CN101878305A - 结合mcp-1的核酸及其用途 - Google Patents

结合mcp-1的核酸及其用途 Download PDF

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Publication number
CN101878305A
CN101878305A CN2008801184556A CN200880118455A CN101878305A CN 101878305 A CN101878305 A CN 101878305A CN 2008801184556 A CN2008801184556 A CN 2008801184556A CN 200880118455 A CN200880118455 A CN 200880118455A CN 101878305 A CN101878305 A CN 101878305A
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China
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tract
nucleic acid
nucleotide sequence
acid molecule
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Pending
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CN2008801184556A
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English (en)
Chinese (zh)
Inventor
W·普尔施克
F·雅罗施
D·尤尔伯格
S·克鲁斯曼
K·布赫纳
C·马什
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TME Pharma AG
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Noxxon Pharma AG
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Publication of CN101878305A publication Critical patent/CN101878305A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2008801184556A 2007-11-30 2008-11-29 结合mcp-1的核酸及其用途 Pending CN101878305A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07023267.3 2007-11-30
EP07023267 2007-11-30
PCT/EP2008/010167 WO2009068318A1 (en) 2007-11-30 2008-11-29 Mcp-i binding nucleic acids and use thereof

Publications (1)

Publication Number Publication Date
CN101878305A true CN101878305A (zh) 2010-11-03

Family

ID=40415282

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801184556A Pending CN101878305A (zh) 2007-11-30 2008-11-29 结合mcp-1的核酸及其用途

Country Status (12)

Country Link
US (2) US20100311816A1 (enExample)
EP (1) EP2229442A1 (enExample)
JP (1) JP5777341B2 (enExample)
KR (1) KR20100092463A (enExample)
CN (1) CN101878305A (enExample)
AU (1) AU2008329070B2 (enExample)
BR (1) BRPI0819845A2 (enExample)
CA (1) CA2707089A1 (enExample)
MX (1) MX2010005916A (enExample)
RU (1) RU2542973C2 (enExample)
WO (1) WO2009068318A1 (enExample)
ZA (1) ZA201002974B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102621331A (zh) * 2012-04-05 2012-08-01 中国医学科学院病原生物学研究所 一种检测或辅助检测结核性胸膜炎的试剂盒

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101572893B1 (ko) 2006-02-14 2015-12-02 녹손 파르마 아게 Mcp-1 결합형 3형 핵산
KR20100092463A (ko) * 2007-11-30 2010-08-20 녹손 파르마 아게 Ｍｃｐ-1 결합형 핵산 및 이의 용도
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
JP2017502075A (ja) * 2013-11-04 2017-01-19 ノクソン ファーマ エージー 腎障害治療の手段および方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007093409A2 (en) * 2006-02-14 2007-08-23 Noxxon Pharma Ag Mcp-i binding nucleic acids

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670321B1 (en) * 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
WO2002081628A2 (en) * 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
US7629456B2 (en) * 2001-10-26 2009-12-08 Noxxon Pharma Ag Modified L-nucleic acid
WO2003093472A2 (de) * 2002-05-06 2003-11-13 Grünenthal GmbH Cgrp bindende nukleinsäuren
EP1530635B1 (en) * 2002-08-01 2011-06-15 Noxxon Pharma AG Ghrelin binding nucleic acids
CA2521950C (en) * 2003-04-15 2009-11-17 Merck & Co., Inc. Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
EP1732571A4 (en) * 2004-03-05 2009-09-09 Archemix Corp CONTROLLED MODULATION OF PHARMACOKINETICS AND BIOLOGICAL DISTRIBUTION OF APTAMERIC THERAPY
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
US8367629B2 (en) * 2006-02-14 2013-02-05 Noxxon Pharma Ag MCP-1 binding nucleic acids and use thereof
KR20100092463A (ko) * 2007-11-30 2010-08-20 녹손 파르마 아게 Ｍｃｐ-1 결합형 핵산 및 이의 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007093409A2 (en) * 2006-02-14 2007-08-23 Noxxon Pharma Ag Mcp-i binding nucleic acids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FREDERIC A. HOUSSIAU等: "Immunosuppressive Therapy in Lupus Nephritis", 《ARTHRITIS & RHEUMATISM》 *
GUILLERMO PE´REZ DE LEMA等: "Chemokine Receptor Ccr2 Deficiency Reduces Renal Disease and Prolongs Survival in MRL/lpr Lupus-Prone Mice", 《J AM SOC NEPHROL》 *
HIROSHI KIMURA等: "Plasma Monocyte Chemoattractant Protein-1 and Pulmonary Vascular Resistance in Chronic Thromboembolic Pulmonary Hypertension", 《AM J RESPIR CRIT CARE MED》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102621331A (zh) * 2012-04-05 2012-08-01 中国医学科学院病原生物学研究所 一种检测或辅助检测结核性胸膜炎的试剂盒
CN102621331B (zh) * 2012-04-05 2014-07-30 中国医学科学院病原生物学研究所 一种检测或辅助检测结核性胸膜炎的试剂盒

Also Published As

Publication number Publication date
WO2009068318A1 (en) 2009-06-04
MX2010005916A (es) 2010-06-11
US20150141496A1 (en) 2015-05-21
JP5777341B2 (ja) 2015-09-09
KR20100092463A (ko) 2010-08-20
CA2707089A1 (en) 2009-06-04
BRPI0819845A2 (pt) 2015-06-16
EP2229442A1 (en) 2010-09-22
AU2008329070A1 (en) 2009-06-04
JP2011504736A (ja) 2011-02-17
RU2010126662A (ru) 2012-01-10
ZA201002974B (en) 2011-07-27
US20100311816A1 (en) 2010-12-09
RU2542973C2 (ru) 2015-02-27
AU2008329070B2 (en) 2014-11-20

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