CN101890039A - Composite medicament used for treating herpes zoster - Google Patents
Composite medicament used for treating herpes zoster Download PDFInfo
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Abstract
The invention discloses a composite medicament used for treating herpes zoster. The composite medicament used for treating the herpes zoster is composed of 5 to 10 mL of 2 percent lidocaine injection, 0.5 to 1.0 mg of VitB12 injection, 5 to 10 mg of dexamethasone injection and 1 to 2 mL of bacillus calmette guerin polysaccharide nucleic acid injection. The medicament is used for point injection for treating the herpes zoster. The medicament has the characteristics of quick response, small dosage, safety, high cure rate, good stability and small harm to a human body. The medicament is suitable for treating the herpes zoster.
Description
Technical field
The present invention is the medicine of field of medicaments, particularly a kind of composition of medicine that is used for the treatment of herpes zoster.
Background technology
Herpes zoster system by varicella zoster virus (VariceMLMLa-virus, VZV) due to.VZV is called after herpes virus hominis 3 types (HHV-3) now, and this virus is brick shape, and three-dimensional symmetric capsid is arranged, and includes double chain DNA molecule.VZV to the resistance of external environment a little less than, in exsiccant crust, lose activity very soon.To the child of this virus immunity power infected after, chickenpox takes place.Become the carrier after part patient is infected and symptom does not take place.Because virus has neurotropism, can hide for a long time in the neuron of spinal nerves posterior root ganglion after the infection, when lower for the resistance or tired, infection, cat fever, anger is got angry etc., virus can regrow breeding, and move to skin along nerve fiber, make the nerve and the skin of being invaded produce fierce inflammation.The characteristics that erythra generally has one-sided property and distributes by nerve segment are made up of the herpes of collection bunch property, and with pain; Age is bigger, and neuralgia is heavier.This sick modern medicine is called herpes zoster, the herpes zoster that is called among the people, and the skirt-roof dragon flies titles such as Serpentis.
The basic medicine specific aim is treated at present, and primary disease has self limiting, and the Therapeutic Principle is pain relieving, antiviral, antiinflammatory, shortens the course of disease, prevention infection.
1. whole body therapeutic (1) antiviral drugs: use valaciclovir, famciclovir as early as possible, these two kinds of precursor medicines are than the oral bioavailability height of acyclovir, the low dose of blood Chinese medicine concentration height that produces.Antiviral activity concentration required time is all than short by intravenous drip acyclovir required time in the serum that the two oral administration reached.Acyclovir has strong anti-herpesvirus effect, suppresses viral dna polymerase, disturbs DNA synthetic.Early stage application can reduce new rash and form, and inhibition of pain is prevented the virus diffusion, reduces visceral lesion and takes place.Oral 200mg, 5 times/d, in continuous 1 week, also available 5mg/kg intravenous drip 3 times/d, continues 5～10 days.Use vidarabine, can disturb herpes virus DNA synthetic in early days; Oral 15mg/ (kgd), 1 time/d of intravenous drip, continuous 10 days.Other antiviral drugs such as acyclovir, ribavirin, polyinosini also can be selected for use because of cheap.(2) analgesic: can oral antondin, aminophenazone/phenobarbital/phenacetin/caffeine (somedon), ibuprofen (ibuprofen), indomethacin etc.Decoction being taken at a draught 12.5mg before sleeping for amitriptyline hydrochloride (amitriptyMLine) to serious post herpetic neuralgia increased progressively 12.5mg in per 2～5 days, and tricyclics such as doxepin (doxepin), imipramine etc., severe patient can be done nerve block or the other nerve block of vertebra.Report is arranged, and the also available nerve block therapy of more serious neuralgia is promptly injected 1% lignocaine, 3～5mML earlier with epidural, and then (contain morphine 1～5mg), 1 time/d, also available He-Ne Lasers is done the irradiation of local disease point to inject morphine complex liquid 10～15mML.(3) interferon (IFN α, γ) and people's Interferon Alfa-2b can take the circumstances into consideration to select for use for the elderly patients of immunologic hypofunction.It is antiviral directly, enhance immunity effector lymphocyte's responsing reaction.Human (0.6～1mg/kg), Measles Vaccine (Measles Vaccine,Live) (0.3～2mML, 1 intramuscular injection), other all can help to shorten the course of disease as transfer factor, thymosin (thymosin) etc.(4) corticosteroid hormone: be in a bad way and can use in early days, to alleviate the fibrosis after the neuroganglion inflammation, reduce neuralgia, general prednisone 30～40mg/d, must unite use with antiviral agents at 7～14 days courses of treatment.
