CN101897753A - Traditional Chinese medicine for treating coronary disease and preparation method thereof - Google Patents
Traditional Chinese medicine for treating coronary disease and preparation method thereof Download PDFInfo
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- CN101897753A CN101897753A CN2010101879164A CN201010187916A CN101897753A CN 101897753 A CN101897753 A CN 101897753A CN 2010101879164 A CN2010101879164 A CN 2010101879164A CN 201010187916 A CN201010187916 A CN 201010187916A CN 101897753 A CN101897753 A CN 101897753A
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Abstract
The invention discloses a traditional Chinese medicine for treating coronary disease and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials by weight: 120g of salvia miltiorrhiza bunge, 100g of pseudo-ginseng root, 50g of earthworm, 100g of leech (prepared) and 50g of dalbergia wood. Various conventional formulations of the traditional Chinese medicine can be prepared by the following steps of: extracting by using ethanol, recovering the solvent, concentrating under reduced pressure, drying and crushing the materials into fine powder. The traditional Chinese medicine has the advantages of short course of treatment, quick response, no medicine resistance, and small toxic or side effect. The traditional Chinese medicine has the effects of promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, clearing and activating the channels and collaterals, and combining dredging and tonifying methods, and has better curative effects on coronary disease and angina pectoris in modern medicine. The symptoms of the coronary disease and angina pectoris comprise chest obstruction caused by blood stasis and qi stagnation, heart pain like prickling or twisting at fixed positions and severe pain at night, even chest pain radiating to the back, or back pain radiating to the chest, or pain radiating to the shoulder and the back along with chest stuffiness; the pain cannot be cured for a long time, and can become severe due to extreme anger and fatigue; the tongue is dark purple with ecchymosis and has thin tongue coat; the pulse string is unsmooth, and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine for the treatment of coronary heart disease, relate to the preparation method of this kind medicine simultaneously.
Background technology
Coronary heart disease is the principal disease that threatens human health, be the No.1 killer of many countries and regions crowds in the world today, the cardiovascular diseases also rises year by year at the sickness rate of China, show according to investigations, the existing patients with coronary heart disease of China has nearly 100,000,000 people, and coronary heart disease has become one of the highest disease of fatality rate in the many diseases of China.Characteristics the such as at present medicine of treatment coronary heart disease is more, and Chinese patent medicine or natural extracts be with its better tolerance, and side effect is little have than remarkable advantages aspect the coronary heart disease preventing and treating, and are existing more by the herbal species of wide clinical application.Mainly contain preparations such as Radix Salviae Miltiorrhizae class, Semen Ginkgo class, flavonoid, Moschus class, Radix Puerariae class, but that the application of said medicine exists the course of treatment is long, cures slowly, expense is high, curative effect is remarkable inadequately.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine for the treatment of coronary heart disease and preparation method thereof, use advantages such as courses of pharmaceuticals weak point of the present invention, instant effect, no Drug resistance and toxic and side effects are little.
Medicament selection Radix Salviae Miltiorrhizae of the present invention, Radix Notoginseng, Pheretima, Lignum Dalbergiae Odoriferae, Hirudo make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat coronary heart disease, medicine of the present invention cures mainly the thoracic obstruction due to the stagnation of QI and blood, so based on blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dredge the meridian passage.Wherein Radix Salviae Miltiorrhizae bitter in the mouth cold nature, go into conscience two warps, promoting blood circulation to disperse blood clots and relieves pain.Hold concurrently during Compendium of Material Medica claims its " broken stagnated blood, mend fresh blood " to have to live and support, blood stasis dispelling is the length of blood trouble not, so be monarch drug; The Radix Notoginseng anastalsis is extensive, again can blood stasis dispelling.Render meritorious service to invigorate blood circulation motionless blood, the hemostasis do not stay the stasis of blood it." beautiful Chinese catalpa medicine is separated " claims it " with battalion's hemostasis, the clots absorbing of promoting blood circulation, and to help the Radix Salviae Miltiorrhizae promoting blood circulation to disperse blood clots and relieves pain.Hirudo salty in the mouth hardship, property are equalled the merit of removing blood stasis is arranged, stimulating the menstrual flow; Pheretima salty in the mouth and cold in nature has the merit of heat clearing away arresting convulsion, collateral dredging diuresis, share the reinforcement acupuncture-stimulating blood stasis dispersing with Hirudo, is ministerial drug altogether; Assistant is with the Lignum Dalbergiae Odoriferae of Xin Wen ventilation perfume, and fragrance is regulated the flow of vital energy to help and invigorated blood circulation to have one's ideas straightened out, and dissipating blood stasis is with analgesic therapy, and all medicines share plays blood circulation promoting and blood stasis dispelling altogether, promoting the circulation of QI to relieve pain, the merit of dredge the meridian passage.Modern pharmacological research proves: Radix Salviae Miltiorrhizae has the effect of heart tonifying, coronary dilating, increase myocardial flow, antithrombotic formation, microcirculation improvement; Radix Notoginseng has antithrombotic, regulates immunity, promotes effects such as hemopoietic, coronary dilating; Hirudo has effects such as anticoagulant, thrombolytic, blood fat reducing, the nutrition of increase cardiac muscle blood; Pheretima has thrombolytic, anticoagulant, arrhythmia and convulsion and sedation; Volatile oil of Lignum Dalbergiae Odoriferae and Aromatic water thereof have anti thrombotic action, and yellow wingceltis have faint anticoagulation, can significantly increase coronary flow, and decreased heart rate slightly increases the heart beating amplitude, does not cause arrhythmia.The Lignum Dalbergiae Odoriferae ethanol extraction has convulsion, analgesic activity.
