CN101784255B - Oral care strip or band and its use and production method - Google Patents

Oral care strip or band and its use and production method Download PDF

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Publication number
CN101784255B
CN101784255B CN200880104460.1A CN200880104460A CN101784255B CN 101784255 B CN101784255 B CN 101784255B CN 200880104460 A CN200880104460 A CN 200880104460A CN 101784255 B CN101784255 B CN 101784255B
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CN
China
Prior art keywords
bar
oral
weight
composition
band
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CN200880104460.1A
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CN101784255A (en
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E·S·阿瓦尼蒂多
S·V·梅洛
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Colgate Palmolive Co
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Colgate Palmolive Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention relates to oral care composition, and the using method and production method of the tape form of said composition, the tape form of the composition can be used to scrubbing or cleaning tooth and oral cavity.Specifically, the present invention relates to a kind of non-traditional denfifrice of banding, which can be for example, adhering to oral cavity especially tooth, and can be assigned as being intended for single use.

Description

Oral care strip or band and its use and production method
Background technology
The formation of bacterial plaque is a reason of gum and periodontal disease and subsequent loss of tooth.Bacterial plaque is thin The mixed-matrix of bacterium, epithelial cell, leucocyte, macrophage and other oral exudates.Bacterium accounts for four points of matrix of bacterial plague Three.The given sample of any bacterial plaque can include up to 400 kinds different types of microorganisms.This mixture includes aerobic simultaneously With anaerobic bacteria, fungi and protozoan.Virus is found that in bacterial plaque sample also.
The matrix of this organism and oral exudate is continuously expanded and is converged with other bacterial plaques for nearby growing.Bacterium Sucrose synthesis levulan and glucan from oral cavity provides energy for microorganism.These glucans, levulan and microorganism shape Into the viscosity skeleton that bacterial plaque is continued to multiply.
Calculus is the yellow of bacterial plaque or white mineralising sediment.Calculus is actually inorganic matter, mainly by calcium and magnesium Phosphate and calcium carbonate composition.Calculus as bacterial plaque is layered to be formed, and only bacterial plaque is layered the mineralising of bacterium.Work as bacterial plaque Protein-carbohydrate matrix build-up calcium and subsequent calcium phosphate crystal body precipitation form calculus during mineralising.Once mineralising calculus shape Into another layer of bacterial adhesion to its surface forms another layer of bacterial plaque, and is subsequently mineralized into calculus.
Bacterial plaque propagation can not be slowed or shut off and damage oral health.Bacterial plaque formed cause carious tooth, gingivitis, periodontosis with And final loss of tooth.Present inventors have recognized that these problems having developed a kind of composition, which is adapted to prevent oral cavity disease Disease, prophylaxis of teeth come off, and realize overall oral health.
Although prior art discloses the purposes of various oral cavity compositions for preventing bacterial plaque, it is still desirable to system in addition Agent, to provide higher utilizability, the performance for preventing mouth disease for improving and higher user's acceptance.The present invention People has understood purposes of traditional denfifrice composition in matrix to create a kind of tooth of non-traditional, portable and consumer satisfaction Band.The content of the invention
The present invention includes oral care product and its using method, and which effectively prevents plaque accumulation prevention of gingivitis.This Invention also includes a kind of dental products and method, and which mitigates subsequent calculus by reducing bacterial plaque.Present invention additionally comprises The method for promoting oral cavity vigor of composition and method to provide the consumer with the product in cleaning oral cavity and provide improvement.
In one embodiment, the present invention includes the oral care product that can be used for the band or strips that clean oral cavity.
Another embodiment of the present invention includes the oral care strips or bar that can adhere to oral surfaces, and which includes necessarily The oral care composition of amount, wherein the oral care composition can clean tooth and/or oral cavity.
Another embodiment of the present invention includes a kind of band or bar, and which includes at least one abrasive material, at least one surface Activating agent, at least one foaming agent, and wherein described band or bar can adhere to oral surfaces, and tooth and/or mouth can be cleaned Chamber, especially by scrub.