2. topical therapeutic (1) compound recipe zinc-copper solution (DaMLibou liquid) or 3% boric acid solution are done local soak, external 3%～5% acyclovir frost, 1% penciclovir frost, Interferon Alpha-2b smears, 0.5% phthiobuzonum liniment etc.(2) herpes zoster ophthalmicus can be with 3% acyclovir collyrium, 0.5% idoxuridine (iodouracil desoxyriboside) liquid, interferon-ALPHA collyrium eye dripping, 3～4 times/d.(3) physiotherapy: available ultraviolet local irradiation, audiofrequency current therapy and he-ne laser irradiation anti-inflammatory analgetic, shorten the course of disease.
Medicine commonly used is the external acyclovir ointment.
Because used medicine is numerous and diverse, effective percentage is low, and curative effect is slow, and with strong points, so be difficult to determine its therapeutic effect.
Summary of the invention
Not obvious in order to overcome the banded antiherpetic thing therapeutic effect of existing treatment, the shortcoming that produce effects is slow the present invention proposes a kind of composition of medicine that is used for the treatment of herpes zoster.This medicine is by the combination of selected medicine, and adopt the method for injection to use, and reaches quick treatment and healing.
The scheme that technical solution problem of the present invention is adopted is: by 2% lidocaine injection 5-10mL, VitB12 injection 0.5-1.0mg, dexamethasone injection 5-10mg, BCG polyose nuclear acid injection 1-2mL combines the composition of medicine that is used for the treatment of herpes zoster.
Good effect, the present invention adopts by 2% lidocaine injection 5-10mL, and VitB12 injection 0.5-1.0mg, dexamethasone injection 5-10mg, the medicine that BCG polyose nuclear acid injection 1-2mML combines carry out acupoint injection therapy treatment herpes zoster.Have that produce effects is fast, medication is few, safety, cure rate height, good stability and to the little characteristics of human body infringement.Be suitable for the medicinal application of treatment herpes zoster.
The specific embodiment
By 2% lidocaine injection 5-10mL, VitB12 injection 0.5-1.0mg, dexamethasone injection 5-10mg, BCG polyose nuclear acid injection 1-2mL combines.
Used ingredient and treatment mechanism:
1, lidocaine injection
Common name: lidocaine hydrochloride injection
English name: MLidocaine HydrochMLoride Injection
Chinese phonetic alphabet name: Yansuan MLiduokayin Zhusheye
This product Main Ingredients and Appearance: lidocaine hydrochloride.Its chemical name is: N-(xylene dichloride base)-2-(lignocaine) acetamide hydrochloride monohydrate.
Molecular formula: C14H22N20HCMLH20
Molecular weight: 288.82
This product is colourless clear liquid.
This product is a local anesthetics of amide derivatives.After the blood absorption or intravenously administrable, the central nervous system there is tangible excitement and suppresses biphasic effect, and can not have pioneer's excitement, when blood drug level is low, analgesia and drowsy, threshold of pain raising occur; Along with dosage strengthens, effect or toxicity strengthen, and anticonvulsant action is arranged during inferior poisoning blood drug level; When surpassing 5mgmL-1, blood drug level can faint from fear.This product can promote K+ outflow in the myocardial cell when low dosage, reduce the self-disciplining of cardiac muscle, and have the arrhythmia effect of anti-chamber; When therapeutic dose, electrical activity, chamber conduction and the myocardium contraction of myocardial cell there is not obvious influence; Blood drug level further raises, and can cause that cardiac conduction speed slows down, and atrioventricular block suppresses myocardial contraction and cardiac output is descended.
After this product injection, tissue distribution is fast and wide, can see through blood-brain barrier and Placenta Hominis.This product anesthetic potency is big, rapid-action, dispersion force is strong, and medicine is eliminated approximately from the part and needed 2 hours, adds epinephrine and can prolong its action time.Most of earlier through the liver particle enzymatic degradation be still have local anesthetic action take off ethyl intermediate metabolites list ethyl glycinamide glutamine dimethylbenzene, toxicity increases, again through the amidase hydrolysis, discharge through urine, about consumption 10% with the original shape discharge, appear in the bile on a small quantity.
