CN101804087A - Burdock concocting method and concocting product thereof - Google Patents
Burdock concocting method and concocting product thereof Download PDFInfo
- Publication number
- CN101804087A CN101804087A CN 201010142720 CN201010142720A CN101804087A CN 101804087 A CN101804087 A CN 101804087A CN 201010142720 CN201010142720 CN 201010142720 CN 201010142720 A CN201010142720 A CN 201010142720A CN 101804087 A CN101804087 A CN 101804087A
- Authority
- CN
- China
- Prior art keywords
- frying
- temperature
- fructus arctii
- concocting
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a burdock concocting method and a concocting product thereof. The method comprises the following steps: a) taking burdock raw materials with the properties, the microscopic features and the arctiin content conforming to the requirements of Chinese Pharmacopoeia, removing impurities and dust, cleaning the materials, and then drying the materials to obtain clean materials; b) transferring the clean materials into a medicine frying machine to be fried; and (c) discharging the materials after the frying is completed, and sieving the dust. The initial temperature of the medicine frying machine in the frying step is 100 DEG C, the temperature is uniformly improved to the frying temperature of 200 to 300 DEG C in 1 minute, the rotating speed of the medicine frying machine in the temperature rising process is 16 r/min, the rotating speed of the medicine frying machine after the frying temperature is reached is 32 r/min, and the total frying time is between 2 and 8 minutes. The properties of herbal pieces of burdock concocting products prepared by the method of the invention conform to the specification, the content of active ingredients does not have obvious difference from that of raw materials, in addition, the content of cold and cool ingredients after the heating and frying is reduced, and the medicine property is moderate. In addition, the content of fatty oil in the burdock concocting products prepared by the method of the invention is reduced, so the lubricating effect is inhabited.
Description
Technical field:
The present invention relates to the field of Chinese medicines, specifically, the present invention relates to a kind of Fructus Arctii concocting method and processed product thereof.
Background technology:
In recent years, along with the continuous propelling of the modernization of Chinese medicine, the research of Chinese medicine, exploitation and production have obtained development rapidly.Plantation at Chinese crude drug has been promoted " Chinese crude drug quality of production management regulation " (GAP), complete GMP authentication and control measures have been set up in important production aspect, the research of chemical composition of Chinese materia medica and material base has obtained the development of advancing by leaps and bounds, and find and develop new drug from Chinese medicine is hot research both domestic and external field always.But be in the state that relatively lags behind as the processing procedure of the decoction pieces of Chinese medicine preparation production important intermediate and the research of quality standard, and the process of preparing Chinese medicine of Chinese medicine is the important critical process that embodies the Chinese medicine characteristic, will have influence on the modernization with Chinese medicine of further developing of Chinese medicine to the ignorance of prepared slice quality.Though " Chinese medicine processing standard " issued in national each province and city in succession, because of the difference of medical material kind, the place of production, process of preparing Chinese medicine season, processing procedure condition, and do not have unified processing standard, and can cause obscuring of medical material kind and decoction pieces kind, the quality of decoction pieces can't be guaranteed.Although the current prepared slices of Chinese crude drugs have been set up some standards, but because technical conditions fall behind, also there is sizable gap with current international practice standard and market demands, especially kind confusion, concocting method variation, no standard or standard backwardness are the main causes that restricts prepared slices of Chinese crude drugs industry and even Chinese medicine industry health, sustainable development at present.On prepared slices of Chinese crude drugs concocted specification, national standard and provincial standard disunity, standard also lacks restraining forces and authority, has caused managerial confusion, is unfavorable for very much the production of Chinese medicine, even causes influence treatment, the serious consequence of curative effect.Therefore, must accelerate to set up the production standard and the quality standard of the high-quality prepared slices of Chinese crude drugs.
Fructus Arctii is the dry mature fruit of feverfew Fructus Arctii Arctium lappa L., has dispelling wind and heat pathogens, lung qi dispersing rash, the effect of resolving toxin and disinhibiting the throat, be used for anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, the mumps erysipelas, carbuncle sore tumefacting virus all has distribution throughout the country.
