CN101926910B - Chinese medicinal herbal compound preparation for killing ichthyophthirius multifiliis and preparation method and application - Google Patents
Chinese medicinal herbal compound preparation for killing ichthyophthirius multifiliis and preparation method and application Download PDFInfo
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Abstract
The invention provides a Chinese medicinal herbal compound preparation for killing ichthyophthirius multifiliis and a preparation method and application thereof. The Chinese medicinal herbal compound preparation consists of the following raw material medicaments in percentage by weight: 30 to 40 percent of papaya, 20 to 34 percent of areca seed, 10 to 14 percent of thinleaf milkwort root-bark, 10 to 13 percent of cassia bark, 10 to 12 percent of pokeberry root and 6 to 10 percent of eucalyptus leaf. The preparation method of the Chinese medicinal herbal compound preparation comprises the following steps of: drying and crushing each raw material medicament respectively, and sieving to obtain dry powder of each raw material medicament; mixing the dry powder of each raw material medicament, adding water for soaking, decocting for two times, filtering, and combining two-time filtrate to obtain filtrate a; and boiling the filtrate a for concentrating to make each liter of filtrate contain 100g of raw material medicaments so as to obtain the Chinese medicinal herbal compound preparation. The Chinese medicinal herbal compound preparation is safe, effective and environmental-friendly and can be used for preventing and treating ichthyophthiriasis of fishes.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese herbal compound preparation of killing the parasitic Ichthyophthirius multifiliis of Fish and its production and application.
Background technology
Ichthyophthirius multifiliis (Ichthyophthirius multifiliis) extensively parasitizes in the gill and skin of various freshwater fishes, causes hamartoplasia, forms white point, is called ichthyophthiriasis.This parasite is caused disease fish respiratory function and body surface excretory function obstacle, thereby causes infected fish kills, causes serious economic loss.Aquatic product circle mainly uses malachite green oxalate or Mercury protonitrate. and mercurous acetate treatment ichthyophthiriasis both at home and abroad, and these medicines all are strong poison and strong carcinogenic teratogen, owing to its residual height, big, the serious pollution of water environment of toxicity, is forbidden using on Aquatic product by national governments.At present, lack the medicine for the treatment of ichthyophthiriasis safely and effectively on the Aquatic product.
Summary of the invention
The object of the invention is to provide that a kind of low toxicity easily decomposes, environment amenable composition and the ratio that can kill the Chinese herbal compound preparation of each of Ichthyophthirius multifiliis life cycle polypide in stage, use this compound preparation can effectively kill little melonworm adult, encapsulation and larva, satisfy and produce the needs of going up the control ichthyophthiriasis.
Another purpose of the present invention is to provide the preparation method of this Chinese herbal compound preparation.
Still a further object of the present invention is to provide the application process of this Chinese herbal compound preparation in the control ichthyophthiriasis.
The objective of the invention is to realize by following technical proposals:
Chinese herbal compound preparation of the present invention is made by the following raw materials by weight percent Chinese herbal medicine: Fructus Chaenomelis (Chaenomeles sinensis) 30-40%, Semen Arecae (Areca catecthu) 20-34%, Radix Polygalae (Polygala tenuifolia) 10-14%, Cortex Cinnamomi (Cinnamomum cassia) 10-13%, Radix Phytolaccae (Phytolacca acinosa) 10-12%, Eucalyptus (Eucalyptus robusta) leaf 6-10%.Kill Ichthyophthirius multifiliis test and any each other two kinds of medicine effects test through single Chinese herbal medicine of planting, finds that six kinds of used Chinese herbal medicine of compound preparation of the present invention can both effectively kill this worm and medicine existence synergism (or not having antagonism at least) to a certain degree each other.These six kinds of Chinese herbal medicine are formed compound recipe by a certain percentage, and its insecticidal effect significantly is better than each single drug effect of planting Chinese herbal medicine.