Another embodiment of the present invention includes a kind of composition, and said composition includes a kind of oral care strips or bar, The band or bar include at least one abrasive material, at least one surfactant and at least one fluoride source, wherein the mouth Chamber tourniquet or bar adhere to oral surfaces, and can clean tooth and/or oral cavity.
Another embodiment of the present invention includes a kind of method in cleaning oral cavity, and which passes through to glue oral care strips or bar Oral surfaces, such as tooth are attached to, wherein the band or bar include at least one abrasive material, at least one surfactant, at least A kind of foaming agent and at least one fluoride source, wherein after the band or bar adhere to oral surfaces, scrubbing oral cavity with clear Clean mouth chamber.
Another embodiment of the present invention includes a kind of external member, it include oral cavity scrub band or bar, wherein the band or Bar can adhere to oral surfaces, wherein the mouthbrush washes bar includes at least one abrasive material, at least one surfactant, at least A kind of fluoride source and at least one foaming agent, wherein the mouthbrush washes bar adheres to oral surfaces, and can clean tooth Tooth and/or oral cavity, and wherein described external member is comprising being redefined for being intended for single use the band of length or bar.
To realize above and other embodiment foundation the object of the invention, as embodied and broadly described herein, the present invention Oral tape or bar include at least one abrasive material, at least one surfactant, at least one fluoride source and a kind of or many Plant optional member, including vitamin, polymer, enzyme, NMF, preservative and above-mentioned every combination.Description of the drawings
Fig. 1 shows a kind of alternative distributor of dental strip for the present invention and application thereof.Detailed description of the invention
As used in text, each numerical value that scope is used in the range of Short Description.In the range of any value may be selected as this The boundary of scope.In addition, the full content of all references cited herein is incorporated herein by reference.If this public affairs A certain definition in opening is inconsistent with the bibliography quoted, and is defined by the disclosure.
The present invention includes a kind of oral tape or bar that can adhere to oral surfaces, and which includes a number of MC Composition, wherein the oral care composition.When used herein, unless otherwise stated, term " oral care composition " Mean the composition comprising the MC composition described in text.In certain embodiments, the oral tape or bar include to A kind of few abrasive material.In another embodiment, the oral tape or bar include at least one fluoride sources.In another kind of enforcement In scheme, the oral tape or bar include the preparation of at least one foam volume for increasing and producing when using.In another kind of embodiment party In case, the oral tape or bar include at least one aromatic.
In certain embodiments, the oral tape or bar are the precut fragment being intended for single use in packaging, and which can glue Oral cavity, such as tooth are invested, and is ruptured using agitation source (such as Conventional toothbrushes) and/or is helped the dental strip molten in oral cavity Solution.Or, the dental strip of the present invention can be wrapped on spool and be entered by the part of Len req is cut or blocked from the spool Row distribution.The strip length can at increment (at increments) comprising perforation or separable region in order to from the tooth Strip length is easily separated.
In another embodiment, the oral tape or bar further include that at least one vitamin, at least one are poly- Compound, at least one fluoride source, at least one enzyme, at least one NMF and/or at least one preservative and above-mentioned each The combination of item.
In certain embodiments, the abrasive material includes, but not limited to abrasive silica, sodium metaphosphate, metaphosphoric acid Potassium, tricalcium phosphate, Tri-Compress, alumina silicate, calcined alumina, bentonite or other siliceous materials or above-mentioned items Combination.
In certain embodiments, the fluoride source include, but not limited to sodium fluoride, potassium fluoride, prodan, one Sodium fluoro phosphate (MFP) (sodium monfluorophosphate), ammonium fluosilicate, stannous fluoride and stannous chloride.
In certain embodiments, the preparation for increasing bubble amt includes, but not limited to mosanom and polyoxy second Alkene.
In certain embodiments, the aromatic is selected from：Wintergreen, peppermint oil, oleum menthae viridis, oleum sassafras, cloves Oil, Aspartame, acesulfame, saccharin, glucose, fructose and sodium cyclohexylsulfamate and above-mentioned every combination.