This product is local anaesthetics and anti-arrhythmic.Be mainly used in infiltration anesthesia, epidural anesthesia, make mucosa anesthesia usefulness and nerve block when topical anesthesia is included in thoracoscopy or abdominal operation.This product also can be used for ventricular premature contraction and ventricular tachycardia behind the acute myocardial infarction, also can be used for the ventricular arrhythmia that the poisoning of Folium Digitalis Purpureae class, cardiac operation and cardiac catheter cause.This product is invalid usually to supraventricular arrhythmia.
2, VitB12 injection
Common name: Alpha Vee-12
English name: Vitamin B
12Injection
Chinese phonetic alphabet name: Weishengsu B
12Zhusheye
This product Main Ingredients and Appearance: vitamin B
12Its chemical name is: Co α-[α-(5,6-dimethylbenzimidazole base)]-Co β-cyanogen cobalt amide.
Molecular formula: C
63H
88CoN
14O
14P
Molecular weight: 1355.38
This product is the clear liquid of pink to redness, and odorless is tasteless.Be anti-anemic drug.Vitamin B12 participates in methyl conversion and folic acid metabolism in the body, promotes the 5-methyl tetrahydrofolate to change tetrahydrofolic acid into.During shortage, cause the DNA dyssynthesis, influence erythrocytic maturation.This product also impels Isosuccinic acid to change succinic acid into, participates in tricarboxylic acid cycle.This interactively is to the synthetic of neurospongium sphingolipid and keep the myelinated nerve fiber telotism, and the nervous lesion of vitamin B12 deficiency disease may be relevant therewith.
Annotate post-absorption rapidly and fully, about 1h blood drug level peaking; Distributed more widely in the body, but mainly be stored in liver, adult's total storage is 4-5mg; Through renal excretion, dosage is bigger, drains the more at 8h for major part.
Be mainly used in because of the megaloblastic anemia of intrinsic factor due to lacking, also can be used for the SACD nervous system lesion, as neuritic auxiliary treatment.
3, dexamethasone injection
This product Main Ingredients and Appearance: dexamethasone acetate.Its chemical name is: 16 Alpha-Methyls-11 β, 17 α, 21-trihydroxy-9 α-fuprednate-1,4-diene-3,20-diketone-21-acetate.
Molecular formula: C24H31FO6
Molecular weight: 434.50
This product is the suspension of subparticle, leaves standstill the back subparticle and sinks, and becomes uniform milky suspension after the jolting.
Aeroseb-Dex, its antiinflammatory, antiallergic, Antishock function are more remarkable than prednisone, and to water-sodium retention with promote that the effect of row's potassium is very light, stronger to hypophysis-adrenal gland's inhibitory action.
1). antiinflammatory action: this product can alleviate and prevent to organize reaction to inflammation, thus the performance that reduces inflammation.Hormone inflammation-inhibiting cell comprises macrophage and leukocyte in the gathering of inflammation part, and suppresses the synthetic of the release of phagocytosis, lysosomal enzyme and inflammation chemistry mediator and discharge.Can alleviate and prevent to organize reaction inflammation, thus the performance that reduces inflammation.
2). immunosuppressive action: comprise preventing or suppressing cell-mediated immunoreation, the anaphylaxis of retardance, reduce T lymphocyte, mononuclear cell, oxyphil cell's number, reduce the binding ability of immunoglobulin and cell surface receptor, and suppress the synthetic of interleukin and discharge, thereby reduce the T lymphocyte to lymphoblastic transformation, and alleviate and formerly send out expansion immunoreactive.Immune complex can be reduced by basement membrane, and the concentration of complement component and immunoglobulin can be reduced.Reached the blood drug level peak value behind the intramuscular injection dexamethasone acetate in 8 hours.Plasma protein binding rate is low than other corticosteroids medicines.
This medicine is mainly used in anaphylaxis and autoimmune inflammation disease.As connective tissue disease, rheumatoid arthritis, serious bronchial asthma, anaphylactic diseases such as dermatitis, ulcerative colitis, acute leukemia, malignant lymphoma etc.
4, BCG polyose nuclear acid injection
Common name: BCG polyose nuclear acid injection,
English name: BCG PoMLysaccharide and NucMLeic Acid preparation
Chinese phonetic alphabet name: Kajiejunduotang hesuan zhusheye
This product Main Ingredients and Appearance: BCG-polysaccharide, nucleic acid.
This product is a colourless transparent liquid.
BCG-polysaccharide, nucleic acid injection by regulate the immunity of body inner cell, humoral immunization,
Stimulate reticuloendothelial system, activated mononuclear-macrophage function strengthens the natural killer cell function and comes the enhancing body resistance against diseases.2, BCG-polysaccharide, nucleic acid injection are by stablizing mastocyte, and sealing IgE function reduces and takes off the granular cell release of active agent, and has the bronchospasm effect due to the anti-acetylcholine, reaches antiallergic and antiasthmatic effect.
This strain immunomodulator is mainly used in prevention and treatment chronic bronchitis, flu and asthma.
The use of composition of medicine:
Adopt acupoint injection therapy, get HUATUOJIAJI acupoint, the incidence dermatomere selects the C2-C4 paravertebral point; Upper limb selects the C5-T1 paravertebral point; The chest and back neuralgia is got the T2-T8 paravertebral point; Waist and belly is got the T8-mL paravertebral point; Sacrum, perineal position are got the S3-C0 paravertebral point; Lower limb select mL2-S2, and skin lesion district Ashi point.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time, 7 is a course of treatment.Adjust concrete treatment cycle according to the time of pain relief simultaneously.
Can significantly shorten the course of disease, alleviating pain and effectively prevent from post herpetic neuralgia from can reduce misery for HZ patient conscientiously by acupoint injection for curing herpes zoster.This scheme can obviously promote the healing of herpes zoster acute stage skin lesion, can alleviate herpes zoster neuralgia degree in early days, fast, improve patients ' life quality, can effectively prevent the generation of post-herpetic neuralgia, HUATUOJIAJI acupoint is called for short paravertebral point, enjoy ancient Chinese medicine doctor to pay attention to from ancient times to the present, its clinical treatment is in extensive range, and curative effect is distinguished, and safety of acupuncture.The application of paravertebral point sees " element ask thorn malaria " the earliest: " 12 malaria persons ..., a thorn following Jiaji person must be again ", in recent years, many scholars use HUATUOJIAJI acupoint to treat post-herpetic neuralgia and have obtained preliminary curative effect.Paravertebral point bypass governor vessel, with bladder meridian through the gas traffic, the same with back shu points, go into part as the defeated pass-out of qi of zang-fu viscera, the planted agent is in internal organs, the anti-notes in the back, reflection internal organs state, treatment zang-fu diseases.The modern medicine dissect physiology also confirms, paravertebral point is very close from distribution form and nerve segment relation, and action of acupuncture Jiaji points not only can influence props up before posterior ramus of spinal nerve also can relate to it, can influence sympathetic nerve, thereby movable relevant with internal organs, have the function of regulating the internal organs QI and blood.We add on traditional paravertebral point basis with neck, sacrum portion paravertebral point as master point, add that Ashi point carries out injection in the cave, can bring into play the meridians dredging at acupuncture point, the integrally-regulated effect of QI and blood regulating, can also make medicine along the through sick institute of meridians, accelerate the absorption process of medicine, give full play to the coordinative role at medicine and acupuncture point, thereby by the effect of channel system generation Yin Yang balancing, strengthening vital QI to eliminate pathogenic factors, thin QI and blood regulating, to reach the purpose of treatment disease.Paravertebral point is positioned at that each vertebral body spinous process of ML thoracic vertebra to the 5 lumbar vertebras is other opens 0.5 cun, and left-right symmetric has the posterior ramus of spinal nerve of respective vertebrae below, the effect with the illness that cures mainly corresponding nerve segment distributed areas on its deep layer anatomical structure.Modern neuro anatomy also confirms.All have posterior ramus of spinal nerve to distribute near the paravertebral point, its deep layer has sympathetic trunk, sympathetic nerve paravertebral ganglion and the ash that interrelates with spinal nerves thereof, distributes from communicating branch.Acupuncture can stimulate above structure and surrounding tissue thereof when injecting in the cave, may make the conduction block of pain sensation fiber, the raising body threshold of pain in the nerve on the one hand, and enhancing body is to the tolerance of pain; The pin propagated sensation that stimulates paravertebral point to cause is on the other hand led reaction, by neural, body fluid regulating action, can influence SNE and discharge chemical mediator, also can reach analgesic activity in varying degrees.At the paravertebral point injectable drug, both can play the therapeutical effect at this acupuncture point, can directly medicine be expelled to around the injured nerve again, give full play to the pharmacological action of medicine.
