JP2010536354A - ヒトおよび動物のブドウ球菌(Staphylococcus)感染症において使用するための新しいタンパク質 - Google Patents

ヒトおよび動物のブドウ球菌(Staphylococcus)感染症において使用するための新しいタンパク質 Download PDF

Info

Publication number
JP2010536354A
JP2010536354A JP2010521353A JP2010521353A JP2010536354A JP 2010536354 A JP2010536354 A JP 2010536354A JP 2010521353 A JP2010521353 A JP 2010521353A JP 2010521353 A JP2010521353 A JP 2010521353A JP 2010536354 A JP2010536354 A JP 2010536354A
Authority
JP
Japan
Prior art keywords
seq
polypeptide
endolysin
sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010521353A
Other languages
English (en)
Japanese (ja)
Inventor
マンフレッド ビーブル
マイケル フォルシュハイム
ホルガー グララート
アンジャ フィリップ
Original Assignee
ヒグロス インベスト ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07114785A external-priority patent/EP2028271A1/en
Application filed by ヒグロス インベスト ゲーエムベーハー filed Critical ヒグロス インベスト ゲーエムベーハー
Publication of JP2010536354A publication Critical patent/JP2010536354A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2010521353A 2007-08-22 2008-08-19 ヒトおよび動物のブドウ球菌(Staphylococcus)感染症において使用するための新しいタンパク質 Pending JP2010536354A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95735107P 2007-08-22 2007-08-22
EP07114785A EP2028271A1 (en) 2007-08-22 2007-08-22 New proteins for use in human and animal staphylococcus infections
US3221108P 2008-02-28 2008-02-28
EP08152096 2008-02-28
PCT/EP2008/006813 WO2009024327A2 (en) 2007-08-22 2008-08-19 New proteins for use in human and animal staphylococcus infections

Publications (1)

Publication Number Publication Date
JP2010536354A true JP2010536354A (ja) 2010-12-02

Family

ID=40019478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010521353A Pending JP2010536354A (ja) 2007-08-22 2008-08-19 ヒトおよび動物のブドウ球菌(Staphylococcus)感染症において使用するための新しいタンパク質

Country Status (8)

Country Link
US (3) US8058225B2 (enExample)
EP (1) EP2185699B1 (enExample)
JP (1) JP2010536354A (enExample)
CN (1) CN101952424A (enExample)
CA (1) CA2696864A1 (enExample)
DK (1) DK2185699T3 (enExample)
NO (1) NO2185699T3 (enExample)
WO (1) WO2009024327A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014519815A (ja) * 2011-05-04 2014-08-21 マイクレオス ヒューマン ヘルス ビー.ブイ. ポリペプチド
JP2015126738A (ja) * 2008-07-03 2015-07-09 ザ ロックフェラー ユニバーシティ Staphylococcibacteriaに対する活性を有するキメラバクテリオファージ溶解素
JP2015521178A (ja) * 2012-05-09 2015-07-27 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
JP2016537979A (ja) * 2013-11-14 2016-12-08 ライサンド アクツィエンゲゼルシャフト 改変されたkz144エンドリシン配列
JP2021112152A (ja) * 2020-01-20 2021-08-05 日本全薬工業株式会社 バクテリオファージ由来エンドライシン
US12263208B2 (en) 2023-06-20 2025-04-01 Topaz Biosciences, Inc. Recombinant cell wall hydrolases

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2185699T3 (enExample) 2007-08-22 2018-04-21
AU2009248095A1 (en) * 2008-05-14 2009-11-19 Biomerieux S.A. Modified Endolysin Ply511
US20090304673A1 (en) * 2008-06-10 2009-12-10 Bernd Buchberger Method of Treatment of Inflammatory Diseases
CA3044121A1 (en) * 2016-11-18 2018-05-24 Lysando Ag New antimicrobial agents against staphylococcus aureus
JP2023522915A (ja) * 2020-04-20 2023-06-01 マイクレオス ヒューマン ヘルス ビー.ブイ. キメラエンドリシンポリペプチド

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2255561B (en) 1991-04-20 1995-06-21 Agricultural & Food Res Lysins from bacteriophages
US5997862A (en) * 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
AU2003261782A1 (en) * 2002-08-28 2004-03-19 Techno Network Shikoku Co., Ltd. Bacteriophages and remedies for bacterial infection
US20070077235A1 (en) * 2004-01-16 2007-04-05 Lawrence Loomis Composition and method of treating mastitis
NO2185699T3 (enExample) * 2007-08-22 2018-04-21