Modern age, pharmacological research found that Fructus Arctii had effects such as antibiotic, antiviral, raise immunity, blood sugar lowering, changes of anti-nephropathy, anti-tumor mutation, and bibliographical information Arctiin and aretigenin are arranged is its main active.The document of comprehensive nearly recent decades as can be seen, to the puppet product that the research of Fructus Arctii mainly concentrates on Fructus Arctii differentiate, in the Fructus Arctii medical material pharmacological research of active component and Fructus Arctii Decoction in the discussion aspect the clinical practice, find constantly that with its new chemical constituent and pharmacologically active giving clinical practice and further researching and developing provides foundation.But relevant Fructus Arctii processing procedure, prepared slice quality standard criterion, plurality of active ingredients are extracted, the research report of separation method is few.China's Fructus Arctii aboundresources, Fructus Arctii should obtain effective development and utilization.
Summary of the invention:
First technical problem to be solved by this invention is to provide a kind of Fructus Arctii concocting method, to improve the quality of existing Fructus Arctii processed product.
Second technical problem to be solved by this invention is to provide a kind of Fructus Arctii processed product, to improve the quality and the curative effect of Chinese medicine finished product.
Technical problem to be solved by this invention can be solved by following technical solution:
As first aspect present invention, a kind of Fructus Arctii concocting method, described method comprises the steps:
A) get character, microscopic features, Arctiin content and meet that " the raw material Fructus Arctii that Chinese pharmacopoeia requires is removed impurity and ash bits, cleans, and drying is totally expected then;
B) will totally expect to be transferred in the medicine roasting machine, fry; With
C) fry and finish the back discharging and sieve the dedust bits.
It is characterized in that: described initial temperature of frying medicine roasting machine in the step is 100 ℃, at the uniform velocity be warming up in 1 minute and fry temperature 200-300 ℃, the reversal rate of medicine roasting machine is 16r/min in the temperature-rise period, reach and fry that the reversal rate of medicine roasting machine is 32r/min after the temperature, always the time of frying is 2-8 minute.
The preferred described temperature of frying of frying in the step is 300 ℃, and always the time of frying is 3-5 minute.
Used term " is always fried the time " to the heating-up time and is added constant temperature time in this civilization.
As second aspect present invention, a kind of Fructus Arctii processed product, described processed product adopt Fructus Arctii concocting method of the present invention to concoct and form.
The decoction pieces character of the Fructus Arctii processed product by the inventive method preparation is up to specification, and content of effective has significant difference and fry its cold and cool composition of back through heating not reduce to some extent than raw material, has relaxed the property of medicine.In addition, reduce, thereby suppressed the property of sliding profit by the fatty oil content in the Fructus Arctii processed product of the inventive method preparation.The present invention is by setting a temperature-rise period and an isothermal process in the process of frying, avoided the inhomogeneous and hot-spot of being heated of Fructus Arctii, by when heating up, lower reversal rate being set higher reversal rate has been set in isothermal process simultaneously and further guarantees being heated evenly of Fructus Arctii.
Description of drawings
Fig. 1 is the HPLC chromatogram of Arctiin reference substance;
Fig. 2 is the HPLC chromatogram of aretigenin reference substance;
Fig. 3 is the HPLC chromatogram of Fructus Arctii processed product in the embodiment of the invention 6.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with concrete example, further set forth the present invention.
According to " the following requirement to the raw material Fructus Arctii in the Chinese pharmacopoeia is screened:
Character: long inverted ovoid, slightly flat, microbend, long 5-7mm, wide 2-3mm.The surface taupe, band atropurpureus speckle has several vertical ribs, and usually middle 1-2 bar is more obvious.The blunt circle in top, wide slightly, end face has annulus, middle tool point-like style vestiges; Base portion is slightly narrow, and the areloe color is lighter.Peel is harder, cotyledon yellowish white, rich oil.Feeble QI, little bitter little suffering in back and numb tongue.The powder taupe.The endocarp stone cell is slightly flat, and the surface is seen and is sharp fusiformis, oblong or sharp oval, inlays closely; Rectangle like or strip are seen in the side, and be curved slightly partially, and long 70-224 μ m, wide 13-70 μ m, wall thickness be approximately to 20 μ m, lignify, and pit is grown crosswise.The class polygon is seen in mesocarp reticulated cell transverse section, and anticlinal wall tool choice refreshments shape thickens: vertical section is seen cell elongation, the reticular texture of the fine and closely woven intersection of wall tool.Prism of calcium oxalate diameter 3-9 μ m is present in the xanchromatic mesocarp parenchyma cell crystal cell boundary fuzzy in flakes.Cotyledon cell is full of aleurone grain, and tiny cluster crystal and fatty oil droplet are arranged in the aleurone grain that has.
