CN101941075A - Synthetic method of antibacterial agent containing nano-silver - Google Patents
Synthetic method of antibacterial agent containing nano-silver Download PDFInfo
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- CN101941075A CN101941075A CN2009101572435A CN200910157243A CN101941075A CN 101941075 A CN101941075 A CN 101941075A CN 2009101572435 A CN2009101572435 A CN 2009101572435A CN 200910157243 A CN200910157243 A CN 200910157243A CN 101941075 A CN101941075 A CN 101941075A
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Abstract
The invention discloses a synthetic method of an antibacterial agent containing nano-silver powder, which has an antibacterial property. The raw materials that the method uses have no toxic and side effects on animals and plants, soluble starch is dissolved in deionized water, heating and stirring are carried out until the soluble starch are fully dissolved, then silver nitrate solution and glucose solution of certain concentration are added respectively, and the golden yellow nano-solver sol antibacterial agent which has good stability is prepared under ultrasound. The nano-silver grains in the sol have small particle size, narrow distribution and regular shape, which are spheroidal and have no toxic and side effects on human bodies, animals and plants. The antibacterial agent can be applied to antibiosis in the fields closely related to human bodies, animals and plants, such as medicine, food packaging, family daily necessities and the like.
Description
Affiliated technical field
The present invention relates to the synthetic method that contains the nano silver particles antiseptic that a kind of preparation has anti-microbial property.Nano Silver is owing to its small-size effect, and skin effect etc. have the performance that is different from block ag material.Nano Silver has stronger biologically active and anti-microbial property, thus Nano Silver can be widely used in fields such as packaging for foodstuff, medical packaging, family daily necessity antibiotic.
Background technology
At present, the preparation method of Nano Silver is varied, mainly contains chemical reduction method, photoreduction met hod, electrochemical process, microemulsion method, microwave method, ultrasonic method, radiation reducing process sputtering method, laser high-temperature combustion method, anode arc plasma discharging method, mechanical milling method and vacuum gas condensation method or the like.
Wherein, the I of the silver particles size that liquid phase reduction technology is simple, make reaches several nanometers, and simple to operate, easy control, therefore is widely adopted, and becomes the main method of preparation Nano Silver in the practical application in industry.Its principle is that silver salt such as silver nitrate and silver sulfate and suitable reducing agent react in liquid phase, the silver-colored cation in the silver salt is reduced to silver atoms, and is grown to simple substance silver particle.
Impurity content with the Nano Silver of the method preparation is higher, and size distribution is wide, and nano silver particles is reunited easily.Therefore, in preparation process, usually need to add the reunion that certain dispersant reduces silver-colored particle, as, organic compound that some are special such as surfactant, polymer or complex can be used as covering (stabilizing agent, dispersant) and come the passivation nanoparticle surface, stop the reunion between the nano particle, thereby prepare dispersed and stability nano silver particles preferably.
In the liquid-phase reduction process, reducing agent commonly used has hydrazine hydrate, natrium citricum, formaldehyde, polyalcohol, organic amine, hydrogen peroxide etc.; Dispersant commonly used has polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), gelatin etc.These reducing agents and dispersant are the chemical reagent to the animals and plants toxic side effect mostly, and environment and biology are had certain potential hazard.
The present invention proposes the synthetic method that a kind of preparation has the antiseptic that contains nano-Ag particles of anti-microbial property.Liquid phase reduction adopts the raw material that human body, animal, plant and environment are had no side effect, and is stabilizing agent with the soluble starch, and glucose is reducing agent, and the preparation of reduction silver nitrate has the nano silver colloidal sol of anti-microbial property under the sonic oscillation condition.Products therefrom does not contain any harmful chemical component, to human body and animal and plant safety and environmental protection, has no side effect.Can be used for human body, the closely-related field of animal and plant antibiotic, as fields such as medical domain, packaging for foodstuff, family daily necessities.
