CN101965913A - Production method for tasteless enteric enrofloxacin microcapsules - Google Patents
Production method for tasteless enteric enrofloxacin microcapsules Download PDFInfo
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- CN101965913A CN101965913A CN2010105125310A CN201010512531A CN101965913A CN 101965913 A CN101965913 A CN 101965913A CN 2010105125310 A CN2010105125310 A CN 2010105125310A CN 201010512531 A CN201010512531 A CN 201010512531A CN 101965913 A CN101965913 A CN 101965913A
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- enrofloxacin
- stearic acid
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Abstract
The invention relates to a production method for tasteless enteric enrofloxacin microcapsules, which comprises the following technical steps: (1) dissolving enrofloxacin to alkali liquor and adding stearic acid in a molten state for a first envelop; (2) mixing with auxiliary materials for pelletizing and rounding, and adding a coating agent for a second layer of envelop in the course of rounding; and (3) baking semi-finished products to obtain finished products. The production method of the invention has the advantages that macromolecular substances are utilized to envelop the enrofloxacin to isolate the enrofloxacin from the external environment, thus not only covering the strong bitterness of the enrofloxacin, but also having no influence on feed palatability; and the enveloped enrofloxacin microcapsules are not dissolved in the acid environment and gradually dissolved in the alkaline environment of the intestinal tract so as to reach the purpose of slow release and prolong the action time of the enrofloxacin.
Description
Technical field
The present invention relates to feed and field of feed additive technology, relate in particular to the production method of tasteless enteric 'Ennoxacin ' micro-capsule.
Background technology
Enrofloxacin has another name called ethyl Ciprofloxacin, Enrofloxacin, and systematic naming method is 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1, and 4-dihydro-4-oxo-3-quinoline carboxylic acid is appointed as the animal specific medicine by country at present.Enrofloxacin is the broad-spectrum sterilization medicine, and mycoplasma is had special efficacy, and Escherichia coli, golden Portugal bacterium, streptococcus etc. are all had sterilization effectiveness.But Enrofloxacin has strong bitter taste, adds the feed intake that has a strong impact on pig in the feed to, causes this product to can not get using in the pig farm.
Summary of the invention
Above-mentioned defective at existing Enrofloxacin existence, applicant of the present invention has carried out improving research, a kind of production method of tasteless enteric 'Ennoxacin ' micro-capsule is provided, can cover the strong bitter taste of Enrofloxacin fully, and product is not dissolved in sour environment, in the enteron aisle alkaline environment, dissolve gradually, reach the purpose of slowly-releasing, prolong action time.
Originally it is as follows to put the technical scheme that invention adopts:
A kind of production method of tasteless enteric 'Ennoxacin ' micro-capsule, preparation process is as follows:
(1) ground floor bag quilt:
Take by weighing the recipe quantity Enrofloxacin, be dissolved in the sodium hydroxide solution of 1～1.2mol/l,, stir under the room temperature, make Enrofloxacin stearic acid mixture in 45～55 ℃ of stearic acid that add molten condition down;
(2) granulation and second layer bag quilt:
The Enrofloxacin stearic acid mixture adding starch that step (1) makes is granulated with round as a ball, in round as a ball process,, obtain the microcapsule granule of almost spherical at particle surface spraying acrylic resin;
(3) oven dry:
'Ennoxacin ' micro-capsule particle semi-finished product oven dry with step (2) makes obtains final finished;
The mass ratio of described each composition is an Enrofloxacin: sodium hydroxide solution: stearic acid: starch: acrylic resin=50～70: 4～6: 8～12: 10～25: 2～12.
Its further technical scheme is: the diameter of microcapsule granule is 50～400 μ m in the described step (2).
Useful technique effect of the present invention is:
The present invention wraps up dissolved state Enrofloxacin molecule earlier with the polymer substance stearic acid, again in the agent of Enrofloxacin particle surface spraying one deck enteric coating, Enrofloxacin and external environment is isolated in the round as a ball process of granulating.Behind bilayer bag quilt, can cover the strong bitter taste of Enrofloxacin fully, and because the characteristic of second layer enteric coating agent acrylic resin is not dissolved product in sour environment, dissolving gradually in the enteron aisle alkaline environment, reach the purpose of slowly-releasing, prolonged the action time of Enrofloxacin.
Description of drawings
Fig. 1 is a process chart of the present invention.
Fig. 2 is the absorption characteristic figure of different processing technology Enrofloxacins.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described.
