CN101848705A - 氯吡格雷组合物的制备方法 - Google Patents

氯吡格雷组合物的制备方法 Download PDF

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Publication number
CN101848705A
CN101848705A CN200480032288A CN200480032288A CN101848705A CN 101848705 A CN101848705 A CN 101848705A CN 200480032288 A CN200480032288 A CN 200480032288A CN 200480032288 A CN200480032288 A CN 200480032288A CN 101848705 A CN101848705 A CN 101848705A
Authority
CN
China
Prior art keywords
clopidogrel
granule
tablet
compositions
microgranule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200480032288A
Other languages
English (en)
Chinese (zh)
Inventor
R·巴拉特拉杰恩
P·哈尔卡尔
S·罗伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of CN101848705A publication Critical patent/CN101848705A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200480032288A 2003-11-03 2004-11-03 氯吡格雷组合物的制备方法 Pending CN101848705A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0325603.9A GB0325603D0 (en) 2003-11-03 2003-11-03 Organic compounds
PCT/EP2004/012437 WO2005048992A1 (en) 2003-11-03 2004-11-03 Process for preparing clopidogrel compositions

Publications (1)

Publication Number Publication Date
CN101848705A true CN101848705A (zh) 2010-09-29

Family

ID=29725839

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480032288A Pending CN101848705A (zh) 2003-11-03 2004-11-03 氯吡格雷组合物的制备方法

Country Status (8)

Country Link
EP (1) EP1682096A1 (pt)
JP (1) JP2007527414A (pt)
CN (1) CN101848705A (pt)
AU (1) AU2004290511A1 (pt)
BR (1) BRPI0416109A (pt)
CA (1) CA2540965A1 (pt)
GB (1) GB0325603D0 (pt)
WO (1) WO2005048992A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070464A2 (en) * 2004-01-21 2005-08-04 Biofarma Ilac Sanayi Ve Ticaret A.S. A tablet formulation of clopidogrel bisulphate
JP2007533744A (ja) * 2004-04-20 2007-11-22 サノフイ−アベンテイス （＋）−（Ｓ）−α−（２−クロロフェニル）−６，７−ジヒドロチエノ［３，２−Ｃ］ピリジン−５（４Ｈ）酢酸メチル臭化水素酸塩、クロピドロゲル（ｃｌｏｐｉｄｒｏｇｅｌ）臭化水素酸塩の多形体型
EP1740594A1 (en) 2004-04-20 2007-01-10 Sanofi-Aventis Clopidogrel salt and polymorphic forms thereof
US20060223845A1 (en) * 2005-02-24 2006-10-05 Eran Turgeman Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
DE202005013839U1 (de) * 2005-09-01 2005-10-27 Helm Ag Pharmazeutische Formulierung für Salze monobasischer Säuren mit Clopidogrel
WO2007054968A2 (en) * 2005-09-20 2007-05-18 Torrent Pahrmaceuticals Limited Novel pharmaceutical compositions of clopidogrel mesylate
IS2385B (is) * 2006-02-10 2008-07-15 Actavis Group Hf. Klópidógrel bísúlfat lyfjasamsetningar
CZ298349B6 (cs) * 2006-03-09 2007-09-05 Zentiva, A. S Farmaceutická kompozice clopidogrelu hydrogenbromidu
JP2009532462A (ja) * 2006-04-05 2009-09-10 カディラ・ヘルスケア・リミテッド 調節放出クロピドグレル製剤
EP1847259B8 (de) * 2006-04-13 2010-04-14 RIEMSER Specialty Production GmbH Poloxamere als Schmiermittel für pharmazeutische Zusammensetzungen enthaltend Thieno[3,2-c]pyridin-Derivate
EP1847258B2 (de) 2006-04-13 2013-01-16 Acino Pharma AG Partialglyceride als Schmiermittel für pharmazeutische Zusammensetzungen enthaltend Thieno[3,2-c]pyridin-Derivate
WO2007128476A1 (en) * 2006-05-04 2007-11-15 Sandoz Ag Pharmaceutical compositions containing clopidogrel hydrochloride
KR20080055355A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
KR20080055356A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
WO2008129468A2 (en) * 2007-04-20 2008-10-30 Wockhardt Research Centre Pharmaceutical compositions of clopidogrel
ES2376057T3 (es) * 2008-02-26 2012-03-08 Laboratorios Lesvi, S.L. Formulaciones farmacéuticas que contienen clopidogrel.
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
ATE482961T1 (de) 2008-04-25 2010-10-15 Sandoz Ag Hydrogensulfat von 2-acetoxy-5-(a- cyclopropylcarbonyl-2-fluorbenzyl)-4,5,6,7- tetrahydrothienoä3,2-cüpyridin und dessen zubereitung
EA024980B1 (ru) 2009-02-17 2016-11-30 КРКА, д.д., НОВО МЕСТО Лекарственные формы, содержащие основание прасугреля или его фармацевтически приемлемые соли присоединения кислоты, и способы их приготовления
JP2013032289A (ja) * 2009-10-28 2013-02-14 Daiichi Sankyo Co Ltd ワックス安定製剤
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
CN101851247B (zh) * 2010-06-04 2013-05-29 浙江华海药业股份有限公司 含有硫酸氢氯吡格雷晶体颗粒的组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363053C (en) * 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions

Also Published As

Publication number Publication date
WO2005048992A1 (en) 2005-06-02
EP1682096A1 (en) 2006-07-26
AU2004290511A1 (en) 2005-06-02
GB0325603D0 (en) 2003-12-10
JP2007527414A (ja) 2007-09-27
CA2540965A1 (en) 2005-06-02
BRPI0416109A (pt) 2007-01-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20100929