CN101850011B - External medicament for treating cervical spondylosis and preparation method thereof - Google Patents
External medicament for treating cervical spondylosis and preparation method thereof Download PDFInfo
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- CN101850011B CN101850011B CN2010101838145A CN201010183814A CN101850011B CN 101850011 B CN101850011 B CN 101850011B CN 2010101838145 A CN2010101838145 A CN 2010101838145A CN 201010183814 A CN201010183814 A CN 201010183814A CN 101850011 B CN101850011 B CN 101850011B
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Abstract
The invention discloses an external medicament for treating cervical spondylosis, which is mainly prepared from frankincense, szechuan lovage rhizome, clematis root and zanthoxylum pipertum DC in a certain weight ratio. The external medicament of the invention has the effects of clearing heat and purging the pathogenic fire, diminishing inflammation, resisting bacteria, clearing and activating the channels and collaterals, stopping pain and pursuing toxicity, is used for treating cervical spondylosis, and has quick response, good curative effect and high cure rate.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of cervical spondylosis and preparation method thereof, belong to the field of Chinese medicines.
Background technology:
Cervical spondylosis claims cervical spine syndrome again, is the general name that osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, cervical intervertebral disk are deviate from disease.It is a kind of illness of changing into the basis with degeneration pathology.Strain for a long time mainly due to cervical vertebra, hyperosteogeny, or intervertebral disk hernia, ligament thicken, and causes cervical vertebra bone marrow, nerve root or vertebral artery pressurized, a series of handicapped clinical syndromes occur.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosening; Vertebral pulp is given prominence to or is deviate from; Bony spur forms; The spinal canal stenosis of ligament plumpness and secondary etc. stimulate or have oppressed the tissues such as nerve root, spinal cord, vertebral artery and cervical region sympathetic nerve of vicinity, and cause the syndrome of various sings and symptoms.Clinical syndrome differentiation mainly is divided into two types of caused by liver and kidney deficiency, anemofrigid-damp arthralgia.Cervical vertebra between head, chest and upper limb, be volume minimum in the spinal vertebrae again, but motility maximum, the highest, the bigger sections that bears a heavy burden of motion frequency are owing to bear various loads, strain, even wound, so regression very easily takes place.After about 30 years old, cervical intervertebral disk just begins to degenerate gradually, and water content reduces, and follows age growth and more obvious, and brings out or impel other position of cervical vertebra to organize regression.The biomechanics angle, 5-6, the stressed maximum of 6-7 cervical vertebra, therefore, much more comparatively the happening part of cervical spondylosis is seen at these sections.Have statistics to show that nearly 25% people suffered from or just suffering from this disease among the crowd about 50 years old, left and right sides Ze Da was almost 100% about 50%, 70 years old in 60 years old, as seen this disease be in, common complaint among the elderly and frequently-occurring disease.
The Therapeutic Method of cervical spondylosis can be divided into operative treatment at present, conservative traction and massaging treatment and these three kinds of modes of treatment with western, the mode of operative treatment is the most quick, but also be the risk maximum, as easy as rolling off a log recurrence, conservative traction and massaging is alleviating pain effectively, but is not have great effect for treatment.Western medicine circle is middle with conservative traction and massaging treatment in operative treatment, and defective is that side effect is big, and the course of treatment is long, can not effect a radical cure.
Summary of the invention:
Therefore, there is very big demand in people's Chinese medicine Drug therapy that curative effect is better treated cervical spondylosis.Up to now, also there be not the relevant report of discovery about pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has worked out the external application of Chinese medicine medicine of the cervical spondylosis that better curative effect is arranged finally, thereby has finished the present invention.
The purpose of this invention is to provide a kind of Chinese medicine composition of more effectively treating cervical spondylosis.
Another object of the present invention has just provided the preparation method of this Chinese medicine composition.
Medicament selection Olibanum of the present invention, Myrrha, Rhizoma Chuanxiong, Fructus Zanthoxyli (different name Pericarpium Zanthoxyli), Radix Clematidis (different name radix smilacis sieboldi), Radix Saposhnikoviae make up.Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat cervical spondylosis.Wherein selecting Olibanum for use is owing to its nature and flavor suffering, hardship, temperature.Go into the heart, liver, spleen channel.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Selecting Myrrha for use is owing to its nature and flavor hardship, suffering, flat.Diffusing blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all Tong , of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain anal fistula.Diseases of the eye.Selecting Rhizoma Chuanxiong for use is owing to its nature and flavor suffering, temperature.Activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Selecting Fructus Zanthoxyli for use is owing to its nature and flavor suffering, temperature, poisonous.Warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing is separated fish raw meat poison, and control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, and cough with dyspnea, anemofrigid-damp arthralgia is had loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.Select for use Radix Clematidis to be because its nature and flavor suffering is salty, warm, poisonous.Wind-damp dispelling, the meridian dredging, expectorant saliva, the hypochondriac lump of loosing is controlled gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria , lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Selecting Radix Saposhnikoviae for use is owing to its property acrid-sweet flavor, temperature.Deliver, dispel the wind, win and wet, pain relieving.Control affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Vinegar, the different name Bitters, nature and flavor are bitter, warm, are included into liver, stomach warp, and dissipating blood stasis, hemostasis, detoxifcation, sterilization, parasiticidal function are arranged, the back bruise of managing property, jaundice, yellowish perspiration, haematemesis, epistaxis, stool hematochezia, pudendal pruritus, skin sore.