In certain embodiments, the abrasive content is for about 1-20% percentage by weights.In certain embodiments, institute It is for about 0.01-5% percentage by weights to state fluoride source content.In certain embodiments, the preparation for increasing foam volume contains Amount is for about 1-90% percentage by weights.In certain embodiments, the fragrance level is for about 0.01-5% percentage by weights. In certain embodiments, the band or bar further include that at least one content is for about the moisturizing of 0.01-5% percentage by weights Agent.
Another embodiment includes a kind of composition, and which includes a kind of to adhere to the mouth that oral surfaces are intended for single use Band or bar are scrubbed in chamber, wherein the mouthbrush washes bar surface area is about 20 to 1000mm2。
The oral care strip may include to can be used for the abrasive material in present invention practice for one or more with composition, its bag Include but be not limited to, abrasive silica such as precipitated silica, its particle mean size up to about 20 microns, for example by The Zeodent 115 that J.M.Huber sells.Useful abrasive material also includes sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, two hydrations Dicalcium Phosphate, alumina silicate, calcined alumina, bentonite or other siliceous materials or above-mentioned every combination.For the two of this paper Silica abrasive polishing material, and other abrasive materials, usual mean particle size range are between about 0.1 to 30 microns, micro- 5 to 15 Between rice.The abrasive silica may be from precipitated silica or silica dioxide gel, such as silica xerogel, such as The United States Patent (USP) 3,538,230 and the United States Patent (USP) 3 of Digiulio of Pader et al., described in 862,307, above-mentioned two patents are led to Cross reference to be incorporated herein in.Certain silica xerogel is by W.R.Grace ＆ Co., Davison Chemical Division is with trade name SyloidSell.The precipitated silica material is included by J.M.Huber Corp with trade name ZeodentThe material sold, including the silica of entitled Zeodent 115 and 119.These abrasive silica exist The United States Patent (USP) 4 of Wason, described in 340,583, the patent is incorporated herein by reference.
In certain embodiments, the oral care strip is used for or with the abrasive material material in composition practice according to the present invention Material includes silica dioxide gel and precipitated amorphous silica, and its oil factor is to be approximately less than 100cc/100g silica, and Scope is between about 45cc/100g to 70cc/100g silica.Oil factor is surveyed using ASTM Rub-Out Method D281 It is fixed.In certain embodiments, the silica is micelle, its mean particle size range between about 3 microns to 12 microns, with And between about 5 to 10 microns.
It is used in particular for the low oil absorption silica abrasive in present invention practice by Davison Chemical Division Of W.R.Grace ＆ Co., Baltimore, Md.21203. are with trade name Sylodent XWASell.For of the invention real The example of the low oil absorption silica abrasive in trampling is Sylodent 650XWA, which is a kind of dioxy being made up of silica gel particle SiClx hydrogel, water content are 29% by weight, about 7 to 10 microns of average diameter, and oil absorption is less than 70cc/100g dioxies SiClx.The abrasive material is about 1 to 40% by weight in the oral care strip of the present invention or with the concentration in composition, at other It is about 5 to 30% in embodiment by weight, is about 10 to 20% in another embodiment by weight.Single bar or In band (i.e. single dose), abrasive material dosage is about 0.01 to 0.4% by weight, by weight about 0.05 to 0.3%, Yi Ji It is about 0.1 to 0.2% in another embodiment by weight.
The oral care strip or band composition can further include one or more fluorine ion source.It is various generation fluorine from The material of son can be used as suitable fluoride source in the present composition.The example of the suitable material for producing fluorine ion sees The United States Patent (USP) 4 of the United States Patent (USP) 3,535,421, Parran of Briner et al., Jr. et al., 885,155 and Widder et al. United States Patent (USP) 3,678,154, above-mentioned patent is incorporated herein by reference.
Representational fluorine ion source includes, but not limited to stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, fluorine Sodium metasilicate, sodium monofluorophosphate (MFP), ammonium fluosilicate and tin fluoride, such as stannous fluoride and stannous chloride, and it is above-mentioned each The combination of item.Some specific embodiments include stannous fluoride or sodium fluoride and its mixture.
In certain embodiments, oral care strip of the invention or band oral cavity composition can also include fluoride sources or confession Fluorine composition, its content are the fluorine ion that be enough to provide about 25ppm to 5000ppm.
