CN101977972B - 包含反应性嵌段共聚物的涂覆溶液 - Google Patents

包含反应性嵌段共聚物的涂覆溶液 Download PDF

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Publication number
CN101977972B
CN101977972B CN2008801271893A CN200880127189A CN101977972B CN 101977972 B CN101977972 B CN 101977972B CN 2008801271893 A CN2008801271893 A CN 2008801271893A CN 200880127189 A CN200880127189 A CN 200880127189A CN 101977972 B CN101977972 B CN 101977972B
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CN
China
Prior art keywords
medical device
block
hydrophilic
reactive
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2008801271893A
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English (en)
Chinese (zh)
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CN101977972A (zh
Inventor
J·G·林哈特
D·A·希普
J·F·孔茨勒
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Bausch and Lomb Inc
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Bausch and Lomb Inc
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Priority claimed from US12/334,618 external-priority patent/US7942929B2/en
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Publication of CN101977972A publication Critical patent/CN101977972A/zh
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Publication of CN101977972B publication Critical patent/CN101977972B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C08F265/06—Polymerisation of acrylate or methacrylate esters on to polymers thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/0427—Coating with only one layer of a composition containing a polymer binder
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/056—Forming hydrophilic coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
    • C08J2333/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • C08J2333/16—Homopolymers or copolymers of esters containing halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2383/10—Block- or graft-copolymers containing polysiloxane sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2453/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Graft Or Block Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Paints Or Removers (AREA)
CN2008801271893A 2007-12-27 2008-12-16 包含反应性嵌段共聚物的涂覆溶液 Expired - Fee Related CN101977972B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1684507P 2007-12-27 2007-12-27
US61/016,845 2007-12-27
US12/334,618 US7942929B2 (en) 2007-12-27 2008-12-15 Coating solutions comprising segmented reactive block copolymers
US12/334,618 2008-12-15
PCT/US2008/086989 WO2009085755A1 (en) 2007-12-27 2008-12-16 Coating solutions comprising segmented reactive block copolymers

Publications (2)

Publication Number Publication Date
CN101977972A CN101977972A (zh) 2011-02-16
CN101977972B true CN101977972B (zh) 2013-03-27

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CN2008801271893A Expired - Fee Related CN101977972B (zh) 2007-12-27 2008-12-16 包含反应性嵌段共聚物的涂覆溶液

Country Status (4)