Summary of the invention
In order to overcome the aforementioned deficiency of reducing agent and stabilizing agent in the liquid phase reduction, the present invention proposes the synthetic method that contains the nano silver particles antiseptic that a kind of preparation has anti-microbial property.
With the soluble starch is stabilizing agent, and employing has no side effect, glucose cheap, that reducing power relaxes is reducing agent, and the preparation of reduction silver nitrate has the nano silver colloidal sol of anti-microbial property under the sonic oscillation condition.Concrete preparation method is: take by weighing a certain amount of soluble starch, it is dissolved in the deionized water, heating is stirred to starch and dissolves fully, forms transparent starch solution; Prepare certain density liquor argenti nitratis ophthalmicus and glucose solution; A certain amount of liquor argenti nitratis ophthalmicus and glucose solution dropwise are added drop-wise in the soluble starch solution, stir; It is the ultrasonic field of 100-400W that mixed solution is placed ultrasonic power, and under 40-70 ℃ the temperature conditions, the reaction certain hour prepares flavous nano silver colloidal sol.
Adopt ultraviolet-visible spectrophotometer that nano silver colloidal sol is characterized, the result shows: an absworption peak appears in the nano silver colloidal sol ultraviolet-visible absorption spectroscopy of preparation at the 401nm place, the absworption peak symmetry is better, and narrow distribution; The transmission electron microscope photo of nano silver colloidal sol shows the nano silver particles regular shape, is spheroidal, narrow diameter distribution, and average grain diameter can be controlled between the 20-100nm according to synthetic technological condition.
Nano silver colloidal sol to preparation has carried out the test of anti-microbial property, and the test bacterial classification is Escherichia coli and staphylococcus aureus, and the result shows: the nano silver colloidal sol of preparation reaches 97.87% to colibacillary sterilizing rate; Sterilizing rate to staphylococcus aureus reaches 86.07%, has bactericidal effect preferably.
The present invention successfully prepares regular shape, narrow diameter distribution, and particle diameter is less and have a nano silver colloidal sol of anti-microbial property.Change the condition of reaction, can prepare particle diameter and be the nano silver colloidal sol about 20-100nm.
The invention has the beneficial effects as follows: the method for preparing nano silver colloidal sol that the present invention proposes, compare with existing Nano Silver preparation method and to have the following advantages:
(1) raw material of Cai Yonging are the grape sugar and starches, nontoxic, as human body, environment, animal and plant not had toxic and side effect material.In reaction system, do not introduce any harmful reactant.
(2) nano silver colloidal sol that adopts this method to prepare does not contain any harmful chemical component, and human body, animal and plant are had no side effect.And have good antibacterial performance, therefore can be used for the closely-related field of human body antibiotic, as fields such as medical domain, packaging for foodstuff, family daily necessities.
(3) because the reducing power of glucose is suitable, control process conditions, can obtain the antibiotic colloidal sol of narrow particle size distribution, good stability.
Therefore, compare with the preparation method of other Nano Silver, the nano silver colloidal sol that adopts raw material that the inventive method uses and making to human body, animal and plant have no side effect, with low cost, regular shape, narrow diameter distribution, particle diameter be less, and Escherichia coli and staphylococcus aureus are had more a lot of antibacterial effects, can Secure Application antibiotic in fields such as medical science, packaging for foodstuff, family daily necessities.
Description of drawings
Accompanying drawing is a typical Nano silver grain transmission electron microscope photo in the antiseptic for preparing of the present invention, and silver particles is the spheroidal of rule.Typical Nano silver grain (60-100nm) in the antiseptic among the figure.
The specific embodiment
Further specify below in conjunction with the specific embodiment of the invention.
Embodiment 1
Take by weighing a certain amount of soluble starch, it is dissolved in the deionized water, heating is stirred to starch and dissolves fully, forms the starch solution of clear, is cooled to room temperature.A certain amount of and certain density liquor argenti nitratis ophthalmicus dropwise is added drop-wise in the starch solution, stirs, get a certain amount of and certain density glucose solution again and be added drop-wise in the mixed solution of above-mentioned starch and silver nitrate, stir simultaneously.To react mixed solution, to place power be the 200W ultrasonic field, and reaction is 180 minutes under 70 ℃ of conditions, obtains flavous nano silver colloidal sol, and average grain diameter is 25nm, and particle is spheroidal, is evenly distributed.
Embodiment 2
Take by weighing a certain amount of soluble starch, it is dissolved in the deionized water, heating is stirred to starch and dissolves fully, forms the starch solution of clear, is cooled to room temperature.A certain amount of and certain density liquor argenti nitratis ophthalmicus dropwise is added drop-wise in the starch solution, stirs, get a certain amount of and certain density glucose solution again and be added drop-wise in the mixed solution of above-mentioned starch and silver nitrate, stir simultaneously.To react mixed solution, to place power be the 250W ultrasonic field, and reaction is 90 minutes under 70 ℃ of conditions, obtains flavous nano silver colloidal sol, and average grain diameter is 65nm, and particle is spheroidal, is evenly distributed.
Embodiment 3
Take by weighing a certain amount of soluble starch, it is dissolved in the deionized water, heating is stirred to starch and dissolves fully, forms the starch solution of clear, is cooled to room temperature.A certain amount of and certain density liquor argenti nitratis ophthalmicus dropwise is added drop-wise in the starch solution, stirs, get a certain amount of and certain density glucose solution again and be added drop-wise in the mixed solution of above-mentioned starch and silver nitrate, stir simultaneously.To react mixed solution, to place power be the 100W ultrasonic field, and reaction is 210 minutes under 45 ℃ of conditions, obtains flavous nano silver colloidal sol, and average grain diameter is 47nm, and particle is spheroidal, is evenly distributed.
It should be noted that, above embodiment only is used for technical scheme of the present invention, it will be understood by those skilled in the art that technical scheme of the present invention is carried out various changes and equivalence replacement, and do not deviate from the principle and the scope of technical solution of the present invention, all should be encompassed in the scope of claim of the present invention.
Claims (4)
1. one kind prepares the synthetic method that contains the nano silver particles antiseptic.Liquid phase reduction is a carrier with the soluble starch, and glucose is reducing agent, and the preparation of reduction liquor argenti nitratis ophthalmicus has the stabilized nano silver sol of anti-microbial property under the sonic oscillation condition.Raw material that is adopted and nano silver colloidal sol antiseptic have no side effect to human body, animal and plant and environment.Can be applicable to antibiotic with human body, the closely related field of animal and plant.
2. preparation according to claim 1 contains the synthetic method of nano silver particles antiseptic, it is characterized in that: the starch that uses no side effects is as carrier, and glucose is as reducing agent.
3. preparation according to claim 1 contains the synthetic method of nano silver particles antiseptic, it is characterized in that: under ultrasound condition, ultrasonic power is 100-400W, and temperature is 40-70 ℃, in the aqueous solution, react certain hour, prepare stable golden yellow nano silver colloidal sol.Change reaction condition and can control the silver particles average grain diameter between 20-100nm.
4. preparation according to claim 1 contains the synthetic method of nano silver particles antiseptic, it is characterized in that: prepared nano silver colloidal sol particle diameter little (average grain diameter is less than 100nm), narrow diameter distribution, regular shape is spheroidal, the silver sol good stability, have reasonable antibacterial effect, it is antibiotic to be widely used in fields such as medicine, packaging for foodstuff, family daily necessity.
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198512A (en) * | 2011-05-13 | 2011-09-28 | 同济大学 | Method for preparing nano silver dispersed by glucose reduction complexing agent |
| CN102416478A (en) * | 2011-11-24 | 2012-04-18 | 中国科学院宁波材料技术与工程研究所 | Environmentally-friendly method for preparing silver nanoparticles of different appearances |
| CN102888428A (en) * | 2011-07-21 | 2013-01-23 | 中国科学院过程工程研究所 | Method for synthesizing nano silver by utilizing Bacillus amyloliquefaciensBacillus amyloliquefaciens LSSE-62 |
| CN103341642A (en) * | 2013-07-26 | 2013-10-09 | 莆田学院 | Cellulose environment-friendly synthesis method of nano silver particles |
| CN104068058A (en) * | 2014-07-01 | 2014-10-01 | 南京林业大学 | Preparation method for graphene oxide bacteria-inhibiting composite material |
| CN104328654A (en) * | 2014-10-31 | 2015-02-04 | 南通大学 | High-performance three-proofing antibiotic fabric and finishing method thereof |
| CN104389181A (en) * | 2014-10-31 | 2015-03-04 | 南通大学 | Nano-silver three-proofing anti-bacterial finishing agent and preparation method thereof |
| CN106065297A (en) * | 2016-08-05 | 2016-11-02 | 宝艺新材料股份有限公司 | A kind of corrugated case with durable antibiotic performance |
| CN106176810A (en) * | 2016-07-13 | 2016-12-07 | 长沙迪谷纳米生物科技有限公司 | Medicinal nano material compositions DG 5 is for the purposes of antimicrobial agent |
| CN106238748A (en) * | 2016-08-31 | 2016-12-21 | 华南理工大学 | The synthetic method of ball shaped nano Argent grain and ball shaped nano Argent grain |
| CN107008921A (en) * | 2017-03-31 | 2017-08-04 | 昆明理工大学 | A kind of method for preparing Nano Silver |
| CN107671305A (en) * | 2017-09-22 | 2018-02-09 | 鲁东大学 | The method that nano silver antibacterial agent is quickly prepared using Ligustrum quihoui fruit extracting solution |
| CN111838179A (en) * | 2020-07-23 | 2020-10-30 | 中国药科大学 | Turbulence-enhanced continuously-prepared broad-spectrum drug-resistant bacterium killing preparation as well as preparation method and application thereof |
| CN111842926A (en) * | 2020-07-23 | 2020-10-30 | 中国药科大学 | Method for continuously preparing silver nanoparticles by turbulence enhancement, and obtained material and application thereof |
| CN112280153A (en) * | 2020-11-16 | 2021-01-29 | 丽的包装(广东)有限公司 | Traditional Chinese medicine granule packaging bag and preparation method thereof |
| CN113331208A (en) * | 2020-03-03 | 2021-09-03 | 东北大学秦皇岛分校 | Stable nano silver-titanium suspension and preparation method thereof |
| CN114842971A (en) * | 2022-04-02 | 2022-08-02 | 上海朋格信息技术有限公司 | Integrated intelligent management system for comprehensive doctor-patient intelligent management and health active management |
| CN115414320A (en) * | 2022-09-14 | 2022-12-02 | 四川农业大学 | 1,8-eucalyptol nanoemulsion gel with antifungal effect |
| CN116172090A (en) * | 2022-12-28 | 2023-05-30 | 贵州湄潭盛兴茶业有限公司 | Processing technology of magnolia flower fragrance type black tea |
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2009
- 2009-07-03 CN CN2009101572435A patent/CN101941075A/en active Pending
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198512A (en) * | 2011-05-13 | 2011-09-28 | 同济大学 | Method for preparing nano silver dispersed by glucose reduction complexing agent |
| CN102888428A (en) * | 2011-07-21 | 2013-01-23 | 中国科学院过程工程研究所 | Method for synthesizing nano silver by utilizing Bacillus amyloliquefaciensBacillus amyloliquefaciens LSSE-62 |
| CN102416478A (en) * | 2011-11-24 | 2012-04-18 | 中国科学院宁波材料技术与工程研究所 | Environmentally-friendly method for preparing silver nanoparticles of different appearances |
| CN102416478B (en) * | 2011-11-24 | 2013-09-18 | 中国科学院宁波材料技术与工程研究所 | Environmentally-friendly method for preparing silver nanoparticles of different appearances |
| CN103341642A (en) * | 2013-07-26 | 2013-10-09 | 莆田学院 | Cellulose environment-friendly synthesis method of nano silver particles |
| CN103341642B (en) * | 2013-07-26 | 2015-12-02 | 莆田学院 | A kind of cellulose green syt method of nano silver particles |
| CN104068058A (en) * | 2014-07-01 | 2014-10-01 | 南京林业大学 | Preparation method for graphene oxide bacteria-inhibiting composite material |
| CN104068058B (en) * | 2014-07-01 | 2016-09-14 | 南京林业大学 | A kind of preparation method of graphene oxide antibacterial composite material |
| CN104328654A (en) * | 2014-10-31 | 2015-02-04 | 南通大学 | High-performance three-proofing antibiotic fabric and finishing method thereof |
| CN104389181A (en) * | 2014-10-31 | 2015-03-04 | 南通大学 | Nano-silver three-proofing anti-bacterial finishing agent and preparation method thereof |
| CN104389181B (en) * | 2014-10-31 | 2016-06-08 | 南通大学 | Anti-antibacterial finishing agent of nanometer silver three and preparation method thereof |
| CN106176810A (en) * | 2016-07-13 | 2016-12-07 | 长沙迪谷纳米生物科技有限公司 | Medicinal nano material compositions DG 5 is for the purposes of antimicrobial agent |
| CN106065297A (en) * | 2016-08-05 | 2016-11-02 | 宝艺新材料股份有限公司 | A kind of corrugated case with durable antibiotic performance |
| CN106065297B (en) * | 2016-08-05 | 2017-11-03 | 宝艺新材料股份有限公司 | A kind of corrugated case with durable antibiotic performance |
| CN106238748A (en) * | 2016-08-31 | 2016-12-21 | 华南理工大学 | The synthetic method of ball shaped nano Argent grain and ball shaped nano Argent grain |
| CN107008921A (en) * | 2017-03-31 | 2017-08-04 | 昆明理工大学 | A kind of method for preparing Nano Silver |
| CN107671305A (en) * | 2017-09-22 | 2018-02-09 | 鲁东大学 | The method that nano silver antibacterial agent is quickly prepared using Ligustrum quihoui fruit extracting solution |
| CN107671305B (en) * | 2017-09-22 | 2019-05-10 | 鲁东大学 | The method for quickly preparing nano silver antibacterial agent using Ligustrum quihoui fruit extracting solution |
| CN113331208A (en) * | 2020-03-03 | 2021-09-03 | 东北大学秦皇岛分校 | Stable nano silver-titanium suspension and preparation method thereof |
| CN113331208B (en) * | 2020-03-03 | 2022-08-09 | 东北大学秦皇岛分校 | Stable nano silver-titanium suspension and preparation method thereof |
| CN111842926A (en) * | 2020-07-23 | 2020-10-30 | 中国药科大学 | Method for continuously preparing silver nanoparticles by turbulence enhancement, and obtained material and application thereof |
| CN111838179A (en) * | 2020-07-23 | 2020-10-30 | 中国药科大学 | Turbulence-enhanced continuously-prepared broad-spectrum drug-resistant bacterium killing preparation as well as preparation method and application thereof |
| CN112280153A (en) * | 2020-11-16 | 2021-01-29 | 丽的包装(广东)有限公司 | Traditional Chinese medicine granule packaging bag and preparation method thereof |
| CN114842971A (en) * | 2022-04-02 | 2022-08-02 | 上海朋格信息技术有限公司 | Integrated intelligent management system for comprehensive doctor-patient intelligent management and health active management |
| CN115414320A (en) * | 2022-09-14 | 2022-12-02 | 四川农业大学 | 1,8-eucalyptol nanoemulsion gel with antifungal effect |
| CN116172090A (en) * | 2022-12-28 | 2023-05-30 | 贵州湄潭盛兴茶业有限公司 | Processing technology of magnolia flower fragrance type black tea |
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Application publication date: 20110112 |