
- 239000008155 medical solution Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
External cream for treating wind cold by utilizing percutaneous absorption technology belongs to the external drugs. The cream external drug is prepared by extracting such traditional Chinese drug components as fineleaf schizonepeta herb, herba ephedrae, radix bupleuri, divaricate saposhnikovia root and the like, mixing the extract liquor with peppermint oil, perilla leaf oil, alcohol and the like and adding the cream matrices such as Vaseline, etc. The cream adopts the percutaneous absorption technology, is applied on the foreheads, temples or armpits of the patient children, has the functions of relieving exterior syndrome with herbs pungent in taste and warm in nature and dispelling cold and dissipating heat, reduces fever from interior to exterior, treat both the incidental and fundamental aspects and has curative effect on the wind cold. Adopting percutaneous absorption, the cream does not need to be taken orally, thus being especially suitable for infants. The unique external cream is administrated to treat cold, therefore, the drug is easy to be smeared on the skin, the drug components can maintain longer time for the skin to absorb and the drug is simpler to use.
Description
Technical field the present invention relates to a kind of medicine for external use.
During the background technology treating baby's cold because thoughtless, the very difficulty of taking medicine, and have an injection or intravenous injection both dangerous, more increase child's misery.The existing defervescence plaster used method that only is employing physics dispels the heat in market is lowered the temperature, and purpose is to bring down a fever and fundamentally treats flu.And if adopt the mode of lotion, then liquid medicine evaporates exsiccation easily, is difficult to make ingredient to keep for skin absorbs for a long time.
Summary of the invention the object of the invention is to disclose a kind of external-application cream that is used for the treatment of affection of exogenous wind-cold type flu.
Cream of the present invention, it consists of by mass: have treatment affection of exogenous wind-cold type flu effect Chinese medicine extraction liquid 20-40, Oleum menthae 1-10, Folium perillae acutae oil 1-10, ethanol 10-20, cream base is replenished and is added to 100%.
The Chinese medicine extraction liquid that wherein has treatment wind-chill cold effect is to adopt Herba Schizonepetae, Herba Ephedrae, Radix Bupleuri, Radix Saposhnikoviae to add 10-20 part water through infusion, filtration and concentrated 3 parts of medicinal liquids obtaining for each 1 part.
Cream base can adopt the common used material that is fit to do cream, as vaseline, and glycerol, liquid paraffin etc.
In above-mentioned cream, also can add acetaminophen by the mass percent of 1%-5%.
Processing technique is: Chinese medicine is obtained Chinese medicine extraction liquid through soaking the infusion filtering and concentrating; Adding ethanol, Oleum menthae, Folium perillae acutae oil dissolving are mixed into admixing medical solutions, and cream base is heated to be liquid state, constantly stir while add admixing medical solutions, make the material uniform mixing become white shape; Be cooled to room temperature sealing bottling and become finished product.During use this product being applied in forehead, temple or oxter etc. locates.Available wet towel is wiped clean gently after a period of time, smears again when needing again.
The present invention adopts transdermal drag delivery, and Herba Schizonepetae, Herba Ephedrae, Radix Bupleuri, Radix Saposhnikoviae have relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, and the heat radiation function of dispeling cold is treatment anemofrigid cold conventional Chinese medicine.Herba Menthae has the effect of inducing sweat, and acetaminophen is the medicine commonly used of bringing down a fever.When being used in combination, Oleum menthae can promote the Transdermal absorption of acetaminophen; Folium perillae acutae oil can promote the Transdermal absorption of other compositions, and self is also produced the effect of inducing sweat of dispeling cold easily after the Transdermal absorption.And alcoholic solution is the solvent of other compositions, can help other compositions to carry out Transdermal absorption, the effect that can produce Physical temperature-lowering after using simultaneously on skin.So, external-application cream of the present invention had both had the Physical temperature-lowering effect of bringing down a fever, and can carry out relieving the exterior syndrome with drugs of pungent in flavor and warm in nature with the Chinese medicine Transdermal absorption, the heat radiation of dispeling cold, inside and outside rule together, treatment affection of exogenous wind-cold type is had obvious curative effects, effective percentage is more than 90%, and owing to adopt Transdermal absorption, though effect is slower, need not take orally, be particularly suitable for infant and use.And the mode that adopts the cream drug treatment to catch a cold innovatively can make medicine spread upon easily on the skin, and ingredient can keep the long period for skin absorbs, uses also simpler.
The specific embodiment
Embodiment 1:
1, choose respectively 1 kilogram of Herba Schizonepetae, Herba Ephedrae, Radix Bupleuri, Radix Saposhnikoviae, soaked 3 hours in 10 kg of water, heating was boiled 3 hours, poured out medicinal liquid, added 5 kilograms of decocting in water again 1 hour, poured out medicinal liquid.Merge medicinal liquid twice, cross the elimination medicinal residues.Again medicinal liquid is left standstill allowed in 3 hours its precipitation, get top clear liquid.Clear liquid heating is made the medicinal liquid evaporation again, stop when medicinal liquid is evaporated to about 3 kilograms (litres), it is standby to be cooled to room temperature.Perhaps adopt the Chinese medicine of other treatment anemofrigid cold to add and subtract, reason is the same, all belongs to the Chinese medicine current techique.
2, above-mentioned Chinese medicine extraction liquid adds 1.5 kilograms ethanol, and the Oleum menthae of 0.3 kilogram Folium perillae acutae oil and 0.2 kilogram stirs and makes abundant dissolving.Obtain about 5 kilograms admixing medical solutions.
3,5 kilograms of Bai Fanlin are heated to be liquid state,,, make each material uniform mixing become white shape ointment Yi Bian constantly stir Yi Bian add 5 kilograms of above-mentioned admixing medical solutions; White vaseline also can adopt glycerol, and other are fit to do the material of cream base liquid paraffin etc.
4, white shape ointment is cooled to room temperature; The sealing bottling becomes finished product.
Embodiment 2:
In the obtained admixing medical solutions of the 1st embodiment the 2nd step, add 0.1 kilogram acetaminophen again, fully mix, proceed the 3rd, the 4th step again.Then obtain and have the bring down a fever cream type medicine for external use of composition of Western medicine.
Claims (4)
1. one kind is adopted transdermal drag delivery to treat the external-application cream that the affection of exogenous wind-cold type is caught a cold, it consists of by mass: have treatment affection of exogenous wind-cold type flu effect Chinese medicine extraction liquid 20-40, Oleum menthae 1-10, Folium perillae acutae oil 1-10, ethanol 10-20, cream base is replenished and is added to 100%.
2. the external-application cream that employing transdermal drag delivery treatment affection of exogenous wind-cold type according to claim 1 is caught a cold, the Chinese medicine extraction liquid that wherein has treatment affection of exogenous wind-cold type flu effect are to adopt Herba Schizonepetae, Herba Ephedrae, Radix Bupleuri, Radix Saposhnikoviae to add water through infusion, filtration and the concentrated medicinal liquid of obtaining.
3. the external-application cream of employing transdermal drag delivery treatment affection of exogenous wind-cold type flu according to claim 1, the mass percent of also pressing 1%-5% adds acetaminophen.
4. the external-application cream of employing transdermal drag delivery treatment affection of exogenous wind-cold type flu according to claim 1, described cream base can adopt the common used material that is fit to do cream, as vaseline, glycerol, liquid paraffin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010521809A CN101982190B (en) | 2010-10-20 | 2010-10-20 | External cream for treating wind cold by utilizing percutaneous absorption technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010521809A CN101982190B (en) | 2010-10-20 | 2010-10-20 | External cream for treating wind cold by utilizing percutaneous absorption technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101982190A true CN101982190A (en) | 2011-03-02 |
| CN101982190B CN101982190B (en) | 2011-11-30 |
Family
ID=43619114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010521809A Expired - Fee Related CN101982190B (en) | 2010-10-20 | 2010-10-20 | External cream for treating wind cold by utilizing percutaneous absorption technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101982190B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288727A (en) * | 2014-10-13 | 2015-01-21 | 杭州莫诺生物科技有限公司 | Special healthy traditional Chinese medicine compound preparation for infantile common cold due to wind-cold |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579431A (en) * | 2003-08-12 | 2005-02-16 | 崔名全 | Cool cream |
-
2010
- 2010-10-20 CN CN201010521809A patent/CN101982190B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579431A (en) * | 2003-08-12 | 2005-02-16 | 崔名全 | Cool cream |
Non-Patent Citations (1)
| Title |
|---|
| 《武警医学》 20080115 王刚等 不同透皮吸收促进剂对扑热息痛体外经皮透过性影响的实验研究 17－19 1－4 第19卷, 第01期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288727A (en) * | 2014-10-13 | 2015-01-21 | 杭州莫诺生物科技有限公司 | Special healthy traditional Chinese medicine compound preparation for infantile common cold due to wind-cold |
| CN104288727B (en) * | 2014-10-13 | 2018-07-20 | 杭州莫诺生物科技有限公司 | A kind of dedicated compound Chinese medicinal preparation of chill cold in children health care |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101982190B (en) | 2011-11-30 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HUBEI JINGGENG BIOLOGICAL ENGINEERING CO., LTD. Free format text: FORMER OWNER: XU ROUYUN Effective date: 20130822 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
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Inventor after: Chen Geng Inventor before: Xu Rouyun |
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| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 515031 SHANTOU, GUANGDONG PROVINCE TO: 438400 HUANGGANG, HUBEI PROVINCE Free format text: CORRECT: INVENTOR; FROM: XU ROUYUN TO: CHEN GENG |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130822 Address after: 438400, No. 153 Yang Fu Road, eight Li Wan, Hong'an County, Hubei Patentee after: HUBEI JINGGENG BIOLOGICAL ENGINEERING CO., LTD. Address before: 515031 Guangdong province Shantou Shanzhang Park Road No. 32, Room 301 Patentee before: Xu Rouyun |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111130 Termination date: 20161020 |
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| CF01 | Termination of patent right due to non-payment of annual fee |