The consumption of Chinese medicinal components of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components is for all having better curative effect in following weight range:
Radix Salviae Miltiorrhizae 50-200 gram, Radix Notoginseng 50-200 gram, Pheretima 30-150 gram, Hirudo (processing) 30-150 gram, Lignum Dalbergiae Odoriferae 20-100 gram.
Be preferably: Radix Salviae Miltiorrhizae 120 grams, Radix Notoginseng 100 grams, Pheretima 50 grams, Hirudo (processing) 100 grams, Lignum Dalbergiae Odoriferae 50 grams.
Medicine of the present invention can adopt Chinese medicine preparation to be prepared into any conventional oral preparations, can be made into capsule, tablet, granule, mixture etc.
Chinese medicinal preparation method of the present invention is as follows: choose Chinese medicine by recipe quantity:
A, get Radix Notoginseng, Lignum Dalbergiae Odoriferae 70% ethanol extraction, alcohol extract 1.
B, get Radix Salviae Miltiorrhizae, use 90% ethanol extraction, alcohol extract 2.
C, get Radix Salviae Miltiorrhizae carry alcohol back medicinal residues again with Pheretima altogether decocting get decocting liquid 3.
D, merge said extracted liquid 1,2,3 and reclaim solvents, concentrating under reduced pressure, drying, be ground into fine powder, with recipe quantity Hirudo fecula mix homogeneously, add appropriate amount of auxiliary materials, filling capsule promptly.
Chinese medicine of the present invention can also be prepared as follows method: choose Chinese medicine by recipe quantity,
A, get Radix Notoginseng and use 70% ethanol extraction, alcohol extract 1.
B, get Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae 90% ethanol extraction, alcohol extract 2.
Medicinal residues are total to decocting with Pheretima again and get decocting liquid 3 after c, Radix Salviae Miltiorrhizae, the Lignum Dalbergiae Odoriferae alcohol extraction.
D, merge said extracted liquid 1,2,3 and reclaim solvents, concentrating under reduced pressure, dry, be ground into fine powder, with recipe quantity Hirudo fecula mix homogeneously, add appropriate amount of auxiliary materials, incapsulate promptly.
Chinese medicine of the present invention can also be prepared as follows method:
Prescription is measured above-mentioned Chinese medicine of the five flavours, and decocting is three times altogether, and each 1.5 hours, merge three times decocting liquid, concentrating under reduced pressure, drying is ground into fine powder, adds appropriate amount of auxiliary materials and incapsulates promptly.
The adjuvant of the described adding of Chinese medicine of the present invention is conventional adjuvant, as disintegrating agent, and lubricant, binding agent.
The described Hirudo fecula of Chinese medicine of the present invention is to be developed into powder after the Hirudo drying.
Chinese medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dredge the meridian passage, is used for the treatment of the thoracic obstruction due to the blood stasis resistance numbness, and disease is seen ambition pain, as thorn as strand, localized pain, at nightfall for very, very then chest pain radiating to the back, or pain draws shoulder and carries on the back, with uncomfortable in chest, with the passing of time do not heal, can be because of rage, tired aggravation.Purplish tongue has ecchymosis, thin fur, stringy and hesitant pulse etc.
The specific embodiment
Below further set forth the beneficial effect of Chinese medicine of the present invention by testing example
1, physical data
Accept out-patient's totally 150 examples for medical treatment, wherein male 100 examples, women 50 examples, maximum 79 years old age, minimal ages 35 years old, wherein professional cadre 10 people, teacher 15 people, workman 75 people, driver 10 people, peasant 40 people.
2, diagnostic criteria
The qi depression to blood stasis of primary disease is a mark, and it lowly is this that heart-yang is not declared function such as deficiency of heart-QI, and ambition pain is as thorn as strand, localized pain, at nightfall for very, chest pain radiating to the back very then, backache radiating to the heart, or draw the shoulder back of the body bitterly, and with uncomfortable in chest, with the passing of time do not heal, can be because of rage, tired aggravation.Purplish tongue has ecchymosis, thin fur, and stringy and hesitant pulse, feeling oppressed in the front has paroxysmal pain person, and with physical and chemical inspection report or expert consultation diagnosis such as hospital's color ultrasound, electrocardios.
3, Therapeutic Method is taken Chinese medicinal capsule of the present invention, every heavy 0.4-0.5 gram, and each 1.2-2.0 gram, was taken Chinese medicine 20-30 of the present invention days at every day three times
The result; Cure 137 examples, 10 examples that take a turn for the better, invalid 3 examples, total effective rate 98%.
