CN101791442B - 用于带涂层表面的促粘附临时掩蔽物 - Google Patents
用于带涂层表面的促粘附临时掩蔽物 Download PDFInfo
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- CN101791442B CN101791442B CN200910261933.5A CN200910261933A CN101791442B CN 101791442 B CN101791442 B CN 101791442B CN 200910261933 A CN200910261933 A CN 200910261933A CN 101791442 B CN101791442 B CN 101791442B
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- FUTVBRXUIKZACV-UHFFFAOYSA-L zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid Chemical compound [Zn+2].[N-]1C(C=C2C(=C(C=C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 FUTVBRXUIKZACV-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/342,465 | 2008-12-23 | ||
| US12/342,465 US20100161039A1 (en) | 2008-12-23 | 2008-12-23 | Adhesion promoting temporary mask for coated surfaces |
| US12/342465 | 2008-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101791442A CN101791442A (zh) | 2010-08-04 |
| CN101791442B true CN101791442B (zh) | 2015-01-28 |
Family
ID=41729955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910261933.5A Expired - Fee Related CN101791442B (zh) | 2008-12-23 | 2009-12-23 | 用于带涂层表面的促粘附临时掩蔽物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100161039A1 (enExample) |
| EP (1) | EP2201915B1 (enExample) |
| JP (1) | JP5758072B2 (enExample) |
| CN (1) | CN101791442B (enExample) |
| AU (1) | AU2009240876B2 (enExample) |
| CA (1) | CA2686527C (enExample) |
| IL (1) | IL202356A (enExample) |
| RU (1) | RU2526885C2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7819914B2 (en) * | 2008-12-16 | 2010-10-26 | Cordis Corporation | Adhesion promoting primer for coated surfaces |
| US8678046B2 (en) * | 2009-09-20 | 2014-03-25 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| US20120130481A1 (en) * | 2010-11-18 | 2012-05-24 | Robert Falotico | Local vascular delivery of adenosine a2a receptor agonists in combination with other agents to reduce myocardial injury |
| US20120130480A1 (en) * | 2010-11-18 | 2012-05-24 | Robert Falotico | Local vascular delivery of adenosine a2a receptor agonists to reduce myocardial injury |
| US9956385B2 (en) * | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
| EP2995278A1 (en) * | 2014-09-09 | 2016-03-16 | Klinikum rechts der Isar der Technischen Universität München | Medical/surgical implant |
| US20150079288A1 (en) * | 2014-11-25 | 2015-03-19 | Caterpillar Inc. | Plug assembly for masking threaded holes |
| CN106880876A (zh) * | 2017-02-24 | 2017-06-23 | 创领心律管理医疗器械（上海）有限公司 | 一种植入性医疗器械的抗菌涂层的制备方法 |
| SG11202007010XA (en) * | 2018-01-26 | 2020-08-28 | ying ying Huang | Method of selectively modifying the abluminal surface and coating the luminal surface of polymeric stent grafts |
| CN108114326A (zh) * | 2018-02-08 | 2018-06-05 | 西南交通大学 | 一种双向双药物洗脱支架及其制备方法 |
| EP3840788A1 (en) * | 2018-08-24 | 2021-06-30 | Qvanteq AG | Vascular device and method for manufacturing a vascular device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006098889A3 (en) * | 2005-03-14 | 2007-06-28 | Conor Medsystems Inc | Expandable medical device with openings for delivery of multiple beneficial agents |
| EP1952789A1 (en) * | 2007-02-01 | 2008-08-06 | Cordis Corporation | Antithorombotic and anti-Restenotic drug eluting stent |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US4969458A (en) * | 1987-07-06 | 1990-11-13 | Medtronic, Inc. | Intracoronary stent and method of simultaneous angioplasty and stent implant |
| US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| US5213898A (en) * | 1989-10-12 | 1993-05-25 | Norsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6241762B1 (en) * | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
| US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
| NO984143L (no) * | 1998-09-09 | 2000-03-10 | Norsk Hydro As | Ny prosess for å fremstille overflatemodifiserende stoffer |
| US6293967B1 (en) * | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
| ATE307625T1 (de) * | 2000-05-12 | 2005-11-15 | Cordis Corp | Wirkstoffabgabesysteme zur behandlung von gefässerkrankungen |
| CA2312051A1 (en) | 2000-07-13 | 2002-01-13 | Quebepharma Inc. | Methylated nucleotide regulation of gene expression |
| US6764507B2 (en) * | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
| US6783793B1 (en) * | 2000-10-26 | 2004-08-31 | Advanced Cardiovascular Systems, Inc. | Selective coating of medical devices |
| US7077859B2 (en) * | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
| US6663662B2 (en) * | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
| US20040073294A1 (en) | 2002-09-20 | 2004-04-15 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
| US8182527B2 (en) * | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
| US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
| US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
| US7412207B2 (en) | 2002-06-21 | 2008-08-12 | Nokia Corporation | Signal path detection for wireless networks including repeaters |
| US6767405B2 (en) * | 2002-07-10 | 2004-07-27 | Carmeda Ab | Apparatus and process for coating articles |
| AU2003287633A1 (en) | 2002-11-08 | 2004-06-03 | Innovational Holdings, Llc | Method and apparatus for reducing tissue damage after ischemic injury |
| US20040147998A1 (en) * | 2003-01-24 | 2004-07-29 | Nolting John E. | Differentially coated stent |
| US20050070996A1 (en) * | 2003-04-08 | 2005-03-31 | Dinh Thomas Q. | Drug-eluting stent for controlled drug delivery |
| EP2433661A1 (en) | 2003-05-28 | 2012-03-28 | Conor Medsystems, Inc. | Anti-restenotic agents to be delivered from a stent |
| CA2527241A1 (en) * | 2003-06-06 | 2004-12-16 | Sumitomo Electric Industries, Ltd. | Drilled porous resin base material, and method of manufacturing porous resin base material with conductive drilled inner wall surface |
| US20050033417A1 (en) * | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
| US7198675B2 (en) * | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
| US7303758B2 (en) * | 2004-01-20 | 2007-12-04 | Cordis Corporation | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury |
| US20050228477A1 (en) * | 2004-04-09 | 2005-10-13 | Xtent, Inc. | Topographic coatings and coating methods for medical devices |
| US7491225B2 (en) * | 2005-02-16 | 2009-02-17 | Boston Scientific Scimed, Inc. | System and method for deploying a drug-eluting external body and tissue scaffold |
| KR20080008364A (ko) * | 2005-05-05 | 2008-01-23 | 헤모텍 아게 | 관 스텐트의 전면 코팅 |
| US7459400B2 (en) * | 2005-07-18 | 2008-12-02 | Palo Alto Research Center Incorporated | Patterned structures fabricated by printing mask over lift-off pattern |
| US7867547B2 (en) * | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
| US20080047930A1 (en) * | 2006-08-23 | 2008-02-28 | Graciela Beatriz Blanchet | Method to form a pattern of functional material on a substrate |
| WO2008033199A1 (en) * | 2006-09-12 | 2008-03-20 | Boston Scientific Limited | Liquid masking for selective coating of a stent |
| US7575593B2 (en) * | 2007-01-30 | 2009-08-18 | Medtronic Vascular, Inc. | Implantable device with reservoirs for increased drug loading |
| US8187255B2 (en) * | 2007-02-02 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
| US8070797B2 (en) * | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
| US20080243241A1 (en) * | 2007-03-28 | 2008-10-02 | Zhao Jonathon Z | Short term sustained drug-delivery system for implantable medical devices and method of making the same |
| ATE521309T1 (de) * | 2008-01-24 | 2011-09-15 | Boston Scient Scimed Inc | Stent zum ausbringen eines therapeutischen mittels von einer seitenfläche einer stentstrebe |
| US8273404B2 (en) * | 2008-05-19 | 2012-09-25 | Cordis Corporation | Extraction of solvents from drug containing polymer reservoirs |
-
2008
- 2008-12-23 US US12/342,465 patent/US20100161039A1/en not_active Abandoned
-
2009
- 2009-11-26 IL IL202356A patent/IL202356A/en active IP Right Grant
- 2009-11-26 EP EP09177243.4A patent/EP2201915B1/en not_active Not-in-force
- 2009-11-27 CA CA2686527A patent/CA2686527C/en active Active
- 2009-11-27 AU AU2009240876A patent/AU2009240876B2/en not_active Ceased
- 2009-12-22 JP JP2009290189A patent/JP5758072B2/ja active Active
- 2009-12-22 RU RU2009147835/14A patent/RU2526885C2/ru active
- 2009-12-23 CN CN200910261933.5A patent/CN101791442B/zh not_active Expired - Fee Related
-
2010
- 2010-08-11 US US12/854,463 patent/US8927049B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006098889A3 (en) * | 2005-03-14 | 2007-06-28 | Conor Medsystems Inc | Expandable medical device with openings for delivery of multiple beneficial agents |
| EP1952789A1 (en) * | 2007-02-01 | 2008-08-06 | Cordis Corporation | Antithorombotic and anti-Restenotic drug eluting stent |
Also Published As
| Publication number | Publication date |
|---|---|
| US8927049B2 (en) | 2015-01-06 |
| RU2009147835A (ru) | 2011-06-27 |
| US20100161039A1 (en) | 2010-06-24 |
| AU2009240876A1 (en) | 2010-07-08 |
| JP2010148876A (ja) | 2010-07-08 |
| CA2686527A1 (en) | 2010-06-23 |
| EP2201915A1 (en) | 2010-06-30 |
| JP5758072B2 (ja) | 2015-08-05 |
| CN101791442A (zh) | 2010-08-04 |
| IL202356A (en) | 2014-06-30 |
| US20100304007A1 (en) | 2010-12-02 |
| EP2201915B1 (en) | 2015-05-27 |
| AU2009240876B2 (en) | 2015-02-05 |
| RU2526885C2 (ru) | 2014-08-27 |
| CA2686527C (en) | 2015-03-17 |
| IL202356A0 (en) | 2010-06-30 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170508 Address after: Swiss Swiss Patentee after: CARDINAL HEALTH SWITZERLAND 515 GmbH Address before: American Florida Patentee before: Cordis Corp. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
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