CN101890143A - Callicarpa nudiflora galangal composite washing liquid, preparation method and application thereof - Google Patents
Callicarpa nudiflora galangal composite washing liquid, preparation method and application thereof Download PDFInfo
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- CN101890143A CN101890143A CN 201010228035 CN201010228035A CN101890143A CN 101890143 A CN101890143 A CN 101890143A CN 201010228035 CN201010228035 CN 201010228035 CN 201010228035 A CN201010228035 A CN 201010228035A CN 101890143 A CN101890143 A CN 101890143A
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- callicarpa nudiflora
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Abstract
The invention discloses callicarpa nudiflora galangal composite washing liquid. The callicarpa nudiflora galangal composite washing liquid is prepared from the following components in percentage by weight: 1 to 2 percent of callicarpa nudiflora galangal extractum, 2 to 10 percent of propylene glycol, 2 to 15 percent of glycerol, 1 to 10 percent of ethanol and the balance of distilled water. The callicarpa nudiflora galangal composite extractum is prepared by the following steps of: selecting medicinal materials, namely callicarpa nudiflora and galangal; pulverizing the callicarpa nudiflora and the galangal; placing the pulverized callicarpa nudiflora and the galangal into water or the ethanol to perform boiling or heating reflux extraction for 1 to 3 times, 30 to 60 minutes each time; combining the extract and filtering; and concentrating the filtrate to prepare the extractum with relative density of 1.1 to 1.2. The washing liquid has the advantages of mild property, safety, no toxicity, convenient use, capacity of preventing and curing diseases of human vulva, vagina and the like and high bioavailability.
Description
Technical field
The present invention relates to a kind of Callicarpa nudiflora galangal composite washing liquid and its production and application, belong to technical field of medicine.
Background technology
Washing liquid according to the relevant laws and regulations of China's drug control, changes dosage form as China's new drug research management as a kind of pharmaceutical dosage form.The extract of Callicarpa nudiflora has multiple dosage form, oral tablet exists disintegrate slow, and the not high defective of bioavailability, exterior-applied formulation LUOHUAZIZHU SHUAN have been listed in country of the national Bureau of Drugs Supervision Chinese patent medicine compilation, but there are yielding characteristics in suppository as medicine for external use, makes troubles to use.Application number is 200510012679.7 patent of invention " Callicarpa nudiflora vagina effervescence and preparation method ", change the dosage form of Callicarpa nudiflora extracting solution into effervescent, steady quality, easy to use, but there are discomforts such as local excitation, pruritus or burning sensation in effervescent when using easily, is not suitable for the part crowd and uses; Yet there are no about Callicarpa nudiflora being made the report of washing liquid dosage form,, yet there are no report and correlational study especially about the Callicarpa nudiflora galangal composite washing liquid aspect.
Summary of the invention
The objective of the invention is to overcome the defective that exists in the prior art, provide a kind of character gentleness, Callicarpa nudiflora galangal composite washing liquid easy to use.
The present invention also aims to provide a kind of preparation method of above-mentioned Callicarpa nudiflora galangal composite washing liquid, this preparation method technology is simple, with low cost.
For achieving the above object, Callicarpa nudiflora galangal composite washing liquid provided by the invention, made by following components in weight percentage content: Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum 1-2%, propylene glycol 2-10%, glycerol 2-15%, ethanol 1-10%, surplus are distilled water, the preparation process of the compound extractum of described Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material, after the pulverizing, place water or ethanol heated and boiled or heating and refluxing extraction 1-3 time, each 30-60min; Extracting solution merge is filtered, get filtrate, the extractum that is concentrated into relative density and is 1.1-1.2 gets final product.
In said components, Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum is principal agent, and all the other are adjuvant, wherein, Callicarpa nudiflora hardship, little suffering, flat; Has antiinflammatory, detoxifcation, convergence, effects such as hemostasis.100% Callicarpa nudiflora decocting liquid, extremely responsive with flat band method to staphylococcus aureus, Staphylococcus albus, to pseudomonas aeruginosa, Bacillus typhi, meningococcus, dysentery bacterium, have a liking for oxygen bacterium, escherichia coli medium sensitivity, to streptococcus, Bacillus proteus slight sensitive; Fungistatic effect and streptomycin, gentamycin and tetracycline to staphylococcus aureus are approximate.Can form thin layer medicine film after the medication, the effect of convergence, drying, protection granulation tissue, promotion ulcer healing is arranged.Rhizoma Alpiniae Officinarum is a zingiberaceous plant Rhizoma Alpiniae Officinarum rhizome, property of medicine suffering, and heat is returned spleen, stomach warp; The effect dispersing cold for relieving pain, warming middle-JIAO to arrest vomiting, effects such as that its water extract has is antibiotic, analgesia, its 100% decocting liquid to anthrax bacillus, α-or beta hemolytic streptococcus, diphtheria and diphtheroid, streptococcus pneumoniae, staphylococcus (golden yellow, lemon yellow, white), bacillus subtilis etc. in various degree antibacterial action (agar plate trench method) is all arranged; Callicarpa nudiflora and Rhizoma Alpiniae Officinarum share, and can strengthen its antibacterial activity.
Preferably, the weight part ratio of Callicarpa nudiflora medical material of the present invention and Rhizoma Alpiniae Officinarum medical material is 1: 0.1-1.
Preferably, water of the present invention or consumption of ethanol be Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material gross weight 5-15 doubly.
For reaching second purpose of the present invention, the preparation method of Callicarpa nudiflora galangal composite washing liquid provided by the invention contains following steps:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material, after the pulverizing, place water or ethanol heated and boiled or heating and refluxing extraction 1-3 time, each 30-60min merges filtration with extracting solution, gets filtrate, is concentrated into the extractum that relative density is 1.1-1.2;
(2) get above-mentioned extractum, than after adding propylene glycol, glycerol and ethanol, add the water mixing and get final product by metering.
Callicarpa nudiflora galangal composite washing liquid of the present invention is as the application of prevention and treatment body's vulva and vagina medicine.
The using method of Callicarpa nudiflora galangal composite washing liquid of the present invention and consumption: during use, get 10 milliliters of this product boiled water to 100 milliliter mixing of heating, clean pudendum, with irrigator it is delivered to vagina deep washing vagina, 1 time on the one, seven days is a course of treatment.
Advantage of the present invention is: the Callicarpa nudiflora galangal composite washing liquid character gentleness of the present invention's preparation, and safety non-toxic, easy to use, can prevent and treat diseases such as body's vulva and vagina targetedly, the bioavailability height, its preparation method technology is simple, and cost is low.
The specific embodiment
Following examples only are used to set forth the present invention, and protection scope of the present invention is not only to be confined to following examples.The those of ordinary skill of described technical field all can be realized purpose of the present invention according to above content disclosed by the invention and scope that each parameter is got.
Embodiment 1
The Callicarpa nudiflora galangal composite washing liquid that present embodiment provides is made by following components in weight percentage content: be gross weight 100% in the Callicarpa nudiflora galangal composite washing liquid, Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum accounts for 1%, propylene glycol accounts for 2%, glycerol accounts for 2%, ethanol accounts for 1%, surplus 94% is a distilled water, the preparation process of the compound extractum of Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 10L water heated and boiled or heating and refluxing extraction 1 time, each 30min, extracting solution is merged filtration, get filtrate, be concentrated into relative density and be 1.2 extractum.
The preparation method of above-mentioned Callicarpa nudiflora galangal composite washing liquid is:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 10L water heated and boiled or heating and refluxing extraction 1 time, each 30min merges extracting solution and filters, and gets filtrate, is concentrated into relative density and is 1.2 extractum;
(2) get the above-mentioned extractum that accounts for Callicarpa nudiflora galangal composite washing liquid gross weight 1%, by metering than after adding the propylene glycol account for Callicarpa nudiflora galangal composite washing liquid gross weight 2%, accounting for Callicarpa nudiflora galangal composite washing liquid gross weight 2% glycerol and account for the ethanol of Callicarpa nudiflora galangal composite washing liquid gross weight 1%, the adding distil water mixing promptly gets Callicarpa nudiflora galangal composite washing liquid, this washing liquid character gentleness, easy to use.
During use, get 10 milliliters of this product boiled water to 100 milliliter mixing of heating, clean pudendum, with irrigator it is delivered to vagina deep washing vagina, 1 time on the one, seven days is a course of treatment.
Embodiment 2
The Callicarpa nudiflora galangal composite washing liquid that present embodiment provides is made by following components in weight percentage content: be gross weight 100% in the Callicarpa nudiflora galangal composite washing liquid, Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum accounts for 2%, propylene glycol accounts for 10%, glycerol accounts for 10%, ethanol accounts for 6%, surplus 72% is a distilled water, the preparation process of the compound extractum of Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 15L water heating and refluxing extraction 2 times, each 40min, extracting solution is merged filtration, get filtrate, be concentrated into relative density and be 1.15 extractum and get final product.
The preparation method of above-mentioned Callicarpa nudiflora galangal composite washing liquid is:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 15L water heating and refluxing extraction 2 times, each 40min merges extracting solution and filters, and gets filtrate, is concentrated into relative density and is 1.15 extractum;
(2) get the above-mentioned Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum that accounts for Callicarpa nudiflora galangal composite washing liquid gross weight 2%, by metering than after adding the propylene glycol account for Callicarpa nudiflora galangal composite washing liquid gross weight 10%, accounting for the glycerol of Callicarpa nudiflora galangal composite washing liquid gross weight 10% and account for the ethanol of Callicarpa nudiflora galangal composite washing liquid gross weight 6%, the adding distil water mixing promptly gets Callicarpa nudiflora galangal composite washing liquid, this washing liquid character gentleness, easy to use.
During use, get 10 milliliters of this product boiled water to 100 milliliter mixing of heating, clean pudendum, with irrigator it is delivered to vagina deep washing vagina, 1 time on the one, seven days is a course of treatment.
Embodiment 3
The Callicarpa nudiflora galangal composite washing liquid that present embodiment provides is made by following components in weight percentage content: be gross weight 100% in the Callicarpa nudiflora galangal composite washing liquid, Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum 1.5%, propylene glycol 6%, glycerol 8%, ethanol 5%, surplus are distilled water, the preparation process of the compound extractum of Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 5L ethanol heating and refluxing extraction 3 times, each 60min, extracting solution is merged filtration, get filtrate, be concentrated into relative density and be 1.1 extractum.
The preparation method of above-mentioned Callicarpa nudiflora galangal composite washing liquid is:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 5L ethanol heating and refluxing extraction 3 times, each 60min merges extracting solution and filters, and gets filtrate, is concentrated into relative density and is 1.1 extractum;
(2) get the above-mentioned extractum that accounts for Callicarpa nudiflora galangal composite washing liquid gross weight 1.5%, by metering than after adding the propylene glycol account for Callicarpa nudiflora galangal composite washing liquid gross weight 6%, accounting for the glycerol of Callicarpa nudiflora galangal composite washing liquid gross weight 8% and account for the ethanol of Callicarpa nudiflora galangal composite washing liquid gross weight 5%, add water mixing Callicarpa nudiflora galangal composite washing liquid, this washing liquid character gentleness, easy to use.
During use, get 10 milliliters of this product boiled water to 100 milliliter mixing of heating, clean pudendum, with irrigator it is delivered to vagina deep washing vagina, 1 time on the one, seven days is a course of treatment.
Embodiment 4
The Callicarpa nudiflora galangal composite washing liquid that present embodiment provides is made by following components in weight percentage content: be gross weight 100% in the Callicarpa nudiflora galangal composite washing liquid, Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum 2%, propylene glycol 2%, glycerol 2%, ethanol 10%, surplus are distilled water, the preparation process of the compound extractum of Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 5L water heated and boiled or heating and refluxing extraction 3 times, each 50min, extracting solution is merged filtration, get filtrate, be concentrated into relative density and be 1.12 extractum.
The preparation method of above-mentioned Callicarpa nudiflora galangal composite washing liquid is:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material 1kg, after the pulverizing, place 5L water heated and boiled or heating and refluxing extraction 3 times, each 50min merges extracting solution and filters, and gets filtrate, is concentrated into relative density and is 1.12 extractum;
(2) get the above-mentioned extractum that accounts for Callicarpa nudiflora galangal composite washing liquid gross weight 2%, by metering than after adding the propylene glycol account for Callicarpa nudiflora galangal composite washing liquid gross weight 2%, accounting for the glycerol of Callicarpa nudiflora galangal composite washing liquid gross weight 2% and account for the ethanol of Callicarpa nudiflora galangal composite washing liquid gross weight 10%, add the water mixing and promptly get Callicarpa nudiflora galangal composite washing liquid, this washing liquid character gentleness, easy to use.
During use, get 10 milliliters of this product boiled water to 100 milliliter mixing of heating, clean pudendum, with irrigator it is delivered to vagina deep washing vagina, 1 time on the one, seven days is a course of treatment.
Below be antibacterial tests and toxicity test about Callicarpa nudiflora galangal composite washing liquid
One, the antibacterial tests of Callicarpa nudiflora galangal composite washing liquid
Below all adopt component and method preparation among the embodiment 2, difference is, during the compound Rhizoma Alpiniae Officinarum extractum of preparation Callicarpa nudiflora, when preparation Callicarpa nudiflora extractum and Rhizoma Alpiniae Officinarum extractum, its raw material that adopts is respectively Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material, Callicarpa nudiflora medical material and Rhizoma Alpiniae Officinarum medical material, purpose is that contrast is a raw material with three groups of medical materials respectively, the extractum of preparation, add the contrast of the antibacterial effect of the washing liquid for preparing behind the adjuvant, adopt arbitrary component and the content announced in the foregoing invention content of the present invention all can carry out following test, following test is that picked at random a kind of component and content is wherein tested, but not to its qualification.
The result is as shown in table 1, Callicarpa nudiflora galangal composite washing liquid to the bacteriostatic activity of staphylococcus aureus (S.aureus), methicillin-resistant staphylococcus aureus (MRSA) and Candida albicans (C.albicans) apparently higher than single with Callicarpa nudiflora or Rhizoma Alpiniae Officinarum.Active suitable to the inhibition of staphylococcus aureus and MRSA with kanamycin sulfate, active suitable to the inhibition of C.albicans with fluconazol.
Table 1 Callicarpa nudiflora Rhizoma Alpiniae Officinarum washing liquid to the antibacterial circle diameters of three kinds of source of disease bacterium (mm, n=3)
Annotate: the filter paper dick diameter is 6mm, and methanol is made negative control.As positive control, antibacterial circle diameter is respectively 30-33 with kanamycin sulfate for S.aureus and MRSA, 28-30mm.As positive control, antibacterial circle diameter is 26-29mm to C.albicans with fluconazol.
Two, the toxicity test of Callicarpa nudiflora galangal composite washing liquid
2.1 Callicarpa nudiflora Rhizoma Alpiniae Officinarum washing liquid its mouse oral toxicity test is got 80 of Kunming mouses, male and female half and half.It is divided into 4 groups at random, and every group of male and female half and half are irritated stomach with the dosage in the table 1 to it respectively.The result is as shown in table 2, and its LD50 by the classification of chemical substance acute toxicity, belongs to actual nontoxic level greater than 10000mg/Kg.
Table 2 Callicarpa nudiflora galangal composite washing liquid its mouse oral The acute toxicity tests
2.2 Callicarpa nudiflora washing liquid acute toxicity skin irritation test
Get 40 of rabbit, male and female half and half.Be divided into 4 groups according to weight, every group of male and female half and half are coated the Callicarpa nudiflora washing liquid respectively for every group, observe its skin respectively at different time.The result is as shown in table 3, and inflammatory reactions such as erythema, edema all do not appear in all rabbit skins, and the acute skin irritation index is 0.
The test of table 3 Callicarpa nudiflora galangal composite washing liquid acute toxicity skin irritation
By above-mentioned test, Callicarpa nudiflora galangal composite washing liquid of the present invention is as the medicine of prevention and treatment body's vulva and vagina, and its safety non-toxic, antibacterial effect are better than only containing the washing liquid of single active component.
Claims (5)
1. Callicarpa nudiflora galangal composite washing liquid, it is characterized in that: made by following components in weight percentage content: Callicarpa nudiflora Rhizoma Alpiniae Officinarum extractum 1-2%, propylene glycol 2-10%, glycerol 2-15%, ethanol 1-10%, surplus are distilled water, the preparation process of the compound extractum of described Callicarpa nudiflora Rhizoma Alpiniae Officinarum is: choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material, after the pulverizing, place water or ethanol heated and boiled or heating and refluxing extraction 1-3 time, each 30-60min; Extracting solution merge is filtered, get filtrate, the extractum that is concentrated into relative density and is 1.1-1.2 gets final product.
2. Callicarpa nudiflora galangal composite washing liquid according to claim 1 is characterized in that: the weight part ratio of described Callicarpa nudiflora medical material and Rhizoma Alpiniae Officinarum medical material is 1: 0.1-1.
3. Callicarpa nudiflora galangal composite washing liquid according to claim 1 and 2 is characterized in that: described water or consumption of ethanol are Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material gross weight 5-15 times.
4. the preparation method of each described Callicarpa nudiflora galangal composite washing liquid of claim 1-3 is characterized in that: contain following steps:
(1) choose Callicarpa nudiflora and Rhizoma Alpiniae Officinarum medical material, after the pulverizing, place water or ethanol heated and boiled or heating and refluxing extraction 1-3 time, each 30-60min merges filtration with extracting solution, gets filtrate, is concentrated into the extractum that relative density is 1.1-1.2;
(2) get above-mentioned extractum, than after adding propylene glycol, glycerol and ethanol, add the water mixing and get final product by metering.
Among the claim 1-3 each described Callicarpa nudiflora galangal composite washing liquid as the application of prevention and treatment body's vulva and vagina medicine.
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Cited By (3)
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CN102266277A (en) * | 2011-07-27 | 2011-12-07 | 九芝堂股份有限公司 | Application of callicarpa nudiflora extract in daily chemical cleaning products |
CN104225091A (en) * | 2014-09-24 | 2014-12-24 | 中山大学 | Callicarpa nudiflora disinfection lotion and preparation process thereof |
CN105012835A (en) * | 2015-08-21 | 2015-11-04 | 海南奇楠沉香生物科技有限公司 | Traditional Chinese medicine composition as well as preparation method and application thereof |
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CN1724034A (en) * | 2005-07-20 | 2006-01-25 | 石药集团中诺药业(石家庄)有限公司 | Vagina effervescent tablets contg. callicarpa nudiflora, and its prepn. method |
CN1739682A (en) * | 2005-09-05 | 2006-03-01 | 北京泛美华医药科技发展有限公司 | Nudiflorous beautyberry soft capsule for body cavity and its prepn |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102266277A (en) * | 2011-07-27 | 2011-12-07 | 九芝堂股份有限公司 | Application of callicarpa nudiflora extract in daily chemical cleaning products |
CN102266277B (en) * | 2011-07-27 | 2014-08-13 | 九芝堂股份有限公司 | Application of callicarpa nudiflora extract in daily chemical cleaning products |
CN104225091A (en) * | 2014-09-24 | 2014-12-24 | 中山大学 | Callicarpa nudiflora disinfection lotion and preparation process thereof |
CN105012835A (en) * | 2015-08-21 | 2015-11-04 | 海南奇楠沉香生物科技有限公司 | Traditional Chinese medicine composition as well as preparation method and application thereof |
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