CN101890160B - 多价重组人乳头瘤病毒疫苗及其应用 - Google Patents
多价重组人乳头瘤病毒疫苗及其应用 Download PDFInfo
- Publication number
- CN101890160B CN101890160B CN200910082730.XA CN200910082730A CN101890160B CN 101890160 B CN101890160 B CN 101890160B CN 200910082730 A CN200910082730 A CN 200910082730A CN 101890160 B CN101890160 B CN 101890160B
- Authority
- CN
- China
- Prior art keywords
- pentamer
- albumen
- vaccine
- hpv16
- recombinant human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940124866 human papillomavirus vaccine Drugs 0.000 title claims abstract description 14
- 229960005486 vaccine Drugs 0.000 claims abstract description 56
- 229920000642 polymer Polymers 0.000 claims abstract description 13
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 10
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 4
- 241000341655 Human papillomavirus type 16 Species 0.000 claims description 36
- 238000002360 preparation method Methods 0.000 claims description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 17
- 239000000872 buffer Substances 0.000 claims description 17
- 241000700605 Viruses Species 0.000 claims description 16
- 239000008363 phosphate buffer Substances 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 238000000746 purification Methods 0.000 claims description 12
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 9
- 102000057593 human F8 Human genes 0.000 claims description 9
- 229940047431 recombinate Drugs 0.000 claims description 9
- 238000004321 preservation Methods 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 5
- 108090000565 Capsid Proteins Proteins 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 229960003180 glutathione Drugs 0.000 claims description 3
- 229920000936 Agarose Polymers 0.000 claims description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
- 108010024636 Glutathione Proteins 0.000 claims description 2
- 101100209954 Human papillomavirus type 16 L1 gene Proteins 0.000 claims description 2
- 238000001042 affinity chromatography Methods 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000013613 expression plasmid Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 claims description 2
- 238000000386 microscopy Methods 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 239000012264 purified product Substances 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000010414 supernatant solution Substances 0.000 claims description 2
- 235000003969 glutathione Nutrition 0.000 claims 2
- 229920002684 Sepharose Polymers 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract description 14
- 206010008342 Cervix carcinoma Diseases 0.000 abstract description 13
- 201000010881 cervical cancer Diseases 0.000 abstract description 13
- 206010059313 Anogenital warts Diseases 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract description 2
- 230000000192 social effect Effects 0.000 abstract description 2
- 238000010369 molecular cloning Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 10
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 241000701806 Human papillomavirus Species 0.000 description 3
- 208000003445 Mouth Neoplasms Diseases 0.000 description 3
- 201000008275 breast carcinoma Diseases 0.000 description 3
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 201000000849 skin cancer Diseases 0.000 description 3
- 201000008261 skin carcinoma Diseases 0.000 description 3
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 201000005619 esophageal carcinoma Diseases 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 208000003154 papilloma Diseases 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 206010038038 rectal cancer Diseases 0.000 description 2
- 201000001275 rectum cancer Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 206010008354 Cervix neoplasm Diseases 0.000 description 1
- 101100102667 Human papillomavirus 58 L1 gene Proteins 0.000 description 1
- 206010021432 Immunisation reaction Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010027145 Melanocytic naevus Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010034811 Pharyngeal cancer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 210000003725 endotheliocyte Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000021145 human papilloma virus infection Diseases 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940031348 multivalent vaccine Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000005582 sexual transmission Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910082730.XA CN101890160B (zh) | 2009-04-28 | 2009-04-28 | 多价重组人乳头瘤病毒疫苗及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910082730.XA CN101890160B (zh) | 2009-04-28 | 2009-04-28 | 多价重组人乳头瘤病毒疫苗及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101890160A CN101890160A (zh) | 2010-11-24 |
CN101890160B true CN101890160B (zh) | 2014-06-18 |
Family
ID=43099619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910082730.XA Active CN101890160B (zh) | 2009-04-28 | 2009-04-28 | 多价重组人乳头瘤病毒疫苗及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101890160B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10238729B2 (en) | 2014-10-24 | 2019-03-26 | Hpvvax, Llc | Cancer and skin lesion treatment |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104710515B (zh) * | 2013-12-17 | 2019-11-29 | 北京康乐卫士生物技术股份有限公司 | 人乳头瘤病毒l1蛋白突变体及其制备方法 |
