CN101797362A - Traditional Chinese medicine composite and preparation method thereof for treating uterine myoma of qi stagnation and blood stasis type - Google Patents
Traditional Chinese medicine composite and preparation method thereof for treating uterine myoma of qi stagnation and blood stasis type Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composite and preparation method thereof for treating uterine myoma of qi stagnation and blood stasis type. The medicine composite comprises the following raw material in part by weight: 1 to 6 raw leech, 5 to 30 tree peony bark, 5 to 20 garden balsam, 5 to 20 Chinese sage herb, 5 to 30 common burreed rhizome, 5 to 30 curcuma zedoary, 5 to 20 euonymus twig and 5 to 20 cassia twig. The preparation method comprises that: the raw leech is smashed into fine powder, after the water decoction, other medicines concentrate into clear paste and is processed to thick paste with ethanol, after being dried and smashed, the thick paste is evenly mixed with the raw leech fine powder and the medicine composite powder is obtained. The medicine composite can be made into tablets, granules or pills. The invention aims to dredge collaterals, eliminate blood stasis, vanish and eliminate stagnation, smooth the collaterals, reconcile qi and blood and remove symptoms. The invention has obvious curative effect for uterine myoma, pelvic cavity inflammatory enclosed mass and other diseases.
Description
Technical field
The invention belongs to a kind of Chinese medicine composition and preparation method, be specifically related to Chinese medicine composition for the treatment of the qi stagnation and blood stasis type hysteromyoma and preparation method thereof.
Background technology
Hysteromyoma is a modal benign tumor in the female sex organ, its clinical manifestation is mainly menorrhagia, menostaxis, lower abdomen enclosed mass, leucorrhoea grow in quantity, the stomachache soreness of waist etc., chronic pelvic inflammatory enclosed mass is many during by the inflammation of chronic pelvic inflammation pelvic cavity connective tissue, due to one or both sides, pelvic cavity uterus have that lamellar thickens, tenderness, enclosed mass.Clinical manifestation is mainly that hypogastric region weigh down to expand, pain, lumbosacral region are ached, menoxenia etc.There is no hysteromyoma, inflammatory masses of pelvic cavity name of disease in the TCM Document, think, for sings and symptomses such as caking, menorrhagia, menostaxis, dysmenorrhea, pelvic cavity distension pain, leukorrhagia among the lower abdomen born of the same parents that hysteromyoma, inflammatory masses of pelvic cavity showed, surely belong to the medical science De “ of motherland mass in the abdomen " the disease category.Disorder person is tangible to levy, and fixes and does not move; False poly-shaping of abdominal mass person, Meeting and departing are irregular." conception vessel is for sick ... woman Dai Xia mass in the abdomen " promptly arranged in " element is asked the bone empty talk ".It is not smooth to propose woman's conception vessel QI and blood, Ze Bing mass in the abdomen." Ling Shu Miraculous Pivot or Divine Axis watery distension " piece of writing is cloud also: " stony mass of uterus is born among the born of the same parents ... day is big with benefit, shape such as cup, and irregular menstrual cycle all is born in the woman." the stony mass of uterus person of its description, promptly rather similar to the clinical hysteromyoma clinical manifestation of the present, and point out that the sick position of stony mass of uterus is at uterus.The traditional Chinese medical science thinks that uterus is the uterus, and " uterus shape of Chinese medicine also comprises the adnexa (fallopian tube, ovary) of both sides except the entity that comprises the uterus." the uterus pathological changes is described, comprise body of uterus and bilateral adnexa thereof.In sum, further illustrate women sub-Disorder purplish or white patches on the skin, sick in the uterus, adnexa, mainly show as among the born of the same parents and lump, unusual through, band, meet the clinical manifestation of existing clinical hysteromyoma, chronic pelvic inflammatory enclosed mass.