Total ash: according to " an appendix IX of Chinese pharmacopoeia version in 2005 K-method is checked, must not be crossed 7.0%.
Acid-insoluble ash: according to " an appendix IX of Chinese pharmacopoeia version in 2005 K-method is checked, must not be crossed 2.0%.
Arctiin content: measure Arctiin (C according to high performance liquid chromatography (Chinese Pharmacopoeia version appendix in 2005 VID)
27H
340
11) must not be less than 5.0%, wherein the test of chromatographic condition and system suitability is carried out according to following:
With the octadecyl silane is filler; Second eyeball one water (27: 73) is mobile phase; The detection wavelength is 280nm, and number of theoretical plate calculates by the Arctiin peak and is not less than 1500.
The preparation of reference substance solution: precision weighing Arctiin 6.5mg puts in the 10ml measuring bottle, adds dissolve with methanol and is diluted to scale, shakes up, promptly.
The preparation of need testing solution: sample thief powder (crossing 40 mesh sieves) 0.5g, the accurate title, decide, and places the 50ml measuring bottle; Add methanol 50ml, supersound process (power 150W, frequency 20kHz) 30min adds methanol to scale, shakes up, and filters, and gets subsequent filtrate, filtering with microporous membrane, promptly.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
Embodiment 2
With the raw material Fructus Arctii (place of production: Zhejiang, total ash is 5.36% weight, and sour ash is 1.10%, and the sweet content of Fructus Arctii is 7.56% weight) remove impurity and ash bits, wash in a pan clean, take out, drying is transferred in 100 ℃ the medicine roasting machine then, at the uniform velocity be warming up in 1 minute and fry 200 ℃ of temperature, the reversal rate of medicine roasting machine is 16r/min in the temperature-rise period, reaches to fry that the reversal rate of medicine roasting machine is 32r/min after the temperature, and always the time of frying is 3 minutes.After finishing to fry, take out and sieve dedust bits, obtain the Fructus Arctii processed product.Take a sample and seal and test in order to the road, back.
Embodiment 3-10
Fry step parameter reference example 2 according to listed in the table 1 and carry out embodiment 3-10 and prepare the Fructus Arctii processed product, and sampling and testing, test result sees Table 8.
Fry step parameter among the table 1 embodiment 2-10
| Embodiment | Fry temperature (℃) | Always fry the time (min) |
| ??2 | ??200 | ??3 |
| ??3 | ??200 | ??5 |
| ??4 | ??200 | ??8 |
| ??5 | ??300 | ??3 |
| ??6 | ??300 | ??5 |
| ??7 | ??300 | ??8 |
| ??8 | ??400 | ??3 |
| ??9 | ??400 | ??5 |
| ??10 | ??400 | ??8 |
According to the Fructus Arctii processed product that obtains among the embodiment 2-10 is carried out the analysis of property of medicine component content.
1, instrument and reagent
Agillent1100serie: high performance liquid chromatograph comprises modular pump, UV-detector, Agillent chromatographic work station (U.S. Agillent company limited); BP211D type electronic balance (100,000/, German Sartorius company).SK5200LH type Ultrasound Instrument (Shanghai High Kudos Science Instrument Co., Ltd.).
Arctiin reference substance (819-9401) is provided by Nat'l Pharmaceutical ﹠ Biological Products Control Institute.The aretigenin reference substance is 99.11% for self-control through the HPLC purity check.Agents useful for same is chromatographically pure, and water is redistilled water.
2, chromatographic condition
Chromatographic column: Hypersil BDS C18 (4.6mm * 250mm, 5 μ m); Mobile phase: methanol: water (1: 1.2); Flow velocity: 1.0ml/min; Detect wavelength: 280nm; Column temperature: 25 ℃.Theoretical cam curve must not be lower than 3000 in Arctiin.
With this understanding, other compositions in the sample can obtain baseline separation with other chromatographic peaks to Arctiin and aretigenin peak, and other compositions in the sample do not disturb the mensuration of Arctiin and aretigenin.
3, the preparation of reference substance solution
Accurately respectively take by weighing Arctiin reference substance 6.17mg and the arctigenin reference substance 4.7mg that is dried to constant weight, put respectively in 10ml and the 50ml volumetric flask, add dissolve with methanol and fixed moltenly get final product to scale.
