CN101952424A - 用于人类和动物葡萄球菌感染的新蛋白 - Google Patents

用于人类和动物葡萄球菌感染的新蛋白 Download PDF

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Publication number
CN101952424A
CN101952424A CN2008801124894A CN200880112489A CN101952424A CN 101952424 A CN101952424 A CN 101952424A CN 2008801124894 A CN2008801124894 A CN 2008801124894A CN 200880112489 A CN200880112489 A CN 200880112489A CN 101952424 A CN101952424 A CN 101952424A
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China
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gly
ala
lys
polypeptide
thr
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CN2008801124894A
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English (en)
Chinese (zh)
Inventor
曼弗雷德·比布尔
迈克尔·福克海姆
霍尔格·格拉勒特
安贾·菲利普
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Profos AG
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Profos AG
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Publication date
Priority claimed from EP07114785A external-priority patent/EP2028271A1/en
Application filed by Profos AG filed Critical Profos AG
Publication of CN101952424A publication Critical patent/CN101952424A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN2008801124894A 2007-08-22 2008-08-19 用于人类和动物葡萄球菌感染的新蛋白 Pending CN101952424A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US95735107P 2007-08-22 2007-08-22
EP07114785.4 2007-08-22
US60/957,351 2007-08-22
EP07114785A EP2028271A1 (en) 2007-08-22 2007-08-22 New proteins for use in human and animal staphylococcus infections
US3221108P 2008-02-28 2008-02-28
EP08152096.7 2008-02-28
US61/032,211 2008-02-28
EP08152096 2008-02-28
PCT/EP2008/006813 WO2009024327A2 (en) 2007-08-22 2008-08-19 New proteins for use in human and animal staphylococcus infections

Publications (1)

Publication Number Publication Date
CN101952424A true CN101952424A (zh) 2011-01-19

Family

ID=40019478

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801124894A Pending CN101952424A (zh) 2007-08-22 2008-08-19 用于人类和动物葡萄球菌感染的新蛋白

Country Status (8)

Country Link
US (3) US8058225B2 (enExample)
EP (1) EP2185699B1 (enExample)
JP (1) JP2010536354A (enExample)
CN (1) CN101952424A (enExample)
CA (1) CA2696864A1 (enExample)
DK (1) DK2185699T3 (enExample)
NO (1) NO2185699T3 (enExample)
WO (1) WO2009024327A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103703127A (zh) * 2011-05-04 2014-04-02 迈克瑞欧斯人体健康有限公司 一种多肽
CN109963578A (zh) * 2016-11-18 2019-07-02 莱桑多公司 针对金黄色葡萄球菌的新抗微生物剂
CN116096398A (zh) * 2020-04-20 2023-05-09 迈克瑞欧斯人体健康有限公司 嵌合内溶素多肽

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010536354A (ja) 2007-08-22 2010-12-02 ヒグロス インベスト ゲーエムベーハー ヒトおよび動物のブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）感染症において使用するための新しいタンパク質
WO2009138475A1 (en) * 2008-05-14 2009-11-19 Profos Ag Modified endolysin ply511
WO2009150171A1 (en) * 2008-06-10 2009-12-17 Profos Ag Method of treatment of inflammatory diseases
EP3263588A1 (en) 2008-07-03 2018-01-03 The Rockefeller University Isolated staphylococcus-specific soluble binding molecule
CA3187222A1 (en) * 2012-05-09 2013-11-14 Contrafect Corporation Biofilm prevention, disruption and treatment with bacteriophage lysin
WO2015070911A1 (en) * 2013-11-14 2015-05-21 Lysando Ag Modified kz144 endolysin sequence
JP7454211B2 (ja) * 2020-01-20 2024-03-22 日本全薬工業株式会社 バクテリオファージ由来エンドライシン
WO2024263589A1 (en) * 2023-06-20 2024-12-26 Topaz Biosciences, Inc. Recombinant cell wall hydrolases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2255561B (en) 1991-04-20 1995-06-21 Agricultural & Food Res Lysins from bacteriophages
US5997862A (en) * 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
JPWO2004020635A1 (ja) * 2002-08-28 2005-12-15 株式会社テクノネットワーク四国 バクテリオファージおよび細菌感染症治療剤
US20070077235A1 (en) * 2004-01-16 2007-04-05 Lawrence Loomis Composition and method of treating mastitis
JP2010536354A (ja) * 2007-08-22 2010-12-02 ヒグロス インベスト ゲーエムベーハー ヒトおよび動物のブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ）感染症において使用するための新しいタンパク質

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103703127A (zh) * 2011-05-04 2014-04-02 迈克瑞欧斯人体健康有限公司 一种多肽
CN108192902A (zh) * 2011-05-04 2018-06-22 迈克瑞欧斯人体健康有限公司 一种多肽
CN109963578A (zh) * 2016-11-18 2019-07-02 莱桑多公司 针对金黄色葡萄球菌的新抗微生物剂
CN116096398A (zh) * 2020-04-20 2023-05-09 迈克瑞欧斯人体健康有限公司 嵌合内溶素多肽

Also Published As

Publication number Publication date
DK2185699T3 (en) 2018-01-22
WO2009024327A3 (en) 2009-05-22
EP2185699B1 (en) 2017-11-22
NO2185699T3 (enExample) 2018-04-21
JP2010536354A (ja) 2010-12-02
US20140065104A1 (en) 2014-03-06
EP2185699A2 (en) 2010-05-19
WO2009024327A2 (en) 2009-02-26
US20120164126A1 (en) 2012-06-28
US8557519B2 (en) 2013-10-15
US20090202512A1 (en) 2009-08-13
US9018155B2 (en) 2015-04-28
US8058225B2 (en) 2011-11-15
CA2696864A1 (en) 2009-02-26

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Application publication date: 20110119