CN1096458A - The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process - Google Patents
The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process Download PDFInfo
- Publication number
- CN1096458A CN1096458A CN 93115237 CN93115237A CN1096458A CN 1096458 A CN1096458 A CN 1096458A CN 93115237 CN93115237 CN 93115237 CN 93115237 A CN93115237 A CN 93115237A CN 1096458 A CN1096458 A CN 1096458A
- Authority
- CN
- China
- Prior art keywords
- fish
- skin
- fish skin
- physiological saline
- saline solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a kind of xenogenesis skin and manufacturing process for the treatment of burn wound, it is characterized in that this xenogenesis skin is the fish skin of making through making processing and drug treating.Manufacturing process adopts following steps: be to soak in 0.25～0.5% pentanedial liquid fish skin in concentration earlier, take out flushing then, handle fish skin again, make its dehydration more than 90%, pack is preserved, before the use, use warm water soaking, use when the compliance of recovering fish skin just can be attached to wound surface.The fish skin of handling through glutaraldehyde has advantages such as thickness is moderate, and form-dependent character is good, cost is low, clinical therapeutic efficacy is good.
Description
The invention belongs to fish skin biological dressing and manufacturing process thereof, this fish skin biological dressing is to stick in fire victim's the burn wound, to reach the purpose of treatment.
At present, when the fire victim was treated, its key point was the covering of wound surface.Fell and terraria skin (as pig, cattle, Corii Caprae seu Ovis etc.) stick in the burn wound, can play good covering treatment.Fell is called alloskin, though therapeutic effect is good, it is in great shortage to originate, and costs an arm and a leg.It is more that the terraria skin claims that xenogenesis skin, particularly Corii Sus domestica are used, but Corii Sus domestica is thicker, and the course of processing need manually be shaved hair, and mechanical skiving is manufactured trouble of operation to about the 0.35mm, and stronger than fell without the Corii Sus domestica rejection property of drug treating, is difficult for adhering to wound surface.The also useful Corii Sus domestica of handling through glutaraldehyde, but quality is harder, and compliance and form-dependent character are poor.And each position of human body all with class cylinder or class spheroidal, particularly joint part, attach imprecision with the dressing of form-dependent character difference, have fold, be easy to infect.In addition, the disease of many infecting both domestic animals and humans is arranged clinically, as brucellosis etc., in processing and making process or because of the not strict danger that causes processing personnel and patient to be subjected to such affect of sterilization.The price of pigskin dressing is more expensive, 20 * 10cm
2A pigskin dressing price up to 51.70 yuan.The medical expense height has increased the weight of patient's financial burden.Because above-mentioned shortcoming makes to be difficult to promote the use of allograft skin and xenogenesis skin treatment burn wound in the burn clinical treatment field.Domestic many burn treatment centers only are that the wound surface of using it in the cutting scab art covers temporarily.Up to now, also do not have a kind ofly can make the generally accepted biological dressing that can be used for various deep burn wounds of clinician.
The objective of the invention is in order to solve the problem of above-mentioned existence, a kind of fish skin (wet or dried) xenogenesis skin and manufacturing process that is used for the treatment of burn wound is provided.It provides a kind of new xenogenesis skin skin source for treatment burn, knife injury wound surface, and it has nontoxic, harmless, non-carcinogenesis, and ample supply and prompt delivery are with low cost, and compliance and form-dependent character are good, and therapeutic effect is good, promotes healing, alleviates disease and characteristics such as aches.
In order to achieve the above object, the invention is characterized in that the xenogenesis skin that is used for the treatment of burn (knife injury) wound surface is the fish skin of making through making processing and drug treating.