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015126738A (ja) * 2008-07-03 2015-07-09 ザ ロックフェラー ユニバーシティ Staphylococcibacteriaに対する活性を有するキメラバクテリオファージ溶解素
JP2014519815A (ja) * 2011-05-04 2014-08-21 マイクレオス ヒューマン ヘルス ビー.ブイ. ポリペプチド
JP2015521178A (ja) * 2012-05-09 2015-07-27 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
JP2018087242A (ja) * 2012-05-09 2018-06-07 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
JP2020189860A (ja) * 2012-05-09 2020-11-26 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
JP2022163214A (ja) * 2012-05-09 2022-10-25 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
US11524046B2 (en) 2012-05-09 2022-12-13 Contrafect Corporation Biofilm prevention, disruption and treatment with bacteriophage lysin
JP7368018B2 (ja) 2012-05-09 2023-10-24 コントラフェクト コーポレイション バクテリオファージ溶解素によるバイオフィルムの防止、破壊および処置
JP2016537979A (ja) * 2013-11-14 2016-12-08 ライサンド アクツィエンゲゼルシャフト 改変されたkz144エンドリシン配列
JP2021112152A (ja) * 2020-01-20 2021-08-05 日本全薬工業株式会社 バクテリオファージ由来エンドライシン
JP7454211B2 (ja) 2020-01-20 2024-03-22 日本全薬工業株式会社 バクテリオファージ由来エンドライシン
US12263208B2 (en) 2023-06-20 2025-04-01 Topaz Biosciences, Inc. Recombinant cell wall hydrolases

Also Published As

Publication number Publication date
WO2009024327A2 (en) 2009-02-26
EP2185699A2 (en) 2010-05-19
NO2185699T3 (enExample) 2018-04-21
DK2185699T3 (en) 2018-01-22
CA2696864A1 (en) 2009-02-26
US9018155B2 (en) 2015-04-28
US20140065104A1 (en) 2014-03-06
WO2009024327A3 (en) 2009-05-22
US8557519B2 (en) 2013-10-15
US20090202512A1 (en) 2009-08-13
EP2185699B1 (en) 2017-11-22
US20120164126A1 (en) 2012-06-28
CN101952424A (zh) 2011-01-19
US8058225B2 (en) 2011-11-15

Similar Documents

Publication Publication Date Title
US9018155B2 (en) Proteins for use in human and animal staphylococcus infections
Haddad Kashani et al. Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies
Schmelcher et al. Bacteriophage endolysins as novel antimicrobials
US20120244595A1 (en) Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins
Rodríguez-Rubio et al. Phage lytic proteins: biotechnological applications beyond clinical antimicrobials
Rodríguez et al. Lytic activity of the virion-associated peptidoglycan hydrolase HydH5 of Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88
US20120171188A1 (en) Artificial Peptidoglycan Lysing Enzymes and Peptidoglycan Binding Proteins
Proença et al. A two‐component, multimeric endolysin encoded by a single gene
Xu et al. Engineered endolysin-based “artilysins” for controlling the gram-negative pathogen Helicobacter pylori
Phothichaisri et al. Potential role of the host-derived cell-wall binding domain of endolysin CD16/50L as a molecular anchor in preservation of uninfected Clostridioides difficile for new rounds of phage infection
CN110300760B (zh) 新的内溶素
García-Cano et al. Expression, purification, and characterization of a bifunctional 99-kDa peptidoglycan hydrolase from Pediococcus acidilactici ATCC 8042
CN107022539B (zh) 一种链球菌广谱嵌合裂解酶GBS-V12b及其编码基因和应用
WO2010003943A1 (en) New enzymatic active enzyme against clostridium
SK500752020A3 (sk) Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie
US20180353575A1 (en) Clostridium difficile bacteriophage lysins for detection and treatment of clostridium difficile bacteria infection
Shestak et al. The choice of chromatographic resin for the purification of recombinant lysostaphin affects its activity
EP2028271A1 (en) New proteins for use in human and animal staphylococcus infections
Fischetti Phage lysins: Novel alternative to antibiotics
HK1137039A (en) New proteins for use in human and animal staphylococcus infections
HK1137039B (en) New proteins for use in human and animal staphylococcus infections
Fernandes et al. Staphylococcus aureus
Shang Structure-Guided Engineering of a Multimeric Bacteriophage-Encoded Endolysin PlyC
Etobayeva Identification and Engineering Bacteriophage Endolysins for Inactivation of Gram-Positive Spore-Forming Bacilli
Gouveia Recombinant Antimicrobial Polypeptides as Alternative Antibacterial Agents