4, the preparation of need testing solution
Get the Fructus Arctii processed product, pulverize, cross 60 mesh sieves, get about 0.5 gram, accurate title is fixed, adds the about 45ml of methanol, and supersound process 25 minutes is taken out, and filters, and filtrate is fixed molten to the 50ml measuring bottle, adds methanol to scale, shakes up, promptly.
5, linear relationship is investigated
Accurate each 2ul of absorption Arctiin reference substance solution (0.617mg/ml), 4ul, 6ul, 8ul, 10ul, 12ul inject high performance liquid chromatograph respectively, by above-mentioned chromatographic condition, measure peak area.With the sample size is abscissa, and peak area is a vertical coordinate, calculates regression equation to be: Y=588.4153X-25.1997, r=0.9998 sees Table 2.
The table 2 Arctiin range of linearity is investigated
| Sample size (μ g) | ??1.234 | ??2.468 | ??3.702 | ??4.936 | ??6.170 | ??7.404 |
| Peak area | ??703.96 | ??1432.10 | ??2135.68 | ??2886.61 | ??3607.22 | ??4216.97 |
The result shows: the Arctiin sample size is in 1.234-7.404 μ g scope, and linear relationship is good.
Accurate each 2ul of absorption aretigenin reference substance solution (0.094mg/ml), 4ul, 6ul, 8ul, 10ul, 12ul inject high performance liquid chromatograph respectively, by above-mentioned chromatographic condition, measure peak area.With the sample size is abscissa, and peak area is a vertical coordinate, calculates regression equation to be: Y=85.6527X-13.3329, r=0.9999.Measurement result sees Table 3.
The table 3 aretigenin range of linearity is investigated
| Sample size (μ g) | ??0.188 | ??0.376 | ??0.564 | ??0.752 | ??0.940 | ??1.128 |
| Peak area | ??162.00 | ??329.07 | ??495.72 | ??669.27 | ??847.96 | ??989.53 |
The result shows: the aretigenin sample size is in 0.188-1.128 μ g scope, and linear relationship is good.
6, precision test
Under the above-mentioned chromatographic condition, get need testing solution, continuous sample introduction 5 times, each 5ul, with the quadrat method deal with data, the RSD of Arctiin peak area is 0.78% as a result, the RSD of aglycon peak area is 0.27%, sees Table 4, shows that the precision of this method is good.
The precision test of table 4 Arctiin and aretigenin
| Sequence number | ??1 | ??2 | ??3 | ??4 | ??5 | ??RSD(％) |
| The Arctiin peak area | ??2365.52 | ??2408.25 | ??2410.53 | ??2406.99 | ??2395.46 | ??0.78 |
| The aretigenin peak area | ??102.56 | ??102.54 | ??101.98 | ??102.24 | ??102.68 | ??0.27 |
7, repeatability test
Get the same test agent that supplies, press the content assaying method operation, carry out 5 parallel laboratory tests, the result shows that the RSD of Arctiin and aretigenin peak area is respectively 0.79% and 1.0%, sees Table 5, shows that repeatability is good.
The repeatability test of table 5 Arctiin and aretigenin
| Sequence number | ??1 | ??2 | ??3 | ??4 | ??5 | ??RSD(％) |
| The Arctiin peak area | ??2077.28 | ??2068.63 | ??2038.37 | ??2045.54 | ??2056.48 | ??0.79 |
| The aretigenin peak area | ??158.59 | ??160.60 | ??157.68 | ??161.59 | ??158.46 | ??1.0 |
8, stability test
At ambient temperature, the same need testing solution of accurate absorption is pressed the sample determination method respectively 0,2, measures peak area in 4,6,8,10 hours.The result shows that chromatographic peak did not have significant change in 10 hours, illustrates that Arctiin and aretigenin are stable in 10h, the results are shown in Table 6.