The understanding of Chinese medicine Dui Yu mass in the abdomen etiology and pathogenesis, ancient medicine early has argumentation.Carry as " Ling Shu Miraculous Pivot or Divine Axis watery distension " piece of writing: " stony mass of uterus is born among the born of the same parents, pathogenic cold invasion in the cervical orifice of the uterus, and the cervical orifice of uterus obturation, gas must not lead to, and stagnant blood ends to stay when rushing down." point out inward invasion of pathogenic cold, qi depression to blood stasis is stayed in the stagnant blood, long-pending Er Cheng mass in the abdomen.Saying: “ Zhi Droplets and blood during " Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments beginning give birth to a piece of writing " opinion " the long-pending beginning is living " fights mutually and then closes cohesion and must not loose and amass also." say again: " blood coagulation is accumulate and is given birth to and do not loose, and body fluid is puckery to be oozed, work and do not go and amass." " married woman's good recipe is annotated in the school " cloud: " blood stasis person in married woman's abdomen, by long-pending or the clean or stagnant stasis of blood of wind and cold of surplus blood in puerperal of moon amenorrhea, disappearing for a long time and not then is long-pending poly-mass in the abdomen." to have illustrated menstrual period, puerperal surplus blood unclean, or the wind and cold stasis of blood stagnates, among the cohesion born of the same parents, long-pending knot does not loose Er the Cheng mass in the abdomen.In addition, anxiety and rage, functional activity of QI being not smooth, the internal organs qi and blood disorder causes qi depression to blood stasis Yi Cheng mass in the abdomen.As " gynecological beautiful chi " cloud: " disease that the married woman gathers is doing of blood all, and how disgruntled the lid married woman is, and disgruntled then liver hinders, and the blood stored in the liver person also, and the married woman is worried more, and heart master blood person also, and conscience had both been hindered, and its blood does not have institute and leads then absurd excessively, and intrinsic energy is not then walked crosswise." emphasize abnormal emotion, depression and stagnation of QI, long-pending Er Cheng mass in the abdomen.Above doctor family common recognition, anxiety and rage, functional activity of QI being not smooth, or multiparity is detained, and invades in the wind and cold, causes thrombosis are gathered and are not loose and become mass in the abdomen.For the pathogenesis core in all etiology and pathogenesis, all doctor families discuss also rather consistent.Carry as " Jing Yue's complete work married woman rule ": " the blood stasis Zuo Disorder that is detained, only the married woman has it ... always by blood moving in, surplus blood is unclean, one contrary to some extent then be detained day long-pending, and Yi Cheng Disorder gradually." " women section criterion " say: " Fu Ren mass in the abdomen, and belong to disorders of blood ... stagnated blood stops coagulating, and becomes mass in the abdomen." errors in Medicine Corrected says: " gas is invisible can not to lump, and the blood that the caking person must be tangible is also." illustrate that " the be detained core pathogenesis of ” Shi mass in the abdomen of blood stasis has been virtuous common recognition of successive dynasties doctor.
Modern Chinese medicine is thought when touching upon the hysteromyoma treatment: " stopping in the blood stasis is the pathogenesis crux of primary disease ", primary disease should carry out dialectical on the basis of differential diagnosis of diseases, have a lot of patients not have obvious clinical manifestation, but reach on the whole in conjunction with etiology, blood stasis is the principal element of primary disease.The tame argumentation of modern doctor, further having established blood stasis is the argument of the main pathogenesis of primary disease." blood stasis is detained, and gradually Yi Cheng Disorder ” ， Disorder person is tangible reaches, so caking appears in hypogastric region; Stagnation of QI and blood, disorder of QI movement, obstruction of the uterine collateral, stagnation of QI and blood may bring about pain is had a pain so lower abdomen is done to expand; Stagnation of blood stasis, fresh blood must not return through, so menorrhagia or menostaxis or dripping unclean; Blood-stasis internal-depression, fresh blood is difficult gives birth to, and essence of water and grain becomes foul liquid to make a bet among the born of the same parents, so profuse leukorrhea.So reciprocal causation, the feelings day of causing a disease is heavy, and delay is difficult, satisfies into stupid difficult obstinate disease.
