CN101933930B - Novel compound anti-coccidiosis medicament and preparation method thereof - Google Patents
Novel compound anti-coccidiosis medicament and preparation method thereof Download PDFInfo
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- CN101933930B CN101933930B CN2010102590749A CN201010259074A CN101933930B CN 101933930 B CN101933930 B CN 101933930B CN 2010102590749 A CN2010102590749 A CN 2010102590749A CN 201010259074 A CN201010259074 A CN 201010259074A CN 101933930 B CN101933930 B CN 101933930B
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- coccidiosis
- toltrazuril
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- coccidium
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Abstract
The invention discloses a medicament for treating coccidiosis, particularly a novel compound anti-coccidiosis medicament and a preparation method thereof. The novel compound anti-coccidiosis medicament is characterized by being prepared from the following components: decoquinate, toltrazuril, polymer carrier, solubilizing agent and anhydrous dextrose. Therefore, the medicament has the advantages that: the indissoluble decoquinate and toltrazuril are prepared into water-soluble substances by using solid dispersion technology and inclusion technology, and the decoquinate and toltrazuril are mixed to fulfill the aim of reducing dosage, improving curative effect and reducing drug resistance; moreover, the synergistic effect of the medicaments can be realized by combining the decoquinate and the toltrazuril, the killing effect is enhanced and the dosage of each medicament is reduced by half.
Description
(1) technical field
The present invention relates to a kind of medicine of treating coccidiosis, particularly a kind of novel composite anti-coccidium medicine and preparation method thereof.
(2) background technology
Coccidiosis is a kind of to the prejudicial parasitic disease of poultry intestinal; Be that various parasites by eimeria cause; Comprise Eimeria acervulina, Eimeria bucephalae, Eimeria maxima, Eimeria tenella, Eimeria necatrix and Eimeria mivati etc.; These parasites breed in enterocyte, destroy the intestinal mucosa integrity, reduce digestion, the absorbability of intestinal.The mortality rate of birds 6%～10% causes by coccidiosis, and causes the reduction of poultry growth rate and feed conversion rate, and the global economy that causes thus loss reaches multi-million dollar every year.At present the control of coccidiosis is main with medicine mainly, and uses chemicals to be still the main means of control, but the life-time service of chemicals makes parasite produce drug resistance easily.The medicine of treatment coccidiosis mainly contains deccox and Toltrazuril at present.Deccox is that a kind of very effective quinolines poultry are used anticoccidial drug, and it mainly passes through stage inhibition sporocyst in the early stage, and mid-term stage is killed early stage schizont and played a role.Since the seventies in 20th century, deccox just has been widely used in the control of birds coccidiosis in many countries, but never uses in China; Toltrazuril belongs to triazineon compounds, has the wide spectrum coccidiostat activity, is widely used in the treatment of chicken coccidiosis; Site of action to coccidiosis is very extensive, and two no sexual cycles of coccidiosis are all had effect, as suppressing schizont; The wall organizator of the karyokinesis of microgametophyte and microgametophyte because interfere coccidiosis nucleus divides and mitochondrion, influences breathing and the metabolic function of polypide; Endocytoplasmic reticulum is expanded, serious ghostization takes place, thereby have the worm of killing effect.But deccox and Toltrazuril are not soluble in water, are difficult for absorbing, and bioavailability is low, is easy to generate drug resistance.
Medical treatment is the main method of preventing and treating chicken coccidiosis at present, but the continuous appearance of drug resistance worm strain, even the continuous appearance of anti-multiple medicine worm strain; Like the appearance of the Eimeria tenella worm strain of anti-diclazuril and Salinomycin, anti-diclazuril and salad ryemycin, requirement must have more varied and medicinal application measure more flexibly, to improve its sensitivity to on-the-spot coccidiosis; Reduce the treating and preventing coccidiosis cost that improves constantly; After introducing a kind of medicine, Drug resistance will soon produce, in order to improve anticoccidial effect; Reduce drug-fast generation, can take drug combination.
(3) summary of the invention
The present invention provides a kind of low dosage, has been specifically designed to novel composite anti-coccidium medicine of treatment coccidiosis and preparation method thereof in order to remedy the deficiency of prior art.