The stability test of table 6 sample solution
| Time (h) | ??0 | ??2 | ??4 | ??6 | ??8 | ??10 | ??RSD(％) |
| The Arctiin peak area | ??2349.58 | ??2346.55 | ??2369.56 | ??2353.12 | ??2335.52 | ??2341.61 | ??0.49 |
| The aretigenin peak area | ??145.90 | ??144.46 | ??146.35 | ??145.06 | ??146.84 | ??147.56 | ??0.78 |
9, average recovery test
Adopt the application of sample absorption method, the Fructus Arctii sample that precision takes by weighing known content (contains Arctiin 8.10%, aretigenin 0.38%), add Arctiin 10ml (1.72mg/ml) and aglycon reference substance 2ml (0.365mg/ml) respectively, measure by the sample determination method, calculate recovery rate, the average recovery rate of Arctiin is 98.74% as a result, RSD is 0.42% (n=5); The average recovery rate of aretigenin is 98.54%, and RSD is 1.95% (n=5), sees Table 7, shows that the response rate of this method is good.
The average recovery result of the test of table 7 Arctiin and aretigenin
10, sample size is measured
Get need testing solution through 0.45 μ m filtering with microporous membrane, the accurate 5ul that draws injects high performance liquid chromatograph, by above-mentioned chromatographic condition analysis, measures the chromatographic peak area of Arctiin and aretigenin, calculates content, and test result sees Table 8 and Fig. 1-9.
Fry property of medicine component content in technological parameter and the processed product among each embodiment of table 8
| Embodiment | Fry temperature (℃) | Always fry the time (min) | Arctiin content (%) | Aretigenin content (%) | Total content (%) |
| ??2 | ??200 | ??3 | ??6.02 | ??0.49 | ??6.51 |
| ??3 | ??200 | ??5 | ??6.16 | ??0.44 | ??6.6 |
| ??4 | ??200 | ??8 | ??6.17 | ??0.53 | ??6.7 |
| ??5 | ??300 | ??3 | ??5.79 | ??0.68 | ??6.47 |
| ??6 | ??300 | ??5 | ??5.41 | ??0.76 | ??6.17 |
| ??7 | ??300 | ??8 | ??3.77 | ??0.95 | ??4.72 |
| ??8 | ??400 | ??3 | ??4.73 | ??0.7 | ??5.43 |
| ??9 | ??400 | ??5 | ??1.75 | ??0.81 | ??2.56 |
| ??10 | ??400 | ??8 | ??0 | ??0.74 | ??0.74 |
As can be seen from Table 7, compare with the raw material Fructus Arctii, the content of Arctiin all has reduction, illustrate that the parch heating can make Arctiin be subjected in various degree destruction, frying temperature when being 400 ℃ especially, the content loss of Arctiin is very big, and in the time of 200-300 ℃, the loss of Arctiin is less.Arctiin is the main effective ingredient that Fructus Arctii plays cold and cool effect, by concocting, suitably reduces its content, relaxes the property of medicine, thus outstanding others.And all corresponding increase of the content of aretigenin, this is because heating is ruptured the glycosidic bond of part Arctiin, sloughs the cause that sugar becomes aretigenin.
Implement also to find when of the present invention that the character of the Fructus Arctii processed product that obtains is not as the character of the Fructus Arctii processed product that obtains in the time of 300 ℃ when frying for 200 ℃.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (3)
1. Fructus Arctii concocting method, described method comprises the steps:
A) get character, microscopic features, Arctiin content and meet that " the raw material Fructus Arctii that Chinese pharmacopoeia requires is removed impurity and ash bits, cleans, and drying is totally expected then;
B) will totally expect to be transferred in the medicine roasting machine, fry; With
C) fry and finish the back discharging and sieve the dedust bits;
It is characterized in that: described initial temperature of frying medicine roasting machine in the step is 100 ℃, at the uniform velocity be warming up in 1 minute and fry temperature 200-300 ℃, the reversal rate of medicine roasting machine is 16r/min in the temperature-rise period, reach and fry that the reversal rate of medicine roasting machine is 32r/min after the temperature, always the time of frying is 2-8 minute.
2. Fructus Arctii concocting method according to claim 1 is characterized in that:
The described temperature of frying of frying in the step is 300 ℃, and always the time of frying is 3-5 minute.