This fish skin is divided into wet fish skin and dried fish skin two classes, and wet fish skin can be placed in the hospital and use; And dried fish skin is for the ease of storage and transport, before the use, also need soak to recover the compliance of fish skin.Dried fish skin has three kinds of manufacturing process; Wet fish skin has a kind of manufacturing process.Be described below respectively below:
Dried fish skin manufacture technology scheme I: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish scale can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, make it meet the requirement of length and width; B, with wash clean with after pruning good fish skin control solid carbon dioxide, be that the concentration of 7.35～7.45 phosphate buffer or physiological saline solution preparation is 0.25～0.5% pentanedial liquid immersion fish skin 7～20 minutes earlier with PH, take out back reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, reuse cryogenic vacuum device (freeze dryer) is handled fish skin, require the fish skin dehydration more than 90%, take out pack into plastic bag or vacuum bag seal package, room temperature is preserved down; Before c, the use, after 30 minutes,, can use to recover the compliance of fish skin with warm physiological saline solution immersion.
Dried fish skin manufacture technology scheme II: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish scale can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, make it meet the requirement of length and width; B, with wash clean with after pruning good fish skin control solid carbon dioxide, after the sterilization in 20～30 minutes of 0.05～0.1% chlohexidine solution soaking, handle fish skin with cryogenic vacuum device (freeze dryer), require the fish skin dehydration more than 90%, taking-up pack into plastic bag or vacuum bag seal package, room temperature is preserved down; Use warm water soaking after 30 minutes before c, the use, to recover the compliance of fish skin, be that to be mixed with concentration be that 0.3～0.5% pentanedial liquid soaked 7～20 minutes for 7.35～7.45 phosphate buffer or physiological saline solution with PH then, take out back reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, can use then.
Dried fish skin manufacture technology scheme III: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water more totally, remove fish scale (fish of no fish scale can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, made it meet the requirement of length and width; B, with wash clean with after pruning good fish skin control solid carbon dioxide, with PH is that to be mixed with concentration be that 0.25～0.5 pentanedial liquid soaked 7～20 minutes for 7.35～7.45 phosphate buffer or physiological saline solution, take out back reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, then with face nailing in the fish skin on clean, aseptic plank, it is fully stretched, under the room temperature behind the nature airing, require the fish skin dehydration more than 65%, pack into plastic bag or stannum platinum vacuum bag seal, again through cobalt
60Radiosterilization; Before c, the use, soaked 0.5～1 hour,, can use to recover its compliance with warm physiological saline solution or 0.05～0.1% chlohexidine liquid.
Wet fish skin manufacturing process: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water totally again, remove fish scale (no squama save this operation), wipe out fish spicule, fin and the flesh of fish of remnants, fish skin is pruned, make it meet the requirement of length and width; B, with wash clean with after pruning good fish skin control solid carbon dioxide, in sterile vessel, with PH is that to be mixed with concentration be that 0.25～0.5 pentanedial liquid soaks for 7.35～7.45 phosphate buffer or physiological saline solution, require solution with the complete submergence of fish skin, to preserve or put into the indoor preservation of refrigerator cold-storage under the container closure room temperature, or the fish skin that will wet under aseptic condition takes out and to put into aseptic plastic bag and seal, and is placed in-80 ℃ of-20 ℃ of cryogenic refrigerators again and preserves; C, use before, room temperature nature rewarming or soak rewarming with warm physiological saline solution, reuse physiological saline solution flushing several times, the glutaraldehyde composition with removal fish skin surface just can use then.
In order to make fish skin keep good compliance, can be in above-mentioned concentration be 0.25～0.5% pentanedial liquid, add content again and be 10～20% glycerol.
Adopt fish skin of the present invention to treat burn, scald and knife injury,, obtained excellent curative, enumerate some examples below through the clinical experiment statistics:
1, Guo * *, man, 23 years old, diagnosis: flame burn 60%, III ° 20%.
Hinder two lower limb debridement skin-grafting in back 22 days, scalp and left instep are skin donor site, stick glutaraldehyde fish skin xenogenesis skin for the skin wound surface behind the bark fetching, form-dependent character is fabulous, and no wrinkle was opened outer dressing on the 3rd day, fish skin sticks well, and edge part heals, the fish skin perk, scalp was for district's healing fully in the 5th day, fish skin separates with scalp, and natural on-off cycles of hair growth is good, and it is (right sufficient in the contrast of district's subsides vaseline oil yarn that left instep sticks healing in the 9th day for the district of fish skin, healing in the 12 day), there are not irritated reaction and other discomforts.
