CN101953430A - Feed, preparation method and use thereof in improvement in reproductive performance of sows - Google Patents
Feed, preparation method and use thereof in improvement in reproductive performance of sows Download PDFInfo
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- CN101953430A CN101953430A CN2010102271847A CN201010227184A CN101953430A CN 101953430 A CN101953430 A CN 101953430A CN 2010102271847 A CN2010102271847 A CN 2010102271847A CN 201010227184 A CN201010227184 A CN 201010227184A CN 101953430 A CN101953430 A CN 101953430A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention relates to a feed, a preparation method and use thereof in improvement in the reproductive performance of sows. The feed is characterized by comprising the following components in percentage by weight: 0.05 to 0.2 percent of N-carbamylglutamic acid and the balance of auxiliary materials. The preparation method comprises the following steps of: 1) removing impurities from the auxiliary materials in percentage by weight, air-drying the auxiliary materials and crushing the auxiliary materials to 20 to 100 meshes; and 2) mixing under stirring the crushed auxiliary materials obtained in the step 1) and the N-carbamylglutamic acid in percentage by weight, and sieving the mixture to obtain the finished product feed. The feed can enhance the reproductive performance of the sows, can promote the synthesis of endogenous arginine in the sows and effectively improve the reproductive performance of the sows to further improve the growth performance of piglets.
Description
[technical field]
The present invention relates to animal feed, relate to feed that a kind of N-of containing carbamylglutamic acid can improve sow reproductive performance, preparation and uses thereof specifically.
[background technology]
Arginine is a kind of important basic amino acid in the animal body, except that the deposition that participates in body protein, also participates in organism metabolism by plurality of enzymes, and is bringing into play the multi-nutrition physiological effect by its metabolin such as nitric oxide (NO) and polyamines etc. in the pig body.In addition, arginine also can be used as sercretogogue (Mateo etc., 2008,2007 of insulin in the pig body; Laspiur etc., 2006; Kim etc., 2004), point out its significance to regulation and control pig growth and development and breeding physiology.In the sow gestation stage, arginine has important function to the growth of embryo, placenta and fetus.During gestation 30～40d, the concentration of arginine and ornithine increases by 23 and 18 times respectively in the pig allantoic fluid, and its nitrogen content accounts for (Mateo etc., 2008) over half of all a-amino acid nitrogen contents.The content of arginine and ornithine raises in the fetus allantoic fluid, increases relevantly with the synthetic NO of preceding 1/2 gestational period placenta and polyamines amount, and placenta growth at this moment is also the fastest, points out most important in the conceptus growth and development process based on the metabolic pathway of arginine.These nutriments can play a role to embryo's generation and implantation, blood vessel generation, placenta growth and growth and fetal growth by regulating intracellular protein turnover and cell proliferation.
It is one of low important nutrition reason of sow breeding potential that the synthetic arginic reduction of farrowing sow enteron aisle and the arginine that causes lack, it also is the main metabolic basis that the piglet of sow nurture can't be realized optimum growh, increase arginic supply for expansion sow placenta capillary, increase capacity of blood vessel, promote the sow placenta to have huge latent effect to the amount of blood supply of fetus and the growth of promotion newborn piglet.But in the alimentary canal of animal; antagonisms such as arginic absorption and tryptophan, lysine and histidine; directly the oral supplementation arginine can not get best result of use; and arginine is unique substrate of synthetic NO, and excessive exogenous L-Arg sharply increases body NO content at short notice, and the negative interaction of excessive NO is outstanding; not only can not protect body to avoid lethal injury; cause body injury widely on the contrary, body is caused strong destruction (Wink etc., 1998).And for now, 800 yuan/ton of arginic interpolation costs are unfavorable for promoting, and improve sow reproductive performance thereby therefore need to improve the arginic level of endogenous.
The N-carbamylglutamic acid is as a kind of novel fodder additive, patent (application number: 200910062913.5) provide the purposes that promotes in the pig growth, comprised as suckling pig, weanling pig, growth pig or replacement gilt and herd boar, particularly at the purposes in the newborn piglet growth, other does not see detailed applications and effect, is not applied to in-pig.Be applied to in-pig about the N-carbamylglutamic acid, the purposes that improves reproductive performance does not see that patent documentation delivers.