3. a Fructus Arctii processed product is characterized in that described Fructus Arctii processed product adopts each described Fructus Arctii concocting method preparation among the claim 1-2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101427203A CN101804087B (en) | 2010-04-09 | 2010-04-09 | Burdock concocting method and concocting product thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101427203A CN101804087B (en) | 2010-04-09 | 2010-04-09 | Burdock concocting method and concocting product thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101804087A true CN101804087A (en) | 2010-08-18 |
| CN101804087B CN101804087B (en) | 2012-04-18 |
Family
ID=42606147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101427203A Active CN101804087B (en) | 2010-04-09 | 2010-04-09 | Burdock concocting method and concocting product thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101804087B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491682A (en) * | 2016-12-23 | 2017-03-15 | 庆阳敦博科技发展有限公司 | A kind of concocting method of Chinese medicine great burdock achene |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569138A (en) * | 2004-05-13 | 2005-01-26 | 上海交通大学 | Preparation method of arctium fruit extract for decreasing blood sugar |
| CN201044820Y (en) * | 2006-12-29 | 2008-04-09 | 成都中医药大学 | Apparatus for detecting duration of Chinese medicine process |
-
2010
- 2010-04-09 CN CN2010101427203A patent/CN101804087B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569138A (en) * | 2004-05-13 | 2005-01-26 | 上海交通大学 | Preparation method of arctium fruit extract for decreasing blood sugar |
| CN201044820Y (en) * | 2006-12-29 | 2008-04-09 | 成都中医药大学 | Apparatus for detecting duration of Chinese medicine process |
Non-Patent Citations (2)
| Title |
|---|
| 《山西医药杂志》 20050630 刘彬彬等 牛蒡子炮制的历史沿革及现况研究 443-445 1-3 第34卷, 第6期 2 * |
| 《辽宁中医杂志》 20051231 刘彬彬等 牛蒡子现代炮制工艺研究 1076-1077 1-3 第32卷, 第10期 2 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491682A (en) * | 2016-12-23 | 2017-03-15 | 庆阳敦博科技发展有限公司 | A kind of concocting method of Chinese medicine great burdock achene |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101804087B (en) | 2012-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102119992B (en) | Pharmaceutical preparation prepared from fresh motherwort and fresh aloe and preparation method thereof | |
| CN101524488B (en) | Preparation method of compound bamboo leave flavone dripping pill | |
| CN102349945B (en) | Method for extracting purified total flavonoids from lindera reflexa hemsl by means of macroporous absorption resin | |
| CN101091749A (en) | Medicinal material of polygonum capilalum, extractive, and quality control method | |
| CN101804087B (en) | Burdock concocting method and concocting product thereof | |
| CN106990182B (en) | The characteristic spectrum of Inula britannica chinensis granule is established and detection method | |
| CN110346494B (en) | Method for simultaneously measuring contents of 4 effective components in erigeron breviscapus | |
| CN100382790C (en) | Compound yew drop pills and its preparation method | |
| CN102058637B (en) | Preparation method of patrimia scabiosaefolia extract | |
| CN115078608B (en) | Method for identifying UPLC characteristic patterns of herba abri and herba abri | |
| CN115267008B (en) | Construction method of characteristic spectrum and comparison spectrum of bamboo juice pinellia ternate and distinguishing method of different processed products of pinellia ternate | |
| CN109528810A (en) | A method of there is the Chinese medical extract of antitumor action using high-speed countercurrent chromatography preparation | |
| CN109541072A (en) | A kind of gentianae macrophyllae preparation process screening technique | |
| CN113759056B (en) | Characteristic spectrum of Chinese lobelia and preparation thereof and construction method thereof | |
| CN112578033B (en) | Method for measuring flavonoid components in classic famous formula Dajianzhong decoction | |
| CN105541831B (en) | Medicine root berberrubine derived from amur cork-tree processed product and separation preparation method and application thereof | |
| CN101744937B (en) | Method for extracting effective components of figwort for resisting cerebral ischemia and method for preparing dropping pills | |
| CN100518798C (en) | Dispersible tablet with gastrodia tuber for treating headache, and its testing method | |
| CN114392290A (en) | Ginseng drying processing method | |
| CN105232656A (en) | Processing method of white peony root decoction pieces containing wine and wheat bran | |
| CN105288190A (en) | Anoectochilus roxburghii extract tablet and preparation method thereof | |
| CN104758333B (en) | Paniculate swallowwort C21 steroidal extracts and its production and use | |
| CN100473399C (en) | Compound wurenchun capsule fortreating organizing and chronic hepatitis | |
| CN103197008A (en) | Method for controlling quality of Yanning granules | |
| CN110702822B (en) | Method for detecting content of pseudo-ginseng in pseudo-ginseng traumatic rheumatism ointment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |