CN101970497B - 抗‑EpCAM抗体及其用途 - Google Patents

抗‑EpCAM抗体及其用途 Download PDF

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Publication number
CN101970497B
CN101970497B CN200880015767.4A CN200880015767A CN101970497B CN 101970497 B CN101970497 B CN 101970497B CN 200880015767 A CN200880015767 A CN 200880015767A CN 101970497 B CN101970497 B CN 101970497B
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CN
China
Prior art keywords
antibody
epcam
seq
fragment
antibody fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880015767.4A
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English (en)
Chinese (zh)
Other versions
CN101970497A (zh
Inventor
A·M·安娜斯塔斯
F·派特隆泽里
R·德桑提斯
S·阿尔波提
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Pharmaceutical Co
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of CN101970497A publication Critical patent/CN101970497A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880015767.4A 2007-04-04 2008-04-02 抗‑EpCAM抗体及其用途 Expired - Fee Related CN101970497B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105628 2007-04-04
EP07105628.7 2007-04-04
PCT/EP2008/053913 WO2008122551A2 (en) 2007-04-04 2008-04-02 Anti-epcam antibody and uses thereof

Publications (2)

Publication Number Publication Date
CN101970497A CN101970497A (zh) 2011-02-09
CN101970497B true CN101970497B (zh) 2017-05-10

Family

ID=38458122

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880015767.4A Expired - Fee Related CN101970497B (zh) 2007-04-04 2008-04-02 抗‑EpCAM抗体及其用途

Country Status (21)

Country Link
US (1) US8318911B2 (cg-RX-API-DMAC7.html)
EP (1) EP2142570B1 (cg-RX-API-DMAC7.html)
JP (1) JP5631733B2 (cg-RX-API-DMAC7.html)
KR (1) KR101683884B1 (cg-RX-API-DMAC7.html)
CN (1) CN101970497B (cg-RX-API-DMAC7.html)
AT (1) ATE512988T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008235566B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0810096A8 (cg-RX-API-DMAC7.html)
CA (1) CA2682296C (cg-RX-API-DMAC7.html)
CY (1) CY1111819T1 (cg-RX-API-DMAC7.html)
DK (1) DK2142570T3 (cg-RX-API-DMAC7.html)
EA (1) EA023679B1 (cg-RX-API-DMAC7.html)
ES (1) ES2367675T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20110620T1 (cg-RX-API-DMAC7.html)
IL (1) IL201196A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009010444A (cg-RX-API-DMAC7.html)
PL (1) PL2142570T3 (cg-RX-API-DMAC7.html)
PT (1) PT2142570E (cg-RX-API-DMAC7.html)
RS (1) RS52040B (cg-RX-API-DMAC7.html)
SI (1) SI2142570T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008122551A2 (cg-RX-API-DMAC7.html)

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CA2513747C (en) 2003-01-24 2017-03-07 University Of Utah Methods of predicting mortality risk by determining telomere length
AU2009329987B2 (en) 2008-12-22 2016-08-04 University Of Utah Research Foundation Monochrome multiplex quantitative PCR
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
JP6400470B2 (ja) * 2011-05-16 2018-10-03 ジェネロン（シャンハイ）コーポレイション リミテッド 多重特異性Ｆａｂ融合タンパク質および使用法
CN110763842A (zh) 2011-06-29 2020-02-07 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
EP2819695B1 (en) * 2012-03-02 2018-06-27 Academia Sinica ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
JP6546158B2 (ja) 2013-05-22 2019-07-17 テロメア ダイアグノスティクス インコーポレイテッド 短いテロメアの存在量の測定
EP3126814B1 (en) 2014-04-01 2019-06-12 Academia Sinica Methods and systems for cancer diagnosis and prognosis
EP2998026B1 (en) 2014-08-26 2024-01-17 Academia Sinica Collector architecture layout design
CN107208145A (zh) 2014-12-30 2017-09-26 端粒诊断公司 多重定量pcr
EP3328897A1 (en) * 2015-07-31 2018-06-06 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
WO2017173091A1 (en) * 2016-03-30 2017-10-05 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
US20190262397A1 (en) 2016-07-26 2019-08-29 Tessa Therapeutics Pte. Ltd. Chimeric antigen receptor
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
AU2019402097A1 (en) 2018-12-17 2021-06-10 Revitope Limited Twin immune cell engager
CN113597432B (zh) * 2019-04-22 2023-05-02 江苏恒瑞医药股份有限公司 抗EpCAM抗体及其应用
CN114026127B (zh) 2019-06-11 2024-10-29 生物蛋白有限公司 条件活性抗epcam抗体、抗体片段、其免疫缀合物以及其用途
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体
WO2022037323A1 (zh) * 2020-08-19 2022-02-24 上海易慕峰生物科技有限公司 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1976951A (zh) * 2004-02-13 2007-06-06 米克罗麦特股份公司 抗EpCAM免疫球蛋白

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US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
IT1245748B (it) 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
US5578287A (en) * 1992-06-09 1996-11-26 Neorx Corporation Three-step pretargeting methods using improved biotin-active agent
JP3427871B2 (ja) * 1996-06-24 2003-07-22 戸田工業株式会社 コバルト被着型針状磁性酸化鉄粒子粉末
ITRM20010079A1 (it) 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.
US7435804B2 (en) * 2004-10-19 2008-10-14 Phage Biotechnology, Inc. Method for obtaining single chain antibodies to human interferon α2b

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1976951A (zh) * 2004-02-13 2007-06-06 米克罗麦特股份公司 抗EpCAM免疫球蛋白

Non-Patent Citations (3)

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Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon,stomach,prostate and lung cancers;P Went，et al;《British Journal of Cancer》;20061231;第94卷;第128-135页 *
Mab17-1A and cytokines for the treatment of patients with colorectal carcinoma;Jan-Erik Frodin,et al;《Hybridoma and Hybridomics》;20021231;第21卷(第2期);第99-101页 *
人上皮细胞黏附分子融合蛋白真核表达载体的构建_表达及初步鉴定;王春艳，等;《细胞与分子免疫学杂志》;20041231;第20卷(第6期);第765-768页 *

Also Published As

Publication number Publication date
KR20100016237A (ko) 2010-02-12
RS52040B (sr) 2012-04-30
JP5631733B2 (ja) 2014-11-26
PL2142570T3 (pl) 2011-11-30
AU2008235566B2 (en) 2013-06-06
ES2367675T3 (es) 2011-11-07
PT2142570E (pt) 2011-09-13
WO2008122551A9 (en) 2009-02-05
KR101683884B1 (ko) 2016-12-07
IL201196A0 (en) 2010-05-17
EP2142570B1 (en) 2011-06-15
US8318911B2 (en) 2012-11-27
JP2010523096A (ja) 2010-07-15
AU2008235566A1 (en) 2008-10-16
EA023679B1 (ru) 2016-06-30
EP2142570A2 (en) 2010-01-13
CA2682296A1 (en) 2008-10-16
MX2009010444A (es) 2009-10-20
BRPI0810096A8 (pt) 2017-12-26
CA2682296C (en) 2017-02-28
CN101970497A (zh) 2011-02-09
US20100092491A1 (en) 2010-04-15
SI2142570T1 (sl) 2012-01-31
CY1111819T1 (el) 2015-10-07
ATE512988T1 (de) 2011-07-15
EA200970923A1 (ru) 2010-04-30
WO2008122551A2 (en) 2008-10-16
BRPI0810096A2 (pt) 2014-10-21
HRP20110620T1 (hr) 2011-09-30
DK2142570T3 (da) 2011-10-03
WO2008122551A3 (en) 2008-12-04

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