The present invention realizes through following technical scheme:
A kind of novel composite anti-coccidium medicine, its special character is: processed by following components in weight percentage:
Said macromolecule carrier is the combination of several kinds of wherein a kind of of Macrogol 4000, polyethylene glycol 6000, polyvinylpyrrolidone or they; Solubilizing agent is the mixture of cyclodextrin and sodium carbonate.
The method for preparing of novel composite anti-coccidium medicine of the present invention comprises the steps:
With deccox, macromolecule carrier mix homogeneously; Heating and melting is to liquid condition under 100 ℃ of-120 ℃ of conditions; Naturally cool to room temperature then; Under 30 ℃ of-40 ℃ of conditions vacuum drying 30-40 minute, pulverize the back and add Toltrazuril, solubilizing agent, add anhydrous glucose again and stir and promptly get novel composite anti-coccidium medicine of the present invention.
Method for using: admix in the 100-150 kilogram drinking water by per 100 gram the present invention made novel composite anti-coccidium medicines and to use.
Therefore the invention has the beneficial effects as follows: adopt solid dispersion technology and inclusion technique; Deccox, the Toltrazuril of indissoluble are prepared into water-soluble substances, and reach the minimizing dosage, improve curative effect through both compatibility; Reduce chemical sproof purpose; Adopt deccox to add the Toltrazuril drug combination and can bring into play drug synergism, strengthen killing effect, it is half that every kind of drug use dosage is reduced.
(4) specific embodiment
Embodiment 1:
The novel composite anti-coccidium medicine is processed by the component of following weight: deccox 2.2 grams, polyethylene glycol 6000 23 grams, Toltrazuril 1.8 grams, cyclodextrin 30 grams, sodium carbonate 8 grams, anhydrous glucose 35 grams.
Embodiment 2:
This novel composite anti-coccidium medicine is processed by the component of following weight: deccox 1.5 grams, polyvinylpyrrolidone 15 grams, Toltrazuril 2.5 grams, cyclodextrin 30 grams, sodium carbonate 20 grams, anhydrous glucose 31 grams.
Embodiment 3:
The method for preparing of this novel composite anti-coccidium medicine, adopt following steps:
With deccox 3 grams, Macrogol 4000 20 grams, polyethylene glycol 6000 10 gram mix homogeneously; Heating and melting is to liquid condition under 110 ℃ of conditions; Naturally cool to room temperature then; Vacuum drying is 35 minutes under 35 ℃ of conditions, is crushed to add Toltrazuril 1.25 grams, cyclodextrin 20 grams, sodium carbonate 5 grams behind 80 orders, adds anhydrous glucose 40.75 grams again and stirs and promptly get novel composite anti-coccidium medicine of the present invention.
Embodiment 4:
The method for preparing of this novel composite anti-coccidium medicine, adopt following steps:
With deccox 2.5 grams, Macrogol 4000 19 grams, polyvinylpyrrolidone 10 gram mix homogeneously; Heating and melting is to liquid condition under 100 ℃ of conditions; Naturally cool to room temperature then; Vacuum drying is 40 minutes under 30 ℃ of conditions, is crushed to add Toltrazuril 2.25 grams, cyclodextrin 35 grams, sodium carbonate 14 grams behind 80 orders, adds anhydrous glucose 17.25 grams again and stirs and promptly get novel composite anti-coccidium medicine of the present invention.
Embodiment 5:
The method for preparing of this novel composite anti-coccidium medicine, adopt following steps:
With deccox 2 grams, polyethylene glycol 6000 10 grams, polyvinylpyrrolidone 10 gram mix homogeneously; Heating and melting is to liquid condition under 120 ℃ of conditions; Naturally cool to room temperature then; Vacuum drying is 30 minutes under 40 ℃ of conditions, is crushed to add Toltrazuril 2 grams, cyclodextrin 20 grams, sodium carbonate 10 grams behind 80 orders, adds anhydrous glucose 46 grams again and stirs and promptly get novel composite anti-coccidium medicine of the present invention.
Method for using: admix in the 100-150 kilogram drinking water by per 100 gram the present invention made novel composite anti-coccidium medicines and to use.
Test effect is observed:
The I stability test:
Get the embodiment of the invention 1 made novel composite anti-coccidium medicine and be distributed into 100 gram/bags, be divided into 3 groups, every group 20 bag put under the different temperature condition continuously and observed 1 month, is defective like caking, variable color, do not lump, invariant color is qualified.Result of the test is seen table 1:
Table 1
Observe through stability test, the embodiment of the invention 1 made novel composite anti-coccidium medicine is observed all normal under different environmental conditions, does not produce phenomenons such as caking, variable color.
II dissolving, suspendible test:
Get the embodiment of the invention 1 made novel composite anti-coccidium medicine and put into water according to different proportion and dissolve, make complete suspendible.Begin to precipitate beaker from first and pick up counting, result of the test is seen table 2:
Table 2
Deccox, Toltrazuril are the material immiscible with water; The present invention has adopted solid dispersion technology and inclusion technique to increase the dissolubility of deccox, Toltrazuril; And the ratio at water and the embodiment of the invention 1 made novel composite anti-coccidium medicine is 1 liter: during 15 grams, the suspendible time reaches more than 10 hours, considerably beyond therapeutic dose; Show that thus the embodiment of the invention 1 made novel composite anti-coccidium medicine can be used for poultry, fowl drinking-water, and strengthened its availability.
Claims (2)
1. composite anti-coccidium medicine is characterized in that: processed by following components in weight percentage:
Macromolecule carrier is the combination of several kinds of wherein a kind of of Macrogol 4000, polyethylene glycol 6000, polyvinylpyrrolidone or they; Solubilizing agent is the mixture of cyclodextrin and sodium carbonate.
2. the method for preparing of composite anti-coccidium medicine according to claim 1 is characterized in that: comprise the steps:
With deccox, macromolecule carrier mix homogeneously; Heating and melting is to liquid condition under 100 ℃ of-120 ℃ of conditions; Naturally cool to room temperature then; Under 30 ℃ of-40 ℃ of conditions vacuum drying 30-40 minute, pulverize the back and add Toltrazuril, solubilizing agent, add anhydrous glucose again and stir and promptly get the composite anti-coccidium medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102590749A CN101933930B (en) | 2010-08-23 | 2010-08-23 | Novel compound anti-coccidiosis medicament and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102590749A CN101933930B (en) | 2010-08-23 | 2010-08-23 | Novel compound anti-coccidiosis medicament and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101933930A CN101933930A (en) | 2011-01-05 |
| CN101933930B true CN101933930B (en) | 2012-05-23 |
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| CN2010102590749A Expired - Fee Related CN101933930B (en) | 2010-08-23 | 2010-08-23 | Novel compound anti-coccidiosis medicament and preparation method thereof |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997784A (en) * | 2015-08-03 | 2015-10-28 | 福建贝迪药业有限公司 | Specific medicine used for treating coccidiosis and preparation method of specific medicine |
| CN107929289A (en) * | 2016-10-11 | 2018-04-20 | 朱隆娅 | A kind of diclazuril pre-mixing agent and preparation method thereof |
| CN107951883A (en) * | 2016-10-14 | 2018-04-24 | 朱隆娅 | A kind of nitre azoles sand how pre-mixing agent and preparation method thereof |
| CN107951891A (en) * | 2016-10-14 | 2018-04-24 | 朱隆娅 | A kind of coccidiostat containing Adprin and preparation method thereof |
| CN107951889A (en) * | 2016-10-14 | 2018-04-24 | 朱隆娅 | A kind of coccidiostat and preparation method thereof |
| CN108175793B (en) * | 2018-01-19 | 2020-10-27 | 江苏凌云药业股份有限公司 | Veterinary drug composition and preparation method and application thereof |
| CN112176081B (en) * | 2020-09-24 | 2022-05-13 | 中国农业大学 | SNP molecular marker related to chicken coccidian decoquinate drug resistance and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101590055B (en) * | 2009-07-07 | 2011-07-06 | 河南亚卫动物药业有限公司 | Water soluble decoquinate and method for preparing same |
| CN101606908B (en) * | 2009-07-10 | 2013-11-20 | 广州华农大实验兽药有限公司 | Decoquinate soluble powder and preparation method thereof |
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