" hard masses should be resolved gradually, diseases with invaded pathogens should be treated by expelling, disease caused by accumulations of pathogen should be treated with therapy of dispersion, the disease with retention of pathogen in the body should be treated by elimination therapy that propose according to " element ask the most pure virginity will discuss greatly "." " can make removing mass, can make the heavily fortified point of bursting." purport; for the hysteromyoma syndrome of blood stasis should be the main method of treatment with the blood circulation promoting and blood stasis dispelling; the palace tumor clinical manifestation of Disorder capsule in view of the lower abdomen of hysteromyoma, chronic pelvic inflammatory enclosed mass caking, course of disease delay that disappear; prescription medicine is a purport with blood circulation promoting and blood stasis dispelling, the Disorder eliminating stagnation that disappears, and is aided with that temperature is logical invigorates blood circulation, and blood stasis is loose, mass in the abdomen disappears, venation lead to; QI-blood circulation smoothness then; menses self-regulated, and pain is from ending, and all cards disappear certainly.
The Drug therapy of hysteromyoma adopts the medicine of antagonism gonadal hormone and the medicine of temporary inhibition ovary more.Antagonism gonadal hormone drug main will have progesterone receptor blocker (mifepristone, dl-18-methyl-norgestrienone), androgen (testosterone propionate, methyltestosterone), GuRH-A (leuprorelin, goserelin, triptorelin).The progesterone receptor blocker when clinical application, the Most patients menolipsis, anemia patient Hb raises, climacteric patient 16% menopause can only be as a kind of expectant treatment method.The androgens medicine has that the acne of causing, hair increase, the low manlike untoward reaction such as blunt of sound, so the less young patient that is used for is used to accompany menorrheal nearly involutional patients with uterine myoma clinically more.GuRH-A because decrease in estrogen, similar climacteric syndrome symptom such as hectic fever, perspiration, sleep difference may occur and influence the metabolism of bone ore deposit when clinical use, and generally medication is no more than 6 months.More than the medicine of treatment hysteromyoma is hormone medicine.Recurrence easily after this type of medicine drug withdrawal, medication can produce perimenopausal syndrome, osteoporosis more than 6 months, or cardiopalmus, hypertension, vaginal dryness appear in succession, libido is low, frequent micturition is anxious, odontoseisis, lumbar and back pain, memory obviously go down etc.Basically there is not clear and definite medicine can effect a radical cure hysteromyoma.The clinical GUIZHI FULING JIAONANG that adopts is treated more.GUIZHI FULING JIAONANG is made up of five kinds of Chinese medicine such as Ramulus Cinnamomi, Poria, Cortex Moutan, the Radix Paeoniae Alba, Semen Persicaes, be used for hysteromyoma (especially small-sized uterus muscle intramural myoma) clinically, chronic pelvic inflammatory enclosed mass, treatments such as the anovulatory dysfunctional uterine hemorrhage of endometrium irregular shedding, ovarian cyst, dysmenorrhea, endometriosis.
Summary of the invention
The invention provides a kind of instant, the Chinese medicine composition of the treatment qi stagnation and blood stasis type hysteromyoma that side effect is little, another object of the present invention provides the preparation method of the Chinese medicine composition of treatment qi stagnation and blood stasis type hysteromyoma.
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises that the raw material of following weight parts makes:
5～20 parts of 5～30 parts of Semen Impatientis of 1～6 part of Cortex Moutan of unprocessed leech
5～30 parts of 5～30 parts of Rhizoma Curcumae of 5～20 parts of rhizoma sparganic of Herba Salviae Chinensis
5～20 parts of 5～20 parts of Ramulus Cinnamomi of Ramulus Euonymi.
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises that the raw material of following weight parts makes:
10 parts of 20 parts of Semen Impatientis of 3 parts of Cortex Moutans of unprocessed leech
18 parts of 18 parts of Rhizoma Curcumae of 10 parts of rhizoma sparganic of Herba Salviae Chinensis
10 parts of 10 parts of Ramulus Cinnamomi of Ramulus Euonymi.
The preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma comprises following operating procedure:
Get unprocessed leech and be ground into the unprocessed leech fine powder, standby;
Get Cortex Moutan, Semen Impatientis, Herba Salviae Chinensis, rhizoma sparganic, Rhizoma Curcumae, Ramulus Euonymi, Ramulus Cinnamomi, add water and do not have powder, decoct 2～3 times, fried in shallow oil 2～3 hours for the first time, fried in shallow oil 1～2 hour for the second time, filter, the clear paste that merging filtrate, concentrating under reduced pressure become adds ethanol and makes and contain the alcohol amount and reach 50%～80%, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol also is condensed into the thick paste of relative density about 1.3, vacuum drying or spray drying, pulverize,, promptly get the powdered drug compositions with above-mentioned unprocessed leech fine powder mixing.
The powdered drug compositions incapsulated make capsule.
In described powdered drug compositions, add adjuvant, mix homogeneously, granulation, drying, compacting is wrapped film-coat and is made tablet in flakes, and described adjuvant is polyvinylpolypyrrolidone, magnesium stearate.
The powdered drug compositions of gained can be made pill.
In described powdered drug compositions, add adjuvant, mix homogeneously, granulation, drying are made granule, and described adjuvant is a cane sugar powder.
Pharmaceutical composition of the present invention shows that through the several animal models experiment its action effect is remarkable, and division is as follows:
1, to the influence of estrogen induced mice uterus weight
With the method for estradiol, preparation Mouse Uterus weightening finish model.Pharmaceutical composition of the present invention is given Wister female rats gastric infusion with basic, normal, high serial dosage, and with the positive medicine group of GUIZHI FULING JIAONANG, be administered once every day, altogether 12 weeks of administration.Experimental result is found: each dosage group of pharmaceutical composition of the present invention all can significantly reduce estrogen level, and low dosage and high dose group estrogen level significantly are lower than the GUIZHI FULING JIAONANG group.The uterus weight amount and the GUIZHI FULING JIAONANG group of high dose group do not have significant difference.Show that Mouse Uterus weightening finish that pharmaceutical composition of the present invention causes estrogen has inhibitory action to a certain degree.
Table 1 pharmaceutical composition of the present invention is to the exponential influence of Rats Organs and Tissues
Compare with normal group: * P＜0.05 * * P＜0.01, compare with model group: △ P＜0.05, △ △ P＜0.01
Table 2 pharmaceutical composition of the present invention compares the influence of estrogen level in the rat blood serum
Compare △ △ P＜0.01 with normal group; Compare with model group
P＜0.05,
P＜0.01
2, to the influence of rat at the body uterine activity
Wistar rat grouping back is got one for every group, elder generation's feminisation is after 2 days, with 3.5% chloral hydrate 1mL/100g intraperitoneal anesthesia rat, open the abdominal cavity, find out the uterus, choosing is clamped apart from the about 0.5cm of vagina end place frog heart clip at a side cornua uteri place, be connected with the muscular tension transducer, treat easypro stable back (10min) duodenum drug administration by injection that contracts in uterus, observe uterus curvilinear motion in the 60min, contrast contraction frequency and amplitude size.Experimental result find each dosage group of pharmaceutical composition of the present invention to all have before the inhibitory action, particularly administration in various degree at the body uterine activity and after the administration relatively.Wherein ((2.16g cream powder/kg) relatively the contraction frequency and the energy in uterus all have significant difference (P＜0.01), shrinkage amplitude variant (P＜0.05) to low dose group behind administration 0.5h with just often for 0.54g cream powder/kg) and high dose group.With normal group relatively, high dose group has significant differences (P＜0.01) behind administration 1h, and just often compare, high dose group has significant differences (P＜0.01) behind administration 1h.Show that pharmaceutical composition of the present invention has inhibitory action to rat at the body uterine activity.
3, antiinflammatory action
This laboratory observation the pharmaceutical composition xylol of the present invention influence bringing out the Mice Auricle edema and Ovum Gallus domesticus album is caused the pedal swelling of rat.Experimental result shows, pharmaceutical composition xylol of the present invention causes mice ear all in various degree inhibitory action, and the auris dextra swelling degree of high dose group has significant difference (P＜0.01) than model control group.Show swelling that pharmaceutical composition of the present invention causes acute inflammation, ooze out certain inhibitory action is arranged.Pharmaceutical composition of the present invention causes rat paw edema to Ovum Gallus domesticus album all in various degree inhibitory action.Wherein small dose group relatively has significant difference (P＜0.05) at 1.5h and model control group, and heavy dose of group relatively has significant difference (P＜0.05) in 1.5h, 2h, 3h and model control group.Show that pharmaceutical composition of the present invention causes swelling that acute inflammation causes, oozes out certain inhibitory action is arranged Ovum Gallus domesticus album.
4, the cotton balls implantation is caused the inhibitory action of rat granulation hyperplasia
Get 50 of Wistar rats, in the subcutaneous implantation of rat one side groin sterilize, dry, the cotton balls of weighing.After animal is clear-headed, press 0.54g/kg, 1.08g/kg, 2.16g/kg (by the kg body weight conversion, be equivalent to 1 times, 2 times, 4 times of clinical Coming-of-Age Day consumption) the dosage gastric infusion, continuous 7d, 40min behind the last medicine, peel off and take out granulation tissue and claim weight in wet base, dry back claims granulation cotton balls dry weight, calculates the granulation hyperplasia suppression ratio.Experimental result shows that each dosage group of pharmaceutical composition of the present invention all has in various degree inhibitory action to granulation hyperplasia.Experimental result shows that pharmaceutical composition of the present invention has certain inhibitory action to the granulation hyperplasia of chronic inflammatory disease.
5, analgesic activity
This laboratory observation pharmaceutical composition of the present invention the hot plate method writhing method is caused the inhibitory action influence of pain.Experiment mice is caused pain by hot plate method, survey earlier normal pain threshold, irritate the administration of stomach clothes respectively by 0.013g/kg, 0.026g/kg, 0.052g/kg dosage then, behind medicine 30,60,90,120min surveys the threshold of pain 1 time, calculate analgesia and suppress percentage rate.Experimental result shows that each dosage group of pharmaceutical composition of the present invention causes the inhibitory action that all has bitterly in various degree to hot plate method, and pain threshold is obviously prolonged, and analgesia suppresses percentage rate and improves.Wherein small dose group when 30min and model group significant difference (P＜0.05) is relatively arranged, significant differences (P＜0.01) is arranged when 90min; Middle dosage and heavy dose are organized when 60min and model group relatively has significant differences (P＜0.01), and significant difference (P＜0.05) is arranged when 90min.Show that drug regimen of the present invention has certain inhibitory action to hot plate method is pain caused.
Experiment mice was pressed 0.013g/kg, 0.026g/kg, the continuous gastric infusion of 0.052g/kg dosage 3 days, 40min behind the last medicine, the acetic acid 0.2ml/ of lumbar injection 0.7% only, behind the record injection acetic acid in the 10min and in the 20min mice turn round the body number of times, and calculating analgesia suppression ratio the incubation period of body appears turning round, in record.Experimental result shows that each dosage group Dichlorodiphenyl Acetate of pharmaceutical composition of the present invention causes the inhibitory action that all has bitterly in various degree, and obviously prolonged the incubation period of pain, and analgesia suppresses percentage rate and improves.Mice 10min, 20min are turned round the body number of times obvious suppression effect (P＜0.01) is arranged.Showing that pharmaceutical composition Dichlorodiphenyl Acetate of the present invention is pain caused has certain inhibitory action.
Above experimental result shows the evident in efficacy of medicine composite for curing hysteromyoma of the present invention.Pharmaceutical composition of the present invention shows estrogen induced mice uterus weight result of the test: pharmaceutical composition of the present invention to the inhibitory action of Mouse Uterus weightening finish significantly greater than GUIZHI FULING JIAONANG.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi.
Its preparation method comprises following operating procedure:
Get above-mentioned unprocessed leech and be ground into the unprocessed leech fine powder, standby;
Get above-mentioned Cortex Moutan, Semen Impatientis, Herba Salviae Chinensis, rhizoma sparganic, Rhizoma Curcumae, Ramulus Euonymi, Ramulus Cinnamomi, add water and do not have powder, decoct 2 times, fried in shallow oil 2 hours for the first time, fried in shallow oil 2 hours for the second time, filter, merge twice filtrate, concentrating under reduced pressure becomes clear paste, adding ethanol makes and contains alcohol amount and reach 75%, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol also is condensed into thick paste, vacuum drying, pulverize,, get mixture with above-mentioned unprocessed leech fine powder mixing, add the magnesium stearate of amount of the mixture 1% and the Pulvis Talci of amount of the mixture 1%, mix homogeneously incapsulates (0.4 gram/grain), promptly gets the medicament composition capsule agent for the treatment of the qi stagnation and blood stasis type hysteromyoma.Take each 3 every day three times.
Embodiment 2:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi.
In its preparation process: decoct 3 times, fried in shallow oil 3 hours for the first time, second and third time fried in shallow oil 1 hour, added ethanol and made and contain the alcohol amount and reach 50%, made the medicament composition capsule agent of treatment qi stagnation and blood stasis type hysteromyoma.Other is with embodiment 1.
Embodiment 3:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours, added ethanol and made and contain the alcohol amount and reach 80%, made the medicament composition capsule agent of treatment qi stagnation and blood stasis type hysteromyoma.Other is with embodiment 1.
Embodiment 4:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
1 part of unprocessed leech, 5 parts of Cortex Moutans, 5 parts of Semen Impatientis, 5 parts of Herba Salviae Chinensiss, 5 parts of rhizoma sparganic, 5 parts of Rhizoma Curcumae, 5 parts of Ramulus Euonymis, 5 parts of Ramulus Cinnamomi.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours, made the medicament composition capsule agent of treatment qi stagnation and blood stasis type hysteromyoma.Take each 2 every day three times.Other is with embodiment 1.
Embodiment 5:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
6 parts of unprocessed leech, 30 parts of Cortex Moutans, 20 parts of Semen Impatientis, 20 parts of Herba Salviae Chinensiss, 30 parts of rhizoma sparganic, 30 parts of Rhizoma Curcumae, 20 parts of Ramulus Euonymis, 20 parts of Ramulus Cinnamomi.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours, made the medicament composition capsule agent of treatment qi stagnation and blood stasis type hysteromyoma.Take each 5 every day three times.Other is with embodiment 1.
Embodiment 6:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours, made the medicament composition capsule agent of treatment qi stagnation and blood stasis type hysteromyoma.Other is with embodiment 1.
Embodiment 7:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours; Add the polyvinylpolypyrrolidone of amount of the mixture 5%, mix homogeneously is used 50% alcohol granulation, 60 ℃ of dryings, and the magnesium stearate of adding amount of the mixture 1%, mixing, tabletting (0.4 gram/sheet), the bag film-coat promptly gets tablet.Take each 3 every day three times.Other is with embodiment 1.
Embodiment 8:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi, 21 parts of cane sugar powders.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours; Add cane sugar powder in mixture, mix homogeneously is used 50% alcohol granulation, 60 ℃ of dryings, and granulate, packing (5 gram/bag) promptly gets granule.Take every day three times, each 1 bag, warm boiled water.Other is with embodiment 1.
Embodiment 9:
The pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma comprises the raw material of following weight parts:
3 parts of unprocessed leech, 20 parts of Cortex Moutans, 10 parts of Semen Impatientis, 10 parts of Herba Salviae Chinensiss, 18 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 10 parts of Ramulus Euonymis, 10 parts of Ramulus Cinnamomi, 21 parts of cane sugar powders.
In its preparation process: decoct 2 times, fried in shallow oil 2 hours for the first time, second fried in shallow oil 2 hours; With water pill (the heavy 0.1g of every ball), oven dry, polishing promptly gets pill.Take each 12 balls every day three times.Other is with embodiment 1.
Claims (7)
1. the pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma is characterized in that the raw material that comprises following weight parts makes:
5～20 parts of 5～30 parts of Semen Impatientis of 1～6 part of Cortex Moutan of unprocessed leech
5～30 parts of 5～30 parts of Rhizoma Curcumae of 5～20 parts of rhizoma sparganic of Herba Salviae Chinensis
5～20 parts of 5～20 parts of Ramulus Cinnamomi of Ramulus Euonymi.
2. the pharmaceutical composition of treatment qi stagnation and blood stasis type hysteromyoma according to claim 1 is characterized in that the raw material that comprises following weight parts makes:
10 parts of 20 parts of Semen Impatientis of 3 parts of Cortex Moutans of unprocessed leech
18 parts of 18 parts of Rhizoma Curcumae of 10 parts of rhizoma sparganic of Herba Salviae Chinensis
10 parts of 10 parts of Ramulus Cinnamomi of Ramulus Euonymi.
3. the preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma according to claim 1 and 2 is characterized in that comprising following operating procedure:
Get unprocessed leech and be ground into the unprocessed leech fine powder, standby;
Get Cortex Moutan, Semen Impatientis, Herba Salviae Chinensis, rhizoma sparganic, Rhizoma Curcumae, Ramulus Euonymi, Ramulus Cinnamomi, add water and do not have powder, decoct 2～3 times, fried in shallow oil 2～3 hours for the first time, fried in shallow oil 1～2 hour for the second time, filter, the clear paste that merging filtrate, concentrating under reduced pressure become adds ethanol and makes and contain the alcohol amount and reach 50%～80%, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol also is condensed into the thick paste of relative density about 1.3, vacuum drying or spray drying, pulverize,, promptly get the powdered drug compositions with above-mentioned unprocessed leech fine powder mixing.
4. the preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma according to claim 3 is characterized in that: the powdered drug compositions is incapsulated make capsule.
5. the preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma according to claim 3, it is characterized in that: in described powdered drug compositions, add adjuvant, mix homogeneously, granulation, drying, compacting in flakes, the bag film-coat is made tablet, and described adjuvant is polyvinylpolypyrrolidone, magnesium stearate.
6. the preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma according to claim 3 is characterized in that: the powdered drug compositions of gained can be made pill.
7. the preparation of drug combination method of treatment qi stagnation and blood stasis type hysteromyoma according to claim 3 is characterized in that: in described powdered drug compositions, add adjuvant, and mix homogeneously, granulation, drying are made granule, and described adjuvant is a cane sugar powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010135948XA CN101797362B (en) | 2010-03-25 | 2010-03-25 | Traditional Chinese medicine composite and preparation method thereof for treating uterine myoma of qi stagnation and blood stasis type |
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| CN201010135948XA CN101797362B (en) | 2010-03-25 | 2010-03-25 | Traditional Chinese medicine composite and preparation method thereof for treating uterine myoma of qi stagnation and blood stasis type |
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| CN101797362A true CN101797362A (en) | 2010-08-11 |
| CN101797362B CN101797362B (en) | 2011-08-03 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500501A (en) * | 2002-11-12 | 2004-06-02 | 王红波 | Compound traditional Chinese medicine formulation for curing hysteromyoma |
| CN101647984A (en) * | 2009-09-18 | 2010-02-17 | 秦中文 | Traditional Chinese medicine for promoting blood circulation and removing blood stasis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500501A (en) * | 2002-11-12 | 2004-06-02 | 王红波 | Compound traditional Chinese medicine formulation for curing hysteromyoma |
| CN101647984A (en) * | 2009-09-18 | 2010-02-17 | 秦中文 | Traditional Chinese medicine for promoting blood circulation and removing blood stasis |
Non-Patent Citations (2)
| Title |
|---|
| 《光明中医》 20081130 阎菊芳 《子宫肌瘤的中医治疗概况》 1854-1855 1-7 第23卷, 第11期 2 * |
| 《四川中医》 19971130 陈柏莲 《消癥汤治疗子宫肌瘤100例临床观察》 78-79 1-7 第24卷, 第3期 2 * |
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