The preparation method of this Chinese herbal compound preparation comprises the steps:
(a) with each crude drug difference crushed after being dried, sieve, get each crude drug dry powder;
(b) with described each crude drug dry powder blend, soak the back and decoct twice, filter, merge filtrate twice, get filtrate a;
(c) filtrate a is boiled concentrated, make drug level be equivalent to the former medicine of 100g/liter, promptly get medicinal liquid of the present invention;
Described crude drug is by weight percentage: Fructus Chaenomelis 30-40%, Semen Arecae 20-34%, Radix Polygalae 10-14%, Cortex Cinnamomi 10-13%, Radix Phytolaccae 10-12%, eucalyptus leaves 6-10%.
The described exsiccant actual conditions of step (a) is dry under 55-65 ℃ in baking oven.
The described order number that sieves of step (a) is the 60-80 order.
The volume of the described water of step (b) is weight 15-30 a times of each crude drug powder mixture.
The coolant-temperature gage of the described immersion of step (b) is 50-80 ℃, and soak time is 50-120 minute.
The described decoction of step (b) is to use slow fire boiling for the first time, decocts 50-60 minute, uses slow fire boiling for the second time, decocts 40-45 minute.
Step (b) is described be filtered into earlier three layers of filtered through gauze after, the reuse silk cover filtering.
Chinese herbal compound preparation of the present invention has the function of killing the parasitic Ichthyophthirius multifiliis of Fish, is used for prevention and treatment Fish ichthyophthiriasis, and external is splashed in water, and dosage is 0.05～0.1 this Chinese herb compound reagent of gram of splashing in every premium on currency.
The present invention compared with prior art has following advantage and beneficial effect:
1, Chinese herbal compound preparation of the present invention, it is big and pollute heavy shortcoming to have overcome malachite green oxalate or the residual height of forbidden drugses such as Mercury protonitrate. and mercurous acetate, toxicity, can effectively kill little melonworm adult, encapsulation and larva, it is low to have toxicity, easily decompose, safety, advantage such as effective has broad prospect of application on Aquatic product.
2, simple on the processing technology of the present invention, factory and individual culturist can prepare satisfactory preparation.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1:
Pawpaw fruit 200 grams, Semen Arecae seed 100 grams, payta 50 grams, Cortex Cinnamomi 50 grams, Radix Phytolaccae 50 grams, eucalyptus leaves 50 grams, gross weight 500 grams.
The pawpaw fruit of present embodiment originates from Hainan, and the Semen Arecae seed originates from Hainan, and payta originates from Sichuan, and Cortex Cinnamomi originates from Guangdong, and Radix Phytolaccae originates from Sichuan, and eucalyptus leaves originates from Sichuan or Guangdong.
Above-mentioned each crude drug is dried to constant weight respectively in 60 ℃ of baking ovens, through pulverizing 80 mesh sieves, gets each crude drug dry powder respectively, be sealed in respectively in the plastic bag, be stored in the dry environment standby.Soaked 1 hour being heated to 50 ℃ tap water with 15L after above-mentioned each crude drug dry powder blend, decoct then, slow fire boiling for the first time 1 hour is after three layers of filtered through gauze, the reuse silk cover filtering, filtering residue slow fire boiling one time 45 minutes again, after three layers of filtered through gauze, the reuse silk cover filtering, merge filtrate twice, boil again concentrated, make drug level be equivalent to 100 the gram former medicine/liter, Chinese herbal compound preparation of the present invention.
With above-mentioned medicinal liquid exsomatize parasite killing and fish body insecticidal test.
1, stripped insecticidal test
Test method: original liquid is diluted to 0.01,0.05 with tap water, the former medicine of 0.1 gram/liter medicinal liquid, in every kind of medicinal liquid, add 100-200 adult, encapsulation and larva respectively, added up the quantity kill these worms at 4 hours;
Result of the test: find to contain in the water the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter, a drug can all be killed little melonworm adult, encapsulation and larva in 4 hours; And the former medicine of 0.01 gram/liter can only kill the part larva, can not kill adult and encapsulation fully, so this concentration can not be used for fish body insecticidal test.
2, fish body insecticidal test
Test method: in Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis or Carassius auratus aquarium, add Chinese herbal compound preparation, make drug level be respectively 0.05,0.1 restrain former medicine/liter, change water every day 1 time, preceding for another example method adds medicinal liquid after changing water, medication in continuous 7 to 10 days, and draw adult and encapsulation every day at the bottom of case, at test under microscope and add up the polypide death toll, the survival rate of the 20th day statistics Ctenopharyngodon idellus or Carassius auratus to the on-test.
Result of the test: through continuous use 7～10 days, the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter water body in, the adult of Carassius auratus and Ctenopharyngodon idellus body surface 95.8%-100% is killed;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of low-grade infection (lose small particles on the gill, only body surface has 3～9 small particles) are respectively 85.6% and 87.4%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of grade and moderate infection (accidental 1～2 small particles on the gill, body surface has 10～20 small particles) are respectively 75.4% and 72.5%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of just having infected (the accidental 1-2 of a body surface small particles does not have small particles on the gill) are respectively 98.2% and 98.5%;
Carassius auratus and its last survival rate of Ctenopharyngodon idellus of obviously infecting little melonworm in the production are respectively 71.3% and 70.4%.
Above presentation of results compound preparation of the present invention Ichthyophthirius multifiliis is had good killing effect, Carassius auratus and the Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis had obvious therapeutic effect.
Embodiment 2:
Pawpaw fruit 150 grams, Semen Arecae seed 170 grams, payta 50 grams, Cortex Cinnamomi 50 grams, Radix Phytolaccae 50 grams, eucalyptus leaves 30 grams, gross weight 500 grams.
The source of each crude drug of present embodiment is with embodiment 1.
Above-mentioned each crude drug is dried to constant weight respectively in 55 ℃ of baking ovens, crosses 80 mesh sieves respectively after crushed, get each crude drug dry powder, be sealed in respectively in the plastic bag, be stored in the dry environment standby.With the water logging bubble 50 minutes that is heated to 60 ℃ after above-mentioned each crude drug dry powder blend with 7.5L, decoct then, slow fire boiling for the first time 1 hour is after three layers of filtered through gauze, the reuse silk cover filtering, filtering residue slow fire boiling one time 45 minutes again, after three layers of filtered through gauze, the reuse silk cover filtering, merge filtrate twice, boil again concentrated, make drug level be equivalent to 100 the gram former medicine/liter, Chinese herbal compound preparation of the present invention.
With above-mentioned medicinal liquid exsomatize parasite killing and fish body insecticidal test.
1, stripped insecticidal test
Test method: original liquid is diluted to 0.01,0.05 with tap water, the former medicine of 0.1 gram/liter medicinal liquid, in every kind of medicinal liquid, add 100-200 adult, encapsulation and larva respectively, added up the quantity kill these worms at 4 hours;
Result of the test: find to contain in the water the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter, a drug can all be killed little melonworm adult, encapsulation and larva in 4 hours; And the former medicine of 0.01 gram/liter can only kill the part larva, can not kill adult and encapsulation fully, so this concentration can not be used for fish body insecticidal test.
2, fish body insecticidal test
Test method: in Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis or Carassius auratus aquarium, add Chinese herbal compound preparation, make drug level be respectively 0.05,0.1 restrain former medicine/liter, change water every day 1 time, preceding for another example method adds medicinal liquid after changing water, medication in continuous 7 to 10 days, and draw adult and encapsulation every day at the bottom of case, at test under microscope and add up the polypide death toll, the survival rate of the 20th day statistics Ctenopharyngodon idellus or Carassius auratus to the on-test.
Result of the test: through continuous use 7～10 days, the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter water body in, the adult of Carassius auratus and Ctenopharyngodon idellus body surface 95.8%-100% is killed;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of low-grade infection (lose small particles on the gill, only body surface has 3～9 small particles) are respectively 81.4% and 84.6%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of grade and moderate infection (accidental 1～2 small particles on the gill, body surface has 10～20 small particles) are respectively 72.3% and 74.2%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of just having infected (the accidental 1-2 of a body surface small particles does not have small particles on the gill) are respectively 97.6% and 98.4%;
Carassius auratus and its last survival rate of Ctenopharyngodon idellus of obviously infecting little melonworm in the production are respectively 70.4% and 69.6%.
Above presentation of results compound preparation of the present invention Ichthyophthirius multifiliis is had good killing effect, Carassius auratus and the Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis had obvious therapeutic effect.
Embodiment 3:
Pawpaw fruit 170 grams, Semen Arecae seed 120 grams, payta 65 grams, Cortex Cinnamomi 55 grams, Radix Phytolaccae 60 grams, eucalyptus leaves 30 grams, gross weight 500 grams.
The source of each crude drug of present embodiment is with embodiment 1.
Above-mentioned each crude drug is dried to constant weight respectively in 65 ℃ of baking ovens, through pulverizing 60 mesh sieves, gets each crude drug dry powder respectively, be sealed in respectively in the plastic bag, be stored in the dry environment standby.Soaked 1 hour being heated to 55 ℃ tap water with 15L after above-mentioned each crude drug dry powder blend, decoct then, slow fire boiling for the first time 1 hour is after three layers of filtered through gauze, the reuse silk cover filtering, filtering residue slow fire boiling one time 45 minutes again is after three layers of filtered through gauze, behind the reuse silk cover filtering, merge filtrate twice, boil again concentrated, make drug level be equivalent to 100 the gram former medicine/liter, Chinese herbal compound preparation of the present invention.
With above-mentioned medicinal liquid exsomatize parasite killing and fish body insecticidal test.
1, stripped insecticidal test
Test method: original liquid is diluted to 0.01,0.05 with tap water, the former medicine of 0.1 gram/liter medicinal liquid, in every kind of medicinal liquid, add 100-200 adult, encapsulation and larva respectively, after 4 hours, add up the quantity kill these worms;
Result of the test: find to contain in the water the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter, a drug can all be killed little melonworm adult, encapsulation and larva in 4 hours; And the former medicine of 0.01 gram/liter can only kill the part larva, can not kill adult and encapsulation fully, so this concentration can not be used for fish body insecticidal test.
2, fish body insecticidal test
Test method: in Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis or Carassius auratus aquarium, add Chinese herbal compound preparation, make drug level be respectively 0.05,0.1 restrain former medicine/liter, change water every day 1 time, preceding for another example method adds medicinal liquid after changing water, medication in continuous 7 to 10 days, and draw adult and encapsulation every day at the bottom of case, at test under microscope and add up the polypide death toll, the survival rate of the 20th day statistics Ctenopharyngodon idellus or Carassius auratus to the on-test.
Result of the test: through continuous use 7～10 days, the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter water body in, the adult of Carassius auratus and Ctenopharyngodon idellus body surface 95.8%-100% is killed;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of low-grade infection (lose small particles on the gill, only body surface has 3～9 small particles) are respectively 84.7% and 85.2%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of grade and moderate infection (accidental 1～2 small particles on the gill, body surface has 10～20 small particles) are respectively 70.8% and 72.1%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of just having infected (the accidental 1-2 of a body surface small particles does not have small particles on the gill) are respectively 98.5% and 98.8%;
Carassius auratus and its last survival rate of Ctenopharyngodon idellus of obviously infecting little melonworm in the production are respectively 70.7% and 68.2%.
Above presentation of results compound preparation of the present invention Ichthyophthirius multifiliis is had good killing effect, Carassius auratus and the Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis had obvious therapeutic effect.
Embodiment 4:
Pawpaw fruit 150 grams, Semen Arecae seed 110 grams, payta 70 grams, Cortex Cinnamomi 65 grams, Radix Phytolaccae 55 grams, eucalyptus leaves 50 grams, gross weight 500 grams.
The source of each crude drug of present embodiment is with embodiment 1.
Above-mentioned each crude drug is dried to constant weight respectively in 65 ℃ of baking ovens, through pulverizing 80 mesh sieves, gets each crude drug dry powder respectively, be sealed in respectively in the plastic bag, be stored in the dry environment standby.Soaked 2 hours being heated to 80 ℃ tap water with 7.5L after above-mentioned each crude drug dry powder blend, decoct then, slow fire boiling for the first time 50 minutes is after three layers of filtered through gauze, the reuse silk cover filtering, filtering residue slow fire boiling one time 45 minutes again is after three layers of filtered through gauze, behind the reuse silk cover filtering, merge filtrate twice, boil again concentrated, make drug level be equivalent to 100 the gram former medicine/liter, Chinese herbal compound preparation of the present invention.
With above-mentioned medicinal liquid exsomatize parasite killing and fish body insecticidal test.
1, stripped insecticidal test
Test method: original liquid is diluted to 0.01,0.05 with tap water, the former medicine of 0.1 gram/liter medicinal liquid, in every kind of medicinal liquid, add 100-200 adult, encapsulation and larva respectively, added up the quantity kill these worms at 4 hours;
Result of the test: find to contain in the water the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter, a drug can all be killed little melonworm adult, encapsulation and larva in 4 hours; And the former medicine of 0.01 gram/liter can only kill the part larva, can not kill adult and encapsulation fully, so this concentration can not be used for fish body insecticidal test.
2, fish body insecticidal test
Test method: in Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis or Carassius auratus aquarium, add Chinese herbal compound preparation, make drug level be respectively 0.05,0.1 restrain former medicine/liter, change water every day 1 time, preceding for another example method adds medicinal liquid after changing water, medication in continuous 7 to 10 days, and draw adult and encapsulation every day at the bottom of case, at test under microscope and add up the polypide death toll, the survival rate of the 20th day statistics Ctenopharyngodon idellus or Carassius auratus to the on-test.
Result of the test: through continuous use 7～10 days, the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter water body in, the adult of Carassius auratus and Ctenopharyngodon idellus body surface 95.8%-100% is killed;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of low-grade infection (lose small particles on the gill, only body surface has 3～9 small particles) are respectively 86.5% and 87.4%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of grade and moderate infection (accidental 1～2 small particles on the gill, body surface has 10～20 small particles) are respectively 72.4% and 69.8%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of just having infected (the accidental 1-2 of a body surface small particles does not have small particles on the gill) are respectively 97.5% and 98.3%;
Carassius auratus and its last survival rate of Ctenopharyngodon idellus of obviously infecting little melonworm in the production are respectively 69.4% and 70.6%.
Above presentation of results compound preparation of the present invention Ichthyophthirius multifiliis is had good killing effect, Carassius auratus and the Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis had obvious therapeutic effect.
Embodiment 5:
Pawpaw fruit 150 grams, Semen Arecae seed 150 grams, payta 60 grams, Cortex Cinnamomi 50 grams, Radix Phytolaccae 60 grams, eucalyptus leaves 30 grams, gross weight 500 grams.
The source of each crude drug of present embodiment is with embodiment 1.
Above-mentioned each crude drug is dried to constant weight respectively in 65 ℃ of baking ovens, through pulverizing 80 mesh sieves, gets each crude drug dry powder respectively, be sealed in respectively in the plastic bag, be stored in the dry environment standby.With the water logging bubble 50 minutes that is heated to 80 ℃ after above-mentioned each crude drug dry powder blend with 15L, decoct then, slow fire boiling for the first time 50 minutes is after three layers of filtered through gauze, the reuse silk cover filtering, filtering residue slow fire boiling one time 40 minutes again, after three layers of filtered through gauze, the reuse silk cover filtering, merge filtrate twice, boil again concentrated, make drug level be equivalent to 100 the gram former medicine/liter, Chinese herbal compound preparation of the present invention.
With above-mentioned medicinal liquid exsomatize parasite killing and fish body insecticidal test.
1, stripped insecticidal test
Test method: original liquid is diluted to 0.01,0.05 with tap water, the former medicine of 0.1 gram/liter medicinal liquid, in every kind of medicinal liquid, add 100-200 adult, encapsulation and larva respectively, after 4 hours, add up the quantity kill these worms;
Result of the test: find to contain in the water the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter, a drug can all be killed little melonworm adult, encapsulation and larva in 4 hours; And the former medicine of 0.01 gram/liter can only kill the part larva, can not kill adult and encapsulation fully, so this concentration can not be used for fish body insecticidal test.
2, fish body insecticidal test
Test method: in Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis or Carassius auratus aquarium, add Chinese herbal compound preparation, make drug level be respectively 0.05,0.1 restrain former medicine/liter, change water every day 1 time, preceding for another example method adds medicinal liquid after changing water, medication in continuous 7 to 10 days, and draw adult and encapsulation every day at the bottom of case, at test under microscope and add up the polypide death toll, the survival rate of the 20th day statistics Ctenopharyngodon idellus or Carassius auratus to the on-test.
Result of the test: through continuous use 7～10 days, the former medicine of medicinal liquid final concentration 0.05,0.1 gram/liter water body in, the adult of Carassius auratus and Ctenopharyngodon idellus body surface 95.8%-100% is killed;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of low-grade infection (lose small particles on the gill, only body surface has 3～9 small particles) are respectively 84.2% and 83.5%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of grade and moderate infection (accidental 1～2 small particles on the gill, body surface has 10～20 small particles) are respectively 70.1% and 69.3%;
Carassius auratus and its survival rate of Ctenopharyngodon idellus of just having infected (the accidental 1-2 of a body surface small particles does not have small particles on the gill) are respectively 98.5% and 97.8%;
Carassius auratus and its last survival rate of Ctenopharyngodon idellus of obviously infecting little melonworm in the production are respectively 68.5% and 66.4%.
Above presentation of results compound preparation of the present invention Ichthyophthirius multifiliis is had good killing effect, Carassius auratus and the Ctenopharyngodon idellus that has infected Ichthyophthirius multifiliis had obvious therapeutic effect.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; the any of other do not deviating from the change done under spirit of the present invention and the principle, modification, substituting, combination, simplifying; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (9)
1. Chinese herbal compound preparation of killing Ichthyophthirius multifiliis, it is characterized in that: described Chinese herbal compound preparation is made by the following raw materials by weight percent medicine: Fructus Chaenomelis 30-40%, Semen Arecae 20-34%, Radix Polygalae 10-14%, Cortex Cinnamomi 10-13%, Radix Phytolaccae 10-12%, Folium eucalypti globueli (Eucalyptus globulus Labill.) 6-10%.
2. according to the preparation method of the described Chinese herbal compound preparation of claim 1, it is characterized in that: comprise the steps:
(a) with each crude drug difference crushed after being dried, sieve, get each crude drug dry powder;
(b) with described each crude drug dry powder blend, soak the back and decoct twice, filter, merge filtrate twice, get filtrate a;
(c) filtrate a is boiled concentrated, make drug level be equivalent to the former medicine of 100g/liter, promptly get medicinal liquid of the present invention;
Described crude drug is by weight percentage: Fructus Chaenomelis 30-40%, Semen Arecae 20-34%, Radix Polygalae 10-14%, Cortex Cinnamomi 10-13%, Radix Phytolaccae 10-12%, Folium eucalypti globueli (Eucalyptus globulus Labill.) 6-10%.
3. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the described exsiccant actual conditions of step (a) is dry under 55-65 ℃ in baking oven.
4. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the described order number that sieves of step (a) is the 60-80 order.
5. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the volume of the described water of step (b) is 15-30 times of the weight of each crude drug powder mixture.
6. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the temperature of the described immersion of step (b) is 50-80 ℃, and soak time is 50-120 minute.
7. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the described decoction of step (b) is to use slow fire boiling for the first time, decocts 50-60 minute, uses slow fire boiling for the second time, decocts 40-45 minute.
8. according to the preparation method of the described Chinese herbal compound preparation of claim 2, it is characterized in that: the described filtration of step (b) is first with after three layers of filtered through gauze, the reuse silk cover filtering.
9. the application of the described Chinese herbal compound preparation of claim 1 in the medicine of preparation control Ichthyophthirius multifiliis disease.
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| CN102670649B (en) * | 2011-12-22 | 2013-04-10 | 河南科技大学 | Drug for preventing and treating ichthyophthiriasis of pet fish |
| CN106038682A (en) * | 2016-07-18 | 2016-10-26 | 暨南大学 | Chinese herbal medicine compound preparation for preventing and treating chthyophthirius multifilis for fish as well as preparation and application of Chinese herbal medicine compound preparation |
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| CN101926910A (en) | 2010-12-29 |
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