CN101863104A - Injection molding process of plastic microfluidic chip - Google Patents
Injection molding process of plastic microfluidic chip Download PDFInfo
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- CN101863104A CN101863104A CN 201010183529 CN201010183529A CN101863104A CN 101863104 A CN101863104 A CN 101863104A CN 201010183529 CN201010183529 CN 201010183529 CN 201010183529 A CN201010183529 A CN 201010183529A CN 101863104 A CN101863104 A CN 101863104A
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- 239000004033 plastic Substances 0.000 title claims abstract description 21
- 229920003023 plastic Polymers 0.000 title claims abstract description 21
- 238000001746 injection moulding Methods 0.000 title claims abstract description 17
- 238000002347 injection Methods 0.000 claims abstract description 39
- 239000007924 injection Substances 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000001816 cooling Methods 0.000 claims abstract description 11
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 10
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000000465 moulding Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 238000013022 venting Methods 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 abstract description 8
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000013461 design Methods 0.000 description 5
- 238000012856 packing Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 239000012994 photoredox catalyst Substances 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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Abstract
The invention discloses a microfluidic chip injection molding process capable forming a micro-channel structure on the surface, which belongs to the technical field of injection molding. The appearance of the formed microfluidic chip is in a plate structure, and the thickness thereof is generally 1.2 to 1.5mm; the chip is provided with the crisscross micro-channel, and the cross section thereof is a rectangle with the depth of about 50mu m and the width between 30 to 100mu m. PMMA raw material is selected, the mold temperature is 85 to 90DEG C, and the melt temperature is 230 to 250DEG C. The injection speed is in a control method of slow-quick-slow, wherein the speed of a high-speed section of about 140mm/s. The injection pressure is 100 to 130MPa, the holding pressure is 50 to 70MPa, the holding time is 2 to 5s, and the cooling time is 30 to 40s. After cooling, the mold is opened, a product is taken out to complete the whole forming process. The invention has the beneficial effects that the injection forming process can form plastic microfluidic chips with high efficiency in a large scale, effectively solves the technical difficult problems of incomplete replication of the micro-channel and the like during the forming process, and promotes the application of an injection molding technology in the micro-mechanical system field.
Description
Technical field
The invention belongs to the injection molding technology field, relate to and a kind ofly can have the microfluidic control chip injection molding technology of MCA by molded surface.
Background technology
Micro-fluidic chip, claim chip lab again, its function is that basic operation units such as sample preparation related in the fields such as biological and chemical, reaction, separation and detection are integrated on the chip of tens of square centimeters (even littler), form network by the microchannel, run through whole system with controlled fluid, in order to substitute the various functions of conventional biological or chemical laboratory, be widely used in fields such as biochemistry, clinical, medicine and environment.The traditional material that is used for the moulding micro-fluidic chip has silicon, glass and quartz etc., mainly adopts etching processing.In recent years plastics because cost is low, kind is many, can process in enormous quantities, technology simply and have advantage such as excellent biological compatibility, become the main material of micro-fluidic chip just day by day.Micro-fluidic chip common plastics kind has PMMA, PC, PDMS, PS and COC etc.
The method that plastic microfluidic chip is comparatively ripe and commonly used is hot-forming.Compare with hot-forming, injection mo(u)lding efficient is higher, is more suitable for producing in enormous quantities, more and more is subjected to people's attention.Because the basal body structure of micro-fluidic chip is a writing board shape, is distributed with thereon and is of a size of tens of microns structure---microchannel, so its yardstick may be crossed over several magnitude; In injection mo(u)lding, the both macro and micro effect exists simultaneously, multiple forming defect may appear in chip, wherein how accurately intactly to copy the key that the microchannel is a chip Forming Quality quality with injection molding way, also is the difficult point of plastic microfluidic chip injection mo(u)lding.
Find that in practice incomplete technical barrier is duplicated in the microchannel during for the injection mo(u)lding of solution plastic microfluidic chip, at first will adopt design and the fabrication scheme that helps improving microchannel degree of duplicating aspect mould, this respect Request For Work people applies for a patent in addition; And aspect moulding process, can not leaning on simply, the adjusting process parameter just can obtain good Forming Quality, must study various technological parameters (injection speed, mold temperature, melt temperature, injection pressure, dwell pressure and dwell time etc.) by ways and meanses such as theory analysis, numerical simulation and experiments micro-structural is duplicated incomplete influence, thereby obtain best molding technique parameter combination, form the injection molding process of plastic microfluidic chip.