The amounts of components of medicine of the present invention also is to draw through the Test Summary of inventor by repeatedly, and drug dose all has curative effect preferably in following weight range:
Olibanum 5 grams-15 gram Myrrhas 15 grams-25 grams
Rhizoma Chuanxiong 15 grams-25 gram Fructus Zanthoxylis 5 grams-15 grams
Radix Clematidis 15 grams-25 gram Radix Saposhnikoviaes 5 grams-15 grams
45 milliliters-55 milliliters of vinegar
Be preferably:
Olibanum 10 gram Myrrhas 20 grams
Rhizoma Chuanxiong 20 gram Fructus Zanthoxylis 10 grams
Radix Clematidis 20 gram Radix Saposhnikoviaes 10 grams
50 milliliters of vinegar
Preparation method of the present invention is as follows, and it comprises the following steps:
One, preferred feedstock medicine
1, Olibanum: remove impurity, smash in bulk;
2, Myrrha: choose decontamination, break into fragment;
3, Rhizoma Chuanxiong: remove impurity, separate large and small, be soaked in water, dry in the sun is cut into slices behind the moistening, drying;
4, Fructus Zanthoxyli: remove fruit stem and seed, put pot interior stir-fry to making sound, oil goes out, and takes out, and cools;
5, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
6, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry.
Two, preparation
1, puts into grinding container by measuring sufficient Olibanum, Myrrha, Rhizoma Chuanxiong, Fructus Zanthoxyli, Radix Clematidis, Radix Saposhnikoviae, be ground into powder;
2, ground Chinese medicinal powder is divided into three equal parts, puts into container respectively;
3, vinegar is added respectively in the ground Chinese medicinal powder, stir, three equal parts evenly are spread out in respectively on three gauzes, wrap, make three parts of plaster with bundle.
Medicine of the present invention has blood circulation promoting, eliminates the cervical region paroxysmal pain, cervical region is sent out functions such as deadlock, numb limbs and tense tendons, dizziness, headache, and it is fast to be used for the treatment of the spondylopathy curative effect, the cure rate height.
The specific embodiment:
Below further set forth the beneficial effect of medicine of the present invention by testing example, these test the routine observations that comprises animal experiment and clinical trial.
The animal experiment report of [test example 1] medicine of the present invention
Get New Zealand man and exempt from 20, the male and female dual-purpose, body weight 2.0~2.5kg is divided into two groups, and 10 every group, wherein one group is the normal amount toxicity test, and another group is the excess toxicity test.
The normal amount toxicity test: the abdominal part rabbit hair of choosing, get said medicine and spread on the rabbit abdominal part, once a day, each medication is 1.5 grams, continuous three days, observes 10 all no abnormal reactions of rabbit every day.
The excess toxicity test: take out the abdominal part rabbit hair, get the above-mentioned medicine for preparing and spread on the rabbit abdominal part, once a day, each medication is 4.5 grams, three times of the medication that is equivalent to be grown up, and logotype three days there is no abnormal response.
Evidence, medicine of the present invention has no side effect.
The clinical observation of [test example 2] Drug therapy cervical spondylosis of the present invention
1, physical data
Accept out-patient's totally 70 examples for medical treatment, wherein male 59 examples, women 11 examples, age 30-40 year 45 examples wherein, 41-50 year 12 examples, 51-60 year 8 examples, 5 examples more than 60 years old.
2, diagnostic criteria
Different according to damaged tissues and structure, cervical spondylosis is divided into following five classes:
One, cervical muscle type
Mainly show as: tetanic, the pain of cervical region, or have whole shoulder and back ache to send out deadlock; . nod, face upward head and rotary head limitation of activity; Dizzy symptom also can appear.
Two, spondylotic radiculopathy
Mainly show as: early symptom is that cervicodynia and cervical region are sent out deadlock; Upper limb radiated pain or numbness, this pain and numb trend and the radiation of domination district along the pressurized nerve root, the position and the posture of the appearance of symptom and alleviation sometimes and patient's cervical region have obvious relation; The Ipsilateral upper limb feels that heavy, grip goes down, and occurs holding thing sometimes and falls.
Three, vertebral artery type
Mainly show as: episodic vertigo, diplopia is with nystagmus.Sometimes follow nauseating, vomiting, tinnitus or auditory dysesthesia.These symptoms change relevant with neck location; Lower limb are unable dampinging off suddenly, but how Consciousness takes place when head and neck is in a certain position.Idol has numb limbs and tense tendons, paraesthesia.
Four, adrenergic type
Mainly show as: dizzy, headache, sleep are poor, hypomnesis, difficult concentrating; . ophthalmic bloated, blurring of vision; Tinnitus, stifled, the auditory dysesthesia of ear; Nasal obstruction, " allergic rhinitis ", foreign body in pharynx sense, xerostomia, vocal cords fatigue etc.; Feel sick even vomiting, abdominal distention, diarrhoea, dyspepsia, belch etc.; Cardiopalmus, uncomfortable in chest, changes in heart rate, arrhythmia, blood pressure etc.; Facial or a certain limbs hyperhidrosis, lossless, fear of cold or heating.
Five, myeloid form
Mainly show as: numbness of lower limbs, heavy, difficulty in walking, both feet are stepped on cotton sense; Upper limb numbness, pain, both hands are unable, dumb, write, setting fastening, hold fine movements such as chopsticks and be difficult to finish, and hold thing easily to fall; Paraesthesia appears in trunk, and the patient often feels in the binding sense just like the belt sample of chest, abdominal part or two lower limb;
3, Therapeutic Method
Be affixed on affected part with a plaster every day, the external application hot water bag, get sit prone position all can, continue 1 hour, continuous 12 days is a course of treatment, massage cervical vertebra 3,4,5 joints are each 10 minutes after drug of topical application every day, the cervical vertebra disease symptoms disappears after three courses of treatment, generally can not recur for many years.
4, efficacy assessment standard
Produce effects: cervical spondylosis is after treatment, and cervicodynia, cervical region are sent out deadlock, upper limb numbness, pain symptom and alleviated, both hands are unable, numbness of lower limbs, heavy, dizzy, headache, feel sick, vomiting, tinnitus transference cure, recover normally to observe 1 year no recidivist.
Take a turn for the better: cervical spondylosis is after treatment, and cervicodynia, cervical region are sent out deadlock, upper limb numbness, pain, and both hands are unable, numbness of lower limbs, heavy, dizzy, headache, nauseating, vomiting, tinnitus symptom take a turn for the better gradually.
Invalid: as not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with medicine treating cervical spondylosis patient 70 examples of the present invention, produce effects 59 examples as a result, obvious effective rate is 84%, 7 examples that take a turn for the better, improvement rate is 10%, invalid 4 examples, total effective rate is 94%.
Claims (3)
1. external used medicine for the treatment of cervical spondylosis is characterized in that: it is to be prepared from by the crude drug in the weight range what follows:
Olibanum 5 grams-15 gram Myrrhas 15 grams-25 grams
Rhizoma Chuanxiong 15 grams-25 gram Fructus Zanthoxylis 5 grams-15 grams
Radix Clematidis 15 grams-25 gram Radix Saposhnikoviaes 5 grams-15 grams
45 milliliters-55 milliliters of vinegar.
2. external used medicine according to claim 1, wherein the consumption of each crude drug is:
Olibanum 10 gram Myrrhas 20 grams
Rhizoma Chuanxiong 20 gram Fructus Zanthoxylis 10 grams
Radix Clematidis 20 gram Radix Saposhnikoviaes 10 grams
50 milliliters of vinegar.
3. according to the preparation method of claim 1 or 2 described external used medicines, it is characterized in that: it comprises the following steps:
(1) preferred feedstock medicine
(1) Olibanum: remove impurity, smash in bulk;
(2) Myrrha: choose decontamination, break into fragment;
(3) Rhizoma Chuanxiong: remove impurity, separate large and small, be soaked in water, dry in the sun is cut into slices behind the moistening, drying;
(4) Fructus Zanthoxyli: remove fruit stem and seed, put pot interior stir-fry to making sound, oil goes out, and takes out, and cools;
(5) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
(6) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(2) preparation
(1) puts into grinding container by measuring sufficient Olibanum, Myrrha, Rhizoma Chuanxiong, Fructus Zanthoxyli, Radix Clematidis, Radix Saposhnikoviae, be ground into powder;
(2) ground Chinese medicinal powder is divided into three equal parts, puts into container respectively;
(3) vinegar is added respectively in the ground Chinese medicinal powder, stir, three equal parts evenly are spread out in respectively on three gauzes, wrap, make three parts of plaster with bundle.
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CN2010101838145A CN101850011B (en) | 2010-05-24 | 2010-05-24 | External medicament for treating cervical spondylosis and preparation method thereof |
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CN101850011B true CN101850011B (en) | 2011-08-31 |
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CN106728245A (en) * | 2016-12-14 | 2017-05-31 | 梁聚芳 | It is a kind of to treat medicinal pillow inner of cervical spondylopathy and preparation method thereof |
CN110694007A (en) * | 2019-09-26 | 2020-01-17 | 浙江正盛医药科技有限公司 | Plaster for dredging channels and activating collaterals and preparation method thereof |
Citations (1)
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CN1073870A (en) * | 1992-10-26 | 1993-07-07 | 常民 | The preparation method of neck-building medicine |
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CN1073870A (en) * | 1992-10-26 | 1993-07-07 | 常民 | The preparation method of neck-building medicine |
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