Claims (5)
1. a Chinese medicine for the treatment of coronary heart disease is characterized in that it mainly is to be made by the following raw materials in weight medicine: Radix Salviae Miltiorrhizae 50-200 gram, Radix Notoginseng 50-200 gram, Pheretima 30-150 gram, Hirudo (processing) 30-150 gram, Lignum Dalbergiae Odoriferae 20-100 gram.
2. the Chinese medicine of treatment coronary heart disease according to claim 1, wherein the consumption of crude drug is: Radix Salviae Miltiorrhizae 120 grams, Radix Notoginseng 100 grams, Pheretima 50 grams, Hirudo (processing) 100 grams, Lignum Dalbergiae Odoriferae 50 grams.
3. the described a kind of preparation method of Chinese medicine for the treatment of coronary heart disease of claim 1 comprises the following steps; A, prescription are measured Radix Notoginseng, Lignum Dalbergiae Odoriferae 70% ethanol extraction, get alcohol extract 1, b, prescription are measured Radix Salviae Miltiorrhizae 90% ethanol extraction, get alcohol extract 2, c, Radix Salviae Miltiorrhizae are carried the back medicinal residues of alcohol and are got decocting liquid 3 with the common decocting of Pheretima again, d, merge said extracted liquid 1,2,3 and reclaim solvents, concentrating under reduced pressure, drying, be ground into fine powder, with prescription water gaging little molehill fecula mix homogeneously filling capsule promptly.
4. the described a kind of Chinese medicinal preparation method for the treatment of coronary heart disease of claim 1, comprise the following steps: that a, prescription measure Radix Notoginseng and use 70% ethanol extraction, get alcohol extract 1, b, prescription are measured Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae 90% ethanol extraction, get alcohol extract 2, medicinal residues are total to decocting with Pheretima again and get decocting liquid 3 after c, Radix Salviae Miltiorrhizae, the Lignum Dalbergiae Odoriferae alcohol extraction, and d, merging said extracted liquid 1,2,3 reclaim solvents, concentrating under reduced pressure, drying, be ground into fine powder and recipe quantity Hirudo fecula mix homogeneously, incapsulate promptly.
5. the described a kind of preparation method of Chinese medicine for the treatment of coronary heart disease of claim 1, comprise the following steps: to write out a prescription and measure the common decocting of above-mentioned Chinese medicine of the five flavours three times, each 1.5 hours, merge three times decocting liquid, concentrating under reduced pressure, drying, be ground into fine powder and incapsulate promptly.
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| CN101897753B CN101897753B (en) | 2011-08-24 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056199A (en) * | 2014-06-26 | 2014-09-24 | 青岛市市立医院 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases |
| CN109331119A (en) * | 2018-11-21 | 2019-02-15 | 周学东 | It is a kind of to have effects that more Chinese medicine composition and its preparation and application |
| CN113499414A (en) * | 2021-08-27 | 2021-10-15 | 威海德尚医中医药科技有限公司 | A Chinese medicinal composition for thrombolysis and preventing cardiovascular diseases, and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772149A (en) * | 2005-11-16 | 2006-05-17 | 许兆顺 | Chinese medicine composition for treating coronary heart disease and its prepn |
| CN101168042A (en) * | 2007-11-07 | 2008-04-30 | 周鲁菲 | Traditional Chinese medicine preparation for curing cardiovascular and cerebrovascular diseases and preparing method |
-
2010
- 2010-05-27 CN CN2010101879164A patent/CN101897753B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772149A (en) * | 2005-11-16 | 2006-05-17 | 许兆顺 | Chinese medicine composition for treating coronary heart disease and its prepn |
| CN101168042A (en) * | 2007-11-07 | 2008-04-30 | 周鲁菲 | Traditional Chinese medicine preparation for curing cardiovascular and cerebrovascular diseases and preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 《中国医药指南》 20080531 宋凌 冠心病心绞痛的中西医结合治疗研究近况与展望 53-57 1-5 第6卷, 第5期 2 * |
| 《湖南中医药导报》 19951231 唐承安 冠心病的中医药证治规律探讨 35-38 1-5 第1卷, 第5期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056199A (en) * | 2014-06-26 | 2014-09-24 | 青岛市市立医院 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases |
| CN109331119A (en) * | 2018-11-21 | 2019-02-15 | 周学东 | It is a kind of to have effects that more Chinese medicine composition and its preparation and application |
| CN113499414A (en) * | 2021-08-27 | 2021-10-15 | 威海德尚医中医药科技有限公司 | A Chinese medicinal composition for thrombolysis and preventing cardiovascular diseases, and its preparation method |
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| CN101897753B (en) | 2011-08-24 |
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Effective date of registration: 20170217 Address after: 151500 Suihua City, Heilongjiang province Lanxi County Xiushui home district building Patentee after: Heilongjiang Qianyuan Kuntai medical instrument Ltd. Address before: 152000 Heilongjiang Province, Suihua City Economic Development Zone Xing Sui Road No. 17 Patentee before: HARBIN PHARMACEUTICAL GROUP SANJING NUOJIE PRARMACEUTICAL Co.,Ltd. |
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