Country Link
EP (2) EP2235094A1 (enExample)
JP (1) JP2011508059A (enExample)
CN (1) CN101977972B (enExample)
WO (1) WO2009085755A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522980B2 (en) 2010-05-06 2016-12-20 Johnson & Johnson Vision Care, Inc. Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same
US20130203813A1 (en) 2011-05-04 2013-08-08 Johnson & Johnson Vision Care, Inc. Medical devices having homogeneous charge density and methods for making same
US9170349B2 (en) 2011-05-04 2015-10-27 Johnson & Johnson Vision Care, Inc. Medical devices having homogeneous charge density and methods for making same
US9505184B2 (en) * 2011-11-15 2016-11-29 Novartis Ag Silicone hydrogel lens with a crosslinked hydrophilic coating
JP2015526745A (ja) * 2012-05-25 2015-09-10 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｖｉｓｉｏｎ Ｃａｒｅ， Ｉｎｃ． 水溶性ｎ−（２ヒドロキシアルキル）（メタ）アクリルアミドポリマー又はコポリマーを含むコンタクトレンズ
US9297929B2 (en) 2012-05-25 2016-03-29 Johnson & Johnson Vision Care, Inc. Contact lenses comprising water soluble N-(2 hydroxyalkyl) (meth)acrylamide polymers or copolymers
US9244196B2 (en) 2012-05-25 2016-01-26 Johnson & Johnson Vision Care, Inc. Polymers and nanogel materials and methods for making and using the same
US10073192B2 (en) 2012-05-25 2018-09-11 Johnson & Johnson Vision Care, Inc. Polymers and nanogel materials and methods for making and using the same
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
AU2014236688B2 (en) 2013-03-21 2019-07-25 Shifamed Holdings, Llc Accommodating intraocular lens
CA2930552C (en) * 2013-11-15 2022-12-13 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
AU2015306613B2 (en) 2014-08-26 2018-01-25 Shifamed Holdings, Llc Accommodating intraocular lens
CN104844746B (zh) * 2015-05-05 2017-03-29 南开大学 一种具有多重刺激响应性的水溶性聚合物及其制备方法
FR3038903B1 (fr) * 2015-07-17 2019-05-24 Universite Du Mans Compose polyurethane ignifuge comprenant des elements oligomeres phosphores de longueur controlee
HK1251302A1 (zh) 2015-10-07 2019-01-25 株式会社实瞳 非含水性眼用镜片的制造方法和非含水性眼用镜片
FR3042794B1 (fr) * 2015-10-23 2020-03-27 Arkema France Procede permettant la creation de structures nanometriques par l'auto-assemblage de copolymeres di-blocs
CN108472129B (zh) 2015-11-18 2021-09-24 施菲姆德控股有限责任公司 组合的调节性人工晶状体
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
KR102089715B1 (ko) * 2016-06-22 2020-03-16 주식회사 엘지화학 공중합체, 이의 제조 방법, 및 이를 포함하는 친수성 코팅 조성물
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
JP6954679B2 (ja) 2016-12-23 2021-10-27 シファメド・ホールディングス・エルエルシー マルチピース調節式眼内レンズ、及び同を作成し、使用するための方法
JP7370052B2 (ja) 2017-05-30 2023-10-27 シファメド・ホールディングス・エルエルシー 調節眼内レンズのための表面処理ならびに関連する方法およびデバイス
JP7082822B2 (ja) 2017-06-07 2022-06-09 シファメド・ホールディングス・エルエルシー 調整可能な屈折力の眼内レンズ
US10836928B2 (en) * 2017-12-15 2020-11-17 Ppg Industries Ohio, Inc. Polyoxazoline curing for packaging coating compositions
CN109820625A (zh) * 2018-09-30 2019-05-31 四川大学 一种交联的人工生物瓣膜处理方法
DE102018127812B4 (de) * 2018-11-07 2020-06-18 Fachhochschule Kiel Kontaktlinse mit einer Oberflächenbeschichtung und Herstellungsverfahren
CN116157434A (zh) * 2020-09-03 2023-05-23 大金工业株式会社 有机硅共聚物
US20250321364A1 (en) * 2024-04-15 2025-10-16 Bausch + Lomb Ireland Limited Surface modified ophthalmic devices