[summary of the invention]
The objective of the invention is to, the feed of a kind of N-of containing carbamylglutamic acid that the above-mentioned defective that exists at prior art provides, this feed can effectively improve sow reproductive performance, promote that endogenous is arginic synthetic in the sow body, improve the reproductive performance of sow, and then improve the growth in piglets performance.
A kind of feed provided by the invention, wherein said feed comprise the following component of percentage meter by weight: 0.05-0.2%N-carbamylglutamic acid and auxiliary material.
Feed provided by the invention, described feed comprise the following component of percentage meter by weight: 0.05-0.2%N-carbamylglutamic acid and 99.8-99.95% auxiliary material.
Feed provided by the invention, described feed comprise the following component of percentage meter by weight: 0.08-0.17%N-carbamylglutamic acid and 99.83-99.92% auxiliary material.
Feed provided by the invention, described auxiliary material comprise one or more the mixture that is selected from mould inhibitor, antioxidant, B B-complex, mineral element additive, corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, the rice bran.
Feed provided by the invention, described mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin; Described antioxidant: TBHQ, n-propyl gallate, vitamin E; Described B B-complex is: vitamin A, D, E, K and B family vitamin; Described mineral element additive is: iron, zinc, copper, manganese, selenium.
The preparation method of feed provided by the invention comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize the 20-100 order;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Feed provided by the invention, the application of described feed in improving sow reproductive performance.
Technique scheme and design thereof:
Except that enumerating, also can be to be applied to other auxiliary materials in the above-mentioned auxiliary material as feed; The N-carbamylglutamic acid can promote in the sow body arginic endogenous synthetic, and then promote the synthetic of NO and polyamines, therefore feed provided by the invention has the sow self of raising arginine and transforms, increase sow and produce live young number and increase piglet birth nest counterpoise, improve the characteristics of sow reproductive performance.
N-carbamylglutamic acid of the present invention is according to application number: 200810187671.8 denomination of invention is the described method preparation of the patent application patent of " N-carbamylglutamic acid preparation method ".
Feed provided by the present invention can be made the complete diet pellet feed, premix or concentrate feed, and the feed form can be graininess or powdery;
Premix is the abbreviation of additive premix, it is with one or more microcomponents (comprising additives such as various trace quantity mineral substance elements, various vitamin, synthesizing amino acid, some drugs) and diluent or carrier proportioning on request, the osculant compound feed products of making after evenly mixing; Premix is a kind of important component of perfect compound feed.
Concentrate feed is meant the remainder of removing energy feed in the complete feed, claims the balance mixed feed abroad, also claims protein-vitamin supplement feed; Mainly comprise protein feeds, constant mineral feed and additive premix.
Perfect compound feed also claims full-time grain mixed feed; It can be directly used in the raising object of feeding, and can satisfy the nutritional need of the object of feeding comprehensively.Mainly comprise nutriments such as energy feed, protein feeds and mineral matter.
[specific embodiment]
Below by the specific embodiment feed provided by the invention is done further more detailed description.
[correlation test]
[test 1]
1.1 the preparation agent of feed for pregnancy sow comprises the steps:
1), with 99.8% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 20 orders;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the 0.2%N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Auxiliary material: corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, rice bran, vitamin A, D, E, K and B family vitamin and iron, zinc, copper, manganese, selenium.
1.2, after promptly feed the gestational period (14d-114d), detect in the full phase sow body of gestation each performance indications and the results are shown in Table 1 and table 2 with the prepared agent of feed for pregnancy sow sow of full phase of gestation of feeding:
The full phase daily ration of table 1 gestation adds the influence (μ mol/L) of 0.2%N-carbamylglutamic acid to sow serum biochemistry index
Annotate: it is different that same line number shoulder is annotated letter, and expression difference reaches the utmost point level of signifiance (P＜0.01)
Daily ration of full phase of table 2 sow gestation adds the influence of 0.2%NCG to its reproductive performance
Annotate: it is different that same line number shoulder is annotated letter, and expression difference reaches the utmost point level of signifiance (P＜0.01)
Result of the test shows that daily ration interpolation of full phase of gestation 0.2%NCG can significantly improve arginine, nitric oxide, the progesterone levels in the sow gestation blood in early stage; And can significantly improve the piglet nest and produce sum, nest product young number alive, birth piglet nest counterpoise, its median fovea produces sum has increased by 1.10, nest produces the young number of living increases by 1.29, and birth piglet nest counterpoise increases 1.25kg, but average piglet birth weight is not had the conspicuousness influence.
[test 2]
2.1 the preparation agent of feed for pregnancy sow comprises the steps::
1), with 99.9% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 60 orders;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the 0.1%N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Auxiliary material: corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, rice bran, vitamin A, D, E, K and B family vitamin, iron, zinc, copper, manganese, selenium.
2.3, the results are shown in Table 3 and table 4 with the described in-pig complete diet pellet of the step 2.2 finished feed sow heavy in pig (14d-114d) of feeding:
Testing index mainly comprises in the process of the test: sow nest farrowing sum, nest produce live young number, still birth rate, weak young rate, mummy rate, abnormal rate.Wherein: the computing formula of still birth rate, weak young rate, mummy rate, abnormal rate is as follows:
Still birth rate (%)=stillborn foetus number/total litter size * 100%
Weak young rate (%)=weak young number/total litter size * 100%
Mummy rate (%)=mummy number/total litter size * 100%
Abnormal rate (%)=lopsided number/total litter size * 100%
The full phase of table 3 sow gestation is added the influence of 0.1%NCG to its reproductive performance
Annotate: it is different that same line number shoulder is annotated letter, and expression difference reaches the utmost point level of signifiance (P＜0.01)
The full phase of table 4 gestation is added the influence of 0.1%NCG to fetal death of sow rate, weak young rate, abnormal rate and mummy rate
Annotate: it is different that same line number shoulder is annotated letter, and expression difference reaches the utmost point level of signifiance (P＜0.01)
As can be seen from Table 3, add NCG in the daily ration and can significantly improve sow nest farrowing sum, nest product young number alive, average birth weight and birth piglet nest counterpoise, wherein test group sow nest farrowing sum is compared with control group and has been improved 1.07, and difference is (P＜0.01) extremely significantly; The nest of sow produces the young number relative comparison group of living and has improved 1.10, and birth piglet nest counterpoise has increased 1.01kg, and difference is (P＜0.01) extremely significantly.
As can be seen from Table 4, add NCG in the daily ration and can reduce still birth rate, descend 0.62%, it can significantly reduce weak young rate, and 5.8% (P＜0.05) descends.And adding NCG in the daily ration has the trend that reduces piglet abnormal rate and mummy tire rate, descends 0.07% and 0.1% respectively.
[test 3]
3.1, be used for the agent of feed for pregnancy sow preparation with feed of the present invention:
1), with 99.95% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 100 orders;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the 0.05%N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Auxiliary material: corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, rice bran, vitamin A, D, E, K and B family vitamin and iron, zinc, copper, manganese, selenium.
Feed 3.2 the feed that step 3.1 is prepared carries out the full phase of in-pig, after promptly feed the gestational period (14d-114d), measure sow reproductive performance, the result is as follows:
The full phase daily ration of table 3.1 sow gestation adds the influence of 0.5 ‰ NCG to its reproductive performance
Annotate: same line number shoulder is annotated the different also case sensitive persons of letter and is represented that difference reaches the level of signifiance (P＜0.05)
Result of the test shows, the pregnant full phase is added nest product sum, nest product young number alive and the average piglet nest counterpoise that 0.05 ‰ N-carbamylglutamic acid (NCG) can significantly improve piglet, thereby improve the reproductive performance of sow, but slightly descend because of the litter size increase causes the average birth weight of piglet, but influence is not remarkable.
[embodiment 1]
The preparation that contains N-carbamylglutamic acid feed of present embodiment comprises the steps:
1), with 99.92% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 70 orders;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the 0.08%N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Auxiliary material: corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, rice bran, vitamin A, D, E, K and B family vitamin iron, zinc, copper, manganese, selenium.
[embodiment 2]
The preparation that contains N-carbamylglutamic acid feed of present embodiment comprises the steps:
1), with 99.83% auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize 20 orders;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the 0.17%N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
Auxiliary material: corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, rice bran, vitamin A, D, E, K and B family vitamin and iron, zinc, copper, manganese, selenium.
Should be noted that at last: above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; although the present invention is had been described in detail with reference to the foregoing description; those of ordinary skill in the field are to be understood that: the technical staff reads after the present specification still and can make amendment or be equal to replacement the specific embodiment of the present invention, does not await the reply within the claim protection domain but these modifications or change all break away from the present patent application.
Claims (7)
1. a feed is characterized in that described feed comprises the following component of percentage meter by weight: 0.05-0.2%N-carbamylglutamic acid and auxiliary material.
2. feed according to claim 1 is characterized in that described feed comprises the following component of percentage meter by weight: 0.05-0.2%N-carbamylglutamic acid and 99.8-99.95% auxiliary material.
3. feed according to claim 1 is characterized in that described feed comprises the following component of percentage meter by weight: 0.08-0.17%N-carbamylglutamic acid and 99.83-99.92% auxiliary material.
4. according to claim 1 or 2 or 3 described feeds, it is characterized in that described auxiliary material comprises one or more the mixture that is selected from mould inhibitor, antioxidant, B B-complex, mineral element additive, corn, dregs of beans, the cottonseed dregs of rice, peanut meal, rapeseed dregs, fish meal, zeolite powder, calcium monohydrogen phosphate, the rice bran.
5. feed according to claim 4 is characterized in that described mould inhibitor: formic acid, calcium formate, sorbic acid, citric acid, horse dimethyl phthalate and allicin; Described antioxidant: TBHQ, n-propyl gallate, vitamin E; Described B B-complex is: vitamin A, D, E, K and B family vitamin; Described mineral element additive is: iron, zinc, copper, manganese, selenium.
6. method for preparing the described feed of claim 1 comprises step:
1), with the auxiliary material impurity elimination of described weight percent meter, dry the back and pulverize the 20-100 order;
2), the auxiliary material after the pulverizing that step 1) is obtained mixes with the N-carbamylglutamic acid of described weight percent meter and whisks, and promptly gets finished feed through sieving.
7. the described feed of claim 1 is characterized in that the application of described feed in improving sow reproductive performance.
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102423006A (en) * | 2011-11-15 | 2012-04-25 | 辽宁禾丰牧业股份有限公司 | Compound feed for lactating sows |
| CN102488076A (en) * | 2011-11-07 | 2012-06-13 | 朝阳圣丰牧业有限公司 | Safe and efficient composite mildew preventive for feed |
| CN102630638A (en) * | 2012-05-10 | 2012-08-15 | 广东温氏食品集团有限公司 | Method for improving the reproductive performance of sows |
| CN102718685A (en) * | 2012-06-01 | 2012-10-10 | 广州九益生物技术有限公司 | Preparation method and application of N-carbamyl-L-glutamic acid manganese complex |
| CN103125747A (en) * | 2013-03-22 | 2013-06-05 | 北京市农林科学院 | Feed additive and application thereof |
| CN103202392A (en) * | 2013-04-23 | 2013-07-17 | 北京市农林科学院 | Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds |
| CN106509450A (en) * | 2016-09-29 | 2017-03-22 | 林州亚太兴牧科技有限公司 | Male mink reproductive performance improving NCG compound, preparation method and use method thereof which the e of |
| CN106689738A (en) * | 2016-11-30 | 2017-05-24 | 上海新邦生物科技有限公司 | Sow and piglet integral nutrition scheme |
| CN108185145A (en) * | 2018-03-29 | 2018-06-22 | 中国科学院亚热带农业生态研究所 | The composite feed additive and preparation method and purposes of sow gestation phase |
| CN108419929A (en) * | 2018-03-29 | 2018-08-21 | 中国科学院亚热带农业生态研究所 | The uridine composition feed addictive and preparation method and purposes of sow gestation phase |
| CN108497186A (en) * | 2018-03-23 | 2018-09-07 | 广东新南都饲料科技有限公司 | A kind of additive premix improving sow reproductive performance |
| CN109845900A (en) * | 2019-03-18 | 2019-06-07 | 广州斯宾农牧科技有限公司 | A kind of composite feed additive and its preparation method and application |
| CN110368132A (en) * | 2019-06-24 | 2019-10-25 | 华中农业大学 | A kind of raising cow in summer estrus synchronization-timing semen deposition effect processing method |
| CN112979504A (en) * | 2021-03-09 | 2021-06-18 | 长沙兴嘉生物工程股份有限公司 | Preparation method and application of argininyl manganese |
| CN117959339A (en) * | 2024-03-28 | 2024-05-03 | 广东海洋大学 | Pharmaceutical composition and application thereof in preparation of product for recovering parent snail fertility of Babylonia |
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Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102488076A (en) * | 2011-11-07 | 2012-06-13 | 朝阳圣丰牧业有限公司 | Safe and efficient composite mildew preventive for feed |
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| CN102423006A (en) * | 2011-11-15 | 2012-04-25 | 辽宁禾丰牧业股份有限公司 | Compound feed for lactating sows |
| CN102630638A (en) * | 2012-05-10 | 2012-08-15 | 广东温氏食品集团有限公司 | Method for improving the reproductive performance of sows |
| CN102630638B (en) * | 2012-05-10 | 2014-01-15 | 广东温氏食品集团股份有限公司 | Method for improving the reproductive performance of sows |
| CN102718685A (en) * | 2012-06-01 | 2012-10-10 | 广州九益生物技术有限公司 | Preparation method and application of N-carbamyl-L-glutamic acid manganese complex |
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| CN103125747B (en) * | 2013-03-22 | 2015-04-29 | 北京市农林科学院 | Feed additive and application thereof |
| CN103202392A (en) * | 2013-04-23 | 2013-07-17 | 北京市农林科学院 | Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds |
| CN106509450A (en) * | 2016-09-29 | 2017-03-22 | 林州亚太兴牧科技有限公司 | Male mink reproductive performance improving NCG compound, preparation method and use method thereof which the e of |
| CN106689738A (en) * | 2016-11-30 | 2017-05-24 | 上海新邦生物科技有限公司 | Sow and piglet integral nutrition scheme |
| CN106689738B (en) * | 2016-11-30 | 2021-04-30 | 上海新邦生物科技有限公司 | Mother-child integrated feeding method |
| CN108497186A (en) * | 2018-03-23 | 2018-09-07 | 广东新南都饲料科技有限公司 | A kind of additive premix improving sow reproductive performance |
| CN108185145A (en) * | 2018-03-29 | 2018-06-22 | 中国科学院亚热带农业生态研究所 | The composite feed additive and preparation method and purposes of sow gestation phase |
| CN108419929A (en) * | 2018-03-29 | 2018-08-21 | 中国科学院亚热带农业生态研究所 | The uridine composition feed addictive and preparation method and purposes of sow gestation phase |
| CN109845900A (en) * | 2019-03-18 | 2019-06-07 | 广州斯宾农牧科技有限公司 | A kind of composite feed additive and its preparation method and application |
| CN110368132A (en) * | 2019-06-24 | 2019-10-25 | 华中农业大学 | A kind of raising cow in summer estrus synchronization-timing semen deposition effect processing method |
| CN110368132B (en) * | 2019-06-24 | 2020-09-15 | 华中农业大学 | Treatment method for improving synchronous estrus-timing insemination effect of dairy cows in summer |
| CN112979504A (en) * | 2021-03-09 | 2021-06-18 | 长沙兴嘉生物工程股份有限公司 | Preparation method and application of argininyl manganese |
| CN112979504B (en) * | 2021-03-09 | 2023-02-28 | 长沙兴嘉生物工程股份有限公司 | Preparation method and application of argininyl manganese |
| CN117959339A (en) * | 2024-03-28 | 2024-05-03 | 广东海洋大学 | Pharmaceutical composition and application thereof in preparation of product for recovering parent snail fertility of Babylonia |
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