Fluoride sources can be added in the composition of the present invention, and its content is for about the composition in one embodiment 0.01% to the 3.0% of weight, or be for about 0.03% to the 1.0% of the composition weight in another embodiment.It is single Content in individual bar or band (i.e. single dose) is for about 0.0001 to 0.003% by weight, for about 0.0005 is arrived by weight 0.003%, it is for about 0.001 to 0.02% by weight in another embodiment.
The oral care strip of the present invention may also include the preparation for increasing foam volume with composition, and foam is adhered to described Produce when the bar or band in oral cavity are scrubbed or stirred.
The exemplary embodiment for increasing the preparation of foam volume includes, but are not limited to polyoxyethylene and some polymer, and which includes But it is not limited to, alginate polymer.
Polyoxyethylene can increase foam volume and the depth of foam that the oral care carrier composition of the present invention is produced.Polyoxyethylene Also commonly referred to as polyethylene glycol (" PEG ") or PEO.The polyoxyethylene molecular weight for being adapted to the present invention for about 200,000 is arrived About 7,000,000.Its molecular weight is for about 600,000 to about 2,000,000 in one embodiment, in another embodiment In be for about 800,000 to about 1,000,000.PolyoxIt is the commodity of the high molecular weight peo of Union Carbide productions Name.
Polyoxyethelene content can be about the 1% of the oral care carrier Ingredients Weight of the oral care composition of the present invention and arrive 90%, in one embodiment for about 5% to 50%, it is for about 10% to 20% in another embodiment.Single bar or In band (i.e. single dose), the dosage of foaming agent is for about 0.01 to 0.9% by weight, by weight 0.05 to 0.5%, Yi Ji It is for about 0.1 to 0.2% by weight in another embodiment.
It is surfactant or compatible table that another kind is optionally included in the preparation in the oral care strips or bar of the present invention The mixture of face activating agent.Suitable surfactant be in wide scope pH quite stable those, such as anion, sun from Son, nonionic or zwitterionic surfactant.
United States Patent (USP) 3 of the suitable surfactant in the United States Patent (USP) 3,959,458, Haefele of Agricola et al., 937,807, and Gieske et al. United States Patent (USP) 4, be described more fully with 051,234, above-mentioned patent is incorporated by reference into Herein.
In certain embodiments, the anion surfactant for this paper includes thering is 10 to 18 carbon originals on alkyl The water soluble salt of the alkyl sulfate (alkyl sulfates) of son, and the sulfonation list of the aliphatic acid with 10 to 18 carbon atoms The water soluble salt of acid glyceride.Lauryl sodium sulfate, sodium lauroyl sarcosine and sodium coconut m fat sodium sulfonate (sodium Coconut monoglyceride sulfonate) be this analog anion surfactants example.Anion table can also be used The mixture of face activating agent.
In another embodiment, the cationic surfactant for the present invention can be broadly defined as with comprising about The derivative of the aliphatic quaternary ammonium compounds of one long alkyl chain of 8 to 18 carbon atoms, such as trimethyl chlorination Ammonium, hexadecylpyridinium chloride, cetyl trimethylammonium bromide, diisobutyl Phenoxyethyl dimethyl benzyl chlorination Ammonium, coconut, cetylpyridinium fluoride and above-mentioned every mixture.
Exemplary cationic surfactant is the quaternary ammonium fluorination of the description of United States Patent (USP) 3,535,421 of Briner et al. Thing, the patent are incorporated herein by reference.Some cationic surfactants are alternatively arranged as the sterilization in the composition Agent.
The Exemplary nonionic surfactant that can be used for the composition of the present invention can be broadly defined as oxyalkylene groups (hydrophily) is condensed the compound for producing with hydrophobic organic compound, and its property can be aliphatic or alkyl aromatic.Suitably The example of nonionic surfactant include, but not limited to polyethers, the polyethylene oxide condensation compound of alkyl phenol, oxirane with The product of expoxy propane and the condensation of reacting ethylenediamine product, the ethylene oxide condensate of fatty alcohol, long-chain tertiary amine oxide, long-chain oxygen Change the mixture of tertiary phosphine, long-chain dioxane sulfoxide and such material.
In certain embodiments, the amphion synthetic surfactant for the present invention can be broadly described as aliphatic The derivative of quaternary ammonium, Phosphonium and sulfonium compound, wherein aliphatic group can be straight or branched, and wherein one of fatty substituents are comprising about 8 to 18 carbon atoms, another includes anion water solubilizing group, such as carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical. The illustrative examples of the surfactant being suitable for inclusion in the composition include, but not limited to sodium alkyl sulfate, lauroyl Sodium sarcosinate, cocoa aminopropyl glycine betaine and polysorbate20 and above-mentioned every composition.
The surfactant or compatible surfactant mixture content in the present compositions can be about entirely 0.1% to the 5.0% of portion's composition weight, is for about 0.3% to 3%, in another embodiment in another embodiment In be for about 0.5% to 2%.In single bar or band (i.e. single dose), the dosage of surfactant for about 0.001 is arrived by weight 0.05%, by weight for about 0.003 to 0.03%, it is for about 0.005 to 0.02% by weight in another embodiment.
The oral care strip or band composition of the present invention may also include aromatic.For the aromatic bag of present invention practice Include, but be not limited to, essential oil and various aromatic aldehydes, ester, alcohol and similar material.The example of the essential oil include oleum menthae viridis, Peppermint oil, wintergreen, oleum sassafras, caryophyllus oil, sage oil, volatile oil extracted from eucalyptus' leaves or twigs, marjoram oil, cinnamon oil, lemon oil, lime oil, circle Shaddock oil and orange oil.Chemicals such as menthol, carvol and anethole are can use also.Some embodiments using peppermint oil and Oleum menthae viridis.
The aromatic be added to the concentration in the oral cavity composition by weight be for about 0.1 to 5%, by weight for About 0.5 to 1.5%.In single bar or band (i.e. single dose), the dosage of aromatic is for about 0.001 to 0.05% by weight, another It is for about 0.005 to 0.015% by weight in a kind of embodiment.
The oral care strip or band composition of the present invention may also include one or more binder to help the band or bar Adhere to oral cavity tissue.Suitable binder includes, but not limited to the polymer with limited water solubility and without water miscible poly- Compound.When saliva is combined with instant compositions, these polymer form film on the hard and soft tissue in oral cavity.It is suitable limited Water dissolvable adhesive includes, but not limited to ethoxy or propyl cellulose.Without the glutinous of composition that is water-soluble and being adapted to the present invention Mixture includes, but not limited to ethyl cellulose, polyoxy resin and silicone.Without water dissolvable adhesive by using a small amount of ethanol or Other can be used safely in oral cavity and the alcohols of human body is added to the present invention.
It is for about 50,000 to about 300,000 that the alternatively possible binder for being suitable for the instant compositions is molecular weight Polyvinylpyrrolidone (" PVP "), suitable PVP can be obtained from GAFChemicals Corporation.
The alternatively possible binder for being suitable for the instant compositions is GantrezWith semisynthetic water-soluble poly The combination of compound hydroxymethyl cellulose (" CMC ").Some embodiments include 2: 1 to 1: 1 (Gantrez：CMC mixing) Thing.Be suitable for the combination be the molecular weight that can be obtained from GAF Chemicals Corporation be for about 30,000 to About 1,000,000 Gantrez and the molecular weight that can be obtained from Aqualon Company are for about 90,000 to about 7,00,000 CMC。
The oral care strip or band composition of the present invention also alternatively includes one or more chelating agent, and which can chelate bacterium Calcium in cell membrane.Bacteria cell wall can be weakened with reference to the calcium and promote bacteria lysis.
Another group of preparation for being suitable for use in the present invention as chelating agent is soluble pyrophosphate.For the present composition In pyrophosphate can be arbitrary alkali metal pyrophosphate.In certain embodiments, salt include four alkali metal pyrophosphates, two Alkali metal DOPP dipyrophosphoric acid salt, three alkali metal list pyrophosphates and above-mentioned every mixture, wherein the alkali metal be sodium or Potassium.The salt is used with its hydration and nonhydrated form.Pyrophosphate for the effective dose of the present composition is typically enough to At least 1.0% pyrophosphate ion, about 1.5% to 6%, about 3.5% to 6% this ion are provided.Single bar or band are (i.e. single Dosage) in chelating agent dosage by weight be for about 0.01 to 0.6%, in another embodiment be for about by weight 0.035 to 0.6%.
The oral care strip or band composition of the present invention also alternatively includes one or more polymer.Such material is this Known to field, with free acid or partly or entirely, the water-soluble alkali (such as potassium and sodium) or ammonium salts of neutralization makes for which With.Some embodiments include maleic anhydride or it is sour with another kind of polymerisable vinylation unsaturated monomer 1: 4 to 4: 1 Copolymer, for example, molecular weight (M.W.) is for about 30,000 to about 1,000,000 ethylene methacrylic ether (methoxy-ethylene).These Copolymer can be obtained from GAF Chemicals Corporation, such as GantrezAN 139(M.W.500,000)、AN 119 (M.W.250,000) and pharmaceutical grade S-97 (M.W.70,000).
Other effective polymer include such as maleic anhydride and ethyl acrylate, hydroxyethyl meth acrylate, 1: 1 copolymer of NVP or ethene, the latter are obtainable, such as Monsanto EMA No.1103, M.W.10,000 and EMA Grade 61, also acrylic acid and methyl or hydroxyethyl meth acrylate, methyl or 1: 1 copolymer of ethyl propylene acid esters, isobutylvinyl ether or NVP.
The normally suitable Olefination or vinylation unsaturated carboxylic acid for polymerization, it is double which includes an activated carbon-carbon olefin Key and at least one carboxyl, that is, it is easy to the acid of olefinic double bonds worked in polymerization comprising one, because the alkene Double bond is present with alpha-beta position relative to carboxyl in monomer molecule, or as a part for terminal methylene group.Such acid Example be acrylic acid, methacrylic acid, ethylacrylic acid, α-chloro-acrylicacid, butenoic acid, β-acryloxy propionic, mountain Pears acid, alpha-chloro sorbic acid, cinnamic acid, β-styrene acrylic, muconic acid, itaconic acid, citraconic acid, mesaconic acid, amylene two Acid, aconitic acid, α-cinnamic acid, 2- benzyl acrylics, 2- cyclohexylacrylics, angelic acid (angelic), umbellic acid, Fumaric acid, maleic acid and acid anhydrides.Other can include ethene with the different alkene monomer of such carboxylic acid monomer's copolymerization Acetate, vinyl chloride, dimethyl maleate ester etc..Copolymer is used for water solubility comprising enough carboxylate groups.
Another kind of polymer formulations include a kind of composition, and which includes the homopolymers of substituted acrylamide and/or insatiable hunger With sulfonic acid and its homopolymers of salt, the polymer of unsaturated sulfonic acid is based especially on, the unsaturated sulfonic acid is selected from acrylamide Alkane sulfonic acid, such as molecular weight are 1,000-2,000,000 2- acrylamide-2-methyl propane sulfonics, and which is described in 1989 years 6 The United States Patent (USP) 4 of moon Zahid on the 27th, 842,847, the patent is incorporated herein by reference.
Another kind of useful polymer formulations include polyaminoacid, especially comprising anion surface active amino acid into Point, such as those of asparatate, glutamic acid and phosphoserine, which is disclosed in the United States Patent (USP) 4,866 of Sikes et al., 161, the patent is incorporated herein by reference.
The oral care strip or band composition of the present invention also alternatively includes one or more enzyme.Useful enzyme includes arbitrary Available protease, glucan hydrolase, endoglycosidase, amylase, change dextranase (mutanases), lipase and viscous egg White enzyme or above-mentioned every compatible blend.In certain embodiments, the enzyme is protease, dextranase, carbohydrate inscribe Enzyme and change dextranase.In another embodiment, the enzyme is papain, endoglycosidase or dextranase and change The mixture of dextranase.Other enzymes for being suitable for the present invention are disclosed in the United States Patent (USP) 5,000,939, U.S. of Dring et al. Patent 4,992,420, United States Patent (USP) 4,355,022, United States Patent (USP) 4,154,815, United States Patent (USP) 4,058,595, United States Patent (USP) 3,991,177 and United States Patent (USP) 3,696,191, above-mentioned patent is incorporated herein by reference.Several compatible enzymes in the present invention Mixture in a kind of enzyme content in one embodiment be for about 0.002% to about 2.0%, in another embodiment In be for about 0.05% to about 1.5%, for about 0.1% to about 0.5% in another embodiment.