The synergism of composition of medicine of the present invention:
Bcg-polysaccharides nucleic acid is mainly by the sensitization to the T cell, produce cell-mediated immunity, sensitized T cell is under antigenic differential stimulus, differentiation and proliferation is also synthetic to discharge a series of cytokines, thus the performance cellular immune function, and BCG polyose nuclear acid injection has two-way immunoregulation effect, can strengthen the function of mononuclear phagocyte, strengthen the NK cell activity, but and inducement interferon, interleukin, improve CD4 and CD4/CD8 value effectively.Fundamentally improve patient's fuselage state, suppress virus and duplicate and improve immunologic function intracellular.Lignocaine removes stream in the block nerves cell membrane Na+; make neurocyte can not produce depolarization; the formation and the conduction of neural impulse are obstructed; no longer cause the outer depolarization and the Na+ that can also pass through to suppress cell membrane of pain p1; thereby stream suppresses leukocyte adhesion in the Ca2+; migration and engulf activity; suppress hematoblastic gathering; release reaction; reduce the formation of microthrombus; microcirculation improvement; thereby inflammation-inhibiting reaction; reduce lasting pain occurrence probability; it can directly block the abnormal movement of the sexy receiver of skin damage, thereby the blocking-up peripheral nerve reduces central excitation by the afferent neural impulse conduction of lesion region; interrupt the pain vicious cycle: take this also to block the hyperfunction effect of reflexive sympathetic nervous system; impel local vascular dilation, improve local blood circulation, help skin lesion and recover.Local anaesthetics has regulating action to the high excitatory state of patient's sympathetoblast, the activation and the sensitization of tegumentary nerve fiber simultaneously.The Alpha Vee-12 that acupoint injection therapy is used, participate in the synthetic of cell DNA, the effect of keeping nervous system homergy and physiological function is also arranged, be used for viral infection also is primary disease medicine commonly used previously more, and dexamethasone has powerful antiinflammatory, antitoxic action, can strengthen the effect of compatibe drug, also can alleviate inflammation necrosis, the trophic nerve of nerve root, the tetrad medication is injected in above-mentioned acupuncture point, fast and effeciently plays the powerful therapeutical effect of medicine.
Each stage that the present invention adopts multiple drug regimen, too many levels, many target spots to act on morbidity be this programme treatment herpes zoster and alleviate that primary disease causes have an intense pain the characteristics of more effective control post-herpetic neuralgia.
Herpes zoster treatment case:
Case 1, Zhang Yuying, woman, 60 years old." left chest and back erythra 20 days, pain 7 days ".Before 20 days, patient left side chest and back occurs continuing violent acupuncture sample pain, and can't fall asleep night, private prosecution cardiopalmus.The patient previously has the inclination the angor medical history.The department of dermatologry situation: the visible large stretch of erythema of left chest and back, on it coated with intensive or be dispersed in the foxtail millet grain to Semen phaseoli radiati size pimple, papulovesicle, vesicle, a little starches crust, blood crusts is zonal distribution, only limits to body surface one side.Once oral acyclovir slice, the vitamin B1 sheet, transfer factor, the antiphlogistic forsythiae ball, symptom did not have alleviation in 10 days.On June 9th, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated, and erythra alleviates simultaneously, and treat 8 pain and disappear, deflorescence, dry.Therapeutic effect is good, with examining two all state of an illness not repeatedly.There is not pain again.
Case 2, Jia Baogang, man, 35 years old." left 2 weeks of chest and back pain, 1 week of erythra ".Before 2 weeks, pain appears in patient left side chest and back, increases the weight of gradually, and after occurring with erythra, sharp ache continues, the acupuncture sample, and can't fall asleep night.The department of dermatologry situation: left chest and back, the visible large stretch of erythema in oxter, on it coated with intensive or be dispersed in foxtail millet grain size pimple, papulovesicle, vesicle, blood blister is zonal distribution, only limits to body surface one side.Once oral acyclovir slice, the vitamin B1 sheet, the vitamin B12 sheet, symptom did not have alleviation in 7 days.On June 13rd, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated, and erythra alleviates simultaneously, and treat 4 pain and disappear, deflorescence, dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 3, Yang Zhaoshi, man, 83 years old." left 2 weeks of back pain, erythra 1 day ".Before 2 weeks, back, a patient left side, pain appears in neck portion, increases the weight of gradually, with cervical spondylosis medication voluntarily, for continuing acupuncture sample pain, merges distending pain, and can't fall asleep night, erythra occurs and examined afterwards in 1 day.The department of dermatologry situation: as seen the nearly cervical vertebra in left back place is dispersed in the foxtail millet grain to Semen Glycines size erythema, pimple.On June 13rd, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated, but erythra increases, prolong and left upper extremity, and left front chest, also there is a little varicelliform eruption at the back, right side, is thought of as general hair style herpes zoster.For the second time after the treatment, erythra does not have and increases the weight of, and treat 5 pain and disappears, and erythra dries up, and disappears.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 4, Wu Tao, woman, 25 years old." right upper extremity pruritus 2 days, erythra companion's 1 week of pain ".Before 1 week, pruritus appears in patient's right upper extremity, and erythra appears in right upper arm, forearm, the big thenar of hand thumb place after 2 days, and companion's pain for continuing spasmic pain, merges prickling-like pain, and can't fall asleep night.The department of dermatologry situation: right upper arm, forearm, the big thenar of hand thumb place as seen be dispersed in or intensive foxtail millet grain to Semen Glycines size erythema, pimple, vesicle, blood blister.On June 13rd, 2010 examined, and gave the acupoint injection for curing, got right side C5-T1 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mML combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.Treatment finishes after back 5 minutes, and pain is promptly not obvious, treats pain for the second time and disappears, and erythra is dry, disappears.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 5, Ji Yumei, woman, 42 years old." right back, hypogastric region erythra, pain 10 days ".Before 10 days, the patient erythra companion pain occurs through the right back of after date, hypogastric region, identifies oneself to gynecological diseases does not give attention, and sharp ache is persistence acupuncture sample recently, merges spasmic pain, and can't fall asleep night.The department of dermatologry situation: right back, hypogastric region, as seen the groin place is dispersed in large stretch of erythema, on it coated with dense distribution foxtail millet grain to Semen Glycines size papulovesicle, vesicle, blood blister is zonal distribution, only limits to body surface one side.On June 19th, 2010 examined, and gave the acupoint injection for curing.That is: get right side T8-mL paravertebral point and S3-C0 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated.After treating 3 times, pain disappears, and deflorescence is dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 6, Zhang Lu, woman, 25 years old." left chest and back erythra, pain 10 days ".Before 10 days, patient left side chest and back erythra, pain, sharp ache is persistence acupuncture sample recently, merges spasmic pain, can't fall asleep night.The department of dermatologry situation: as seen left chest and back erythra, pain are dispersed in erythema, and to Semen phaseoli radiati size papulovesicle, vesicle is zonal distribution to part, only limits to body surface one side coated with dense distribution foxtail millet grain.On June 19th, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mML combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated.After treating 3 times, pain disappears, and deflorescence is dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 7, Pang Caiqin, woman, 58 years old." left chest and back pain, erythra 20 days ".Before 20 days, the left front chest pain companion of patient erythra is fixed spasm, with angina pectoris treatment, does not have and alleviates, and can't fall asleep night.The department of dermatologry situation: as seen left chest and back is dispersed in large stretch of erythema, on it coated with dense distribution foxtail millet grain to Semen phaseoli radiati size pimple, papulovesicle, vesicle, the incrustation of part ulceration is zonal distribution, only limits to body surface one side.On June 