Summary of the invention
The present invention proposes a kind of injection molding process of plastic microfluidic chip, has solved the plastic microfluidic chip moulding problem of microchannel width at 30～100 μ m.
For achieving the above object, a kind of injection molding process of plastic microfluidic chip may further comprise the steps:
(A) plastic raw materials selects for use polymethyl methacrylate (PMMA) to be preset in the drying machine, 90 ℃ of baking temperatures, 6 hours time.
(B) mould and die preheating to 85～90 ℃, injector barrel plastic melt temperature range is set at 230～250 ℃.
(C) plastic raw materials enters barrel from the hopper of injector, plastifies into the viscous state melt through heating and melting and screw rod rotation, and mold cavity injected by nozzle by the promotion of screw rod in the back under certain pressure.
When (D) injecting, slow-fast-slow form that injection speed adopts, injection speed is set at: first section 80-100mm/s, second section 110-140mm/s, the 3rd section 48-80mm/s; Than the low velocity injection, guarantee that the materials flow forward all enters die cavity, to fill die cavity at a high speed, guarantees die venting at a slow speed then at last earlier.Injection pressure is at 100～130MPa; Dwell pressure is 50～70MPa, and the dwell time is 2～5s, and cool time is at 30～40s.
(E) cooling finishes, the mould die sinking, and push rod is released goods, finishes the overall process of moulding.
Effect of the present invention and benefit are: adopt this injection molding process can high efficiency moulding plastics micro-fluidic chip in enormous quantities, efficiently solve in the microfluidic control chip injection molding process microchannel and duplicate the incomplete technical barrier of Denging, to further improve the manufacture level of micro-fluidic chip, promote the application of injection molding technology in the micro mechanical system field.
Description of drawings
Fig. 1 is a microfluidic chip structure schematic diagram of the present invention.
Fig. 2 (A) is chip, cast gate and runner schematic diagram front view.
Fig. 2 (B) is chip, cast gate and runner schematic diagram vertical view.
The specific embodiment
Be described in detail specific embodiments of the invention below in conjunction with technical scheme and accompanying drawing.
The present invention is used for micro-fluidic chip shown in moulding Fig. 1 (A), profile is a slab construction, thickness is generally 1.2～1.5mm, and the cross microchannel is arranged on it, and the microchannel cross sectional shape is for the degree of depth shown in Fig. 1 (B) is about 50 μ m, width is at the rectangle of 30～100 μ m.Injection molding process mainly is divided into injection stage, packing stage and cooling stage.At the PMMA raw material of selecting for use, melt temperature is set at 230～250 ℃.At 100～130MPa, melt is injected mold cavity according to different shaping area control injection pressures, system switches to packing stage, finishes forming process after cooling.
To the influence of microchannel moulding degree of duplicating, experimental result shows that mold temperature plays a decisive role to improving microchannel degree of duplicating; Injection speed and melt temperature are secondary causes, and relative other factor affecting power of injection pressure are relatively poor, but must remain on a higher level.Mold temperature is set between 85～90 ℃, and mold temperature is low excessively, and microchannel degree of duplicating is difficult to improve, and mold temperature is too high, easily makes micro-fluidic chip produce defectives such as surperficial shrink mark and buckling deformation.During injection, slow-fast-slow control form that injection speed adopts is injected than low velocity earlier, guarantee that the materials flow forward enters die cavity reposefully, and then to fill die cavity at a high speed, before descending, finishes melt temperature filling, the last filling at a slow speed so that the gas in the die cavity is discharged smoothly to the place, microchannel; Wherein high regime is got about 140mm/s, to improve microchannel degree of duplicating.Injection pressure is set in 100～130MPa, finishes the filling at place, microchannel under high speed and high pressure; But injection pressure is also unsuitable too high, and too high injection pressure easily makes micro-fluidic chip produce buckling deformation.Dwell pressure is 50～70MPa, and the dwell time is 2～5s; To the similar situation of injection pressure influence, dwell pressure and dwell time are also unsuitable too high and long.Cool time is at 30～40s.Cooling finishes back die sinking taking-up goods and finishes whole forming process.
Embodiment 1:
Single cross micro-fluidic chip, the long 80mm of goods, wide 30mm, thickness are 1.2mm, a mould 2 chambeies, the microchannel section depth is that 50 μ m, width are 70 μ m, material selection PMMA.
(A) drying is good PMMA puts into the injection machine hopper, the barrel design temperature: 230 ℃ at nozzle, 250 ℃ in a district, 245 ℃ in two districts, 220 ℃ in three districts;
(B) mold temperature is set at 89 ℃;
(C) the mould closure enters injection stage, and injection pressure is: one section 100MPa, two sections 110MPa, three sections 110MPa, be 2.6s inject time, slow-fast-slow form that injection speed adopts, and injection speed is set at: first section 90mm/s, second section 140mm/s, the 3rd section 60mm/s;
(D) enter packing stage, dwell pressure is 70MPa, and the dwell time is 4s;
(E) enter cooling stage, cool time is at 30s;
(F) cooling finishes, and goods are taken out in the mould die sinking.
Product size detects: test samples is 6, choosing the cross section, 3 microchannels of micro-fluidic chip length direction 3 place's diverse locations measures, measure through China one boat Great Wall, Beijing metrological testing technology research institute, mean value is 69 μ m between the different sheets of microchannel width, maximum absolute error 2.5 μ m satisfy the design and use requirement of groove width precision for ± 3～6 μ m.
Embodiment 2:
Diesis micro-fluidic chip (two cross microchannels are arranged on every), the long 62mm of goods, wide 60mm, thickness are 1.2mm, a mould 2 chambeies, the microchannel section depth is that 50 μ m, width are 50 μ m, material selection PMMA.
(G) drying is good PMMA puts into the injection machine hopper, the barrel design temperature: 230 ℃ at nozzle, 250 ℃ in a district, 245 ℃ in two districts, 220 ℃ in three districts;
(H) mold temperature is set at 89 ℃;
(I) the mould closure enters injection stage, and injection pressure is: one section 100MPa, two sections 110MPa, three sections 120MPa, be 2.6s inject time, slow-fast-slow form that injection speed adopts, and injection speed is set at: first section 90mm/s, second section 140mm/s, the 3rd section 60mm/s;
(J) enter packing stage, dwell pressure is 70MPa, and the dwell time is 4s;
(K) enter cooling stage, cool time is at 30s;
(L) cooling finishes, and goods are taken out in the mould die sinking.
Product size detects: test samples is 6, choosing the cross section, 6 microchannels of micro-fluidic chip length direction 3 place's diverse locations measures, measure through China one boat Great Wall, Beijing metrological testing technology research institute, mean value is 48 μ m between the different sheets of microchannel width, maximum absolute error satisfies the design and use requirement of groove width precision for ± 3～6 μ m at 5.9 μ m.
Claims (2)
1. the injection molding process of a plastic microfluidic chip is characterized in that may further comprise the steps:
(A) plastic raw materials selects for use polymethyl methacrylate to be preset in the drying machine, 90 ℃ of baking temperatures, 6 hours time;
(B) mold heated to 85～90 ℃.Injector barrel plastic melt temperature range is set at 230～250 ℃;
(C) mould matched moulds, plastic raw materials enters barrel from the hopper of injector, plastifies into the viscous state melt through heating and melting and screw rod rotation, and the back is by injecting mold cavity by nozzle under the promotion of screw rod;
When (D) injecting, slow-fast-slow form that injection speed adopts, injection speed is set at: first section 80-100mm/s, second section 110-140mm/s, the 3rd section 48-80mm/s; Than the low velocity injection, guarantee that the materials flow forward all enters die cavity, to fill die cavity at a high speed, guarantees die venting at a slow speed then at last earlier; Injection pressure is at 100～130MPa, and dwell pressure is 50～70MPa, and the dwell time is 2～5s, and cool time is at 30～40s;
(E) cooling finishes, the mould die sinking, and push rod is released goods, finishes the overall process of moulding.
2. the injection molding process of plastic microfluidic chip according to claim 1, it is characterized in that: in described step (D), slow-fast-slow form that injection speed adopts, injection speed is set at: first section 90mm/s, second section 140mm/s, the 3rd section 60mm/s.
