CN103395152A - Preparation method of annular high-polymer microfluidic chip - Google Patents
Preparation method of annular high-polymer microfluidic chip Download PDFInfo
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- CN103395152A CN103395152A CN2013103416654A CN201310341665A CN103395152A CN 103395152 A CN103395152 A CN 103395152A CN 2013103416654 A CN2013103416654 A CN 2013103416654A CN 201310341665 A CN201310341665 A CN 201310341665A CN 103395152 A CN103395152 A CN 103395152A
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Abstract
The invention aims at providing an annular high-polymer microfluidic chip which is characterized in that the annular high-polymer microfluidic chip is prepared with a curing and forming technology based on an annular sleeve cylinder mold. The preparation method comprises the steps that: (1) a high-molecular polymer material liquid-state pre-polymer, melt, or organic solvent mixed liquid is injected into a specially designed annular sleeve cylinder microfluidic chip mold; (2) the high-molecular polymer in the mold is completely cured with a curing and forming technology; and (3) the cured and formed high-polymer chip is peeled from the mold, such that the annular microfluidic chip is obtained.
Description
Technical field
The present invention relates to little manufacture field, particularly relate to a kind of preparation method of annular high polymer micro-flow control chips.
Background technology
Since micro-fluidic chip is born, micro-and " entirely " is the developing direction of micro-fluidic chip technology always.So-called micro-refers to that the dimension volume of chip and corollary equipment thereof, institute take up space as far as possible little; So-called " entirely " refers to that the functional unit of chip and corollary equipment thereof is many as far as possible and comprehensive.At present, rely on existing micro-processing technology, various functional units and device can both integration in micro-fluidic chip, but existing micro-fluidic chip mostly is the plane formula chip, the chip of the various shapes that for example developed at present, comprise card form, disc type, 3D multilayer planar formula etc.If can develop a kind of circular micro-fluidic chip, will volume and the space of micro-fluidic chip further be dwindled, can further promote to a great extent the microminiaturization of chip system.
In recent years, macromolecule polymer material such as dimethyl silicone polymer (PDMS), polymethyl methacrylate (PMMA), Merlon (PC), PET (PET) etc. have caused micro-fluidic chip area research person's very big concern, because these materials itself have very excellent optical signature, and lower cost for material, easy to process.Therefore, be very suitable for the preparation of annular chip.
Summary of the invention
For above-mentioned problem, the purpose of this invention is to provide a kind of annular high polymer micro-flow control chips, it is characterized in that this micro-fluidic chip is to be prepared by the curing molding technology based on annulus socket type mould, its preparation method comprises the following characteristics step:
1. the mixed liquor of liquid performed polymer, fused mass or the organic solvent of macromolecule polymer material is injected the micro-fluidic chip mould of a specially designed annulus socket type;
2. use the curing molding technology to impel the high molecular polymer in mould to solidify fully;
3. the polymer chip after curing molding and mould are peeled off, obtained the annular micro-fluidic chip.
In above-mentioned steps, the material of described micro-fluidic chip comprises dimethyl silicone polymer, polymethyl methacrylate, Merlon, polyvinyl chloride, polyformaldehyde, polystyrene, PET, polypropylene, polytetrafluoroethylene (PTFE) etc.
In above-mentioned steps, the material of described annulus socket type mould is metal or alloy, for example metal nickel mould, stainless steel mould; Can be also high-melting plastics, such as polytetrafluoroethylene (PTFE) mould etc.
In above-mentioned steps, the inner surface of described annulus socket type mould has the micro-structural with the micro-fluidic chip complete complementary, for example microfluidic channel, micro chamber, micro-mixer; Micro-structural can be the inner surface in outer toroid, can be also the inner surface at interior annulus.
In above-mentioned steps, for the ease of peeling off of polymer chip and mould, the outer toroid of described annulus socket type mould and interior annulus have at least one to be dismountable.The bottom of annulus socket type mould is full-closed structure, top can be closed can be also open.
In above-mentioned steps, described curing molding technology comprises the method for injection mo(u)lding, polymerizing curable moulding or solvent evaporates curing molding.
In above-mentioned steps, the described micro-fluidic chip surface that is prepared based on the curing molding technology of annulus socket type mould has open micro-structural, further, with a film ring shape cover plate and said chip bonding, can prepare the micro-fluidic chip of closed.The bonding of above-mentioned film ring shape cover plate can be stickup, laser weld or ultrasonic bonding.
The preparation method of a kind of high polymer micro-flow control chips provided by the present invention, described high molecular polymer micro-fluidic chip is cirque structure, the space that can save micro-fluidic chip, be particularly suitable for micro-total analysis system.Described annular high polymer micro-flow control chips can be the open loop type structure, can be also the closed loop structure; The head and the tail that are described high polymer micro-flow control chips can be connected fully, and head and the tail do not connect fully yet, remain with certain interval between head and the tail.
Description of drawings
Fig. 1. the perspective view of a kind of cylinder type mould provided by the invention.
Fig. 2. a kind of outer surface provided by the invention has the preparation process schematic diagram of the annular high polymer micro-flow control chips of micro-structural.
Fig. 3. a kind of inner surface provided by the invention has the preparation process schematic diagram of the annular high polymer micro-flow control chips of micro-structural.
Fig. 4. outer surface has the bonding schematic diagram of the annular chip of micro-structural.
Fig. 5. inner surface has the bonding schematic diagram of the annular chip of micro-structural.
Specific embodiments
The following examples are further described the present invention in connection with Figure of description.
A kind of outer surface of embodiment has the annular PDMS micro-fluidic chip of micro-structural
As shown in Figure 1, this mould is cylinder type for a kind of annular dimethyl silicone polymer (PDMS) chip, the mould structure that uses, and uses the nickel electrocasting method to prepare and obtains.Wherein has micro-structural on the inwall of outer toroid, for example with the microprotrusion structure of microchannel complementation.
The preparation process of annular PDMS micro-fluidic chip as shown in Figure 2, toward the PDMS performed polymer (monomer: initator=10: 1), eliminate bubble in vacuum of casting filling liquid in above-mentioned cylinder type mould; Place 1h in 80 ℃ of baking ovens, make its complete polymerizing curable; With annulus dismounting in mould, then outer toroid and micro-fluidic chip are peeled off, the annular PDMS micro-fluidic chip that the final outer surface that obtains as shown in the figure has micro-structural, the outer surface of this micro-fluidic chip has open MCA.As shown in Figure 4, get another PDMS film, it is close to the microchannel surface of said chip, after realizing bonding, be prepared from the annular PDMS micro-fluidic chip with closed MCA.
2 one kinds of inner surfaces of embodiment have the annular PMMA micro-fluidic chip of micro-structural
As shown in Figure 1, this mould is cylinder type for a kind of annular polymethyl methacrylate (PMMA) chip, the mould structure that uses, and uses the nickel electrocasting method to prepare and obtains.Wherein has micro-structural on the outer wall of interior annulus, for example with the microprotrusion structure of microchannel complementation.
The preparation process of annular PMMA micro-fluidic chip as shown in Figure 3, is filled the PMMA molten mass of 180 ℃ of liquid state toward casting in above-mentioned cylinder type mould, eliminate bubble in vacuum; Cooling, it is solidified fully; With annulus dismounting in mould, then outer toroid and micro-fluidic chip are peeled off, the annular PMMA micro-fluidic chip that the final inner surface that obtains as shown in the figure has micro-structural, the inner surface of this micro-fluidic chip has open MCA.As shown in Figure 5, get another PET pressure sensitive film, it is close to the microchannel surface of said chip, after compressing the stickup bonding, be prepared from the annular PMMA micro-fluidic chip with closed MCA.
Claims (10)
1. the preparation method of an annular high polymer micro-flow control chips, is characterized in that this high polymer micro-flow control chips is to be prepared by the curing molding technology based on annulus socket type mould, and its preparation method comprises the following characteristics step:
1. the mixed liquor of liquid performed polymer, fused mass or the organic solvent of macromolecule polymer material is injected the micro-fluidic chip mould of a specially designed annulus socket type;
2. use the curing molding technology to impel the high molecular polymer in mould to solidify fully;
3. the polymer chip after curing molding and mould are peeled off, obtained the annular micro-fluidic chip.
2. according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the material of described micro-fluidic chip comprises dimethyl silicone polymer, polymethyl methacrylate, Merlon, polyvinyl chloride, polyformaldehyde, polystyrene, PET, polypropylene, polytetrafluoroethylene (PTFE) etc.
3., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the material of described annulus socket type mould is metal or alloy, can be also high-melting plastics.
4. according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the inner surface of described annulus socket type mould has the micro-structural with the micro-fluidic chip complete complementary, micro-structural can be the inner surface in outer toroid, can be also the inner surface at interior annulus.
5., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the outer toroid of described annulus socket type mould and interior annulus have at least one to be dismountable.
6., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the bottom of described annulus socket type mould is full-closed structure, top can be closed can be also open.
7., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, described curing molding technology comprises the method for injection mo(u)lding, polymerizing curable moulding or solvent evaporates curing molding.
8. according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, the described micro-fluidic chip surface that is prepared based on the curing molding technology of annulus socket type mould has open micro-structural,, with a film ring shape cover plate and said chip bonding, can further prepare the micro-fluidic chip of closed.
9., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, described annular high polymer micro-flow control chips can be the open loop type structure, can be also the closed loop structure; The head and the tail that are described high polymer micro-flow control chips can be connected fully, and head and the tail do not connect fully yet, remain with certain interval between head and the tail.
10., according to the preparation method of a kind of annular high polymer micro-flow control chips claimed in claim 1, it is characterized in that, described high polymer micro-flow control chips is cirque structure, and the space that can save micro-fluidic chip, be particularly suitable for micro-total analysis system.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106807460A (en) * | 2016-12-20 | 2017-06-09 | 深圳太辰光通信股份有限公司 | A kind of preparation method of the microchannel for slab guide sensor chip |
| CN107813300A (en) * | 2017-12-07 | 2018-03-20 | 北京康力优蓝机器人科技有限公司 | A kind of flexible intelligent module and its manufacture method available for robot |
| CN108662279A (en) * | 2018-05-23 | 2018-10-16 | 河海大学常州校区 | The micro-fluidic passive flux regulating valve of annular membrane and flow control method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2550156Y (en) * | 2002-07-18 | 2003-05-14 | 中国科学院大连化学物理研究所 | Micro flow control plastic chip injection mould |
| JP2008126472A (en) * | 2006-11-20 | 2008-06-05 | Univ Of Electro-Communications | Precision welding method for micro fluid chip |
| CN101786317A (en) * | 2010-01-18 | 2010-07-28 | 大连理工大学 | Hot runner injection forming mold for micro-fluidic chip |
| CN101863104A (en) * | 2010-05-26 | 2010-10-20 | 大连理工大学 | Injection molding process of plastic microfluidic chip |
-
2013
- 2013-08-07 CN CN2013103416654A patent/CN103395152A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2550156Y (en) * | 2002-07-18 | 2003-05-14 | 中国科学院大连化学物理研究所 | Micro flow control plastic chip injection mould |
| JP2008126472A (en) * | 2006-11-20 | 2008-06-05 | Univ Of Electro-Communications | Precision welding method for micro fluid chip |
| CN101786317A (en) * | 2010-01-18 | 2010-07-28 | 大连理工大学 | Hot runner injection forming mold for micro-fluidic chip |
| CN101863104A (en) * | 2010-05-26 | 2010-10-20 | 大连理工大学 | Injection molding process of plastic microfluidic chip |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106807460A (en) * | 2016-12-20 | 2017-06-09 | 深圳太辰光通信股份有限公司 | A kind of preparation method of the microchannel for slab guide sensor chip |
| CN107813300A (en) * | 2017-12-07 | 2018-03-20 | 北京康力优蓝机器人科技有限公司 | A kind of flexible intelligent module and its manufacture method available for robot |
| CN107813300B (en) * | 2017-12-07 | 2019-01-04 | 北京康力优蓝机器人科技有限公司 | A kind of layering casting method for the flexible intelligent module can be used for robot |
| CN108662279A (en) * | 2018-05-23 | 2018-10-16 | 河海大学常州校区 | The micro-fluidic passive flux regulating valve of annular membrane and flow control method |
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Application publication date: 20131120 |