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136250A (en) 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4153641A (en) 1977-07-25 1979-05-08 Bausch & Lomb Incorporated Polysiloxane composition and contact lens
US4355147A (en) 1981-02-26 1982-10-19 Bausch & Lomb Incorporated Polysiloxane with polycyclic modifier composition and biomedical devices
US4327203A (en) 1981-02-26 1982-04-27 Bausch & Lomb Incorporated Polysiloxane with cycloalkyl modifier composition and biomedical devices
US4740533A (en) 1987-07-28 1988-04-26 Ciba-Geigy Corporation Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof
US5270418A (en) 1987-04-02 1993-12-14 Bausch & Lomb Incorporated Polymer compositions for contact lenses
US4910277A (en) 1988-02-09 1990-03-20 Bambury Ronald E Hydrophilic oxygen permeable polymers
US4954587A (en) 1988-07-05 1990-09-04 Ciba-Geigy Corporation Dimethylacrylamide-copolymer hydrogels with high oxygen permeability
US5070215A (en) 1989-05-02 1991-12-03 Bausch & Lomb Incorporated Novel vinyl carbonate and vinyl carbamate contact lens material monomers
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
US5079319A (en) 1989-10-25 1992-01-07 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5010141A (en) 1989-10-25 1991-04-23 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5310779A (en) 1991-11-05 1994-05-10 Bausch & Lomb Incorporated UV curable crosslinking agents useful in copolymerization
US5358995A (en) 1992-05-15 1994-10-25 Bausch & Lomb Incorporated Surface wettable silicone hydrogels
US5260000A (en) 1992-08-03 1993-11-09 Bausch & Lomb Incorporated Process for making silicone containing hydrogel lenses
US5321108A (en) 1993-02-12 1994-06-14 Bausch & Lomb Incorporated Fluorosilicone hydrogels
US5616757A (en) 1993-04-08 1997-04-01 Bausch & Lomb Incorporated Organosilicon-containing materials useful for biomedical devices
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
ES2191779T3 (es) 1995-12-07 2003-09-16 Bausch & Lomb Composiciones de silicona polimeras con bajo contenido en agua y modulo reducido.
KR100468803B1 (ko) 1995-12-07 2005-04-19 바슈 앤드 롬 인코포레이티드 실리콘히드로겔의모듈러스를감소시키는데유용한단량체단위
US5708094A (en) 1996-12-17 1998-01-13 Bausch & Lomb Incorporated Polybutadiene-based compositions for contact lenses
CA2328897A1 (en) 1998-05-05 1999-11-11 Bausch & Lomb Incorporated Plasma surface treatment of silicone hydrogel contact lenses
US6550915B1 (en) 1998-12-21 2003-04-22 Bausch & Lomb Incorporated Surface treatment of fluorinated contact lens materials
US6213604B1 (en) 1999-05-20 2001-04-10 Bausch & Lomb Incorporated Plasma surface treatment of silicone hydrogel contact lenses with a flexible carbon coating
US6630243B2 (en) * 1999-05-20 2003-10-07 Bausch & Lomb Incorporated Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating
US6200626B1 (en) * 1999-05-20 2001-03-13 Bausch & Lomb Incorporated Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization
CN1313842C (zh) * 1999-10-12 2007-05-02 庄臣及庄臣视力保护公司 接触透镜涂层选择及其制造工艺
US6599559B1 (en) 2000-04-03 2003-07-29 Bausch & Lomb Incorporated Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers
US6428839B1 (en) 2000-06-02 2002-08-06 Bausch & Lomb Incorporated Surface treatment of medical device
US6891010B2 (en) 2001-10-29 2005-05-10 Bausch & Lomb Incorporated Silicone hydrogels based on vinyl carbonate endcapped fluorinated side chain polysiloxanes
US6958169B2 (en) 2002-12-17 2005-10-25 Bausch & Lomb Incorporated Surface treatment of medical device
JP2004339165A (ja) * 2003-05-16 2004-12-02 Asahi Kasei Corp 医療用具用コート材およびこれを用いた白血球除去フィルター
WO2005068571A1 (ja) * 2004-01-15 2005-07-28 Menicon Co., Ltd. 眼用レンズ表面のコーティング剤
WO2007024500A1 (en) * 2005-08-25 2007-03-01 Medtronic Vascular, Inc. Controlled radical polymerization-derived block copolymer compositions for medical device coatings
WO2007064594A2 (en) * 2005-11-29 2007-06-07 Bausch & Lomb Incorporated New coatings on ophthalmic lenses
US7811555B2 (en) * 2005-12-30 2010-10-12 Cordis Corporation Tri-branched biologically active copolymer
JP4832910B2 (ja) * 2006-01-31 2011-12-07 株式会社メニコン 眼用レンズ表面用コーティング剤およびそれにより得られる眼用レンズ

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Publication number Publication date
EP2235094A1 (en) 2010-10-06
EP2597113A1 (en) 2013-05-29
WO2009085755A1 (en) 2009-07-09
JP2011508059A (ja) 2011-03-10
CN101977972A (zh) 2011-02-16

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