US10799574B2 (en) | 2014-10-24 | 2020-10-13 | Hpvvax. Llc | Method and composition for treating cancer or skin lesion using a vaccine |
MX2018010338A (es) * | 2016-02-27 | 2018-11-09 | Hpvvax Llc | Metodo y composicion para tratamiento del cancer o una lesion de la piel utilizando una vacuna. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
-
2009
- 2009-04-28 CN CN200910082730.XA patent/CN101890160B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101245099A (zh) * | 2007-02-14 | 2008-08-20 | 马润林 | 重组人乳头瘤病毒l1衣壳蛋白的氨基酸序列及其应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10238729B2 (en) | 2014-10-24 | 2019-03-26 | Hpvvax, Llc | Cancer and skin lesion treatment |
Also Published As
Publication number | Publication date |
---|---|
CN101890160A (zh) | 2010-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN113559253B (zh) | 用于治疗或预防人乳头瘤病毒感染的多型hpv肽的组合物和方法 | |
Frazer et al. | Prevention of cancer through immunization: prospects and challenges for the 21st century | |
CN101890160B (zh) | 多价重组人乳头瘤病毒疫苗及其应用 | |
CN107080833A (zh) | 作为广谱人类乳头状瘤病毒(hpv)疫苗的乳头状瘤病毒样颗粒(vlp) | |
CN101897963B (zh) | 一种手足口病病毒疫苗 | |
KR20140036244A (ko) | 알루미늄 아주반트를 포함하는 hpv 백신 제제 및 그의 제조 방법 | |
Kalnin et al. | Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes | |
CN103936840B (zh) | 重组的人乳头瘤病毒33型l1蛋白及其用途 | |
Uddin et al. | Strategies for developing oral vaccines for human papillomavirus (HPV) induced cancer using nanoparticle mediated delivery system | |
CN101530614A (zh) | 五价重组人乳头瘤病毒疫苗 | |
CN105597092A (zh) | 含有白介素15的防治hpv感染的疫苗喷雾剂 | |
CN104045696B (zh) | 重组的人乳头瘤病毒16型l1蛋白及其用途 | |
CN101530615A (zh) | 二价重组人乳头瘤病毒疫苗 | |
CN103288931B (zh) | 人类乳头瘤病毒免疫原性多肽、其制备方法及应用 | |
CN104045695B (zh) | 重组的人乳头瘤病毒18型l1蛋白及其用途 | |
JP6178520B2 (ja) | 新規な抗hpv医薬製剤の用途 | |
RU2377305C1 (ru) | Мукозальная вакцина для иммунотерапии заболеваний, обусловленных вирусами папилломы человека, и способ лечения с ее использованием (варианты) | |
CN101530612A (zh) | 16型重组人乳头瘤病毒疫苗 | |
CN110639013A (zh) | 一种以il-33为佐剂的hpv纳米疫苗组合物及其制备方法 | |
CN103316335B (zh) | 一种适于口服的脊髓灰质炎病毒疫苗 | |
El Battioui et al. | Progress in the development of vaccines against human papillomavirus | |
Woo et al. | Study of cell-mediated response in mice by HPV16 L1 virus-like particles expressed in Saccharomyces cerevisiae | |
Lyu et al. | Achievements, challenges and prospects for the development of broadly protective multivalent vaccines and therapeutic antibodies against hand, foot and mouth disease | |
Kardani et al. | HPV prophylactic vaccines: Second-generation or first-generation vaccines | |
Sangar et al. | Development of Prophylactic Bivalent and Quadrivalent Human Papillomavirus (HPV) Vaccines: A Review |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: BEIJING HEALTH GUARD BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: BEIJING HEALTHY GUARD BIOTECHNOLOGY INC. |
|
CP01 | Change in the name or title of a patent holder |
Address after: Longsheng industrial park No. 7 100176 street Beijing Rongchang economic and Technological Development Zone No. 2 building 201, unit 202 Patentee after: Beijing Health Guard Biotechnology Co., Ltd. Address before: Longsheng industrial park No. 7 100176 street Beijing Rongchang economic and Technological Development Zone No. 2 building 201, unit 202 Patentee before: Beijing Healthy Guard Biotechnology Inc. |
|
C53 | Correction of patent for invention or patent application | ||
C56 | Change in the name or address of the patentee | ||
CB03 | Change of inventor or designer information |
Inventor after: Liu Yongjiang Inventor after: Ma Runlin Inventor after: Chen Xiaojiang Inventor before: Ma Runlin Inventor before: Chen Xiaojiang |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: MA RUNLIN CHEN XIAOJIANG TO: LIU YONGJIANG MA RUNLIN CHEN XIAOJIANG |
|
CP02 | Change in the address of a patent holder |
Address after: Longsheng industrial park No. 7 100176 street Beijing Rongchang economic and Technological Development Zone No. 2 building 201 unit Patentee after: Beijing Health Guard Biotechnology Co., Ltd. Address before: Longsheng industrial park No. 7 100176 street Beijing Rongchang economic and Technological Development Zone No. 2 building 201, unit 202 Patentee before: Beijing Health Guard Biotechnology Co., Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Multivalent recombinant human papilloma virus vaccine and application thereof Effective date of registration: 20200525 Granted publication date: 20140618 Pledgee: Haidian Beijing science and technology enterprise financing Company limited by guarantee Pledgor: BEIJING KANGLEWEISHI BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2020990000517 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210628 Granted publication date: 20140618 Pledgee: Haidian Beijing science and technology enterprise financing Company limited by guarantee Pledgor: BEIJING KANGLEWEISHI BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2020990000517 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |