CN101773643A - Chinese medicine preparation for treating mammary gland proliferation diseases and preparation method thereof - Google Patents
Chinese medicine preparation for treating mammary gland proliferation diseases and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicine preparation for treating mammary gland proliferation diseases and a preparation method thereof. The Chinese medicine preparation is mainly formed by fourteen Chinese medicine materials such as rhizoma cyperi, curcuma zedoary, rheum officinale, leech, white paeony root, rhizoma sparganii, Paris polyphylla, ground beetle, Scutellaria baicalensis, almond, peach kernel, prepared rehmannia root, licorice root and the like, is a pure Chinese medicine preparation, is used to mainly treat mammary gland proliferation diseases caused by liver stagnation, blood stasis and qi stagnation, not only can relive stagnation and soften hardness but also can regulate menstruation, invigorate blood circulation and relieve pain, and has the advantages of obvious curative effect and small toxic side effect. According to clinical experiments, the Chinese medicine preparation is proved to be a safe, effective and quick-effect Chinese medicine preparation, the effectiveness is above 95 percent, the remission rate is above 85 percent, the clinical effect is obvious and no relapse occurs after treatment.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of mastopathy, relate in particular to a kind of Chinese medicine preparation for the treatment of hyperplasia of mammary glands, also disclose the preparation method of this medicine simultaneously, belong to traditional Chinese medical science pharmaceutical technology field.
Background technology
Hyperplasia of mammary glands also claims chronic mastopathy, is one of women's frequently-occurring disease, commonly encountered diseases.Along with the continuous development of social modernization, the quickening of people's work, rhythm of life, operating pressure is strengthening, and the sense of crisis in the competition is also strengthening, and this all may become the reason that the hyperplasia of mammary glands people increases year by year.Think that medically the imbalance of hyperplasia of mammary glands and endocrine function is relevant, estradiol, prolactin level are too high, or the ratio of estradiol and progesterone increases, and cause excessive increment of mammary gland tissue or subinvolution and fall ill.Theory of Chinese medical science thinks that its basic pathogenesis is changed to that stagnation of QI due to depression of the liver, phlegm-damp condense, Chong and Ren channel disorder, and irritability is not smooth, and the mechanism of qi dysfunction of the spleen in transportation and transformation dashes to appoint and loses in conditioning, further increases the weight of condensing of phlegm-damp, stagnation of QI and blood may bring about pain.
Treat for this disease doctor trained in Western medicine versatility hormone and operation, common Western medicine has hormone antagonist medicine (tamoxifen etc.), androgens medicine and prolactin antagonist medicine, but all side effect is big, and medicining cycle is long, unsuitable conventional the use.Operative treatment is difficult for being accepted and recurrence easily by patient because of well-known reason.
Though the traditional Chinese medical science has Chinese medicine preparation such as " RUPIXIAO ", " RUKANG PIAN " for the treatment of this disease, on the symptomatic treatments such as treating and still rest on relief of symptoms, palliate the agonizing sufferings, curative effect is undesirable.
To sum up, the home and abroad still lacks a kind of determined curative effect, safe and effective therapeutic method and medicine at present.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of hyperplasia of mammary glands, have activating QI to alleviate the depression, dissipating phlegm and resolving masses, Chong and Ren Meridians regulating effect, determined curative effect, clinical symptoms is improved obviously, cures the back and is difficult for recurrence.
The invention also discloses the preparation method of this medicine, be applicable to suitability for industrialized production.
To hyperplasia of mammary glands pathogeny and Therapeutic Principle, selected following pure Chinese crude drug is made Chinese medicine preparation: (by weight) through the scientific composition compatibility according to China's Chinese medicine in the present invention
Cornu Cervi 20-200 part, Rhizoma Cyperi 15-150 part, rhizoma sparganic 10-100 part, Rhizoma Curcumae 10-100 part, Rhizoma Paridis 10-100 part, Radix Et Rhizoma Rhei 15-150 part, Eupolyphaga Seu Steleophaga 10-100 part, Hirudo 3-30 part, Radix Scutellariae 5-50 part, Semen Armeniacae Amarum 5-50 part, Semen Persicae 15-150 part, Radix Rehmanniae Preparata 5-50 part, Radix Glycyrrhizae 5-50 part, Radix Paeoniae Alba 10-100 part.
The preferred following materials of weight proportions of Chinese medicine composition of the present invention is prepared from:
Cornu Cervi 40-160 part, Rhizoma Cyperi 30-120 part, rhizoma sparganic 20-80 part, Rhizoma Curcumae 20-80 part, Rhizoma Paridis 20-80 part, Radix Et Rhizoma Rhei 30-120 part, Eupolyphaga Seu Steleophaga 20-80 part, Hirudo 6-24 part, Radix Scutellariae 10-40 part, Semen Armeniacae Amarum 10-40 part, Semen Persicae 30-120 part, Radix Rehmanniae Preparata 10-40 part, Radix Glycyrrhizae 10-40 part, Radix Paeoniae Alba 20-80 part.
The preferred following materials of weight proportions of Chinese medicine composition of the present invention is prepared from:
80 parts on Cornu Cervi, 60 parts of Rhizoma Cyperis, 40 parts of rhizoma sparganic, 40 parts of Rhizoma Curcumae, 40 parts of Rhizoma Paridis, 40 parts of 60 parts of, Eupolyphaga Seu Steleophaga of Radix Et Rhizoma Rhei, 12 parts of Hirudos, 20 parts of Radix Scutellariaes, 20 parts in Semen Armeniacae Amarum, 60 parts in Semen Persicae, 20 parts of Radix Rehmanniae Preparata, 20 parts in Radix Glycyrrhizae, 40 parts of the Radix Paeoniae Albas.
Chinese medicine composition of the present invention can be made various dosage forms by the conventional preparation method in this area, as capsule, tablet, granule, pill etc.
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
More than 14 the flavor, Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Hirudo, the Radix Paeoniae Alba are ground into 80～120 order fine powders, mixing; Rhizoma sparganic, Rhizoma Paridis, Eupolyphaga Seu Steleophaga, Radix Scutellariae, Semen Armeniacae Amarum, Semen Persicae, Radix Rehmanniae Preparata, Radix Glycyrrhizae eight flavors decoct with water 3 times, amount of water is respectively 1O, 8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃); With the powder mixing of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Hirudo, the Radix Paeoniae Alba, temperature drying below 85 ℃, pulverize, sieve, make Chinese medicine preparation according to the conventional preparation method of Chinese medicine then.As capsule, tablet, granule, pill etc.
Indication: soothing the liver, circulation of qi promoting, resolving depression, reduce phlegm, eliminating stagnation, Chong and Ren Meridians regulating.Be used for the treatment of adenosis of breast, vexed, irritability, insomnia, forgetful, menoxenia etc.
Usage and consumption: oral meal, each 3-5 grain, every day 3 times.28 days is a course of treatment, 5-7 days at interval, can continue second course of treatment.Also can take continuously.
Function with cure mainly: lump in breast is with the susceptible to anger growth and decline, and is general through before increasing the weight of, and through the back alleviation of pain, with feeling of oppression over the chest and distention of hypochondrium, is apt to strongly fragrant irritability, and the soreness of waist is weak, and is tired, menoxenia, stringy and thready pulse.Be used for the treatment of adenosis of breast, vexed, irritability, insomnia, forgetful, menoxenia etc.
For showing the therapeutic effect of Chinese medicine composition of the present invention, clinical selected 850 examples are diagnosed as the patient who suffers from all kinds of disease of hyperplasia of mammary glands glands, treat with Chinese medicine composition of the present invention, carry out statistical analysis through system's clinical observation and are summarized as follows:
One, diagnostic criteria
Diagnosis basis by relevant nodules of the breast in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine's promulgation in 1994: 1. majority quadrant outside breast has flat lump, that lays one's hand on has a tough hard tubercle of beans size, tenderness can be arranged, and owe clearly on the lump border, with the surrounding tissue adhesion; 2. breast may distending pain, and the growth and decline with susceptible to anger whenever increase the weight of before the menstruation of being everlasting, and alleviate after the menstruation; 3. be more common in 20～40 years old women; 4. the scanning of mammary gland near infrared ray helps diagnosis.Capable in case of necessity histopathological examination is got rid of other breast lesions.
Two, curative effect determinate standard
Clinical cure: lump disappears, and mastalgia disappears, and does not recur in 3 months after the drug withdrawal.
Produce effects: the lump maximum gauge dwindles more than 1/2, and mastalgia disappears.
Effectively: the lump maximum gauge dwindles less than 1/2, and mastalgia alleviates; Or lump dwindles more than 1/2, and mastalgia alleviates not obvious.
Invalid: lump does not dwindle, or increases hardening on the contrary, or simple mastalgia alleviation, and lump does not dwindle.
Three, therapeutic effect
Above-mentioned 850 routine patients are through 1～3 course of therapy of Chinese medicine composition of the present invention, and healing person's 580 examples account for 68.23%, and produce effects 175 examples account for 20.58%, responder's 90 examples.Account for 10.59%.Nonresponder's 5 examples account for 0.59%.Total effective rate can reach 99.41%.
Model case:
Case 1: Zhang, the woman, 32 years old, because of two swelling of the breast pieces companions through preceding pain one month, come my institute's first visit on May 9th, 2005, examine quarter: two swelling of the breast piece pain, the companion is depressed joyless, spiritlessness and weakness, the tongue fur BOHUANG, arteries and veins is profound thin.Last menstrual period on April 26th, 2006, have a medical check-up: two breasts are gone up quadrant outward, and right newborn LOQ has the block lumps of three sheets, in the matter, and tenderness, about 1 * 1cm size.Ultrasound diagnosis is shown: two cyclomastopathy, diagnosis: hyperplasia of mammary glands.Give each 4 of Chinese medicinal composition capsules of the present invention, every day three times, withdraw menstrual period, and on June 30th, 2005, the check of treatment back was followed up a case by regular visits to through half a year: the no pain of two breasts, no lump, sick announcement recovery from illness.
Case 2: the Wang, the woman, 35 years old, accompanied pain 14 months because of two swelling of the breast pieces, come me to examine first visit by gate on April 21st, 2006, examine quarter: two swelling of the breast piece pain, companion's sternal rib pain, susceptible to lose temper due to restlessness, depression, thin white fur of tongue, arteries and veins is profound thin.Have a medical check-up: the outer upper and lower quadrant of two breasts has four piece lamellar lumps, and matter is soft, tenderness, and about 1.5 * 1.5cm size, ultrasound diagnosis is shown: two cyclomastopathy, diagnosis: hyperplasia of mammary glands.Give each 5 of Chinese medicinal composition capsules of the present invention, every day three times, withdraw menstrual period, and on June 11st, 2006 followed up a case by regular visits to and checked after the treatment: no breast pain, and two swelling of the breast pieces disappear, and sick the announcement fully recovered.
Case 3: Huang, woman, 42 years old.The main suit suffered from the hyperplasia of mammary glands history more than 20 year, was interrupted treatment.Nearly 1 week, delayed menstruaion,, not extremely two swelling of the breast pieces did not increase the hardening twinge because of the tired induced insomnia of working.Check: facial pigmentation is obvious, all lays one's hand on and lump directly over two breasts outside reaches, and Huang Zhongjie is still clear, light tenderness, and mobility can.Molybdenum target X-ray sheet shows: two breasts are dispersed in the lamellar ghost, do not see calcification point, examine to be " bilateral breast proliferative disease ".Give each 5 of Chinese medicinal composition capsules of the present invention, serve on 1 month every day three times, lump is deliquescing gradually, hyper-menorrhea.The menstruation in 2 months of continuous clothes is all risen on time, and lump disappears substantially, and pigmented spots disappear on the face, sick announcement recovery from illness.
Case 4: Lee, woman, 38 years old.First visit on February 15 in 2009.Bimastism distending pain 2 years.Patient's disposition depression, the bimastism inspection can touch a plurality of lesser tubercle, obscure boundary, matter is more tough, and tenderness is arranged, dark red, the white and thin fur of tongue, stringy and thready pulse.B ultrasonic and X line molybdenum target are taken the photograph the sheet prompting: two cyclomastopathy.Give each 5 of Chinese medicinal composition capsules of the present invention, every day three times, withdraw menstrual period, and after 2 months, the patient tells symptom and disappears substantially, and two newborn lesser tubercle deliquescing are dwindled, and treatment is after 3 months, and B ultrasonic shows that lump in breast disappears.Recovery from illness.
Chinese medicine composition of the present invention is for stagnation of QI expectorant coagulates, the Chong and Ren channel disorder syndrome is established.Have soothing the liver, circulation of qi promoting, resolving depression, reduce phlegm, the effect of eliminating stagnation, Chong and Ren Meridians regulating.Cornu Cervi dissipating blood stasis for subsidence of swelling pain relieving in the side is treatment newborn painful abdominal mass (cyclomastopathy) key medicine and be monarch.The Rhizoma Cyperi depressed liver-energy dispersing and QI regulating, Radix Et Rhizoma Rhei a surname stasis of blood, rhizoma sparganic, Rhizoma Curcumae removing blood stasis, circulation of qi promoting ends logical, the lung heat clearing of assistant Radix Scutellariae is defended, Semen Armeniacae Amarum profit the heart-nutriment, Semen Persicae tonifying liver void, the Radix Rehmanniae Preparata nourishing kidney is dry, Eupolyphaga Seu Steleophaga, the broken hard removing obstruction inchannels to removing blood stasis of Hirudo, Rhizoma Paridis reducing swelling and alleviating pain, Radix Paeoniae, Radix Glycyrrhizae are comforted taste, are separated poison of drug, and blood stasis had both gone then QI and blood from recovering in the network.All medicines and closing are played activating QI to alleviate the depression, dissipating phlegm and resolving masses, the merit of Chong and Ren Meridians regulating altogether.
Good effect of the present invention is: mainly be made up of 14 flavor Chinese medicines such as Rhizoma Cyperi, the Radix Paeoniae Alba, it is pure Chinese medicinal preparation, the mainly for treating mammary gland proliferative disease is because of person due to the stagnation of liver-QI stagnation of QI and blood, can the resolving depression eliminating stagnation, again can the regulating menstruation and activating blood pain relieving, curative effect is obvious, treating both the principal and secondary aspects of a disease, toxic and side effects is little, and clinical symptom disappearance is rapid, cures the no rebound phenomena in back.Through 2000 many cases clinical verifications, turn out to be safety, effectively, curative effect Chinese medicine preparation rapidly, effective percentage is more than 95%, remission rate is more than 85%.
The specific embodiment
Further specify technical solution of the present invention below by specific embodiment
Embodiment 1
Cornu Cervi 80g, Rhizoma Cyperi 60g, Rhizoma Curcumae 40g, Radix Et Rhizoma Rhei 60g, Hirudo 12g, Radix Paeoniae Alba 40g are ground into fine powder, mixing; Rhizoma sparganic 40g, Rhizoma Paridis 40g, Eupolyphaga Seu Steleophaga 40g, Radix Scutellariae 20g, Semen Armeniacae Amarum 20g, Semen Persicae 60g, Radix Rehmanniae Preparata 20g, Radix Glycyrrhizae 20g decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃).With the powder mixing of Six-element medicine such as Cornu Cervi, temperature drying below 85 ℃, pulverize, sieve, add Mel furnishing pill, other should meet People's Republic of China's version pharmacopeia in 2010 pill item.
Embodiment 2
Take by weighing Cornu Cervi 160g, Rhizoma Cyperi 120g, Rhizoma Curcumae 80g, Radix Et Rhizoma Rhei 120g respectively, Hirudo 24g, Radix Paeoniae Alba 80g are ground into fine powder, mixing; Rhizoma sparganic 80g, Rhizoma Paridis 80g, Eupolyphaga Seu Steleophaga 80g, Radix Scutellariae 40g, Semen Armeniacae Amarum 40g, Semen Persicae 120g, Radix Rehmanniae Preparata 40g, Radix Glycyrrhizae 40g decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃).With the powder mixing of Six-element medicine such as Cornu Cervi, temperature drying below 85 ℃, pulverize, sieve, make various dosage forms according to the conventional preparation method of Chinese medicine then, as capsule, tablet, granule, pill etc.
Embodiment 3
Get Cornu Cervi 40g, Rhizoma Cyperi 30g, Rhizoma Curcumae 20g, Radix Et Rhizoma Rhei 30g, Hirudo 6g, Radix Paeoniae Alba 20g are ground into fine powder, mixing; Rhizoma sparganic 20g, Rhizoma Paridis 20g, Eupolyphaga Seu Steleophaga 20g, Radix Scutellariae 10g, Semen Armeniacae Amarum 10g, Semen Persicae 30g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 10g decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃).With the powder mixing of Six-element medicine such as Cornu Cervi, temperature drying below 85 ℃, pulverize, sieve, canned one-tenth capsule, other should meet the People's Republic of China's 2010 years version pharmacopeia capsule item.
Embodiment 4
Take by weighing Cornu Cervi 80g, Rhizoma Cyperi 60g, Rhizoma Curcumae 40g, Radix Et Rhizoma Rhei 60g, Hirudo 12g, Radix Paeoniae Alba 40g are ground into fine powder, mixing; Rhizoma sparganic 40g, Rhizoma Paridis 40g, Eupolyphaga Seu Steleophaga 40g, Radix Scutellariae 20g, Semen Armeniacae Amarum 20g, Semen Persicae 60g, Radix Rehmanniae Preparata 20g, Radix Glycyrrhizae 20g decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃).With the powder mixing of Six-element medicine such as Cornu Cervi, temperature drying below 85 ℃, pulverize, sieve, make capsule according to the conventional preparation method of Chinese medicine then.
Claims (4)
1. Chinese medicine preparation for the treatment of hyperplasia of mammary glands is characterized in that being made by following parts of medicines by weight:
Cornu Cervi 20-200 part, Rhizoma Cyperi 15-150 part, rhizoma sparganic 10-100 part, Rhizoma Curcumae 10-100 part, Rhizoma Paridis 10-100 part, Radix Et Rhizoma Rhei 15-150 part, Eupolyphaga Seu Steleophaga 10-100 part, Hirudo 3-30 part, Radix Scutellariae 5-50 part, Semen Armeniacae Amarum 5-50 part, Semen Persicae 15-150 part, Radix Rehmanniae Preparata 5-50 part, Radix Glycyrrhizae 5-50 part, Radix Paeoniae Alba 10-100 part.
2. Chinese medicine preparation according to claim 1 is characterized in that being made by following parts of medicines by weight:
Cornu Cervi 40-160 part, Rhizoma Cyperi 30-120 part, rhizoma sparganic 20-80 part, Rhizoma Curcumae 20-80 part, Rhizoma Paridis 20-80 part, Radix Et Rhizoma Rhei 30-120 part, Eupolyphaga Seu Steleophaga 20-80 part, Hirudo 6-24 part, Radix Scutellariae 10-40 part, Semen Armeniacae Amarum 10-40 part, Semen Persicae 30-120 part, Radix Rehmanniae Preparata 10-40 part, Radix Glycyrrhizae 10-40 part, Radix Paeoniae Alba 20-80 part.
3. Chinese medicine preparation according to claim 1 is characterized in that being made by following parts of medicines by weight:
80 parts on Cornu Cervi, 60 parts of Rhizoma Cyperis, 40 parts of rhizoma sparganic, 40 parts of Rhizoma Curcumae, 40 parts of Rhizoma Paridis, 60 parts of Radix Et Rhizoma Rhei, 40 parts of Eupolyphaga Seu Steleophagas, 12 parts of Hirudos, 20 parts of Radix Scutellariaes, 20 parts in Semen Armeniacae Amarum, 60 parts in Semen Persicae, 20 parts of Radix Rehmanniae Preparata, 20 parts in Radix Glycyrrhizae, 40 parts of the Radix Paeoniae Albas.
4. according to the production method of claim 1 or 2 or 3 described Chinese medicine preparation, it is characterized in that: above 14 flavors, Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Hirudo, the Radix Paeoniae Alba are ground into 80～200 order fine powders, mixing; Rhizoma sparganic, Rhizoma Paridis, Eupolyphaga Seu Steleophaga, Radix Scutellariae, Semen Armeniacae Amarum, Semen Persicae, Radix Rehmanniae Preparata, Radix Glycyrrhizae eight flavors decoct with water 3 times, amount of water is respectively 10,8,6 times, and decocting time is 3,2,1 hours, collecting decoction, filter, filtrate is concentrated into the thick paste of relative density 1.25-1.30 (80 ℃); With the powder mixing of Cornu Cervi, Rhizoma Cyperi, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Hirudo, the Radix Paeoniae Alba, temperature drying below 85 ℃, pulverize, sieve, make Chinese medicine preparation according to the conventional preparation method of Chinese medicine then.
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| CN104707105A (en) * | 2015-03-11 | 2015-06-17 | 范志民 | Traditional Chinese medicine preparation for treating mammary gland hyperplasia and preparation method thereof |
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| CN1970065A (en) * | 2006-11-30 | 2007-05-30 | 灵宝市商业医院 | Medicament for treating hyperplasia of prostate |
| CN101129948A (en) * | 2007-09-29 | 2008-02-27 | 陕西思壮药业有限公司 | Pharmaceutical composition for treating gynecology hysteromyoma and processes for producing same |
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| CN1970065A (en) * | 2006-11-30 | 2007-05-30 | 灵宝市商业医院 | Medicament for treating hyperplasia of prostate |
| CN101129948A (en) * | 2007-09-29 | 2008-02-27 | 陕西思壮药业有限公司 | Pharmaceutical composition for treating gynecology hysteromyoma and processes for producing same |
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| Title |
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| 《实用中西医结合临床》 20051025 张红霞等 中药内服外用治疗乳腺增生50例 第5卷, 第05期 2 * |
| 《山东中医药大学学报》 19940920 申殿栋，季志云，申玲 乳腺增生病中医治疗近况 第18卷, 第05期 2 * |
| 《湖北中医杂志》 20050510 魏子刚 乳腺增生症的辨证分型治疗 第27卷, 第05期 2 * |
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| CN104707105A (en) * | 2015-03-11 | 2015-06-17 | 范志民 | Traditional Chinese medicine preparation for treating mammary gland hyperplasia and preparation method thereof |
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