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| CN 201010183529 CN101863104A (en) | 2010-05-26 | 2010-05-26 | Injection molding process of plastic microfluidic chip |
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| CN 201010183529 CN101863104A (en) | 2010-05-26 | 2010-05-26 | Injection molding process of plastic microfluidic chip |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107501A (en) * | 2010-11-17 | 2011-06-29 | 深圳市昌红模具科技股份有限公司 | Machining method for preventing exhaust piece die of printer from deforming |
| CN102205594A (en) * | 2011-05-11 | 2011-10-05 | 慈溪市盛艺模具有限公司 | Steam type highlight and traceless injection-molding and forming process for complex precise product |
| CN102350972A (en) * | 2011-09-06 | 2012-02-15 | 郭传渠 | Thermoplastic soft vehicle logo and manufacturing method thereof |
| CN102896008A (en) * | 2012-10-18 | 2013-01-30 | 哈尔滨工业大学 | Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials |
| CN103112116A (en) * | 2013-02-03 | 2013-05-22 | 广东安帝斯智能家具组件有限公司 | Machining process and automatic processing equipment for eccentric wheel of furniture connecting piece |
| CN103395152A (en) * | 2013-08-07 | 2013-11-20 | 苏州扬清芯片科技有限公司 | Preparation method of annular high-polymer microfluidic chip |
| CN103736528A (en) * | 2013-12-19 | 2014-04-23 | 北京化工大学常州先进材料研究院 | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column |
| CN103920544A (en) * | 2014-04-14 | 2014-07-16 | 南京理工大学 | Method for preparing polydimethylsiloxane (PDMS) micro-fluidic chip |
| CN104072922A (en) * | 2014-07-08 | 2014-10-01 | 森鹤乐器股份有限公司 | Production method of antibacterial white key skins |
| CN104175447A (en) * | 2014-08-07 | 2014-12-03 | 浙江锦盛包装有限公司 | Process for forming thick-wall transparent products |
| CN105346036A (en) * | 2015-12-09 | 2016-02-24 | 天津城建大学 | Multicavity mold injection molding process of PC slender rod |
| CN109624197A (en) * | 2018-12-06 | 2019-04-16 | 东莞勤德五金制品有限公司 | The fever pedestal processing technology of electronic cigarette |
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2010
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107501A (en) * | 2010-11-17 | 2011-06-29 | 深圳市昌红模具科技股份有限公司 | Machining method for preventing exhaust piece die of printer from deforming |
| CN102205594A (en) * | 2011-05-11 | 2011-10-05 | 慈溪市盛艺模具有限公司 | Steam type highlight and traceless injection-molding and forming process for complex precise product |
| CN102205594B (en) * | 2011-05-11 | 2014-03-26 | 慈溪市盛艺模具有限公司 | Steam type highlight and traceless injection-molding and forming process for complex precise product |
| CN102350972A (en) * | 2011-09-06 | 2012-02-15 | 郭传渠 | Thermoplastic soft vehicle logo and manufacturing method thereof |
| CN102896008B (en) * | 2012-10-18 | 2014-12-10 | 哈尔滨工业大学 | Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials |
| CN102896008A (en) * | 2012-10-18 | 2013-01-30 | 哈尔滨工业大学 | Bonding method for micro-fluidic chip based on polymethyl methacrylate (PMMA) and other polymeric materials |
| CN103112116A (en) * | 2013-02-03 | 2013-05-22 | 广东安帝斯智能家具组件有限公司 | Machining process and automatic processing equipment for eccentric wheel of furniture connecting piece |
| CN103395152A (en) * | 2013-08-07 | 2013-11-20 | 苏州扬清芯片科技有限公司 | Preparation method of annular high-polymer microfluidic chip |
| CN103736528A (en) * | 2013-12-19 | 2014-04-23 | 北京化工大学常州先进材料研究院 | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column |
| CN103736528B (en) * | 2013-12-19 | 2017-01-18 | 北京化工大学常州先进材料研究院 | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column |
| CN103920544A (en) * | 2014-04-14 | 2014-07-16 | 南京理工大学 | Method for preparing polydimethylsiloxane (PDMS) micro-fluidic chip |
| CN103920544B (en) * | 2014-04-14 | 2015-06-17 | 南京理工大学 | Method for preparing polydimethylsiloxane (PDMS) micro-fluidic chip |
| CN104072922A (en) * | 2014-07-08 | 2014-10-01 | 森鹤乐器股份有限公司 | Production method of antibacterial white key skins |
| CN104175447A (en) * | 2014-08-07 | 2014-12-03 | 浙江锦盛包装有限公司 | Process for forming thick-wall transparent products |
| CN105346036A (en) * | 2015-12-09 | 2016-02-24 | 天津城建大学 | Multicavity mold injection molding process of PC slender rod |
| CN109624197A (en) * | 2018-12-06 | 2019-04-16 | 东莞勤德五金制品有限公司 | The fever pedestal processing technology of electronic cigarette |
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Application publication date: 20101020 |