Water also is present in the oral cavity composition of the present invention.Water is used for the preparation of business oral cavity composition, answers deionization simultaneously Without organic impurities.Water is generally used for the remainder for supplying the composition, and its content is for about the weight of the oral cavity composition 10% to 50%, about 20% to 40%, or about 10% to the 15% of amount.The amount of the water includes that the free water for adding is added and which The water that arbitrary composition of its material such as D-sorbite or the present invention is concomitantly introduced into.
When preparing oral care strip or band composition, it is sometimes desirable to add certain thickener to provide preferable denseness. In some embodiments, water soluble salt of the thickener for carbopol, carragheen, hydroxyethyl cellulose and cellulose ether, Such as sodium carboxymethylcellulose and carboxymethyl hydroxyethyl cellulose sodium.Natural gum such as karaya, Arabic tree can also be added Glue and tragacanth.Gluey zeopan or fine silica can be used as the composition of the thickener composition further to change Enter the quality of the composition.Amount of thickener is used with 0.5% to the 5.0% of all compositions weight.
In some embodiments of the oral cavity composition, in addition it is also necessary to add NMF to prevent the composition contact Harden during air.Some NMFs are alternatively the sweet taste needed for dentifrice composition is provided or fragrance.The NMF, with pure Based on NMF, content in terms of the dentifrice composition weight, in one embodiment typically about 15% to 70%, Or for about 30% to 65% in another embodiment.
Suitable NMF includes edible polyalcohol, for example glycerine, D-sorbite, xylitol, propane diols and other The mixture of polyalcohol and these NMFs.The mixture of glycerine and D-sorbite can be used as this in certain embodiments The NMF composition of the dentifrice composition described in text.
In addition to mentioned component, embodiment of the present invention can include plurality of optional denfifrice composition, some of which into Divide as described below.Optional composition is included, for example, but not limited to, binder, foaming agent, aromatic, sweetener, in addition anti- Bacterial plaque agent, abrasive material and colouring agent.These and other optional composition is further described in the United States Patent (USP) 5,004 of Majeti, 597th, the United States Patent (USP) 3,959,458 of Agricola et al., and Haefele United States Patent (USP) 3,937,807, above-mentioned patent passes through Reference is incorporated herein in.
The composition of the present invention can use the method production that dental products field is commonly used.
In a kind of exemplary, the dental strip production method is：In ethanol dissolve acrylate copolymer and PVP, and mix 2 minutes to form premix 1 with 2600rpm.
Active component such as vitamin, hexadecylpyridinium chloride (" CPC "), fluoride, abrasive material and any other Required active component is added in premix 1, and mixes 2 minutes to form premix 2 with 2600rpm.
Toothpaste matrix is added to into premix 2, and is mixed 2 minutes with 3000rpm.Final slurry cast is in hydrophobic surface On, about 0.2 millimeter of wet thickness.Film is dried 1-2 hours at about 175-180 DEG C in air circulating oven.
The present invention is related to the composition as herein described to oral application safe and effective amount in terms of its method.These numbers Amount, for example, about 20mm2To 2000mm2The bar or band, about 15 seconds to about 12 hours are kept in mouth.In addition, the oral cavity Care strip or band separate cleaning tooth or can be used together with toothbrush.
Following examples are further described and illustrate the exemplary embodiment in the scope of the invention.The embodiment is only made Illustrate to use and should not be construed as limiting the invention, because spirit and model of many modifications without departing from the present invention may be had Enclose.EmbodimentEmbodiment 1
Embodiment 1 illustrate for the denfifrice and " dental strip " composition for single dose exemplary implementation side Case.In certain embodiments, the single dose can be bar that is precut or boring a hole to allow user's facility to use scheduled volume Bar.In other embodiments, the bar is not pre-cut, and user is torn off or cuts the bar of Len req.
Table 1
When upper front tooth is applied to, the substantially surface area of the dental strip dosage is for about 200mm2(40mm×5mm)。
Embodiment 2
Embodiment 2 illustrates various exemplary embodiments of the dental strip, mean value of the table 1 based on 5 respondents Illustrate the sensory feel of the embodiment.
Table 2
Table 3
Annotation：Structure：Frangible=1, flexible=5.Adhesion：Difference=1, good=5.Should adhere to good before scrub and be maintained up to Decompose with scrub.Dissolving：Difference=1, good=5.Target was decomposed completely for the 20-30 seconds.Foam volume：Difference=1, good=5.Target with Children's denfifrice is identical.Residue：Many=1, without=5.Target is nothing.Taste grade：Without=1, strong=5.Bitter taste：Many=1, nothing =5.Target is nothing.Embodiment 3
Embodiment 3 illustrates various exemplary embodiments of the dental strip for the present invention for discharging immediately.Table 4：For The dental strip composition that active component discharges immediately
Other active components can be used, including：Chlorhexidine, gluconate, ethyl-para-hydroxybenzoate, enzyme are for example GOX, HOX, tannase, papain, glucoamylase, hydrogen peroxide, Q10, biotin, vitamin A and D, stannous fluoride, Zinc citrate, essential oil, herbal medicine such as lily magnolia, rosemary, green tea.Embodiment 4
Embodiment 4 illustrates various exemplary embodiments of the dental strip of the present invention for sustained release.Table 5：For The dental strip composition of active component sustained release

Claims (9)

1. a kind of method of cleaning mammalian mouth, methods described includes：
I oral tape or bar are adhered to dental surface by ()；And
(ii) the oral cavity bar or band are stirred, so as to oral cavity bar described in mechanical disruption or band and/or the promotion oral cavity bar or band Dissolving,
Wherein described oral tape or bar are included：
At least one abrasive silica of (a) 1-20% weight；
At least one surfactant of (b) 0.1-5% weight；
The preparation of at least one increase foam volume of (c) 1-90% weight；With
D () helps the binder that the oral tape or bar adhere to tooth for one or more, wherein the binder includes hydroxyl second Base cellulose, hydroxypropyl cellulose, ethyl cellulose, polyoxy resin, silicone or molecular weight are 50,000 to 300,000 poly- second Alkene pyrrolidone,
Wherein described oral tape or bar can adhere to tooth and can clear up tooth, and
Wherein methods described is non-treatment method.
2. the method for claim 1, wherein the oral tape or bar are precut fragments.
3. method as claimed in claim 1 or 2, wherein the oral tape or bar are further comprising at least one vitamin, virtue Pastil, at least one polymer, at least one fluoride source, at least one enzyme and/or at least one preservative or above-mentioned each The combination of item.
4. method as claimed in claim 3, wherein the fluoride source is selected from one of the following：Sodium fluoride, potassium fluoride, fluorine Sodium metasilicate, sodium monofluorophosphate (MFP), ammonium fluosilicate and stannous fluoride.
5. the method for claim 1, wherein the preparation for increasing foam volume is in mosanom and polyoxyethylene It is a kind of.
6. method as claimed in claim 3, wherein the one kind of the aromatic in the following：Wintergreen, peppermint oil, Oleum menthae viridis, oleum sassafras, caryophyllus oil, Aspartame, acesulfame, saccharin, glucose, fructose and sodium cyclohexylsulfamate, And above-mentioned every combination.
7. method as claimed in claim 3, wherein at least one fluoride source content is 0.01-5% weight.
8. method as claimed in claim 3, wherein the content of the aromatic is 0.01-5% weight.
9. method as claimed in claim 1 or 2, wherein the oral tape or bar comprising at least one content are further The NMF of 0.01-5% weight.
CN200880104460.1A 2007-08-30 2008-07-16 Oral care strip or band and its use and production method Expired - Fee Related CN101784255B (en)

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RU2455972C2 (en) 2012-07-20
AU2008293813C1 (en) 2012-01-12

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