CN101945885A - 用作糖皮质激素受体激动剂的甾类衍生物 - Google Patents

用作糖皮质激素受体激动剂的甾类衍生物 Download PDF

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Publication number
CN101945885A
CN101945885A CN2008801268528A CN200880126852A CN101945885A CN 101945885 A CN101945885 A CN 101945885A CN 2008801268528 A CN2008801268528 A CN 2008801268528A CN 200880126852 A CN200880126852 A CN 200880126852A CN 101945885 A CN101945885 A CN 101945885A
Authority
CN
China
Prior art keywords
naphtho
dodecahydro
dimethyl
propyl
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801268528A
Other languages
English (en)
Chinese (zh)
Inventor
哈坎·布莱德
卡尔·埃德曼
托马斯·汉森
卡罗琳纳·拉维茨
马蒂·莱皮斯托
特斯法勒德特·穆希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101945885A publication Critical patent/CN101945885A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2008801268528A 2007-12-20 2008-12-18 用作糖皮质激素受体激动剂的甾类衍生物 Pending CN101945885A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1540407P 2007-12-20 2007-12-20
US61/015,404 2007-12-20
PCT/SE2008/051489 WO2009082342A1 (en) 2007-12-20 2008-12-18 Steroid derivatives acting as glucocorticosteroid receptor agonists

Publications (1)

Publication Number Publication Date
CN101945885A true CN101945885A (zh) 2011-01-12

Family

ID=40801455

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801268528A Pending CN101945885A (zh) 2007-12-20 2008-12-18 用作糖皮质激素受体激动剂的甾类衍生物

Country Status (10)

Country Link
US (1) US20110160167A1 (cg-RX-API-DMAC7.html)
EP (1) EP2235037A1 (cg-RX-API-DMAC7.html)
JP (1) JP2011507836A (cg-RX-API-DMAC7.html)
KR (1) KR20100102121A (cg-RX-API-DMAC7.html)
CN (1) CN101945885A (cg-RX-API-DMAC7.html)
AU (1) AU2008341590A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0821139A2 (cg-RX-API-DMAC7.html)
CA (1) CA2707618A1 (cg-RX-API-DMAC7.html)
RU (1) RU2010124799A (cg-RX-API-DMAC7.html)
WO (1) WO2009082342A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110105420A (zh) * 2019-06-04 2019-08-09 博诺康源(北京)药业科技有限公司 一种布地奈德杂质ep-zg的合成方法
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010003698A (es) 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
EP3407916B1 (en) 2016-01-29 2023-12-20 Merck Sharp & Dohme LLC Phosphonate linkers and their use to facilitate cellular retention of compounds
WO2025231369A1 (en) * 2024-05-03 2025-11-06 Emory University Veragranine analogs, pharmaceutical compositions, and uses in managing pain or inflammatory conditions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
DE3540537A1 (de) * 1985-11-15 1987-05-21 Klaus Kurt Koelzer Verstaerkungsmaterial
WO2005063777A1 (en) * 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382033A (zh) * 2016-10-14 2019-10-25 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制
CN110382033B (zh) * 2016-10-14 2022-04-15 范安德尔研究所 用于设计高效力糖皮质激素的结构与机制
CN110105420A (zh) * 2019-06-04 2019-08-09 博诺康源(北京)药业科技有限公司 一种布地奈德杂质ep-zg的合成方法

Also Published As

Publication number Publication date
BRPI0821139A2 (pt) 2015-06-16
RU2010124799A (ru) 2012-01-27
EP2235037A1 (en) 2010-10-06
US20110160167A1 (en) 2011-06-30
CA2707618A1 (en) 2009-07-02
AU2008341590A1 (en) 2009-07-02
KR20100102121A (ko) 2010-09-20
JP2011507836A (ja) 2011-03-10
WO2009082342A1 (en) 2009-07-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110112