As shown in Figure 1, process of the present invention is divided following three steps:
One, Enrofloxacin ground floor bag quilt: take by weighing the former powder of recipe quantity Enrofloxacin earlier, be dissolved in 1～1.2mol/l sodium hydroxide solution, add the stearic acid (50 ℃) of molten condition, stir under the room temperature (temperature is reduced to normal temperature), make Enrofloxacin stearic acid mixture;
Two, Enrofloxacin stearic acid mixture is granulated and second layer bag quilt: above-mentioned mixture is added appropriate amount of auxiliary materials starch granulate with round as a ball, in round as a ball process, at particle surface spraying second layer enteric coating agent acrylic resin, obtain the microcapsule granule of almost spherical, the microcapsule granule diameter is 50～400 μ m.
Three, oven dry:, obtain final finished with the above-mentioned tasteless enteric 'Ennoxacin ' micro-capsule semi-finished product oven dry that obtains.
In order better to explain the present invention, the present invention will be further described below in conjunction with the specific embodiment.
Take by weighing the 50kg Enrofloxacin earlier, be dissolved in the sodium hydroxide solution that 4kg concentration is 1mol/l,, stir under the room temperature, make Enrofloxacin stearic acid mixture in 45 ℃ of stearic acid that add the 8kg molten condition down.Above-mentioned Enrofloxacin stearic acid mixture is added 25kg starch granulates with round as a ball as auxiliary material, in round as a ball process, at particle surface spraying 12kg second layer enteric coating agent acrylic resin, obtain the microcapsule granule of almost spherical, the microcapsule granule diameter is 50～400 μ m.Tasteless enteric 'Ennoxacin ' micro-capsule particle semi-finished product oven dry with obtaining obtains final finished.
Take by weighing the 60kg Enrofloxacin earlier, being dissolved in 5kg concentration is in the 1.1mol/l sodium hydroxide solution, in 50 ℃ of stearic acid that add the 10kg molten condition down, stirs under the room temperature, makes Enrofloxacin stearic acid mixture.Above-mentioned Enrofloxacin stearic acid mixture is added 10kg starch granulates with round as a ball as auxiliary material, in round as a ball process, at particle surface spraying 5kg second layer enteric coating agent acrylic resin, obtain the microcapsule granule of almost spherical, the microcapsule granule diameter is 50～400 μ m.Tasteless enteric 'Ennoxacin ' micro-capsule particle semi-finished product oven dry with obtaining obtains final finished.
Embodiment 3
Take by weighing the 70kg Enrofloxacin earlier, being dissolved in 6kg concentration is in the 1.2mol/l sodium hydroxide solution, in 55 ℃ of stearic acid that add the 12kg molten condition down, stirs under the room temperature, makes Enrofloxacin stearic acid mixture.Above-mentioned Enrofloxacin stearic acid mixture is added 10kg starch granulates with round as a ball as auxiliary material, in round as a ball process, at particle surface spraying 2kg second layer enteric coating agent acrylic resin, obtain the microcapsule granule of almost spherical, the microcapsule granule diameter is 50～400 μ m.Tasteless enteric 'Ennoxacin ' micro-capsule particle semi-finished product oven dry with obtaining obtains final finished.
Fig. 2 shows the absorption characteristic of different processing technology Enrofloxacins.As seen from Figure 2, under the situation of same medicine amount, adopt 'Ennoxacin ' micro-capsule that production method of the present invention makes and compare without the Enrofloxacin pulvis of parcel, concentration in pig blood and maximum RT all improve greatly, medicine uptake rate height, the slow releasing function effect is remarkable.
Above-described only is preferred implementation of the present invention, the invention is not restricted to above embodiment.Be appreciated that other improvement and variation that those skilled in the art directly derive or associate under the prerequisite that does not break away from spirit of the present invention and design, all should think to be included within protection scope of the present invention.
Claims (2)
1. the production method of a tasteless enteric 'Ennoxacin ' micro-capsule is characterized in that processing step is as follows:
(1) ground floor bag quilt:
Take by weighing the recipe quantity Enrofloxacin, be dissolved in the sodium hydroxide solution of 1～1.2mol/l,, stir under the room temperature, make Enrofloxacin stearic acid mixture in 45～55 ℃ of stearic acid that add molten condition down;
(2) granulation and second layer bag quilt:
The Enrofloxacin stearic acid mixture adding starch that step (1) makes is granulated with round as a ball, in round as a ball process,, obtain the microcapsule granule of almost spherical at particle surface spraying acrylic resin;
(3) oven dry:
'Ennoxacin ' micro-capsule particle semi-finished product oven dry with step (2) makes obtains final finished;
The mass ratio of described each composition is an Enrofloxacin: sodium hydroxide solution: stearic acid: starch: acrylic resin=50～70: 4～6: 8～12: 10～25: 2～12.
2. according to the production method of the described tasteless enteric 'Ennoxacin ' micro-capsule of claim 1, it is characterized in that the diameter of microcapsule granule in the described step (2) is 50～400 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010105125310A CN101965913A (en) | 2010-10-20 | 2010-10-20 | Production method for tasteless enteric enrofloxacin microcapsules |
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| CN2010105125310A CN101965913A (en) | 2010-10-20 | 2010-10-20 | Production method for tasteless enteric enrofloxacin microcapsules |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302472A (en) * | 2011-09-08 | 2012-01-04 | 河南迪冉生物科技有限公司 | Enrofloxacin microcapsule and preparation method thereof |
| CN103070830A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Production method for 20-percent tilmicosin granules |
| CN103239422A (en) * | 2012-04-26 | 2013-08-14 | 浙江康德权科技有限公司 | Preparation method of smellless coated enrofloxacin preparation |
| CN105055374A (en) * | 2015-09-16 | 2015-11-18 | 山西沃德华兽生物技术有限公司 | Slow-release type sarafloxacin hydrochloride microcapsule and preparation method thereof |
| CN105078899A (en) * | 2015-08-26 | 2015-11-25 | 四川农业大学 | Enrofloxacin stratified high molecular taste mashing skeleton particle and preparation method thereof |
| CN107823186A (en) * | 2017-11-20 | 2018-03-23 | 四川兴华药业有限责任公司 | A kind of Enrofloxacin enteric powder formula and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723902A (en) * | 2005-06-10 | 2006-01-25 | 冯莉萍 | 'Ennoxacin' micro-capsule, and its prepn. method |
| CN101273980A (en) * | 2007-06-08 | 2008-10-01 | 佛山市海纳川药业有限公司 | Preparation of Enrofloxacin microcapsule and method of preparing the same |
-
2010
- 2010-10-20 CN CN2010105125310A patent/CN101965913A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723902A (en) * | 2005-06-10 | 2006-01-25 | 冯莉萍 | 'Ennoxacin' micro-capsule, and its prepn. method |
| CN101273980A (en) * | 2007-06-08 | 2008-10-01 | 佛山市海纳川药业有限公司 | Preparation of Enrofloxacin microcapsule and method of preparing the same |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302472A (en) * | 2011-09-08 | 2012-01-04 | 河南迪冉生物科技有限公司 | Enrofloxacin microcapsule and preparation method thereof |
| CN102302472B (en) * | 2011-09-08 | 2012-08-01 | 河南迪冉生物科技有限公司 | Enrofloxacin microcapsule and preparation method thereof |
| CN103239422A (en) * | 2012-04-26 | 2013-08-14 | 浙江康德权科技有限公司 | Preparation method of smellless coated enrofloxacin preparation |
| CN103239422B (en) * | 2012-04-26 | 2015-07-08 | 浙江康德权科技有限公司 | Preparation method of smellless coated enrofloxacin preparation |
| CN103070830A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Production method for 20-percent tilmicosin granules |
| CN103070830B (en) * | 2013-01-22 | 2014-08-13 | 无锡正大畜禽有限公司 | Production method for 20-percent tilmicosin granules |
| CN105078899A (en) * | 2015-08-26 | 2015-11-25 | 四川农业大学 | Enrofloxacin stratified high molecular taste mashing skeleton particle and preparation method thereof |
| CN105078899B (en) * | 2015-08-26 | 2018-06-29 | 四川农业大学 | A kind of Enrofloxacin cladding macromolecule flavoring skeleton particle and preparation method thereof |
| CN105055374A (en) * | 2015-09-16 | 2015-11-18 | 山西沃德华兽生物技术有限公司 | Slow-release type sarafloxacin hydrochloride microcapsule and preparation method thereof |
| CN105055374B (en) * | 2015-09-16 | 2017-11-03 | 山西沃德华兽生物技术有限公司 | A kind of spacetabs type hydrochloric acid sarafloxacin microcapsules and preparation method thereof |
| CN107823186A (en) * | 2017-11-20 | 2018-03-23 | 四川兴华药业有限责任公司 | A kind of Enrofloxacin enteric powder formula and preparation method |
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Application publication date: 20110209 |