CA2540965A1 - Process for preparing clopidogrel compositions - Google Patents

Process for preparing clopidogrel compositions Download PDF

Info

Publication number
CA2540965A1
CA2540965A1 CA002540965A CA2540965A CA2540965A1 CA 2540965 A1 CA2540965 A1 CA 2540965A1 CA 002540965 A CA002540965 A CA 002540965A CA 2540965 A CA2540965 A CA 2540965A CA 2540965 A1 CA2540965 A1 CA 2540965A1
Authority
CA
Canada
Prior art keywords
clopidogrel
granules
particles
aggregates
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002540965A
Other languages
English (en)
French (fr)
Inventor
Ramaswami Bharatrajan
Pallavi Kharkar
Sunil Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2540965A1 publication Critical patent/CA2540965A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002540965A 2003-11-03 2004-11-03 Process for preparing clopidogrel compositions Abandoned CA2540965A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0325603.9A GB0325603D0 (en) 2003-11-03 2003-11-03 Organic compounds
GB0325603.9 2003-11-03
PCT/EP2004/012437 WO2005048992A1 (en) 2003-11-03 2004-11-03 Process for preparing clopidogrel compositions

Publications (1)

Publication Number Publication Date
CA2540965A1 true CA2540965A1 (en) 2005-06-02

Family

ID=29725839

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002540965A Abandoned CA2540965A1 (en) 2003-11-03 2004-11-03 Process for preparing clopidogrel compositions

Country Status (8)

Country Link
EP (1) EP1682096A1 (pt)
JP (1) JP2007527414A (pt)
CN (1) CN101848705A (pt)
AU (1) AU2004290511A1 (pt)
BR (1) BRPI0416109A (pt)
CA (1) CA2540965A1 (pt)
GB (1) GB0325603D0 (pt)
WO (1) WO2005048992A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070464A2 (en) * 2004-01-21 2005-08-04 Biofarma Ilac Sanayi Ve Ticaret A.S. A tablet formulation of clopidogrel bisulphate
AU2005236034A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Polymorphic forms of methyl (+) - (S) -alpha- (2-chlorophenyl) -6, 7-dihydrothieno [3,2-c]pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
UA84335C2 (ru) 2004-04-20 2008-10-10 Санофи Авентис Клопидогрель и его полиморфные формы
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
DE202005013839U1 (de) * 2005-09-01 2005-10-27 Helm Ag Pharmazeutische Formulierung für Salze monobasischer Säuren mit Clopidogrel
WO2007054968A2 (en) * 2005-09-20 2007-05-18 Torrent Pahrmaceuticals Limited Novel pharmaceutical compositions of clopidogrel mesylate
IS2385B (is) * 2006-02-10 2008-07-15 Actavis Group Hf. Klópidógrel bísúlfat lyfjasamsetningar
CZ2006160A3 (cs) * 2006-03-09 2007-09-05 Zentiva, A. S Farmaceutická kompozice clopidogrelu hydrogenbromidu
US20100145053A1 (en) * 2006-04-05 2010-06-10 Cadila Healthcare Limited Modified release clopidogrel formulation
DE502006005452D1 (de) * 2006-04-13 2010-01-07 Rentschler Pharma Gmbh Poloxamere als Schmiermittel für pharmazeutische Zusammensetzungen enthaltend ThienoÄ3,2-cÜpyridin-Derivate
PL1847258T5 (pl) 2006-04-13 2013-06-28 Acino Pharma Ag Częściowe glicerydy jako środki poślizgowe dla kompozycji farmaceutycznych zawierających pochodne tieno[3,2-c]pirydyny
WO2007128476A1 (en) * 2006-05-04 2007-11-15 Sandoz Ag Pharmaceutical compositions containing clopidogrel hydrochloride
KR20080055356A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
KR20080055355A (ko) * 2006-12-15 2008-06-19 에스케이케미칼주식회사 보관안정성이 우수한 클로피도그렐 함유 포접 복합체
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
ES2408380T3 (es) * 2007-04-20 2013-06-20 Wockhardt Limited Composiciones farmacéuticas de clopidogrel
ES2376057T3 (es) * 2008-02-26 2012-03-08 Laboratorios Lesvi, S.L. Formulaciones farmacéuticas que contienen clopidogrel.
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
DE602008002820D1 (de) 2008-04-25 2010-11-11 Sandoz Ag Hydrogensulfat von 2-Acetoxy-5-(a-cyclopropylcarbonyl-2-fluorbenzyl)-4,5,6,7-tetrahydrothienoÄ3,2-cÜpyridin und dessen Zubereitung
SI2398468T1 (sl) 2009-02-17 2017-03-31 Krka, D.D., Novo Mesto Farmacevtske sestave, ki obsegajo prasugrel ali njegove farmacevtsko sprejemljive kislinske adicijske soli in postopek za njihovo pripravo
JP2013032289A (ja) * 2009-10-28 2013-02-14 Daiichi Sankyo Co Ltd ワックス安定製剤
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
CN101851247B (zh) * 2010-06-04 2013-05-29 浙江华海药业股份有限公司 含有硫酸氢氯吡格雷晶体颗粒的组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363053C (en) * 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions

Also Published As

Publication number Publication date
CN101848705A (zh) 2010-09-29
GB0325603D0 (en) 2003-12-10
JP2007527414A (ja) 2007-09-27
AU2004290511A1 (en) 2005-06-02
BRPI0416109A (pt) 2007-01-02
EP1682096A1 (en) 2006-07-26
WO2005048992A1 (en) 2005-06-02

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Legal Events

Date Code Title Description
FZDE Dead