CN101954116A - Manufacturing method of xenoskin used for burns and scalds - Google Patents
Manufacturing method of xenoskin used for burns and scalds Download PDFInfo
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- CN101954116A CN101954116A CN2010102667191A CN201010266719A CN101954116A CN 101954116 A CN101954116 A CN 101954116A CN 2010102667191 A CN2010102667191 A CN 2010102667191A CN 201010266719 A CN201010266719 A CN 201010266719A CN 101954116 A CN101954116 A CN 101954116A
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- xenoskin
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Abstract
The invention relates to a manufacturing method of xenoskin used for burns and scalds. Skin of older pigs is taken as raw material, and the method mainly includes that foreign matter on fur is removed, subcutaneous fat is chipped off, and cutting into pieces, double layer vacuum packaging, Co60 radiation for densification and sterilization, freezing and warehousing are carried out. When in use, the xenoskin is taken out from a freezer and is placed in room temperature environment, and the xenoskin can be applied to burn wound after the xenoskin is rewarmed.The invention has the advantages of simple process, low cost, long storage period and use convenience; meanwhile sterilization and disinfection effect on pigskin is improved, infectious capability is improved, rejection is delayed, bacterium growth is prevented, wound healing time is reduced, and effect in clinical application is good.
Description
Technical field
The present invention relates to a kind of biological dressing manufacture method, being specially a kind of is the manufacture method that is applicable to the burn and scald xenogenesis skin that burn wound covers in the medical treatment of raw material with the Corii Sus domestica.
Background technology
Medically thinking, is to reduce to infect to effective covering of burn patient burn wound, prevents that protein, power and water from separating matter and losing, and keeps homeostatic method.At present, it is of a great variety to be used for wound-surface cover both at home and abroad, as from body skin, alloskin.
Because the alloskin source is few, and clinical effectiveness such as biological dressing Polymer Synthesizing dressing artificial skin are not good, therefore, the research and the application of allograft skin are paid much attention to, observe from the obducent performance clinical effectiveness of touching upon, with from body skin the best, alloskin takes second place.But in anatomical physiology and clinical observation, find, the structure of xenogenesis skin Corii Sus domestica and the structural similarity of application on human skin, it can stick on the wound surface preferably, play the effect that reduces interior water evaporates of body and control infection, clinical effectiveness is satisfied, but manufacture method more specifically is but not progressive, causes the effect of xenogenesis skin to can not get embodying better.
Summary of the invention
Technical problem solved by the invention is to provide a kind of manufacture method of burn and scald xenogenesis skin, to solve the shortcoming in the above-mentioned background technology.
Technical problem solved by the invention realizes by the following technical solutions:
The manufacture method of burn and scald xenogenesis skin is a raw material with the skin of the white pig that grows up, comprises the foreign body that removes on the fur, the subcutaneous fat of pruning, cut-parts, double-layer vacuum packing, Co60 radiation sterilization, steps such as freezing warehouse-in preservation.
Its concrete steps and operating sequence are as follows:
Raw material is prepared: select for use 40 to 60Kg white health pig to live to kill, shave hair, clean, peel Corii Sus domestica, the subcutaneous fat of pruning.
Make: the raw material skin is cut into the skin graft of long 40-50cm, wide 20-40cm, of the anti-thick skin graft of 0.4-0.8mm that is whittled into of electronic drum dermatome.
Clean and packing: after cleaning with pure water, aluminum platinum packaging bag vacuum packaging.
Sterilization: after the packing, the Corii Sus domestica of handling is shone with Co60, irradiation dose 25KGY, exposure time is 30-40 minute.
Freezing warehouse-in is preserved: place the refrigerator-freezer between-4 ℃ to-18 ℃ to preserve more than 3 hours.
And needs of patients only need take out finished product before when using from refrigerator-freezer, places under the normal temperature laboratory state, waits to recover promptly to can be used for burn wound after the room temperature.
Beneficial effect:
The present invention has characteristics such as technology is simple, and cost is low, and the phase of depositing is long, and is easy to use simultaneously.It is applicable to that the wound surface of burn in the medical treatment, scald, wound covers treatment, owing to adopted the Co60 irradiation sterilization, improved the disinfection effect of Corii Sus domestica, strengthened anti-infection ability, and postponed rejection, prevent bacterial growth, shorten wound healing time, in clinical practice, have good effect.
The specific embodiment
Giving an actual example below describes the present invention, and wherein the choice variable in each stage is:
In embodiment one:
Raw material is prepared: select for use the white health pig of 50Kg to live to kill, shave hair, clean, peel Corii Sus domestica, the subcutaneous fat of pruning.
Make: the raw material skin is cut into the skin graft of long 42cm, wide 25cm, of the anti-thick skin graft of 0.5mm that is whittled into of electronic drum dermatome.
Clean and packing: after cleaning with pure water, aluminum platinum packaging bag vacuum packaging.
Sterilization: after the packing, the Corii Sus domestica of handling is shone with Co60, irradiation dose 25KGY, exposure time is 30 minutes.
Freezing warehouse-in is preserved: place-10 ℃ refrigerator-freezer to preserve.
In the present embodiment, patient is shank burn, burn surface area 20cm
2, shallow II degree burn is taken the finished product of preserving after 5 hours, places under the normal temperature laboratory state, wait to recover to be affixed on burn wound after the room temperature, and healing after changing dressings every other day 15 days, the cicatrix area is 5cm
2
In embodiment two:
Raw material is prepared: select for use the white health pig of 50Kg to live to kill, shave hair, clean, peel Corii Sus domestica, the subcutaneous fat of pruning.
Make: the raw material skin is cut into the skin graft of long 45cm, wide 28cm, of the anti-thick skin graft of 0.5mm that is whittled into of electronic drum dermatome.
Clean and packing: after cleaning with pure water, aluminum platinum packaging bag vacuum packaging.
Sterilization: after the packing, the Corii Sus domestica of handling is shone with Co60, irradiation dose 25KGY, exposure time is 35 minutes.
Freezing warehouse-in is preserved: place-8 ℃ refrigerator-freezer to preserve.
In the present embodiment, patient is shank burn, burn surface area 34cm
2, shallow II degree burn is taken the finished product of preserving after 4 hours, places under the normal temperature laboratory state, wait to recover to be affixed on burn wound after the room temperature, and healing after changing dressings every other day 17 days, the cicatrix area is 15cm
2
In embodiment three, patient is shank burn, burn surface area 28cm
2, shallow II degree burn does not adopt any processing, recovers naturally, and be 24 days recovery time, and the scar area is 20cm
2
By above-mentioned three embodiment as can be seen, the burn and scald xenogenesis skin dressing of made of the present invention, therapeutic effect is obvious, and is difficult for staying cicatrix.
And through clinical proof, at shallow II degree, dark II degree, degree of mixing, cut crust wound surface and skin donor site and use, can reduce body fluid and electrolytical losing, prevent the wound surface bacterial infection, promote epithelial growth, reduce cicatrix, the healing wound surface is smooth smooth, and the healing natural law significantly shortens, dressing change frequency obviously reduces, and alleviates patient's pain.Healing rate reaches more than 96.5%.Wherein wound surface is cut the crust healing rate at the skin donor site of shallow II degree and sword pachydermia below 20% and little wound surface and is 100%.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (1)
1. the manufacture method of burn and scald xenogenesis skin is characterized in that, is raw material with the skin of the white pig that grows up, removes the foreign body on the fur, the subcutaneous fat of pruning, and cut-parts, the double-layer vacuum packing, the Co60 radiation sterilization, freezing warehouse-in is preserved;
Its concrete steps and operating sequence are as follows:
Raw material is prepared: select for use 40 to 60Kg white health pig to live to kill, shave hair, clean, peel Corii Sus domestica, the subcutaneous fat of pruning;
Make: the raw material skin is cut into the skin graft of long 40-50cm, wide 20-40cm, of the anti-thick skin graft of 0.4-0.8mm that is whittled into of electronic drum dermatome;
Clean and packing: after cleaning with pure water, aluminum platinum packaging bag vacuum packaging;
Sterilization: after the packing, the Corii Sus domestica of handling is shone with Co60, irradiation dose 25KGY, exposure time is 30-40 minute;
Freezing warehouse-in is preserved: place the refrigerator-freezer between-4 ℃ to-18 ℃ to preserve more than 3 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102667191A CN101954116A (en) | 2010-08-31 | 2010-08-31 | Manufacturing method of xenoskin used for burns and scalds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102667191A CN101954116A (en) | 2010-08-31 | 2010-08-31 | Manufacturing method of xenoskin used for burns and scalds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101954116A true CN101954116A (en) | 2011-01-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102667191A Pending CN101954116A (en) | 2010-08-31 | 2010-08-31 | Manufacturing method of xenoskin used for burns and scalds |
Country Status (1)
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| CN (1) | CN101954116A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189950A (en) * | 2014-09-04 | 2014-12-10 | 成都清科生物科技有限公司 | Amniotic biological agent and preparation method thereof |
| CN104940982A (en) * | 2015-01-19 | 2015-09-30 | 长沙达瑞奇实业有限公司 | Preparation method of dressing skin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096458A (en) * | 1993-11-25 | 1994-12-21 | 徐国士 | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process |
| CN1387923A (en) * | 2002-07-11 | 2003-01-01 | 中国人民解放军第二军医大学 | Heterogeneous cell-free hypodermal framework and its prepn |
| CN101537207A (en) * | 2009-04-28 | 2009-09-23 | 中国人民解放军总医院第一附属医院 | Preparation method of tissue engineering xenoskin |
-
2010
- 2010-08-31 CN CN2010102667191A patent/CN101954116A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096458A (en) * | 1993-11-25 | 1994-12-21 | 徐国士 | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process |
| CN1387923A (en) * | 2002-07-11 | 2003-01-01 | 中国人民解放军第二军医大学 | Heterogeneous cell-free hypodermal framework and its prepn |
| CN101537207A (en) * | 2009-04-28 | 2009-09-23 | 中国人民解放军总医院第一附属医院 | Preparation method of tissue engineering xenoskin |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189950A (en) * | 2014-09-04 | 2014-12-10 | 成都清科生物科技有限公司 | Amniotic biological agent and preparation method thereof |
| CN104940982A (en) * | 2015-01-19 | 2015-09-30 | 长沙达瑞奇实业有限公司 | Preparation method of dressing skin |
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Application publication date: 20110126 |
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