2, the king *, man, 30 years old, diagnosis: dimethylbenzene flame burn 1%, depth～III °.
Patient is by instep, a dimethylbenzene flame burn left side, the sufficient heart and heel portion, and sufficient heart portion is depth～III °, and remainder is a depth.Instep, a left side and left heel same depth wound surface were hindered the back the 7th day, the former sticks the glutaraldehyde fish skin and once sticks, the healing in the 19th day of tight wound closure, the latter pastes the conventional wrapping of aseptic petrolatum oil gauze, every changing dressings, healing in the 24th day, left sufficient heart portion sticks the secondary fish skin, deep healing in the 19th day, the about 5 * 5cm of III ° wound surface
2, sticking fish skin 26 healings after the soak for the third time, during the treatment, patient does not have irritated reaction, and body temperature is not high, and is anosis painful.
3, old * *, the woman, 29 years old, diagnosis: boiled water was scalded left leg, light 1%.
Hindered the back the 3rd day, left leg light wound surface blister skin is broken, after the sterilization, sticks and can walk after the glutaraldehyde fish skin is wrapped up with descending, and pain is slight, recovery from illness in the 10th day, and fish skin comes off.
4, poplar * *, the man, 26 years old, in the work accidentally by the glass RIF skin 1 * 1.5cm that prunes
2, haemophilia, will ream at that time from body skin Hui Zhi, find when changing dressings after two days that the autologous skin slippage of Hui Zhi does not survive, decision covers wrapping with fish skin, opened in the 3rd day gauze bandage see fish skin sticking apply good, not bitterly, not wrapping again, wound was grown in the 7th day, and fish skin comes off naturally.
5, Shen * *, man, 33 years old, because of petrol burn 5% light (traffic accident), the right hand back of the body and the finger back of the body begin to stick wrapping with petrolatum oil gauze, and patient's pain is obvious, and transudate is many, drenched gauze, used the glutaraldehyde fish skin on the 4th day instead and stick burn the back of the hand wound surface, pain relieving immediately, readme are very comfortable, hinder the back and removed outer gauze on the 6th day, the dry no sepage of wound surface, subcutaneous no hydrops, half exposes treatment, inactive all antibiotic, patient temperature is normal, does not have discomfort, recovery from illness in the 12 day, fish skin comes off naturally, no allergy and rejection.
6, Zhu * *, woman, 42 years old, the gas flame that is liquefied burn 20%, right side thigh portion deep sticks the wound surface wrapping with petrolatum oil gauze after the debridement, sepage is many, pain, fever, use the glutaraldehyde fish skin after three days instead and stick right burst portion wound surface, wrap up, opened outer dressing on the 5th day, fish skin sticks, no hydrops, about 37.5 ℃ of body temperature, half exposes treatment, recovery from illness in 21 days, and fish skin removes.
7, blue * *, the woman, 56 years old, liquefied gas burn 85%, III ° 30, depth 25%, light 30%, right burst portion deep is about 8%, hinders back operation in the 6th day, covers with fish skin after crust is cut by right burst portion, removes partly exposure of gauze, big healing of the 23rd day wound surface on the 4th day.
8, the king *, woman, 38 years old; by acetone acid flame burn 60%(extremity), III ° 45%, the both hands wrist is an III ° annular eschar; subtract as untimely incision and to open, both hands refer to can to transport obstacle downright bad because of blood, hinders the two capable eschar longitudinal incisions of armlet of frying in shallow oil of back 4 hours row and subtract; subtract and dehisce to cover sealing with fish skin; the protection wound surface is hindered the 6th day two forearm both hands of row in back and two lower limb cutting scabs operation and is seen, and two forearms are fresh with the wound surface of fish skin covering; do not have and infect, play the effect of close and protect wound surface.
9, just *, the man, 48 years old, the gas flame that is liquefied burn 100%, III ° 94% merges respiratory tract burn.Be admitted to hospital the back patient because of chest annular eschar, restriction breast abdominal respiration, hinder back five hours capable bilateral thoracic wall eschar longitudinal incisions, fish skin covers wound closure, breathing is improved, blood oxygen pressure rises to 95mmHg from 70mmHg, overall health of patients be improved significantly with the striving the time of later emergency measures.
Handle the ability that fish skin is used for no infection behind the wound surface without glutaraldehyde, in case the traumatic infection fish skin can corruption, dissolve, do not have the covering effect.
After glutaraldehyde is handled fish skin, can make the proteopexy on fish skin surface, be necessary, effectively sterilization, anti-corrosion measure.Owing to proteic degeneration, inactivation, greatly reduce the rejection of human body simultaneously to it.In addition, the fish skin toughness of handling through glutaraldehyde strengthens.
The pH value of tissue liquid is 7.35～7.45, and the pH value of all and contacted medicine of tissue or material exceeds above-mentioned scope, all can cause tangible pain.So when being mixed with pentanedial liquid, solvent is selected 7.35～7.45 phosphate buffer and physiological saline solution for use.
The present invention has the following advantages: 1, with fish skin as the xenogenesis skin, its thickness meets the requirements prescribed fully, generally about 0.2～0.6mm, need not to resemble also needs skiving processing the Corii Sus domestica, it is simple to make processing; 2, fish skin itself has good compliance, and form-dependent character is good, no wrinkle; 3, the fish skin aboundresources is with low cost, and in Fish processing factory, the fish skin that peels is to be used for cooking beverage, and is with low cost, reduced patient's medical expense; 4, clinical therapeutic efficacy is good, and no allergy and rejection alleviate pain, promotes healing; 5, as wound surface when big, when a fish skin is difficult to cover, the use that can easily several fish skin be stitched together, and the Corii Sus domestica stitching is more bothersome, has alleviated doctor's workload; 6, fish skin nontoxic, harmless, non-carcinogenesis, relevant expert's result of study show the long cancer of shark, and the be easy to carry about with one disease of infecting both domestic animals and human of Corii Sus domestica, as brucellosis etc.; 7, dried fish skin is convenient to storage and transport, has brought convenience for the use of hospital.
Below be embodiments of the invention: embodiment 1, with fresh morrhua, after cleaning, the fish skin holostrome is peeled, prune, the wide 100mm that is not less than of skin, length is not less than 200mm for well, after the water control of fish skin done, with PH is that 7.35 phosphate buffers were mixed with concentration 0.4% glutaraldehyde immersion fish skin 7～20 minutes, take out back reuse physiological saline solution flushing 3～4 times, to remove fish skin surface glutaraldehyde composition, reuse cryogenic vacuum device (freeze dryer) is handled, make its dehydration, generally require vacuum to reach 133 * 10
-3Pa, when fish skin dehydration after 90% or more, pack into after the taking-up plastic bag or vacuum bag seal package, room temperature just preserve down can, certain, also can be placed on the indoor preservation of refrigerator cold-storage.Before the use, after 30 minutes,, can use when fish skin recovers compliance with warm physiological saline solution immersion.
Embodiment 2, fresh shark is clean, the fish skin holostrome is peeled, fish skin is pruned, make it meet the length and width requirement, generally to rectificate * wide be more than 200 * 100mm, behind the surplus water of fish skin cleaning and controlled drying, the sterilization in 20～30 fens of chlohexidine solution soaking with 0.1%, taking-up is handled fish skin with cryogenic vacuum device (freeze dryer), make its dehydration, when fish skin dehydration reaches 90% when above, taking-up pack into plastic bag or stannum platinum vacuum packaging bag seal package, room temperature is preserved down, also can put into refrigerator cold-storage and preserve.Before the use, with warm water soaking after 30 minutes, to recover the compliance of fish skin, be that to be mixed with concentration be that 0.5% pentanedial liquid soaked 7～20 minutes for 7.45 physiological saline solution with PH then, take out back reuse physiological saline solution flushing 3～4 times, to remove fish skin surface glutaraldehyde composition, just can use then.
The difference of embodiment 1 and embodiment 2 only is the variation with the sequencing of glutaraldehyde processing, and the dried fish skin that embodiment 1 makes can provide use for the hospital of no pentanedial liquid.
Embodiment 3, fresh Spanish mackerel is cleaned, the fish skin holostrome is peeled, fish skin is pruned, remove unnecessary fish spicule, the fin and the flesh of fish, long * wide be more than 200 * 100mm, with the fish skin cleaning and controlled drying of cleaning, with PH be 7.40 physiological saline solution to be mixed with concentration be that 0.25% pentanedial liquid soaked fish skin 7～20 minutes, take out back reuse physiological saline solution and wash several times, to remove fish skin surface glutaraldehyde composition, under aseptic condition, on clean aseptic plank, it is fully stretched face nailing in the fish skin, nature airing under the room temperature, require the fish skin dehydration more than 90%, pack into then plastic bag or stannum platinum vacuum bag seal, again through cobalt
60Radiosterilization.Before the use, soaked 0.5～1 hour, after fish skin recovers good compliance, just can use with warm physiological saline solution or 0.05% chlohexidine liquid.
Embodiment 4, after Anguillar japonica cleaned, the fish skin holostrome is peeled, fish skin is pruned, remove unnecessary fish spicule, the fin and the flesh of fish, length * wide requirement more than 200 * 100mm for well, in aseptic vessel, with PH be 7.35 phosphate buffers to be mixed with concentration be 0.3% pentanedial liquid, adding content again is 15% glycerol (can keep the good compliance of fish skin like this), and fish skin is immersed in the above-mentioned solution fully, can preserve preserving or put into refrigerator cold-storage under the container closure room temperature, in addition, aseptic plastic bag is put in the fish skin that also can will wet under aseptic condition taking-up or vacuum bag seals, and is placed in-80～-20 ℃ of cryogenic refrigerators again and preserves.Before the use, but nature rewarming or with warm physiological saline solution rewarming, reuse physiological saline solution flushing 3～4 times to remove the glutaraldehyde composition on fish skin surface, just can be used then under the room temperature.
The invention provides a kind of new xenogenesis skin, the fish skin through glutaraldehyde is handled has the quality softness, and thickness is moderate, and form-dependent character is good, good compliance, low cost, advantage such as clinical treatment is good.
Claims (6)
1, a kind of xenogenesis skin that is used for the treatment of burn (knife injury) wound surface is characterized in that this xenogenesis skin is the fish skin of making through manufacturing processing and drug treating.
2, the manufacturing process of the described treatment burn of a kind of manufacturing claim 1 (knife injury) wound surface xenogenesis skin, it is characterized in that the fish skin of doing also can adopt following step to make: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish scale can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, reach the requirement of length and width;
B, with behind wash clean and the fish skin control solid carbon dioxide that trims, be that to be mixed with concentration be 0.25～0.5% pentanedial liquid immersion 7～20 minutes for 7.35～7.45 phosphate buffer or physiological saline solution earlier with PH, take out back reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, reuse cryogenic vacuum device (freeze dryer) is handled fish skin, require the fish skin dehydration more than 90%, take out pack into plastic bag or vacuum bag packages, room temperature is preserved down;
Before c, the use, after 30 minutes,, can use to recover the compliance of fish skin with warm physiological saline solution immersion.
3, the manufacturing process of the xenogenesis skin of the described treatment burn of a kind of manufacturing claim 1 (knife injury) wound surface, it is characterized in that the fish skin done adopt below step make: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish phosphorus can save this operation), wipe out remaining fish spicule, fin and the flesh of fish;
B, with behind wash clean and the fish skin control solid carbon dioxide that trims, after the sterilization in 20～30 minutes of 0.05～0.1% chlohexidine solution soaking, handle fish skin with cryogenic vacuum device (freeze dryer), require the fish skin dehydration more than 90%, taking-up pack into plastic bag or stannum platinum vacuum bag seal package, room temperature is preserved down;
Use warm water soaking after 30 minutes before c, the use, to recover the compliance of fish skin, with PH is that to be mixed with concentration be that 0.3～0.5% pentanedial liquid soaked 7～20 minutes for 7.35～7.45 phosphate buffer or physiological saline solution, take out reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, can use.
4, the manufacturing process of the described treatment burn of a kind of manufacturing claim 1 (knife injury) wound surface xenogenesis skin, it is characterized in that dried fish skin also can adopt following step to make: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish phosphorus can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, make its length and width regular; B, the surplus water control of fish skin is dried, with PH is that to be mixed with concentration be that 0.25～0.5% pentanedial liquid soaked 7～20 minutes for 7.35～7.45 phosphate buffer or physiological saline solution, take out back reuse physiological saline solution flushing several times, to remove fish skin surface glutaraldehyde composition, then with face nailing in the fish skin on clean aseptic plank, it is fully stretched, nature airing under the room temperature, require the fish skin dehydration more than 65%, pack into plastic bag or stannum platinum vacuum bag seal, again through cobalt
60Radiosterilization; Before c, the use, soaked 0.5～1 hour,, can use to recover the compliance of fish skin with warm physiological saline solution or 0.05～0.1% chlohexidine liquid.
5, a kind of manufacturing process of manufacturing the xenogenesis skin of the described treatment burn of claim 1 (knife injury) wound surface, it is characterized in that the fish skin that wets adopt below step make: a, with the fish wash clean, the fish skin holostrome is peeled, wash with water clean again, remove fish scale (fish of no fish phosphorus can save this operation), wipe out remaining fish spicule, fin and the flesh of fish, fish skin is pruned, reach the requirement of length and width degree, the water control of fish skin is done;
B, in sterile vessel, the fish skin PH that surplus water is done in control is that to be mixed with concentration be the immersion of 0.25～0.5 glutaraldehyde for 7.35～7.45 phosphate buffer or physiological saline solution, require solution with the complete submergence of fish skin, the indoor preservation of refrigerator cold-storage is preserved or put into to container closure room temperature, or the fish skin that will wet under aseptic condition takes out and to put into aseptic plastic bag and seal, and is placed in-80 ℃～-20 ℃ cryogenic refrigerators again and preserves;
C, use before room temperature nature rewarming or soak rewarming with warm physiological saline solution, reuse physiological saline solution flushing several times, the glutaraldehyde composition with removal fish skin surface so just can use.
6, manufacturing process according to claim 5 is characterized in that adding content again in concentration is 0.25～0.5% pentanedial liquid is 10～20% glycerol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93115237 CN1096458A (en) | 1993-11-25 | 1993-11-25 | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93115237 CN1096458A (en) | 1993-11-25 | 1993-11-25 | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1096458A true CN1096458A (en) | 1994-12-21 |
Family
ID=4990899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93115237 Pending CN1096458A (en) | 1993-11-25 | 1993-11-25 | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1096458A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954116A (en) * | 2010-08-31 | 2011-01-26 | 长沙达瑞奇实业有限公司 | Manufacturing method of xenoskin used for burns and scalds |
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
| WO2017035615A1 (en) * | 2015-09-03 | 2017-03-09 | Companhia Energética Do Ceará - Coelce | Tilapia skin processing method and use thereof for covering skin injuries |
| CN108478869A (en) * | 2018-04-17 | 2018-09-04 | 上海市第六人民医院 | A kind of Regeneration and Repair bionical matrix of de- cell black carp skin and its preparation method and application |
| WO2020097710A1 (en) * | 2018-11-14 | 2020-05-22 | JÚNIOR, Edmar Maciel Lima | Method for obtaining freeze-dried animal skin, freeze-dried animal skin, use thereof and kit |
| CN113164645A (en) * | 2018-11-14 | 2021-07-23 | 埃德马尔·马西埃尔·利马·朱尼尔 | Method for obtaining a decellularized extracellular matrix, use and kit thereof |
-
1993
- 1993-11-25 CN CN 93115237 patent/CN1096458A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102781485A (en) * | 2009-10-07 | 2012-11-14 | 克雷西斯公司 | A scaffold material for wound care and/or other tissue healing applications |
| CN101954116A (en) * | 2010-08-31 | 2011-01-26 | 长沙达瑞奇实业有限公司 | Manufacturing method of xenoskin used for burns and scalds |
| WO2017035615A1 (en) * | 2015-09-03 | 2017-03-09 | Companhia Energética Do Ceará - Coelce | Tilapia skin processing method and use thereof for covering skin injuries |
| CN108778351A (en) * | 2015-09-03 | 2018-11-09 | 塞阿拉能源公司 | Method for improving Java tilapia skin and its purposes for covering skin injury |
| US11135337B2 (en) | 2015-09-03 | 2021-10-05 | Companhia Energética Do Ceará (Coelce) | Tilapia skin processing method and use thereof for covering skin injuries |
| CN108478869A (en) * | 2018-04-17 | 2018-09-04 | 上海市第六人民医院 | A kind of Regeneration and Repair bionical matrix of de- cell black carp skin and its preparation method and application |
| WO2020097710A1 (en) * | 2018-11-14 | 2020-05-22 | JÚNIOR, Edmar Maciel Lima | Method for obtaining freeze-dried animal skin, freeze-dried animal skin, use thereof and kit |
| CN113164643A (en) * | 2018-11-14 | 2021-07-23 | 埃德马尔·马西埃尔·利马·朱尼尔 | Method for obtaining freeze-dried animal skin, use and kit thereof |
| CN113164645A (en) * | 2018-11-14 | 2021-07-23 | 埃德马尔·马西埃尔·利马·朱尼尔 | Method for obtaining a decellularized extracellular matrix, use and kit thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2710938T3 (en) | Hemostatic glove device | |
| Bunyan | Treatment of burns and wounds by the envelope method | |
| CN108079364B (en) | A kind of frog skin burn wound biological dressing preparation method | |
| CN103041457A (en) | Emergency tourniquet | |
| CN1096458A (en) | The fish skin of treatment burn (knife injury) wound surface (wet or dried) xenogenesis skin and manufacturing process | |
| CN101264196B (en) | Externally-applied medicinal composition for treating surgical wound and preparation of ointment thereof | |
| Cope | The treatment of wounds through the ages | |
| CN103623455B (en) | A kind of preparation method of biological wound-protecting film | |
| CA1165243A (en) | Method and composition for treatment of wounds | |
| Gerster | The rules of aseptic and antiseptic surgery | |
| Sabbatani et al. | The Bolognese surgeon Giuseppe Ruggi: how and why the aseptic surgery was introduced in Bologna in the middle half of the XIX century | |
| Kit | Lacerations & Abrasions | |
| Devey et al. | Wounds and bandages | |
| CN103623456B (en) | A kind of Biological membrane device for wound surface and preparation method thereof | |
| O'Hara | Beauty and the beast: nursing care of the patient undergoing leech therapy | |
| Douglas | The treatment of burns and other extensive wounds with special emphasis on the transparent jacket system | |
| US20060051431A1 (en) | Methods of managing multi-tissue injuries | |
| Hespe et al. | Burns: Acute Care and Reconstruction | |
| CN107158206A (en) | A kind of preparation method of plantar wart exterior-applied medical wine | |
| Bidwell | Minor surgery | |
| Skeet | What to Do when Someone has a Bad Cut or Wound | |
| Andreasen | Magnesium sulphate powder in the treatment of wounds and ulcers | |
| CN1281256C (en) | Chinese medicine for treating trauma and its preparation method | |
| Da Costa | Modern Surgery-Chapter 2. Asepsis and Antisepsis | |
| CN112336787A (en) | Ointment for treating burns and scalds and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |