CN101849674A - Heath-care food prepared from red yeast rice and epigallocatechin-3-gallate - Google Patents
Heath-care food prepared from red yeast rice and epigallocatechin-3-gallate Download PDFInfo
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- CN101849674A CN101849674A CN201010101426A CN201010101426A CN101849674A CN 101849674 A CN101849674 A CN 101849674A CN 201010101426 A CN201010101426 A CN 201010101426A CN 201010101426 A CN201010101426 A CN 201010101426A CN 101849674 A CN101849674 A CN 101849674A
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Abstract
The invention discloses a health-care food prepared from red yeast rice and epigallocatechin-3-gallate, which belongs to the technical field of health-care foods. Tablet or capsule health-care foods are prepared by using the red yeast rice and the epigallocatechin-3-gallate and by using sodium carboxymethylcellulose and magnesium stearate as auxiliary materials, wherein the weight of the red yeast rice is 55 to 80 percent based on the total weight and the weight of the epigallocatechin-3-gallate is 5.5 to 7.7 percent based on the total weight; and the auxiliary materials comprises 5 to 30 percent of microcrystalline cellulose, 1 to 2 percent of sodium carboxymethylcellulose, 0.1 to 1 percent of magnesium stearate and 1 to 3 percent of talcpowder based on the total weight. The health-care food prepared from the red yeast rice and the epigallocatechin-3-gallate has the advantage that: compared with the prior art, the health-care food can help lower the blood pressure, has auxiliary tumor-resistance and is very favorable for improving the health of sub-healthy people. The product has the characteristics of safety and high efficiency, can be taken for a long time and has no toxic and side effects; and the product quality is stable and reliable in a period of validity.
Description
Technical field
The invention belongs to the health food technology field, particularly a kind of health food of making by red colouring agent for food, also used as a Chinese medicine and Epigallo-catechin gallate (EGCG) (EGCG); Have auxiliary antilipemic and auxiliary antineoplastic health-care effect.
Background technology
Through verification, red colouring agent for food, also used as a Chinese medicine is invented in the Han dynasty, is traditional food and Chinese medicine.The record of " red colouring agent for food, also used as a Chinese medicine is cooked meat " is arranged among the five generation people Tao Guzai " clear different record ".Multiple book on Chinese herbal medicine of successive dynasties, all on the books as " book on Chinese herbal medicine through separating ", " new compilation of materia medica ", " Amplification on Materia Medica addendum ", Compendium of Material Medica, " book on Chinese herbal medicine is equipped with medicine " and " Chinese medicine voluminous dictionary " to red colouring agent for food, also used as a Chinese medicine.Especially Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is the most complete to the record of red colouring agent for food, also used as a Chinese medicine.Comprehensive successive dynasties book on Chinese herbal medicine, red colouring agent for food, also used as a Chinese medicine is sweet in flavor and warm in property, and is nontoxic.The thoughts of returning home, liver, spleen, large intestine channel.Have promoting blood circulation and removing blood stasis, reinforcing spleen to promote digestion, the dehumidifying function of eliminating the phlegm cures mainly dizziness, headache, fat many phlegm, the trusted subordinate has a pain, traumatic injury, diseases such as women's post partum longtime lochia.
" red colouring agent for food, also used as a Chinese medicine " records appendix of one nine nine zero year versions " medicinal material that this pharmacopeia is not recorded in the prescribed preparation and processed product " in the Pharmacopoeia of the People's Republic of China as Chinese medicine, all is made up of this medicine in the prescription of this pharmacopeia prescribed preparation " Re-creating Bolus ", " wine of stimulating the circulation of the blood and cause the muscles and joints to relax "." Inner Mongol medicinal material standard " in 1988 version, " Beijing's Chinese medicine concocted specification " in 1986 version all is loaded with red colouring agent for food, also used as a Chinese medicine.General dose is 6-12g every day.
Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is the most detailed to the red colouring agent for food, also used as a Chinese medicine record, and multiple book on Chinese herbal medicine of successive dynasties is also all on the books to red colouring agent for food, also used as a Chinese medicine, and general consumption 3 money to 5 money (10-15g) are done powder more and taken after mixing it with water or be decocted in water for oral dose.
The mechanism of EGCG reducing blood lipid mainly is by the metabolism of the absorption that suppresses exogenous cholesterol in the enteron aisle, raising LCAT activity and HDL level, adjusting apolipoprotein and lipoprotein levels, acceleration cholesterol and promotes the drainage of cholesterol to regulate the TC metabolism; By the activity that suppresses pancreatic lipase reduced absorption to exogenous TG, that the activity that reduces FAS has reduced that fat joins is synthetic, strengthen the HL activity has quickened the metabolism of TG and promoted the drainage of aliphatic acid to regulate the TG metabolism.
Simultaneously, EGCG can suppress the transcriptional activity of some transcription factors, EGCG can reduce VEGF (VEGF, vascular endothelial growth factor) expression of activation of the composition of transcriptional regulatory agent EGFR and protein kinase C, these change relevant with the minimizing of the inhibition of VEGF promoter activity and the interior VEGF product of cell, suppressed the tumour cell vegf expression, also dose dependent ground suppresses the VEGF secretion of endothelial cell and tumour cell, generates and tumor growth thereby suppressed tumor vessel.
Summary of the invention
The object of the present invention is to provide a kind of health food of making by red colouring agent for food, also used as a Chinese medicine and Epigallo-catechin gallate (EGCG) (EGCG), have auxiliary antilipemic and auxiliary anti-tumor function.The personnel that are particularly useful for sub-health state get back to health status.Through evidence, take nontoxic, side effect safely, effectively, for a long time.
The present invention mainly utilizes red yeast rice to cooperate Epigallo-catechin gallate (EGCG) (EGCG), is auxiliary material with sodium carboxymethylcellulose and magnesium stearate, both can make tablet and also can make capsule.Wherein the amount of red yeast rice accounts for the 55%-80% of gross weight, and the amount of Epigallo-catechin gallate (EGCG) (EGCG) is than the 5.5%-10% that accounts for gross weight; Microcrystalline cellulose excipients accounts for the 5%-30% of gross weight, sodium carboxymethylcellulose 1-2%, dolomol 0.1-1%, talcum powder 1-3%.
Red yeast rice provided by the invention is to adopt traditional monascus parpureus Went (Monascus purpureus) bacterial classification, gets through solid fermentation production, and the content of Lovastatin is between 5-20mg/g in the red yeast rice.
Epigallo-catechin gallate (EGCG) provided by the invention (EGCG) extracts from green tea.Prepare this product, need to buy Epigallo-catechin gallate (EGCG) (EGCG) content and extract product (HPLC testing result) at the green tea of 70%-95%, simultaneously for reducing the side effect of product, the content of caffeine accounts for the gross weight that green tea extracts product should be less than 0.5%.
A key character of the present invention is the composition of the different mechanisms of action is combined dexterously, and they are acted synergistically by different way, and then reaches the effect of auxiliary antilipemic, and can effectively prevent other disease.The functional component Lovastatin is the competitive inhibitor of HMG-CoA reductase (rate-limiting enzyme that cholesterol is synthetic) in the first red yeast rice, and specificity reduces cholesterolemia (T-CHOL, LDL and VLDL), also can reduce triglycerides; Its two be EGCG can be in protein and mRNA level suppress adipocyte TG biosynthesis effect and proliferation function, thereby show effect for reducing blood fat; Its three Lovastatin and EGCG all can increase HDL, can effectively prevent angiocardiopathy more; Its four because EGCG can suppress the absorption of human body to cholesterol, therefore in prescription, can reduce the consumption of Lovastatin every day (being red colouring agent for food, also used as a Chinese medicine), to overcome the side effect that heavy dose of Lovastatin may cause.Therefore, both take by the science compatibility, and its effect is better than taking heavy dose of one-component for a long time, and security increases.
Simultaneously, EGCG has clear and definite antitumous effect again, so we are strict with EGCG in the green-tea extract when selecting raw material content must play guaranteeing role well to the prevention other diseases like this greater than 70%.
Of the present inventionly be that a little compared with prior art: the present invention is with red colouring agent for food, also used as a Chinese medicine and EGCG scientific matching, and product safety is efficient, takes safe, nontoxic, side effect for a long time.
Functional trial is the result show, this product has the effect of auxiliary antilipemic well; The safety evaluatio result of the test shows, this product safe without toxic side effect; Study on the stability is the result show, this product steady quality before the deadline is reliable.
The specific embodiment
Embodiment 1:2500g red yeast rice, 375g green-tea extract (wherein EGCG content is greater than 70%) adds microcrystalline cellulose 800g, sodium carboxymethylcellulose 60g, dolomol 30g, talcum powder 100g makes 10000 tablets of tablets according to a conventional method.Every heavy 0.400-0.410g.The dose of every day should be above four.
Claims (3)
1. a health food of being made by red colouring agent for food, also used as a Chinese medicine and Epigallo-catechin gallate (EGCG) is characterized in that, utilizes red yeast rice to cooperate Epigallo-catechin gallate (EGCG), is auxiliary material with sodium carboxymethylcellulose and magnesium stearate, makes tablet or capsule; Wherein the amount of red yeast rice accounts for the 55%-80% of gross weight, and the amount of Epigallo-catechin gallate (EGCG) is than the 5.5%-10% that accounts for gross weight; Microcrystalline cellulose excipients accounts for the 5%-30% of gross weight, sodium carboxymethylcellulose 1-2%, dolomol 0.1-1%, talcum powder 1-3%.
2. health food according to claim 1 is characterized in that, described red yeast rice is to adopt traditional monascus parpureus Went bacterial classification, gets through solid fermentation production, and the content of Lovastatin is between 5-20mg/g in the red yeast rice.
3. health food according to claim 1 is characterized in that, described Epigallo-catechin gallate (EGCG) extracts from green tea; Adopt Epigallo-catechin gallate (EGCG) content to extract product at the green tea of 70%-95%, the content of caffeine accounts for the gross weight that green tea extracts product should be less than 0.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101014268A CN101849674B (en) | 2010-01-27 | 2010-01-27 | Heath-care food prepared from red yeast rice and epigallocatechin-3-gallate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101014268A CN101849674B (en) | 2010-01-27 | 2010-01-27 | Heath-care food prepared from red yeast rice and epigallocatechin-3-gallate |
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| CN101849674A true CN101849674A (en) | 2010-10-06 |
| CN101849674B CN101849674B (en) | 2012-08-22 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705704A (en) * | 2013-10-14 | 2014-04-09 | 北京天安康健生物科技有限公司 | Monascus garlic powder health care product with lipid lowering function and application thereof |
| CN115887520A (en) * | 2022-11-18 | 2023-04-04 | 江苏德和生物科技有限公司 | Composition with auxiliary lipid-lowering effect, preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103584B (en) * | 1985-05-13 | 1986-10-08 | 宁夏轻工业设计研究所 | Process for manufacturing polysaccharide tablets of erythropigment |
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2010
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705704A (en) * | 2013-10-14 | 2014-04-09 | 北京天安康健生物科技有限公司 | Monascus garlic powder health care product with lipid lowering function and application thereof |
| CN115887520A (en) * | 2022-11-18 | 2023-04-04 | 江苏德和生物科技有限公司 | Composition with auxiliary lipid-lowering effect, preparation method and application |
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| Publication number | Publication date |
|---|---|
| CN101849674B (en) | 2012-08-22 |
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