CN101796416B - 采用纳米颗粒的荧光共振能量转移检测 - Google Patents

采用纳米颗粒的荧光共振能量转移检测 Download PDF

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Publication number
CN101796416B
CN101796416B CN200880105993.1A CN200880105993A CN101796416B CN 101796416 B CN101796416 B CN 101796416B CN 200880105993 A CN200880105993 A CN 200880105993A CN 101796416 B CN101796416 B CN 101796416B
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fret
particle
dye
particles
fluorescent
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CN101796416A (zh
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R·帕皮内尼
J·W·哈德
W·E·麦克劳克林
D·L·维扎
T·纪
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Eastman Kodak Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/33306—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3342—Polymers modified by chemical after-treatment with organic compounds containing sulfur having sulfur bound to carbon and hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN200880105993.1A 2007-09-07 2008-09-02 采用纳米颗粒的荧光共振能量转移检测 Expired - Fee Related CN101796416B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97061707P 2007-09-07 2007-09-07
US60/970,617 2007-09-07
US12/201,190 2008-08-29
US12/201,190 US8841134B2 (en) 2006-04-10 2008-08-29 Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications
PCT/US2008/010305 WO2009032236A1 (en) 2007-09-07 2008-09-02 Fluorescence resonance energy transfer detection with nanoparticles

Publications (2)

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CN101796416A CN101796416A (zh) 2010-08-04
CN101796416B true CN101796416B (zh) 2014-06-11

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US (1) US8841134B2 (enExample)
EP (1) EP2188634A1 (enExample)
JP (1) JP5313249B2 (enExample)
CN (1) CN101796416B (enExample)
CA (1) CA2707281A1 (enExample)
WO (1) WO2009032236A1 (enExample)

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IT1405070B1 (it) * 2010-10-14 2013-12-16 Univ Bologna Alma Mater Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile
WO2013036743A1 (en) 2011-09-09 2013-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Imaging agents for imaging protease activity and uses thereof
JP6083849B2 (ja) * 2012-07-20 2017-02-22 国立大学法人静岡大学 試料中の標的物質を検出又は定量する方法及びキット
JP6083731B2 (ja) * 2012-09-11 2017-02-22 国立大学法人埼玉大学 Ｆｒｅｔ型バイオプローブ及びｆｒｅｔ計測方法
JP6296050B2 (ja) * 2013-03-08 2018-03-20 コニカミノルタ株式会社 蛍光標識用樹脂粒子
KR101554385B1 (ko) * 2013-03-22 2015-09-21 한국과학기술원 형광 공명 에너지 전이(ｆｒｅｔ)를 이용한 초고해상도 형광 물질 영상화 방법 및 장치
CN103242671B (zh) * 2013-04-28 2014-05-07 商丘师范学院 一种o,o二齿型有机二氟化硼荧光染料及其制备方法
CN103242674B (zh) * 2013-04-28 2014-04-02 孔凯明 一种o,o二齿型有机二氟化硼荧光染料及其制备方法
US9957345B2 (en) 2014-08-18 2018-05-01 International Business Machines Corporation 3D printing with PHT based materials
US10023735B2 (en) 2014-08-18 2018-07-17 International Business Machines Corporation 3D printing with PHT/PHA based materials and polymerizable monomers
US9758620B2 (en) 2015-09-03 2017-09-12 International Business Machines Corporation Tailorable viscoelastic properties of PEG-hemiaminal organogel networks
US9873766B2 (en) 2015-11-24 2018-01-23 International Business Machines Corporation Systems chemistry approach to polyhexahydrotriazine polymeric structures
CN105928919A (zh) * 2016-05-06 2016-09-07 上海大学 利用荧光共振能量转移技术检测纳米颗粒表面硬蛋白冠形成过程参数的方法
CN106117525B (zh) * 2016-06-27 2018-01-05 温州医科大学 pH敏感嵌段聚合物、FRET复合物及其制备方法
EP3418348A1 (en) * 2017-06-21 2018-12-26 Université de Strasbourg Dye-loaded fluorescent polymeric nanoparticles as nano-antenna
WO2019126565A1 (en) * 2017-12-20 2019-06-27 The Regents Of The University Of Colorado, A Body Corporate Lipid derivatives for in vitro or in vivo delivery
JP6822554B2 (ja) * 2018-03-26 2021-01-27 東レ株式会社 色変換組成物、色変換シートならびにそれを含む光源ユニット、ディスプレイおよび照明装置
CN108872172B (zh) * 2018-06-21 2021-05-25 东南大学 一种基于bsa的超分辨成像探针及其制备方法和应用
GB201815329D0 (en) * 2018-09-20 2018-11-07 Sumitomo Chemical Co Light-emitting particle
US11391730B2 (en) * 2019-12-31 2022-07-19 Robert Bosch Gmbh Sensor refresh systems
KR102375074B1 (ko) * 2020-01-28 2022-03-16 한국광기술원 단백질 분해효소 검출입자를 포함한 검출액 및 이를 제조하는 방법
US20230110606A1 (en) * 2020-01-31 2023-04-13 Auragent Bioscience, Llc Ultrabright fluorescent nanocomposite structures for enhanced fluorescent bioassays
CN111239110B (zh) * 2020-02-10 2022-07-22 西北师范大学 一种具有聚集诱导发光性能的卟啉衍生物应用于电化学发光体系的构建方法
CN111318722B (zh) * 2020-04-27 2022-10-11 青海民族大学 一种荧光铜纳米粒子及其制备方法和在检测核黄素和硫离子含量中的应用
CN114196392B (zh) * 2021-11-02 2023-07-18 山西大学 基于巯基功能化碳点检测阿霉素的双模式比率光学探针及其制备方法和应用

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US20090061532A1 (en) 2009-03-05
JP2010538298A (ja) 2010-12-09
CA2707281A1 (en) 2009-03-12
US8841134B2 (en) 2014-09-23
WO2009032236A1 (en) 2009-03-12
EP2188634A1 (en) 2010-05-26
CN101796416A (zh) 2010-08-04
JP5313249B2 (ja) 2013-10-09

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