21st, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mML combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated, and erythra obviously alleviates.After treating 3 times, pain disappears, and erythra is dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 8, Wang Huilan, woman, 60 years old." left low-back pain 20 days, 1 week of erythra ".Before 2 weeks, patient left side low-back pain for persistence distending pain companion muscular soreness, with cupping for treatment, does not have and alleviates, and can't fall asleep night, and pain the most very locates to occur erythra before 1 week.The department of dermatologry situation: the visible intensive Semen phaseoli radiati size pimple of left lower back, papulovesicle, vesicle, big portion ulceration forms large stretch of rotten to the corn.On June 22nd, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated, and erythra obviously alleviates.After the treatment, pain disappears for the second time, and erythra is dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 9, Pu Baoyuan, man, 54 years old." left 1 week of chest and back erythra, pain 2 days ".Before 1 week, erythra appears in the left front chest of patient, does not give attention, and sharp ache before 2 days is persistence acupuncture sample, and can't fall asleep night.The department of dermatologry situation: as seen left chest and back is dispersed in large stretch of erythema, on it coated with dense distribution foxtail millet grain to Semen phaseoli radiati size pimple, papulovesicle is zonal distribution, only limits to body surface one side.On June 22nd, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was obviously alleviated.After treating 3 times, pain disappears, and deflorescence is dry.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
Case 10, Zhang Jingyu, man, 25 years old." left chest and back erythra, 1 week of pain ".Before 1 week, erythra companion pain appears in patient left side chest and back, does not give attention, and sharp ache is persistence acupuncture sample recently, and can't fall asleep night.The department of dermatologry situation: as seen left chest and back is dispersed in large stretch of erythema, on it coated with dense distribution foxtail millet grain to Semen phaseoli radiati size pimple, papulovesicle, vesicle, blood blister is zonal distribution, only limits to body surface one side.On June 22nd, 2010 examined, and gave the acupoint injection for curing.That is: get left side T2-T8 paravertebral point; And skin lesion district Ashi point.By 2% lidocaine injection 10mL, VitB12 injection 0.5mg, dexamethasone injection 5mg, BCG polyose nuclear acid injection 1mL combines.Extract compatibility medicinal liquid mix homogeneously with disposable 2.5mL syringe, No. 5 syringe needles, choose an Ipsilateral paravertebral point and an Ashi point 3-6 acupuncture point according to the skin lesion position at every turn, inserting needle behind the routine disinfection skin, paravertebral point become an angle of 90 degrees inserting needle with skin, depth of needle: 0.5-1 cun; Ashi point moves towards along skin lesion, normal skin between papulovesicle or erythema group becomes 15 degree angle inserting needles, the most very locate the basilar part of skin lesion up to papulovesicle group or pain, the back pumpback depletion of blood of waiting the to bring about the desired sensation admixing medical solutions that reinjects, paravertebral point injection 2.0mL, each Ashi point of the average dispensing of all the other medicinal liquids, every day 1 time.The same day, pain was alleviated to some extent.Obviously alleviated in second day, erythra alleviates, treat 3 times after, pain disappears, deflorescence is dried up.Therapeutic effect is good, with examining all state of an illness not repeatedly.There is not pain again.
In the effective time 24 hours, how after treatment, promptly there is pain symptom obviously to improve in 5-30 minute.
Utilize the statistics effect of composition of medicine treatment herpes zoster of the present invention:
Composition of medicine of the present invention has obvious effect to deflorescence.By the clinical trial statistics, it is to the herpes zoster effective percentage 100% of different times, cure rate 100%.
Claims (1)
1. composition of medicine that is used for the treatment of herpes zoster is characterized in that: by 2% lidocaine injection 5-10mL, and VitB12 injection 0.5-1.0mg, dexamethasone injection 5-10mg, BCG polyose nuclear acid injection 1-2mL combines.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091455A (en) * | 2018-08-24 | 2018-12-28 | 内蒙古医科大学附属医院 | A kind of clinical research methods of paravertebral point injection Vidarabine Monophosphate |
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2010
- 2010-07-07 CN CN2010102193602A patent/CN101890039A/en active Pending
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| 伊丁丁: "硬膜外自控镇痛在带状疱疹中的镇痛效果观察 ", 《实用医技杂志》 * |
| 伊丁丁: "硬膜外自控镇痛在带状疱疹中的镇痛效果观察", 《实用医技杂志》, no. 28, 10 October 2008 (2008-10-10) * |
| 吴芝英等: "卡介菌多糖核酸液穴位注射治疗带状疱疹50例 ", 《现代中西医结合杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109091455A (en) * | 2018-08-24 | 2018-12-28 | 内蒙古医科大学附属医院 | A kind of clinical research methods of paravertebral point injection Vidarabine Monophosphate |
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